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   宫颈鳞癌组织 的翻译结果: 查询用时:0.046秒
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宫颈鳞癌组织     
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  cervical squamous cell carcinoma
     Expression of E-cadherin, CD_ (44)V_6 and nm23-H_1 in cervical squamous cell carcinoma tissue
     宫颈鳞癌组织中上皮性钙黏附蛋白、CD_(44)V_6、nm23H_1的表达
短句来源
     Results:The positive rate of PTEN protein was significantly lower in cervical squamous cell carcinoma( 61.4%)than that in normal tissues (100%) (P<0.05);
     结果:宫颈鳞癌组织中PTEN蛋白阳性表达率(61.4%)明显低于正常宫颈组织(100%)(P<0.05);
短句来源
     Expression of Metastasis Suppressor Gene KAI1/CD82 in Cervical Squamous Cell Carcinoma and Its Clinical Significance
     宫颈鳞癌组织中转移抑制基因KAI1/CD82的表达及其临床意义
短句来源
     Correlations between the expressions of Beclin 1 gene and the clinicopathologic factors of cervical squamous cell carcinoma were statistically analyzed. Results The rates of negative, weak, strong expression of Beclin 1 in cervical squamous cell carcinoma were 43.2% (35/81), 34.6% (28/81) or 22.2% (18/81) respectively, and the significantly lower than those in normal cervix and CIN Ⅱ-Ⅲ(P=0.011).
     结果宫颈鳞癌组织中Beclin1阴性、弱阳性、强阳性表达率依次是43.2%(35/81)、34.6%(28/81)、22.2%(18/81),与正常宫颈和宫颈上皮内瘤样病变组相比,Beclin1在宫颈鳞癌中的表达显著下调(P=0.011)。
短句来源
     Object: To study the expressions of S100A4, matrix metalloproteinases (MT1-MMP, MMP-2 and MMP-9) and tissue inhibitor of metalloproteinases (TIMP-1, TIMP-2) at the gene and protein levels in cervical squamous cell carcinoma and explore the role of matrix metalloproteinases mediated by S100A4 in lymphatic metastasis of cervical squamous cell carcinoma.
     目的:本研究在基因和蛋白水平检测 S100A4、基质金属蛋白酶(MT1-MMP、 MMP-2 和 MMP-9)及金属蛋白酶组织抑制剂(TIMP-1、TIMP-2)在宫颈鳞癌组织中的表达,探讨 S100A4 介导的基质金属蛋白酶(MMPs)在宫颈鳞癌淋巴转移中的作用。
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  cervical squamous carcinoma
     (2) Positive expression rates of P16~(INK4A) in cervical squamous carcinoma,CIN Ⅰ,CIN Ⅱ,CIN Ⅲ and chronic cervicitis were 100%,20.0%,46.7%,100.0% and 10.0%.
     (2)宫颈鳞癌组织、CINⅠ级、CINⅡ级、Ⅲ级及慢性宫颈炎标本中P16INK4A阳性率分别为100%、20.0%、46.7%、100.0%和10.0%;
短句来源
     Results:(1) The positive expression rates of S100A4 and E-cadherin were 35.4%(23/65) and 33.8%(22/65)in cervical squamous carcinoma,respectively.
     结果:(1)宫颈鳞癌组织中S100A4蛋白和E-cad的表达率分别为35.4%(23/65)和33.8%(22/65);
短句来源
     (3) The expression of S100A4 was negatively correlated to E-cadherin in cervical squamous carcinoma(r=-0.257,P<0.05).
     (3)S100A4蛋白和E-cad在宫颈鳞癌组织的表达呈负相关(r=-0.257,P<0.05)。
短句来源
     Objective:To detect the expression of HIF-1α and the level of serum VEGF in cervical squamous carcinoma and discuss their relationship with clinical-Pathological factors of cervical carcinoma.
     检测宫颈鳞癌组织中缺氧诱导因子-1α(HIF-1α)的表达及血清血管内皮细胞生长因子(VEGF)水平,探讨二者与宫颈癌临床病理因素的关系;
短句来源
     Expression of NF-κBp65,p53 protein in tissues of cervical squamous carcinoma
     宫颈鳞癌组织中核因子-κBp65和p53蛋白的表达
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  cervical squamous carcinoma tissues
     Methods: SP Immunohistochemistry method was performed to examine the expression of NFκ-Bp65 and IκB-α protein in 38 cases of cervical squamous carcinoma tissues,27 cases of cancer adjacent specimens,21 cases of cervical intraepithelial neoplasia.
     方法:采用免疫组织化学技术(SP法),分别检测38例宫颈鳞癌组织、27例癌旁组织、21例CIN组织中NF-κBp65、IκB-α的表达。
短句来源
     Expression of TM and VEGF in cervical squamous carcinoma tissues and their significance
     TM与VEGF在宫颈鳞癌组织中的表达和意义
短句来源
     Methods The expressions of NF-κBp65 and p53 protein in 38 cases of cervical squamous carcinoma tissues, 21 cases of cervical intracpithelial neoplasia and 12 cases of normal cervical tissues were examined by SP Immunohistochemistry method.
     方法 采用免疫组织化学技术(S P法),分别检测38例宫颈鳞癌组织、21例CIN组织和12例正常宫颈组织中NF κBp65和p53蛋白的表达。
短句来源
     NRDRB1 mRNA was detected in 15 of 27(55.6%) cervical squamous carcinoma tissues,significantly higher than that in normal cervical epithelial tissues(P<0.05). NRDR were detected in normal cervical epithelium but NRDRB1 mRNA and protein were not.
     NRDRB1 mRNA及蛋白在宫颈鳞癌组织中表达(15/27,55.6%),明显高于正常宫颈上皮组织(P<0.05),正常宫颈上皮除NRDR外,未检测到NRDRB1 mRNA及其蛋白。
短句来源
     Methods:RT-PCR,immunofluorescence,immuno-precipitation,immunoblotting,MALDI-TOF mass spectrometry analysis were used to detect NRDRB1 mRNA and protein expression in normal cervical epithelium and cervical squamous carcinoma tissues.
     方法:采用RT-PCR、免疫荧光、免疫沉淀、免疫印迹、MALDI-TOF质谱分析等技术,检测正常宫颈上皮及宫颈鳞癌组织中NRDRB1mRNA及蛋白表达。
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  squamous cervical carcinoma
     Expression and significance of KAI1/CD82 and E-Cadherin in Human squamous cervical carcinoma
     KAI1/CD82、E-Cadherin在宫颈鳞癌组织中的表达及其意义
短句来源
     The Expression of Apoptosis Inhibition Gene, Survivin in Squamous Cervical Carcinoma and Its Association with the Expression of P53 and HPV16
     Survivin在宫颈鳞癌组织中的表达及其与p53基因表达和HPV-16感染相关性的研究
短句来源
     Expression and significance of tenascin in human squamous cervical carcinoma
     Tenascin在宫颈鳞癌组织中的表达及其意义
短句来源
     Relationship between apoptosis and clinical biological behavior of squamous cervical carcinoma
     宫颈鳞癌组织中细胞凋亡的表达与临床生物学行为的关系
短句来源
     Aim:To analysis the relationship between apoptosis and the clinical biological behavior of squamous cervical carcinoma.
     目的 :探讨细胞凋亡在宫颈鳞癌组织中的表达及其与宫颈鳞癌组织学分级、盆腔淋巴结转移及临床分期的关系。
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      cervical squamous cell carcinoma
    Prognostic factors for patients with FIGO Stage-IB cervical squamous cell carcinoma: Does the tumor size (≤ 4 cm or > 4 cm) real
          
