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便秘为主型ibs
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  constipation-predominant ibs
     Methods: Based on Rome II criteria, 36 IBS patients, including 24 diarrhea-predominant IBS (D-IBS), 12 constipation-predominant IBS (C-IBS), and 10 healthy subjects were enrolled in the study.
     方法:根据RomeⅡ标准纳入IBS患者36例,其中腹泻为主型IBS(D-IBS)24例,便秘为主型IBS(C-IBS)12例,同时纳入正常对照者10名。
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  相似匹配句对
     (3)D shape.
     D
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     (2)C shape;
     C ;
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     In the western countries, IBS of diarrhea is more common than IBS of constipation. In our country, the morbidity of different sub-IBS hasn't been recorded in detail.
     在西方国家,腹泻IBS一般多于便秘IBS;
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     ( 3 )multimorphologytype .
     ( 3 )多形性淋巴细胞为主 ;
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     Most pateitns had Type Ⅱ diabetes mellitus.
     以2糖尿病为主;
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  constipation-predominant ibs
Although only two medications, tegaserod for constipation-predominant IBS and alosetron for diarrhea-predominant IBS, are specifically indicated, a wide variety of treatment options are available and are discussed in this review.
      
The best example of this is the finding that methanogenic organisms in IBS patients are wholly associated with constipation-predominant IBS.
      
The 5-HT4 agonist tegaserod shows modest benefit in constipation-predominant IBS, improving stool frequency, consistency, and bloating as well as global improvement.
      
The best example of this is the finding that methanogenic organisms in IBS patients are wholly associated with constipation-predominant IBS.
      
RRIV during deep breathing was significantly lower in constipation-predominant IBS patientsthan in controls or diarrhea-predominant IBS patients(16.5 ± 3.1% vs 20.5 ± 4.8% and 21.5± 4.6%, P >amp;lt; 0.001).
      
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Objective To evaluate the clinical characteristics of irritable bowel syndrome (IBS) subgroups in Zhejiang province, and discuss the significance of this clinical typing in Chinese IBS patients. Methods From January 2001 to January 2002, 540 consecutive Roma Ⅱ criteria- positive IBS patients were evaluated by gastroenterologists from Digestive Disease Center in Zhejiang province (DDCZ). Patients were classified to three subgroups as constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D) and alternating...

Objective To evaluate the clinical characteristics of irritable bowel syndrome (IBS) subgroups in Zhejiang province, and discuss the significance of this clinical typing in Chinese IBS patients. Methods From January 2001 to January 2002, 540 consecutive Roma Ⅱ criteria- positive IBS patients were evaluated by gastroenterologists from Digestive Disease Center in Zhejiang province (DDCZ). Patients were classified to three subgroups as constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D) and alternating constipation and diarrhea IBS (IBS-A) according to the predominant bowel habit. All patients completed the demographic checklists, symptoms questionnaire and quality of life (QoL) by Chinese version of the SF-36. 126 patients were voluntarily assigned to 8-week therapies with Pinaverium bromide (100 mg three times daily). Results IBS-C and IBS-A were more common in female patients, whereas male patients experienced more cases of IBS-D (P<0.01). More IBS-D patients had drinking habitas compared with IBS-C patients (P<0.05). More IBS-D patients were smokersas compared with IBS-A patients(P<0.05). There were no significant differences in age distribution among three IBS subgroups(P>0.05); (2) IBS consisted of IBS-D (47.8 %), IBS-A(32.2%) and IBS-C(20.0 %), respectively. In regards to the IBS predominant bowel symptoms, there were significant differences among IBS subgroups. Abdominal pain (frequency>2 days per week and duration>1 hour per day) were more frequent in IBS-A patients , while IBS-D patients more frequently experienced of passage of mucus, dyspeptic symptoms and anxiety(P<0.05); (3) The QoL in three subgroup was impaired in vitality, general health and mental health. Compared with IBS-D, QoL in IBS-C scored significantly lower on physical function, role emotion, general health and mental health scales (P<0.05); (4) The total symptom improvement rate and symptom remission rate were achieved by 60.8 % and 30.4 % in IBS-C patients, and 94.9% and 57.6% in IBS-D patients, while 77.3% and 59.1% in IBS-A patients, respectively. Few IBS-C patients noted symptom remission than IBS-D and IBS-A (P<0.05). Conclusion There are different demographic characteristics, clinical symptoms, quality of life and symptom efficacy among the three IBS subgroups.

