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荷胰腺癌
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  pancreatic tumor borne
     The Imaging of ~(99)Tc~m-HYNIC-TOC in Pancreatic Tumor Borne Nude Mice
     肿瘤显像剂~(99)Tc~m-HYNIC-TOC荷胰腺癌裸鼠的显像
短句来源
     The distribution of 99TcmHYNICTOC in mice and its imaging features in the SSRpositive pancreatic tumor borne in nude mice are investigated in detail.
     进行了生长抑素受体显像剂99Tcm-HYNIC-TOC的正常小鼠体内分布、异常毒性及荷胰腺癌裸鼠的显像研究。
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  bearing pancreas carcinoma
     99mTc-Sandostatin imaging was performed in 16 nude mice bearing pancreas carcinoma, tumor to normal tissues ratio (T/N) was calculated.
     对16只荷胰腺癌裸鼠模型行99mTc—Sandostatin显像,计算瘤体与对侧正常组织的放射性比值(T/N);
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  “荷胰腺癌”译为未确定词的双语例句
     Six hours after ~(99m)Tc-sandostatin administration,the T/NT ratio was 2.53±0.84.Five mice showed negative findings,and the T/NT ratio was 1.04±0.06.Positive correlations were obtained between the T/NT ratio and the expression of SSTR1 and SSTR2 mRNA,especially SSTR2(r=0.807,P<0.01).
     5只荷胰腺癌裸鼠显像弱阳性或阴性,6 hT/NT比值为1.04±0.06。 肿瘤组织有SSTR1、SSTR2、SSTR5 mRNA表达,SSTR1、SSTR2的表达水平与肿瘤显像阳性裸鼠T/NT比值呈正相关,r分别为0.597(P<0.05)和0.807(P<0.01)。
短句来源
     Methods Nude mice bearing human pancreas carcinoma xenograft were established in advance. ~(99m)Tc-sandostatin imaging was performed in 18 nude mice and tumor to normal tissue ratio(T/NT) was calculated. mRNA expression of SSTR1,SSTR2 and SSTR5 in tumor tissue was detected by RT-PCR.
     方法建立荷胰腺癌动物模型,对18只荷胰腺癌裸鼠模型行99mTc-sandostatin显像,勾画感兴趣区,计算瘤体与对侧正常组织的放射性比值(T/NT),用RT-PCR方法检测肿瘤组织SSTR1、SSTR2、SSTR5 mRNA的表达水平,对各SSTR亚型表达水平与T/NT比值进行相关性分析。
短句来源
     cell membrane intacting, chromatin condensation, nucleic fragmentation and apoptotic body formation were also observed with electron microscope. The expression of Fas and Fas-L on the membrane of pancreatic adenocarcinoma cell increased after treatment with As2O3. The survival time of tumor loading nude mice treated with As2O3 was prolonged (P<0.01, vs control group).
     As2O3也可显著抑制荷胰腺癌裸鼠腹水的生成,延长生存期(P<0.01),Fas、Fas-L表达在As2O3作用后2d上升,3d达最高,以后表达量下降。
短句来源
     Objective To evaluate the value of ~(99m)Tc-sandostatin scintigraphy in targeted diagnosis of pancreas carcinoma and the correlation with expression of somatostatin receptor(SSTR) reporter gene in tumor tissue.
     目的探讨荷胰腺癌裸鼠模型肿瘤组织生长抑素受体(SSTR)报告基因的mRNA表达水平与99mTc-sandostatin显像对肿瘤的靶向诊断价值及二者的相关性。
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     Objective To study the effect of intra-tumor injection of slow-release 5-FU on pancreatic carcinoma cells in nude mice,and on changes in serum tumor markers and cellular immunity of patients with pancreatic carcinoma.
     目的 观察5 -氟尿嘧啶( 5 FU)缓释剂对荷胰腺癌裸鼠肿瘤细胞及胰腺癌患者血清肿瘤标记物和细胞免疫的影响。
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  相似匹配句对
     ARTERIES OF PANCREAS
     的动脉
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     Pancreatic Cancer
    
短句来源
     5-[~(125)I]Iodo-2′-deoxyuridine in the of Pancreatic Cancer in Mice
     ~(125)I-UdR在腺癌瘤鼠治疗中的应用
短句来源
     Carcinoma of the Pancreas
     (腺癌)(Ⅰ)
短句来源
     Therapeutic effects of survivin antisense oligonucleoUde on nude mice bearing human pancreatic carcinoma xenograft
     survivin反义寡核苷酸对腺癌瘤裸鼠的治疗作用
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Objective To prepare 111 Inpentetreotide for clinical applications Methods The pentetreotide was synthesized in our own laboratory An OctreoScanlike kit containing our synthetic pentetreotide and a set of other reagents were made for labeling with 111 In With the kit, 111 Inpentetreotide could be prepared on site Results The product showed high labeling yield (>99%) and good stability in vitro (>95% up to 8 h after reconstitution) Biological properties were evaluated by pharmacological experiments The rapid...