    Thymidine phosphorylase expression is preserved after radiotherapy in patients with cervical squamous cell carcinoma
          
    STn and CEA antigens were expressed very weakly in the normal cervical epithelium but strongly in the cancer cells, indicating the antigens to be oncogenic antigens of cervical squamous cell carcinoma.
          
    This finding may reflect an important role of these carbohydrate chains in the process of metastasis of cervical squamous cell carcinoma to regional lymph nodes.
          
    Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
          
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      cervical squamous carcinoma
    We studied the chemosensitivity to various anticancer agents of human cervical squamous carcinoma ME180 cells, and two resistant subclones, ME180/TNF and ME180/Pt, which also differ in their EGF receptor (EGFR) expression.
          
    Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma
          
      squamous cervical carcinoma
    Phase II evaluation of dianhydrogalactitol in the treatment of advanced non-squamous cervical carcinoma
          


    Quantitative study of Argyrophilic neucleolar organizer region(AgNOR)was performed on 109 cases of cervicalbenign and malignant lesions.We found that the mean value of AgNOR in the three different lesions of chronic cervicitis,cervicalatypical hyperplasia and cervical squamous carcinoma has a significant difference(P<0.0l),and the count of AgNOR in histologicgrade Ⅰ squamous carcinoma is lower than that in grade Ⅱ(P<0.00l).The l0-years survival rate of cervical squamous carcinomapatients with mean value of AgNOR≥5(18%)is...

    Quantitative study of Argyrophilic neucleolar organizer region(AgNOR)was performed on 109 cases of cervicalbenign and malignant lesions.We found that the mean value of AgNOR in the three different lesions of chronic cervicitis,cervicalatypical hyperplasia and cervical squamous carcinoma has a significant difference(P<0.0l),and the count of AgNOR in histologicgrade Ⅰ squamous carcinoma is lower than that in grade Ⅱ(P<0.00l).The l0-years survival rate of cervical squamous carcinomapatients with mean value of AgNOR≥5(18%)is significantly lower than those<5(46%)(P<0.05).These results suggested thatthe count of AgNOR might be considered as a new quantitive marker in differentiating diagnosis of benign and malignant cervicallesions,chosing optimum treatment schemes,and deducing the prognosis of cervical carcinoma.