目的总结浙江省IBS人群不同亚型的发病特点。探讨符合我国IBS人群的临床分型标准。方法通过浙江省消化中心全省网络,从2001年1月至2002年1月,收集各医院消化科门诊就诊的符合罗马Ⅱ诊断怀准的IBS患者540例,并按患者的排便习惯分为三型即腹泻为主型(IBS-D),便秘为主型(IBS-C)和腹泻便秘交替型(IBS-A)。其中126例接受匹维溴胺100mgt.i.d8周治疗,观察匹维溴胺对不同亚型IBS的疗效差异。本研究采用问卷调查方式,问卷内容包括:一般资料、症状问卷量表和生活质量量表(SF-36)。结果①在IBS-C和IBS-A患者中,女性明显高于男性,而IBS-D患者中,男性更为多见(P<0.05)。IBS-D的患者饮酒的比例明显高于IBS-C的患者(P<0.05)。IBS-D吸烟的比例明显高于IBS-A的患者(P<0.05)。年龄分布在不同亚型患者无显著差异;②不同亚型的IBS中IBS-D占47.8%,IBS-A为32.2%,IBS-C为20.0%,不同亚型IBS患者的结肠症状和结肠外症状分布有所不同。腹痛≥1 h/d和腹痛频率≥2 d/周在IBS-A最多见,而IBS-D患者较多出现黏液便、焦虑和消化...

目的总结浙江省IBS人群不同亚型的发病特点。探讨符合我国IBS人群的临床分型标准。方法通过浙江省消化中心全省网络,从2001年1月至2002年1月,收集各医院消化科门诊就诊的符合罗马Ⅱ诊断怀准的IBS患者540例,并按患者的排便习惯分为三型即腹泻为主型(IBS-D),便秘为主型(IBS-C)和腹泻便秘交替型(IBS-A)。其中126例接受匹维溴胺100mgt.i.d8周治疗,观察匹维溴胺对不同亚型IBS的疗效差异。本研究采用问卷调查方式,问卷内容包括:一般资料、症状问卷量表和生活质量量表(SF-36)。结果①在IBS-C和IBS-A患者中,女性明显高于男性,而IBS-D患者中,男性更为多见(P<0.05)。IBS-D的患者饮酒的比例明显高于IBS-C的患者(P<0.05)。IBS-D吸烟的比例明显高于IBS-A的患者(P<0.05)。年龄分布在不同亚型患者无显著差异;②不同亚型的IBS中IBS-D占47.8%,IBS-A为32.2%,IBS-C为20.0%,不同亚型IBS患者的结肠症状和结肠外症状分布有所不同。腹痛≥1 h/d和腹痛频率≥2 d/周在IBS-A最多见,而IBS-D患者较多出现黏液便、焦虑和消化不良(P<0.05);③ SF-36生活质量显示三个亚型IBS患者均在活力、总体健康和精神健康维度的生活质量下降尤为明显。IBS-C患者的生活质量普遍低于另外两型。IBS-C患者的生理功能、情感职能、总体健康和精神健康维度的生活质量显著低于IBS-D患者(P<0.05);④匹维溴胺对IBS-C的总有效率和显效率分别60.8%和30.4%,IBS-D分圳为94.9%和57.6%,IBS-A分别为77.3%和59.1%。匹维溴胺治疗不同业型的IBS患者总有效率和湿效率比较均有显著差异(P<0.05)。匹维溴胺对IBS-C患者的显效率显著低于另外两型(P<0.05)。结论按排便习惯分型的IBS患者在流行病学、临床表现、生活质量及对治疗反应等方面均有一定的差异,这一分型对临床有一定的指导意义。

Background: Brain-gut peptides are a group of small molecular polypeptids, having dual function of neurotransmitters and hormones which play important role in the pathogenesis of irritable bowel syndrome (IBS). Aims: To investigate the changes and clinical significance of brain-gut peptides such as vasoactive intestinal peptide (VIP), neuropeptide Y (NPY) and neurotensin (NT) in patients with IBS. Methods: Based on Rome II criteria, 36 IBS patients, including 24 diarrhea-predominant IBS (D-IBS), 12 constipation-predominant...