Objective To prepare 111 Inpentetreotide for clinical applications Methods The pentetreotide was synthesized in our own laboratory An OctreoScanlike kit containing our synthetic pentetreotide and a set of other reagents were made for labeling with 111 In With the kit, 111 Inpentetreotide could be prepared on site Results The product showed high labeling yield (>99%) and good stability in vitro (>95% up to 8 h after reconstitution) Biological properties were evaluated by pharmacological experiments The rapid blood clearance (<1%ID/g by 30 min) and high urine excretion (>20%ID of renal up to 4 h post administration) were observed in biodistribution study of the normal mice Moreover, high T/B ratios (366 up to 8 h postinjection) and T/NT ratios (T/blood 409012, T/muscle 500021 by 4 h), as well as good quality images were demonstrated in a pancreas tumor bearing mouse model Conclusions The pentetreotide ligand, kit and its 111 In labeling product, prepared in our laboratory, have a good physicochemical and biological properties for the clinical application as an imaging agent of somatostatin receptor positive tumors

目的制备肿瘤阳性显像剂111Inpentetreotide并进行实验研究。方法固相多肽合成法制备配体pentetreotide,正交实验确定111In标记药盒DOCT的组分及各组分间的配比,测定药盒及其标记产物111Inpentetreotide的理化性质,建立相关的质控方法,并通过药理实验确定其生物性能和安全性。结果合成产物pentetreotide鉴定后制成用于111In标记的药盒;药盒在使用现场与111InCl3溶液反应后,可得到标记率>99%的111Inpentetreotide,并在室温下稳定至标记后8h(放化纯度>95%)。正常小鼠分布实验显示111Inpentetreotide有很快的血清除速率(注射后30min全血百分注射剂量<1%)和较高的尿排泄(给药后4h>20%)。荷胰腺癌裸鼠的生物分布和γ显像表明:显像剂的血液清除很快,放射性主要从泌尿系统排泄,给药后5min膀胱显影,至30min双肾和膀胱的放射性达50%ID;T/B比值在给药后逐渐增高,至8h可达366,给药后1~24h均可进行荷胰腺癌裸鼠模型肿瘤阳性显像,4~8h的图像质量最佳。结论研制的生长抑素...

目的制备肿瘤阳性显像剂111Inpentetreotide并进行实验研究。方法固相多肽合成法制备配体pentetreotide,正交实验确定111In标记药盒DOCT的组分及各组分间的配比,测定药盒及其标记产物111Inpentetreotide的理化性质,建立相关的质控方法,并通过药理实验确定其生物性能和安全性。结果合成产物pentetreotide鉴定后制成用于111In标记的药盒;药盒在使用现场与111InCl3溶液反应后,可得到标记率>99%的111Inpentetreotide,并在室温下稳定至标记后8h(放化纯度>95%)。正常小鼠分布实验显示111Inpentetreotide有很快的血清除速率(注射后30min全血百分注射剂量<1%)和较高的尿排泄(给药后4h>20%)。荷胰腺癌裸鼠的生物分布和γ显像表明:显像剂的血液清除很快,放射性主要从泌尿系统排泄,给药后5min膀胱显影,至30min双肾和膀胱的放射性达50%ID;T/B比值在给药后逐渐增高,至8h可达366,给药后1~24h均可进行荷胰腺癌裸鼠模型肿瘤阳性显像,4~8h的图像质量最佳。结论研制的生长抑素受体肿瘤阳性显像剂11?

The distribution of 99TcmHYNICTOC in mice and its imaging features in the SSRpositive pancreatic tumor borne in nude mice are investigated in detail. The results show that the blood radioactivity decreased rapidly and the tracer excretes mostly from the urinary tract after injection. SSRpositive pancreatic tumor borne in nude mice can be imaged 1 hour after injection and the image becomes optimal 3 hours later. The clear image indicates that the 99TcmHYNICTOC prepared in this experiment...

