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宫颈鳞癌的
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  cervical squamous cell carcinoma
     Expressions of p65 and MMP-2,MMP-9,TIMP-2,TIMP-1 in cervical squamous cell carcinoma
     p65及MMP-2、MMP-9、TIMP-2、TIMP-1在宫颈鳞癌的表达状态
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     RESULTS: The rates of negative, weak, moderate, and strong expression of KAI1 in cervical squamous cell carcinoma were 52.5% (52/99), 16.2% (16/99), 15.2% (15/99), and 16.2% (16/99), respectively, significantly lower than those in normal cervix, and CIN Ⅱ-Ⅲ (P=0.000).
     结果:宫颈鳞癌中KAI1阴性、弱、中、强表达依次为52.5%穴52/99雪、16.2%穴16/99雪、15.2%穴15/99雪、16.2%穴16/99雪,与正常宫颈和宫颈上皮内瘤变组相比,KAI1在宫颈鳞癌的表达存在显著下调(P=0.000)。
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     Objective: To study whether CD15s antigen and P-selectin were associated with the metastasis of cervical squamous cell carcinoma(CSCC).
     目的:探讨CD15s抗原、P-选择素(P-selectin)是否与宫颈鳞癌的转移相关。
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     Both univariate and multivariate analyses showed expression of KAI1 has no correlation with prognosis of cervical squamous cell carcinoma (P>0.05).
     单因素和多因素分析均显示KAI1表达与宫颈鳞癌的预后无相关(P>0.05)。
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     Expression of PDGF-AmRNA and protein in cervical squamous cell carcinoma and its clinical significance
     PDGF-AmRNA与PDGF-A蛋白在宫颈鳞癌的表达及其临床意义
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  cervical squamous carcinoma
     Conclusion NF-κBp65 and p53 play important role in the development of cervical squamous carcinoma.
     结论 NF κBp65和p53蛋白在宫颈鳞癌的发病过程中起着重要的作用。
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     Expression of fucose in human cervical squamous carcinoma tissues and its clinical significance
     岩藻糖基抗原在宫颈鳞癌的表达及意义
短句来源
     the positive rate of fhit was lower than those in CIN and chronic cervicitis(P<0.01). (2)The positive rate of survivin protein were 69.51%(57/82), 30%(12/40) and 15%(3/20) in cervical squamous carcinoma, CIN and chronic cervicitis(P<0.01).
     (2)survivin蛋白在宫颈鳞癌组织中的阳性表达率为69.51%,与慢性宫颈炎及CIN的差别有统计学意义(P<0.01),并随宫颈鳞癌的临床分期(Ⅰ~Ⅲ)递增(P<0.05),而且与患者年龄、有无淋巴转移有关(P<0.05),与病理分级无关(P>0.05)。
短句来源
     The MMP/TIMP ratios were increased with the stage of cervical squamous carcinoma. Conclusion:The MMP-2, MMP-9 proteins and TIMP-2, TIMP-1 protains may act as an index to indicate the process of the infiltration and metastasis in cervical squamous carcinoma.
     结论:MMP-2,MMP-9,TIMP-2,TIMP-1的表达与宫颈鳞癌的发生发展密切相关,MMPs/TIMPs可能是评价宫颈鳞癌分期和病理分级的—个可靠指标。
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     The reduced membranous β catenin and E cadherin expression might be related to the invasion and metastasis of cervical squamous carcinoma.
     β cat与E cad胞膜表达缺失可能与宫颈鳞癌的侵袭和转移有关。
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  “宫颈鳞癌的”译为未确定词的双语例句
     ④The positive expression of P21~ waf and Ki67 showed negative correlation in the progress from CIN to SCC(P< 0.05 , r=-0.446 ).
     ④P21waf与Ki67的阳性表达在CIN演变到宫颈鳞癌的过程中呈现负相关性(P<0.05,r=-0.406)。
短句来源
     4)The positive expression of P21~(waf) and Ki67 showed negative correlation in the progress form CIN to SCC(P<0.05,r=-0.446).
     4)P21waf与Ki67的阳性表达在CIN演变到宫颈鳞癌的过程中呈负相关(P<0.05,r=-0.406)。
短句来源
     The expression of CD44V6 and EGFR proteins was closely correlated with pathological grade,lymph node metastasis(P<0.05、P<0.01),but not with clinical stage(P>0.05).
     CD44V6和EGFR的蛋白表达与宫颈鳞癌的临床分期无关(P>0.05),与病理组织学分级、淋巴结转移有关(P<0.05、P<0.01)。
短句来源
     Results:The portions of p16INK4A and p14ARF–positive samples increase in the following row: normal cervix - CINⅠ- CINⅡ- CINⅢ-SCC,which had significant differences (P1=0.000,P2=0.000). The positive correlations were found between the p16INK4A and the p14ARF expressions in consecutive cervical lesions (r=1).
     结果:按照正常宫颈—CINⅠ—CINⅡ—CINⅢ—宫颈鳞癌的顺序,p16INK4A及p14ARF的阳性率逐渐升高,具有显著差异(P1=0.000,P2=0.000),p16INK4A和p14ARF在各级宫颈病变中的表达呈正相关(r=1)。
短句来源
     Conclusion KAI1/CD82 and(E-Cadherin) interactions may depress lymphonode metastasis in cervical carcinoma.
     结论KAI1/CD82可能与膜蛋白E-Cadherin相互作用抑制宫颈鳞癌的淋巴结转移;
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  cervical squamous cell carcinoma
Prognostic factors for patients with FIGO Stage-IB cervical squamous cell carcinoma: Does the tumor size (≤ 4 cm or > 4 cm) real
      