    应用核仁组成区蛋白嗜银(AgNOR)技术,对109例宫颈良、恶性病变进行了AgNOR定量研究。结果表明:1.慢性宜颈炎、宫颈非典型增生、宫颈鳞癌三种病变的AsNOR均值有显著差异(P<0.01)。2.宫颈鳞癌组织学1级AgNOR计数低于组织学Ⅱ级(P<0.001)。3.随访10年以上的73例宫颈鳞癌患者,核仁组成区蛋白高均值组(≥5)的患者生存时间显著短于低均值组(<5)(P<0.05),10年生存率分别为18%与46%。作者认为,AgNOR计数可作为一种新的肿瘤定量指标,在宫颈良、恶性病变的鉴别诊断、选择最佳治疗方案、推测宫颈癌预后等方面具有重要的临床价值。

    AgNORs were analyzed with AgNOR staining in 73 specimens of cervical squamous carcinoma. The results showed that AgNORs of the specimens with Ⅱ histological grade were higher than that of grade Ⅰ, (5. 53±1. 47and, 4. 40±1. 34, respectively), and the patients whose AgNORs were≥5. 0, have a lower 10-year survival rate than the patients whose AgNORs were< 5. 0, P<0. 02. This indicated that there was a good correlation between AgNORs and histolgical grade or prognosis of the cervical squamous carcinoma,AgNORs could...

    AgNORs were analyzed with AgNOR staining in 73 specimens of cervical squamous carcinoma. The results showed that AgNORs of the specimens with Ⅱ histological grade were higher than that of grade Ⅰ, (5. 53±1. 47and, 4. 40±1. 34, respectively), and the patients whose AgNORs were≥5. 0, have a lower 10-year survival rate than the patients whose AgNORs were< 5. 0, P<0. 02. This indicated that there was a good correlation between AgNORs and histolgical grade or prognosis of the cervical squamous carcinoma,AgNORs could be regarded as a valuable index to judge the malignant grade and the prognosis of cervical squamous carcinoma.

    对73例随访10年以上的宫颈鳞癌进行AgNOR计数分析,发现组织学D级的肿瘤细胞核内AgNOR均值高于组织学Ⅰ级者为5.53±1.47及4.40±1.34)。10年生存率亦有差异性,AgNOR均值≥5者10年生存率为18%,而<5的10年生存率为46%(P<0.02)。结果表明,AgNOR计数与宫颈鳞癌的组织学分级及临床预后有关。本文认为AgNOR计数可作为一种肿瘤定量指标,对判定肿瘤恶性程度,预测宫颈癌预后具有一定参考价值。

    Objective: To study the possibility of complex formation of the E7 protein encoded by human papillomavirus (HPV) binding to retinoblastoma gene product (pRb) in fresh samples of squamous cervical carcinoma (SCC). Methods: HPV 6/11, 16, 18, 33 DNA were detected in 40 samples of by polymerase chain reaction technique (PCR). The complexes of HPV E7pRb were examined in fresh tissues of HPV contained SCC through capture enzeme linked immunosorbent assay (captureELISA). Results: 45.0% (18/40) of the samples were...

    Objective: To study the possibility of complex formation of the E7 protein encoded by human papillomavirus (HPV) binding to retinoblastoma gene product (pRb) in fresh samples of squamous cervical carcinoma (SCC). Methods: HPV 6/11, 16, 18, 33 DNA were detected in 40 samples of by polymerase chain reaction technique (PCR). The complexes of HPV E7pRb were examined in fresh tissues of HPV contained SCC through capture enzeme linked immunosorbent assay (captureELISA). Results: 45.0% (18/40) of the samples were proved to be HPV positive by PCR. Out of 18 samples with HPV positive samples, the complexes of HPV E7pRb were deteced in 9 cses, including 1 HPV18 positive and 8 HPV16 positives. The complexes of HPV E7pRb were not found in 2 cases of positive HPV 6/11. No correlation was observed between the E7 protein binding to pRb and the histological grade of cervical carcinoma (P<0.05). There was correlation with clinical staging, the number of cases showing that the E7 protein pRb complex in stage Ⅰ was significantly higher than that in stages ⅡⅣ (P<0.05). Conclusions: The complex of “high risk” HPV E7pRb was demonstrated in fresh tissues of SCC. There is no correlation between the complex and histological grade of SCC. The complex formation may occur in the early developmental stage of cervical cancer.

    目的:检测子宫颈鳞癌组织中是否存在人乳头状瘤病毒(HPV)E7蛋白与Rb基因产物(pRb)的结合物(HPVE7-pRb)。方法:运用聚合酶链反应(PCR)技术,对40例宫颈鳞癌组织中HPV6/11、16、18、33型DNA进行检测,并用捕获酶联免疫吸附试验,探查HPV感染的标本中有否HPVE7-pRb存在。结果:40例中,检出HPVDNA18例(45.0%)。18例中9例存在HPVE7-pRb,其中1例为HPV18,8例为HPV16。2例HPV6/11未检出HPVE7-pRb。临床Ⅰ期患者HPVE7-pRb的检出率高于Ⅱ~Ⅳ期患者(P<0.05)。HPVE7与pRb的结合,与宫颈癌病理分级无关(P>0.05)。结论:在宫颈鳞癌组织中存在HPVE7-pRb;HPVE7与pRb的结合过程发生在宫颈癌变的较早阶段。

     
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