助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   硝基喜树碱 的翻译结果: 查询用时:0.52秒
图标索引 在分类学科中查询
所有学科
药学
更多类别查询

图标索引 历史查询
 

硝基喜树碱
相关语句
  nitrocamptothecin
     Conclusion The method is shown to be accurate and convenient, and suitable for preclinical pharmacokinetic studies of 9 nitrocamptothecin.
     结论 该法操作简便、快速 ,适用于 9 硝基喜树碱临床前药代动力学研究
短句来源
     Aim To develop a sensitive, specific and accurate method for quantifying 9 nitrocamptothecin in rat plasma and tissues and to study the distribution of 9 nitrocamptothecin in rat tissues.
     目的 建立高效液相色谱法测定大鼠血浆及组织样品中 9 硝基喜树碱 ,并研究其在大鼠体内的分布特点。
短句来源
     Objective To develop a novel HPLC UV method for determination of 9 nitrocamptothecin (9 NC) in the rat′s bile.
     目的建立大鼠胆汁中 9 硝基喜树碱的高效液相色谱梯度洗脱方法。
短句来源
     Nitrocamptothecin(1)semi-solid lipid nanoparticles(SSLN)were prepared by emulsification at a hightemperature and solidification at a low temperature. The shape, particle size, encapsulation efficiency, z potential andpharmacokinetics in rats of 1 SSLN were investigated.
     采用高温乳化蒸发-低温固化法制备9-硝基喜树碱(1)半固体脂质纳米粒,并考察其形态、粒径、包封率、z电位及大鼠静脉给药后体内药物动力学行为。
短句来源
     A two steps way of preparing 20(S) 9 nitro 10 hydroxycamptothecin from 20(S) 9 nitrocamptothecin which involves in oxidation and photorearrangement is discussed. The yield and the cost of this way are superior to the known way.
     以 9-硝基喜树碱为原料 ,经过过氧化氢氧化成氮氧化物 ,再经光化重排反应制得 9-硝基 - 10羟基喜树碱 ,该方法合成收率略高于文献值 ,且成本价格远低于文献方法。
短句来源
更多       
  “硝基喜树碱”译为未确定词的双语例句
     Synthesis of 20(S)-9-Nitro-camptothecin
     20(S)-9-硝基喜树碱的合成
短句来源
     Improved Synthesis of 20(S)-9-nitrocamptothecin
     20(S)-9-硝基喜树碱的合成工艺改进
短句来源
     Study on Metabolites of 9-Nitrocamptothecin in Rats by HPLC-MS~(n)
     大鼠体内9-硝基喜树碱代谢物的HPLC-MS~n分析
短句来源
     20(5)-Camptothecin (CPT) is a natural alkaloid extracted from the leaves and fruits of Camptotheca acuminata, and 9-nitro-20(S)-camptothecin (9-NC), an analog of CPT, has been proved the antitumor activity.
     喜树碱(20(S)-camptothecin,CPT)是从植物喜树中提取得到的一种细胞毒素生物碱,9-硝基喜树碱(9-nitro-20(S)-camptothecin,9-NC)是其活性衍生物。
短句来源
     Dissolution medium was 0.05% Tween-80 0.1 mol L-1 hydrochloric acid, rational speed was 75 r-min-1 and temprature was (37.0 + 0.5) C .
     建立了以0.05%吐温-80-0.1mol·L~(-1)HCl 500mL为溶出介质,温度(37.0±0.5)℃,桨法,转速75r·min~(-1)作为9-硝基喜树碱片剂的溶出方法,该方法均一性、稳定性良好。
短句来源
更多       
  相似匹配句对
     Camptothecin
     喜树碱
短句来源
     Synthesis of 20(S)-9-Nitro-camptothecin
     20(S)-9-硝基喜树碱的合成
短句来源
     Research Progress of 9-Nitrocamptothecin
     9-硝基喜树碱的研究进展
短句来源
     Camptothecin derivatives——a kind of antitumor agents
     抗癌药——喜树碱衍生物
短句来源
     Nitro-cellulose wood coatings
     硝基木器漆
短句来源
查询“硝基喜树碱”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  nitrocamptothecin
Comparative disposition of the antineoplastic agent 9-nitrocamptothecin and the inactive isomer 12-nitro camptothecin in CASE-be
      
Anticancer exffect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
      
Purpose: To test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9-NC) against human breast, colon and lung cancer xenografts in nude mice when administered in liposome aerosol.
      
In previous studies we have found that administration of dilauroylphosphatidylcholine (DLPC) liposome aerosols containing 9-nitrocamptothecin (9-NC) inhibits the growth of human breast, colon and lung cancer xenografts.
      
Purpose: Preclinical and phase I clinical data suggest that 9-nitrocamptothecin (9NC) is an agent with potential anticancer activity.
      
更多          
  nitro-camptothecin
Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burde
      
A Phase II Study of 9-Nitro-Camptothecin in Patients with Previously Treated Metastatic Breast Cancer
      
Aims: This Phase II study was conducted to determine the efficacy and toxicity of 9-nitro-camptothecin (9-NC) in patients with previously treated metastatic breast cancer.
      
A Phase II study of 9-nitro-camptothecin in patients with previously treated metastatic breast cancer.
      


A two steps way of preparing 20(S) 9 nitro 10 hydroxycamptothecin from 20(S) 9 nitrocamptothecin which involves in oxidation and photorearrangement is discussed. The yield and the cost of this way are superior to the known way.

