The expression of Cox-2 had a very close correlation with that of VEGF(r=0.716,P=0.000), and also correlated with the expression of MVD significantly(r=0.458,P=0.000).
The positive expression rate of E2F-3 in cancer tissues was 53.8%(21/39), which was significantly lower than 91.7%(11/12) in normal bladder tissue (P<0.05).
Results:The positive expression rate of E2F-1 in cancer tissues was 82.1%(32/39), which was significantly higher than 41.7%(5/12) in normal bladder tissue (P<0.05).
The homozygous mutation genotype UGT2B7(T/T) displayed in higher frequency in benzidine exposed bladder cancer patients than in normal population in the same city [P=0.006, OR3.30,95%CI(1.36-7.98) ].
In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients.
Combined-Modality Treatment and Organ Preservation in Bladder Cancer
Pretreatment Proliferation and Local Control in Bladder Cancer after Radiotherapy with or without Concurrent Chemotherapy
The clinical significance of flow cytometric deoxyribonucleic acid measurement of deparaffinized specimen in bladder tumor
Aneuploid was the most indicative parameter of the recurrence in bladder tumors.
Chromosomes of 41 bladder carcinomas were studied. The results showed that with the increase of histopathological grading of transitional cell carcinoma and decrease of cell differentiation, both the number and structure of chromosome, had markedly changed. The presence of four types of abnormal chromosome and some double minutes (DMS) may be of some significance in bladder carcinoma, and it is demonstrated that the chromosomal abnormalities and histopathological grading may have certain correlation in bladder...
Chromosomes of 41 bladder carcinomas were studied. The results showed that with the increase of histopathological grading of transitional cell carcinoma and decrease of cell differentiation, both the number and structure of chromosome, had markedly changed. The presence of four types of abnormal chromosome and some double minutes (DMS) may be of some significance in bladder carcinoma, and it is demonstrated that the chromosomal abnormalities and histopathological grading may have certain correlation in bladder carcinoma.
Marked hypercalcemia would be caused by ectodermic solid tumor remote from the bone and Without any indication of bone invasion. It suggested that certain humoral factor secreted by the tumor may contribute to the pathogenesis.We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma. Gel filtration chromatography of tumor extract demonstrates a single...
Marked hypercalcemia would be caused by ectodermic solid tumor remote from the bone and Without any indication of bone invasion. It suggested that certain humoral factor secreted by the tumor may contribute to the pathogenesis.We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma. Gel filtration chromatography of tumor extract demonstrates a single major peak of bone resorption activity (BRA, 45Ca release from calvarial bone) that elutes with an apparent MW of about 15,000 dalton. The BRA is associated with increased release of immunoreactive PGE 2 and both can be inhibited by indomethacin and boiling. In TCC and DMBA, the BRA were co-eluted with an activity of stimulating aden-ylate cyclase in rat osteosarcoma cells ROS 17/2.8. It appears that these factors are unique BRF, which are different from other known factors that can cause bone resorption.
Cytokeratin and Carcinoembryonic Antigen (CEA) in bladder cancer cells were studied in 28 and 26 cases respectively using Avitin-Biotin-peroxidase Complex (ABC) method. The results showed that the low molecular weight cytokeratin and CEA expressed during the embryo development were also expressed in transitional cell carcinomas. Both were increased with the increase of pathological grade and de- creased with degree of cancer cell differentiation. It is suggested that tha differences of both cytokeratin and CEA...
Cytokeratin and Carcinoembryonic Antigen (CEA) in bladder cancer cells were studied in 28 and 26 cases respectively using Avitin-Biotin-peroxidase Complex (ABC) method. The results showed that the low molecular weight cytokeratin and CEA expressed during the embryo development were also expressed in transitional cell carcinomas. Both were increased with the increase of pathological grade and de- creased with degree of cancer cell differentiation. It is suggested that tha differences of both cytokeratin and CEA in the different pathological grading of bladder car- cinoma might be an index related to the differentiation of cancer cell. The results also showed that by using higher sensitive method and specific antibody, the antigen of cancer cell may be demonstrated well in formalin-fixed, fresh or older, paraffin- embedded tissues.
在膀胱癌
in bladder
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