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瓣叶     
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  leaflets
     Methods: Porcine aortic valve leaflets and whole aortic roots were decellularized by 3 different protocols. Decellularization procedure in group Ⅰ involved treatment with 0.01% trypsin, 1% Triton, and nuclease for 24 h;
     方法:分别采用3种不同的去细胞方法对新鲜猪主动脉瓣叶及带瓣主动脉管道进行脱细胞处理:0.01%胰蛋白酶+1%Triton+核酸酶组用含有0.01%胰蛋白酶-1%Triton和核酸酶的去细胞溶液37℃持续震荡24h;
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     [Result] When mitral valve were at closed position, the first major stress in the most areas of MCSV was 0.22 to 0.7 Mpa, the largest first and second major stress was 1.64 Mpa and 0.54 Mpa, both occurred in the base of the leaflets.
     瓣膜关闭时,大部分区域第一主应力为0.22~0.70Mpa,主瓣叶最大应力为1.64Mpa,出现在瓣叶基部与瓣环连接区;
短句来源
     ②The leaflets of tricuspid valve were removed along tricuspid annulus,including posterior leaflet,septal leaflet and 1/3-1/2 lateral anterior leaflet;
     ②将后叶、隔叶以及前叶近足侧1/3-1/2的部分,沿瓣环根部将瓣叶切下;
短句来源
     Methods The porcine aortic valve leaflets were acellularized by using 1% Triton-X 100,0.01% trypsin-0.02% EDTA,DNase I,RNase I. Biomechanical characteristics of fresh valves and acellularized valves were tested.
     方法经1%TritonX100、0.01%胰酶0.02%EDTA、DNaseI及RNaseI处理制备去细胞猪主动脉瓣叶支架,测定瓣叶去细胞前、后的生物力学特性;
短句来源
     The anterior leaflets were enlarged and elongated in 97.2% of the specimens and 83.3% of them had good quality and nearly normal subleaflet structure with good mobility.
     前叶中 97.2 %瓣体延长扩大 ,83 .3 %瓣叶质量和瓣下结构及动度基本正常。
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  valve leaflet
     The tissue-engineered heart valve leaflet,developed by seeding newborn bovine aortic endothelial cells on decellularized porcine aortic valve leaflet,was subjected to precondition treatment for 24 h to observe the remnant endothelial cells(flows from 30 ml/min to 400 ml/min,frequency:30 beats/min). A tissue-engineered heart valve leaflet created in static condition was taken as control.
     以脱细胞猪主动脉瓣作支架,新生牛主动脉内皮细胞作种子细胞构建组织工程心脏瓣叶,静态培养4 d后,置入反应器内进行预适应处理24 h(流量由30 ml/min调至400 ml/min,频率30次/min),观察内皮细胞残留情况,并与静态培养的瓣膜相比较。
短句来源
     The collagen scaffold were seeded with the cells of aortic wall and aortic endothelium of canine, and implanted in the abdominal aorta to assess the reconstruction of the valve leaflet.
     将犬主动脉壁间质细胞和主动脉内皮细胞种植于胶原膜上 ,进而将此瓣叶植入犬腹主动脉内 3个月 ,观察材料吸收和瓣叶结构的变化。
短句来源
     Methods:A fresh porcine aortic valve leaflet was decellularized by “low osmotic pressure of Tris buffer-0.5%SDS-RNase and DNase”,and assessed by histology,scanning electron microscopy,and the levels of DNA content to confirm the removal of cells.
     方法:新鲜猪主动脉瓣叶,采用“低渗液-0.5%SDS-核酸酶”处理,进行大体、光镜、电镜观察和DNA含量测定。
短句来源
     Objective: To investigate the feasibility of using acellularized porcine heart valve leaflet as a scaffold for tissue engineering.
     目的 :探讨脱细胞猪主动脉瓣叶构建组织工程心脏瓣膜支架的可行性。
短句来源
     Concentration stress leads to calcifying the valve leaflet near the point of calcification further seriously.
     当瓣叶出现钙化时 ,钙化点及其周围产生应力集中 ,促进钙化的进一步加剧。
短句来源
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  valve leaflets
     Methods: Porcine aortic valve leaflets and whole aortic roots were decellularized by 3 different protocols. Decellularization procedure in group Ⅰ involved treatment with 0.01% trypsin, 1% Triton, and nuclease for 24 h;
     方法:分别采用3种不同的去细胞方法对新鲜猪主动脉瓣叶及带瓣主动脉管道进行脱细胞处理:0.01%胰蛋白酶+1%Triton+核酸酶组用含有0.01%胰蛋白酶-1%Triton和核酸酶的去细胞溶液37℃持续震荡24h;
短句来源
     Methods The porcine aortic valve leaflets were acellularized by using 1% Triton-X 100,0.01% trypsin-0.02% EDTA,DNase I,RNase I. Biomechanical characteristics of fresh valves and acellularized valves were tested.
     方法经1%TritonX100、0.01%胰酶0.02%EDTA、DNaseI及RNaseI处理制备去细胞猪主动脉瓣叶支架,测定瓣叶去细胞前、后的生物力学特性;
短句来源
     Conclusion: Fn and FnCTD_(64) precoating can promote BMSCs adhesion and proliferation on decellular porcine aortic heart valve leaflets.
     结论:Fn和FnCTD64能明显增加BMSCs在去细胞猪主动脉瓣叶表面的黏附和增殖。
短句来源
     Objective:To observe bovine aortic endothelial cells(BAECs) proliferation after they were seeded on decellu-lar porcine heart valve leaflets pre-conditioned by different methods.
     目的:猪脱细胞主动脉瓣叶经不同的方法预处理后,种植新生牛主动脉内皮细胞(BAECs),观察细胞的增殖状态。
短句来源
     Valve leaflets stained directly with H E can observe the growth of cells rapidly and conveniently.
     提示 ,瓣叶 H- E直接染色可方便快捷地观察种植细胞的生长状况
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  valve cusp
     Significantly less foam cells were in each valve cusp area(4.0±2.5) than that of untreated group.
     MMF治疗组小鼠病变明显较轻,每个瓣叶所含泡沫细胞显著少于高脂组(P<0. 001)。
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      leaflets
    The lipid composition of the embryo leaflets forming a bud, or "treble clef", and that of fully opened leaves changed throughout the growth season.
          
