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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
We investigated the molecular mechanism of Lovastatin anti-tumor function through the study of its effect on membrane ion flow, gap junctional intercellular communication (GJIC), and the pathways of related signals in MCF-7 mammary cancer cells.
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These results indicate that DATS can augment the activation of T cells and enhance the anti-tumor function of macrophage, suggesting that DATS may be potentially useful in tumor therapy.
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Construction of eukaryotic expressing vector pCH503 of CH50 and its chemotaxis and anti-tumor function by expressionin vivo in m
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An eukaryotic expressing vector that expresses CH50, a recombinant polypeptide of human fibronectin, in mice was constructed, and its chemotactic and anti-tumor function byin vivo gene transfection was investigated.
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The main features of CH50, a recombinant polypeptide of human fibronectin, activating macrophagesin vivo and its anti-tumor function were investigated.
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| | Previous works from Herberman'sLab,and later from ours and otherLabs have shown that activated ma-crophages from tumor bearing micehave the ability to kill tumor cells andto suppress immune response in vitro.It has been considered that these cellsmay play an important role in thehost response against tumor cellsand may also impair the host immunefunction,leading eventually to hostdeath.Thus it would be interest toinvestigate the modulation of suppres-sor macrophages by reducing theirsuppressor activity but ... | | 巯基乙酸盐(Thioglycollate)诱发的小鼠腹腔激活巨噬细胞显示了天然的抑制活性,即对Con A,PHA,PWM和LPS致分裂原诱导的T,B淋巴细胞的增殖能产生显著的抑制效应,同时也能抑制脾脏NK细胞对YAC-1肿瘤靶细胞的杀伤功能。但是这些巨噬细胞却同时具有明显的抗肿瘤的细胞静止效应。在体外用脂多糖(LPS,10微克/毫升)处理粘附性激活巨噬细胞明显地降低了对NK活性和T,B淋巴细胞增殖功能的抑制,然而这些免疫调变巨噬细胞仍然保持了显著的抗肿瘤的细胞静止效应。实验还表明,这类激活巨噬细胞的抑制功能不为前列腺素合成酶的抑制剂In-dom所阻断,从而提示了它们的免疫抑制效应似乎不是前列腺素介导的。本实验结果提示,体外用脂多糖处理后的免疫调变巨噬细胞是一类具有抗肿瘤功能和低免疫抑制性的巨噬细胞亚群,这为进一步研究它们的产生以及作用机理准备了条件。 | | 文摘来源 | | This study was aimed at looking | | 人体单核-巨噬细胞通过塑料培皿粘附技术从外周血单个核细胞(PBMNC)中分离,并在体外短期培养。培养8天后,这些细胞已发生形态和功能上的分化,成为成熟的巨噬细胞。培养8天的巨噬细胞和PBMNC的比例为2:1和1:1时能引起NK活性的显著抑制。本实验应用4小时~(51)Cr释放试验来测定NK细胞对K562肿瘤细胞的细胞毒性。然而,培养1天的粘附性单核细胞不能观察到对NK活性的抑制。这提示,巨噬细胞对NK活性的抑制与体外分化、成熟、激活有关。培养1天和8天的单核-巨噬细胞对肿瘤靶细胞MBL-2和EAC都有很强的细胞静止效应。应用免疫调变剂脂多糖(LPS)体外处理粘附性单核细胞或巨噬细胞,仅培养8天的巨噬细胞能显著增强NK活性,而培养1天的单核细胞不能引起这种功能。这表明,免疫调变效应的诱导期发生在细胞明显增大的巨噬细胞形成期。与此同时,免疫调变巨噬细胞增强了IL-1的分泌和保持了抗肿瘤功能,从而证明,培养8天的巨噬细胞其抗肿瘤和免疫调节两类功能是可以分离的。本实验应用免疫调变剂寻找到既抗肿瘤又增强NK活性的人体新表型的... | | 文摘来源 | | Selenium contents in Chinese medicinal herbs of 310 kinds are analysed and determinea uring spectrofluormeter in this paper. Of which they are classified as: root and rhizoma (87 kinds) ; seeds and fruits (76 kinds) ; whole plants ( 32 kinds); leaves (6 kinds); flowers (15 kinds); barks (13 kinds); iana (12 kinds); resinous plants (4 kinds) ; algal plants (5 kinds) ; other plant species (7 kinds) ; animal species (22 kinds); entomic species (4 kinds) , minerals (27 kinds); of winch there are 30 kinds of Chi... | | 本文应用荧光分光光度法分析测定了310种中草药中的含硒量,其中分:根及根茎类(87种)、种子果实类(76种)、全草类(32种)、叶类(6种)、花类(15种)、皮类(13种)、藤木类(12种)、树脂类(4种)、藻菌类(5种)、其它类(7种)、动物类(22种)、昆虫类(4种)、矿物类(27种),其中防治克山病药材(30种)、抗肿瘤药材(30种)。含硒量均值分别为:0.132、0.126、0.095、0.195、0.141、0.053、0.037、0.066、0.077、0.087、1.042、0.162、3.879及3.260和3.543ppm。防治克山病及抗肿瘤类药材含硒均值比植物各类分别高18~88及18~96倍,比动物类药材高3~4倍,与矿物类药材含量相当。这表明中草药中的微量元素硒及硒的化合物在防治克山病、抗肿瘤的功能中起着重要的作用。文中还对我国人、畜的硒中毒、硒的缺乏,对其环境因素及应用硒防治疾病进行了讨论。 | | 文摘来源 | |   | | << 更多相关文摘 |
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