Background: Brain-gut peptides are a group of small molecular polypeptids, having dual function of neurotransmitters and hormones which play important role in the pathogenesis of irritable bowel syndrome (IBS). Aims: To investigate the changes and clinical significance of brain-gut peptides such as vasoactive intestinal peptide (VIP), neuropeptide Y (NPY) and neurotensin (NT) in patients with IBS. Methods: Based on Rome II criteria, 36 IBS patients, including 24 diarrhea-predominant IBS (D-IBS), 12 constipation-predominant IBS (C-IBS), and 10 healthy subjects were enrolled in the study. The plasmal levels of VIP, NPY and NT were measured by radioimmunoassay (RIA). Results: The plasmal level of VIP was significantly higher in D-IBS patients than that in the normal controls (P<0.05), but there was no significant difference between C-IBS patients and the normal controls (P>0.05). The plasma NPY level in both D-IBS and C-IBS patients was significantly lower than that in the normal controls (P<0.05, P<0.01), and that in the C-IBS patients was significantly lower than that in the D-IBS patients. The plasma NT level in both D-IBS and C-IBS patients was significantly higher than that in the normal controls (P<0.05), while there was no significant difference between the two subtypes (P>0.05). Conclusions: Plasma brain-gut peptides levels in patients with IBS may be related to diarrhea and constipation. The plasma NT level is higher in both D-IBS and C-IBS patients than that in the normal controls, whereas there are differences of VIP and NPY in different subtypes of IBS. Brain-gut peptides act as important factors in regulating gastrointestinal motor and sensational function, which provide inevitable inner relationship of the genesis and development of IBS.

背景:脑肠肽作为一类具有神经递质和激素双重功能的小分子多肽,在肠易激综合征(IBS)的发病机制中起重要作用。目的:研究血管活性肠肽(VIP),神经肽Y(NPY)和神经降压素(NT)水平在IBS患者血浆中的变化及其临床意义。方法:根据RomeⅡ标准纳入IBS患者36例,其中腹泻为主型IBS(D-IBS)24例,便秘为主型IBS(C-IBS)12例,同时纳入正常对照者10名。采用放射免疫测定分别检测受试者血浆VIP、NPY和NT水平。结果:D-IBS患者血浆VIP水平显著高于正常对照组(P<0.05),而C-IBS患者血浆VIP水平与正常对照组比较无显著差异(P>0.05);D-IBS和C-IBS患者血浆NPY水平均显著低于正常对照组(P<0.05和P<0.01),其中C-IBS患者又显著低于D-IBS患者(P<0.05);D-IBS和C-IBS患者血浆NT水平均显著高于正常对照组(P<0.05),但两亚型间比较无显著差异(P>0.05)。结论:IBS患者血浆脑肠肽水平与腹泻或便秘症状有一定的联系,表现为D-IBS和C-IBS患者的血浆NT水平均显著升高,而NPY和VIP水平因IBS亚型的不同而有差异...

背景:脑肠肽作为一类具有神经递质和激素双重功能的小分子多肽,在肠易激综合征(IBS)的发病机制中起重要作用。目的:研究血管活性肠肽(VIP),神经肽Y(NPY)和神经降压素(NT)水平在IBS患者血浆中的变化及其临床意义。方法:根据RomeⅡ标准纳入IBS患者36例,其中腹泻为主型IBS(D-IBS)24例,便秘为主型IBS(C-IBS)12例,同时纳入正常对照者10名。采用放射免疫测定分别检测受试者血浆VIP、NPY和NT水平。结果:D-IBS患者血浆VIP水平显著高于正常对照组(P<0.05),而C-IBS患者血浆VIP水平与正常对照组比较无显著差异(P>0.05);D-IBS和C-IBS患者血浆NPY水平均显著低于正常对照组(P<0.05和P<0.01),其中C-IBS患者又显著低于D-IBS患者(P<0.05);D-IBS和C-IBS患者血浆NT水平均显著高于正常对照组(P<0.05),但两亚型间比较无显著差异(P>0.05)。结论:IBS患者血浆脑肠肽水平与腹泻或便秘症状有一定的联系,表现为D-IBS和C-IBS患者的血浆NT水平均显著升高,而NPY和VIP水平因IBS亚型的不同而有差异。脑肠肽作为调节胃肠运动功能和感觉功能的重要因素,可能与IBS的发生、发展有必然的内在联系。

 
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