    It was found that these structures are located in the hydrophobic interior between the outer and inner leaflets of the cytoplasmic membrane and do not contain intramembrane particles that are commonly present on freeze-fracture replicas.
          
    The replacement of leaflets by tendrils in the afila variety led to a reduction in total dry weight and the area of photosynthesizing surfaces.
          
    The loss of leaflets was partly compensated for by rapid expansion of stipules at early stages of plant development and by the hypertrophy of tendrils at later stages.
          
    The elevated content of ABA in tissues of wild-type plants was associated with the preferential development of leaflets and a larger transpiratory surface compared with those in the afila form.
          
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      valve leaflet
    Loss of compliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction.
          
    Transesophageal echocardiography revealed formation of an aneurysm confined to the anterior mitral valve leaflet.
          
    A 43-year-old patient with preexisting mitral valve prolapse andCardiobacterium hominis endocarditis with partial destruction of the posterior mitral valve leaflet is described.
          
    Successful treatment was achieved with partial resection of the posterior mitral valve leaflet and antibiotic therapy.
          
    Valve leaflet ICs from all valves, expressed predominantly β1 integrin but not β3 or β4 integrin.
          
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      valve leaflets
    The valve leaflets and cultured ICs from all valves expressed α1, α2, α3, α4, and α5 integrins to varying degrees and percentages with very little expression of α6 and αV.
          
    It is becoming clear that converging pathways coordinate early heart valve development and remodeling into functional valve leaflets.
          
    It was probably produced by the close apposition of the face of the closed mitral valve leaflets to an accentuated bulge of the interventricular septum.
          
    Regurgitant and stenotic flow across the mitral valve, abnormal motion of the valve leaflets and abnormalities of the papillary muscles were identified.
          
    Ultrasonography easily demonstrated the valve leaflets in 87 % of patients; all were observed in the distal portion of the internal jugular (IJ) veins.
          
    更多          
      valve cusp
    The Chorda muscularis persistens, an arrest of development, is a variation of the connection between the papillary muscles and the valve cusps whereby the papillary muscle is connected with the valve cusp without a chorda tendinea.
          
    Absence of an aortic valve cusp, a cause of severe aortic regurgitation in infancy
          
    Isolated Congenital Absence of a Single Pulmonary Valve Cusp
          
    Surgery consisted of creating a valve cusp from the posterior wall of the pulmonary artery at the base of the pulmonary trunk.
          
    A sequential device achieves better emptying of the vasculature than the uniform device and maximises venous valve cusp clearance.
          


    The use of flexible stent was proved very effective in reduction of loading stresses and in increase of durability of the tissue prosthesis.In order to study suitability of such a stent.a serial studies have been carried out in our hospital since 1978.The frame was made of acetal copolymer.The three posts of the frame were in equal distance with 15mm in height.The flexible stent was reinforced by application of a thin and small stellite ring fitted onto the annulus and covered with knitted Dacron cloth.A silastic...

    The use of flexible stent was proved very effective in reduction of loading stresses and in increase of durability of the tissue prosthesis.In order to study suitability of such a stent.a serial studies have been carried out in our hospital since 1978.The frame was made of acetal copolymer.The three posts of the frame were in equal distance with 15mm in height.The flexible stent was reinforced by application of a thin and small stellite ring fitted onto the annulus and covered with knitted Dacron cloth.A silastic foam ring was enclosed within the sewing ring which permits elasticity.Serial tests of the flexible stent pertaining to its antifatigue.anticreep.tensile strength, elasticity, chemical property, biological property have been made.These tests demonstrated that both the physical and chemical properties of the stent were stable, when exerting a pressure of 130mmHg evenly on the valve, the posts deflected towards the center from 0.9 to 1.0mm.while the deflection of the steel wire stent and stainless steel stent being 0.2mm and 0.5mm respectively.Histoio-gical examination of acetal copolymer-implanted tissue showed only slight reaction.According to the above data, the clinical use of the flexible stent bioprosth-esjs was therefore considered suitable.From October 1980 to March 1981, 14 patients had undergone mitral valve replacement and 1 died of heart failure.The 13 survivals for 4-10 months after operation were followed up.The results revealed significant reduction of cardiac size in x-ray studies and which marked improvement of cardiac function.NO thromboembolism occured.