以 9-硝基喜树碱为原料 ,经过过氧化氢氧化成氮氧化物 ,再经光化重排反应制得 9-硝基 - 10羟基喜树碱 ,该方法合成收率略高于文献值 ,且成本价格远低于文献方法。

Objective To develop a novel HPLC UV method for determination of 9 nitrocamptothecin (9 NC) in the rat′s bile. Method The samples were separated on a Hypersil BDS C 18 column after being diluted by acetonitrile water (1∶1). The mobile phase consisted of acetonitrile and water, and a gradient elution program was applied. The UV detector was set at 370 nm. Result The liner calibration curves were obtained in the concentration range of 0 5 ~ 25 μg/mL . The limit of quantification was 0 5 μg/mL...

Objective To develop a novel HPLC UV method for determination of 9 nitrocamptothecin (9 NC) in the rat′s bile. Method The samples were separated on a Hypersil BDS C 18 column after being diluted by acetonitrile water (1∶1). The mobile phase consisted of acetonitrile and water, and a gradient elution program was applied. The UV detector was set at 370 nm. Result The liner calibration curves were obtained in the concentration range of 0 5 ~ 25 μg/mL . The limit of quantification was 0 5 μg/mL . Conclusion The method was simple and successfully applied to determining the concentrations of 9 NC in the bile samples, and it also offered a way to the preliminary study on the metabolites of 9 NC in the rat′s bile.

目的建立大鼠胆汁中 9 硝基喜树碱的高效液相色谱梯度洗脱方法。方法胆汁样品经乙腈 水 ( 1∶1 )稀释后 ,直接进样。检测波长为 370nm ,采用HypersilBDSC18柱 ( 5 μm,1 5 0mm× 4 6mmI D )分离 ,使用以乙腈 2 %甲酸水溶液为流动相的二元梯度洗脱方法。结果线性范围为 0 5~2 5 μg/mL,定量限为 0 5 μg/mL。结论本法操作简便 ,成功应用于胆汁中 9 硝基喜树碱的含量的测定及胆汁中 9 硝基喜树碱代谢物的初步研究。

Aim To develop a sensitive, specific and accurate method for quantifying 9 nitrocamptothecin in rat plasma and tissues and to study the distribution of 9 nitrocamptothecin in rat tissues. Methods Plasma and tissue samples were prepared based on a simple liquid liquid extraction and separation through a Hypersil BDS C 18 column. The mobile phase for plasma samples and tissue samples consisted of a mixture of acetonitrile water formic acid (35∶65∶2) and a mixture of acetonitrile water formic acid...

Aim To develop a sensitive, specific and accurate method for quantifying 9 nitrocamptothecin in rat plasma and tissues and to study the distribution of 9 nitrocamptothecin in rat tissues. Methods Plasma and tissue samples were prepared based on a simple liquid liquid extraction and separation through a Hypersil BDS C 18 column. The mobile phase for plasma samples and tissue samples consisted of a mixture of acetonitrile water formic acid (35∶65∶2) and a mixture of acetonitrile water formic acid (30∶70∶2), respectively. The UV detector was set at 370 nm. Results A linear calibration curve of 9 nitrocamptothecin in plasma was obtained in the concentration range of 25- 1 600 μg·L -1 , and the quantitation limit of plasma and tissues was 25 μg·L -1 . A linear range of concentrations for 9 nitrocamptothecin in heart, lung, spleen, stomach, fat, womb, and ovary was 10- 1 000 ng·g -1 , and the quantitation limit was 10 ng·g -1 . A linear range of concentrations for 9 nitrocamptothecin in brain, kidney, liver, intestine, smooth muscle, skeletal muscle, and tectical was 5-500 ng·g -1 , and the quantitation limit was 5 ng·g -1 . The intra and inter run precision was measured to be below 11%. The inter run accuracy was less than 5% for the analyte. After iv administration of 9 nitrocamptothecin, the drug was distributed extensively in rat in vivo . The concentration in lung was the highest, and the drug was accumulated in lung and liver. Following ig administration, the concentration in stomach was higher than that in other organs. Conclusion The method is shown to be accurate and convenient, and suitable for preclinical pharmacokinetic studies of 9 nitrocamptothecin.

目的 建立高效液相色谱法测定大鼠血浆及组织样品中 9 硝基喜树碱 ,并研究其在大鼠体内的分布特点。方法 血浆及组织样品经液 液萃取后 ,分别以乙腈 水 甲酸 ( 3 5∶65∶2 )或乙腈 水 甲酸 ( 3 0∶70∶2 )为流动相 ,使用HypersilBDSC1 8色谱柱进行分离 ,检测波长为UV 3 70nm。结果 该法测定 9 硝基喜树碱在血浆中线性范围为 2 5~160 0 μg·L- 1 。药物iv后在大鼠体内广泛分布 ,肺中浓度最高 ,并在肺和肝中有蓄积现象。ig给药后 ,药物在胃中浓度最高 ,肠组织次之 ,大多数组织中药物浓度较低。结论 该法操作简便、快速 ,适用于 9 硝基喜树碱临床前药代动力学研究

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关硝基喜树碱的内容
在知识搜索中查有关硝基喜树碱的内容
在数字搜索中查有关硝基喜树碱的内容
在概念知识元中查有关硝基喜树碱的内容
在学术趋势中查有关硝基喜树碱的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社