The distribution of 99TcmHYNICTOC in mice and its imaging features in the SSRpositive pancreatic tumor borne in nude mice are investigated in detail. The results show that the blood radioactivity decreased rapidly and the tracer excretes mostly from the urinary tract after injection. SSRpositive pancreatic tumor borne in nude mice can be imaged 1 hour after injection and the image becomes optimal 3 hours later. The clear image indicates that the 99TcmHYNICTOC prepared in this experiment a very promising SSR tracer.

进行了生长抑素受体显像剂99Tcm-HYNIC-TOC的正常小鼠体内分布、异常毒性及荷胰腺癌裸鼠的显像研究。正常小鼠及荷胰腺癌裸鼠的体内分布表明:该显像剂血液清除快,主要通过泌尿系统排泄。注射后1h肿瘤即显影,4h肿瘤与对侧肢体肌肉的T与NT摄取比达到7.7,此时肿瘤显像效果最佳。异常毒性实验表明99Tcm-HYNIC-TOC无异常毒性。

Objective To investigate the effect and mechanism of As2O3 on the growth of pancreatic adenocarcinoma cell in vitro and in vivo. Methods Pancreatic adenocarcinoma cell line SW-8902 was treated with 0. 125-2 μmol/L of As2O3 for 2~10 days. Morphological changes, growth inhibiting and expression of Fas, Fas-L were observed. Eighty BALB/c-nu/nu nude mice were randomly divided into 4 group. 1 ×10~7 pancreatic adenocarcinoma cells(SW-8902) were injected into the abdomen of the nude mice. The mice in group 1 (control...

Objective To investigate the effect and mechanism of As2O3 on the growth of pancreatic adenocarcinoma cell in vitro and in vivo. Methods Pancreatic adenocarcinoma cell line SW-8902 was treated with 0. 125-2 μmol/L of As2O3 for 2~10 days. Morphological changes, growth inhibiting and expression of Fas, Fas-L were observed. Eighty BALB/c-nu/nu nude mice were randomly divided into 4 group. 1 ×10~7 pancreatic adenocarcinoma cells(SW-8902) were injected into the abdomen of the nude mice. The mice in group 1 (control group) were treated with normal saline, and the mice in group 2,3 and 4 were treated with 5, 10 and 20 mg/kg of As2O3. The survival period of the nude mice was evaluated. Results The pancreatic adenocarcinoma cell treated with 1~2 μmol/L As2O3 presented typical apoptotic features; subdiploid DNA cell peak was detected by flow cytometry; marked DNA ladder was showed in agarose electrophoresis; cell membrane intacting, chromatin condensation, nucleic fragmentation and apoptotic body formation were also observed with electron microscope. The expression of Fas and Fas-L on the membrane of pancreatic adenocarcinoma cell increased after treatment with As2O3. The survival time of tumor loading nude mice treated with As2O3 was prolonged (P<0.01, vs control group). Conclusions As2O3 increased the expression of Fas and Fas-L on the membrane of pancreatic adenocarcinoma cells. As2O3 can induce pancreatic adenocarcinoma cell apoptosis , inhibit the cell growth in vitro or in vivo, and prolong the survival period of tumor loading nude mice.

目的 观察As2O3对胰腺癌细胞株体外生长和裸鼠腹腔种植腹水生成的影响及其作用机制。方法 0.125~2μmol/L的As2O3与胰腺癌细胞株SW-8902共同孵育,观察不同浓度、不同作用时间对胰腺癌细胞生长的抑制作用、作用后胰腺癌细胞的凋亡特征及Fas Fas-L表达的变化。80只BALB/C-nu/nu裸鼠腹腔内接种胰腺癌细胞株SW-8902,并随机分为4组,然后分别腹腔内注射生理盐水及不同剂量的As2O3,观察各组裸鼠的生存时间。结果 1~2μmol/L的As2O3作用后,胰腺癌细胞呈典型的凋亡特征性改变,流式细胞仪检测在G1期前出现亚二倍体凋亡峰,DNA电泳呈现特征性Ladder,细胞核内可见染色质浓缩、碎裂和边聚。As2O3也可显著抑制荷胰腺癌裸鼠腹水的生成,延长生存期(P<0.01),Fas、Fas-L表达在As2O3作用后2d上升,3d达最高,以后表达量下降。结论 As2O3诱导胰腺癌细胞凋亡,抑制裸鼠胰腺癌腹腔种植及腹水的生成,延长生存期、Fas、Fas-L表达上调是As2O3诱导肿瘤细胞凋亡的途径之一。

 
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