    本文介绍第二军医大学第一附属医院研制的弹性架猪异种瓣。支架由聚甲醛构成,采用三瓣叶等距设计,架高15mm;经物理,化学及生物学试验,证明性能稳定,富有弹性,抗蠕变,抗疲劳性能好。动物体内埋藏,对组织无不良反应。于1980年10月开始应用于临床,至1981年1月共14例,1例术后死亡与瓣膜无关,其余13例长期生存,心功能均有明显改善,近期效果满意。本文对弹性支架性能及设计问题进行了讨论。

    The main echocardiographic findings in 7 surgically confirmed cases of rupturedaneurysm of sinus of Valsalva were discontinuity of the anterior wall of the aorticroot and an abnormal echo from the aneurysmal sac anterior to the discontinuity,seen in all 7 M-mode echocardiograms.The enlarged right sinus of Valsalva protruding intothe right ventricular outflow tract and aneurysmal wall echo dropout were visualizedin all 5 two-dimensional echocardiograms.Signs of secondary hemodynamic alterationssuch as left ventricular...

    The main echocardiographic findings in 7 surgically confirmed cases of rupturedaneurysm of sinus of Valsalva were discontinuity of the anterior wall of the aorticroot and an abnormal echo from the aneurysmal sac anterior to the discontinuity,seen in all 7 M-mode echocardiograms.The enlarged right sinus of Valsalva protruding intothe right ventricular outflow tract and aneurysmal wall echo dropout were visualizedin all 5 two-dimensional echocardiograms.Signs of secondary hemodynamic alterationssuch as left ventricular volume overload,increased left atrial internal dimension,diastolic flutter of the mitral valve,systolic and/or diastolic flutter and high A wavesof the tricuspid valve,and premature pulmonic valve opening during diastole were alsoseen.Echocardiography may be a safe and valuable method for preoperative diagnosisof the disease.

    本文报道7例经手术证实的主动脉窦瘸破裂的超声心动图表现,7例在 M 型超声心动图上均示有主动脉根部前壁回声中断及其前方有异常瘤壁回声反射(风袋),5例扇型显象见右主动脉窦扩大并突向右室流出道,瘤壁局部回声缺失。此外还有心腔扩大、主动脉瓣与二尖瓣叶、三尖瓣叶或肺动脉瓣叶的曲线异常等继发性改变。讨论了上述表现的机制及诊断价值,认为超声心动图不失为术前诊断主动脉窦瘤破裂的安全而正确的方法。

    Whether the mitral valve is calcified has a close relation with the selection for the operation of rheumatic mitral disease.25 cases of the disease were examined by cardiac ultrasonic examinations preoperatively and postoperatively. Those valves speciemens were examined by X-ray,gross observation and ultra-isonic reexaminaion. The degree of its calcification and fibrosis, and the clas-sfications of ultrasonic images are introduced in this article. The examinations show that the discovery rate for the calcification...

    Whether the mitral valve is calcified has a close relation with the selection for the operation of rheumatic mitral disease.25 cases of the disease were examined by cardiac ultrasonic examinations preoperatively and postoperatively. Those valves speciemens were examined by X-ray,gross observation and ultra-isonic reexaminaion. The degree of its calcification and fibrosis, and the clas-sfications of ultrasonic images are introduced in this article. The examinations show that the discovery rate for the calcification of mitral pathological changes s 44-56%.The calcification is mainly distributed in the front and rear combinations, and then, in the mitral valve. The fibrosis mostly appear at the both combinations, and then, the rear combination .The degree of calcification and fibrosis of the mitral valve is related to mitral stenosis. The calcification may be taken as an indication in surgical prosthesis criteria. The degree of fibrosis alone is considered the mitral valve replacement.

    本组对25例风湿性二尖瓣病变术前进行心脏超声检查,术后将切除的25个完整瓣膜标本分别X线拍片、大体检查、及标本超声复查。本文提出了二尖瓣钙化、纤维化的程度,超声图像分类的标准。从4种检查方法对比说明二尖瓣病变钙化发现率为44~56%。钙化分布以前后联合为主,瓣叶其次。纤维化分布两个联合处最多,其次后联合。二尖瓣的钙化,纤维化的程度与瓣口狭窄有一定关系。钙化明显可作为外科换瓣治疗的指征,仅有Ⅲ度纤维化可考虑换瓣治疗。

     
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