Thymidine phosphorylase expression is preserved after radiotherapy in patients with cervical squamous cell carcinoma
      
STn and CEA antigens were expressed very weakly in the normal cervical epithelium but strongly in the cancer cells, indicating the antigens to be oncogenic antigens of cervical squamous cell carcinoma.
      
This finding may reflect an important role of these carbohydrate chains in the process of metastasis of cervical squamous cell carcinoma to regional lymph nodes.
      
Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
      
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  cervical squamous carcinoma
We studied the chemosensitivity to various anticancer agents of human cervical squamous carcinoma ME180 cells, and two resistant subclones, ME180/TNF and ME180/Pt, which also differ in their EGF receptor (EGFR) expression.
      
Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma
      


Of the 1,265 cases of carcinoma of cervix admitted between 1965~1975,there were542(42.84%)carcinomas in situ and 489(38.65%)stage Ia carcinomas.In our hospital,stage Ia means infiltration of cancer cells within 3 mm beyond basement membrane.Incomparison with the pathology of surgical specimens,913 punch biopsies missed17(1.86%)invasive carcinomas while none was missed in cone biopsies.All the caseswere treated surgically by various procedures.The overall 5-yr survival rate was99.79% and there was no death due...

Of the 1,265 cases of carcinoma of cervix admitted between 1965~1975,there were542(42.84%)carcinomas in situ and 489(38.65%)stage Ia carcinomas.In our hospital,stage Ia means infiltration of cancer cells within 3 mm beyond basement membrane.Incomparison with the pathology of surgical specimens,913 punch biopsies missed17(1.86%)invasive carcinomas while none was missed in cone biopsies.All the caseswere treated surgically by various procedures.The overall 5-yr survival rate was99.79% and there was no death due to cancer per se.Eight cases with residual cancertissue in the vaginal vault were supplemented by postoperative irradiation,and theywere living and well 5~15 yr after treatment.

本文目的是探讨489例Ⅰ_a 期宫颈鳞癌不同手术范围的疗效。诊断的标准是癌细胞突破宫颈上皮基底膜向间质内浸润深度在3毫米以内。诊断的方法是点状活检及锥切检查。资料示点状活检漏诊宫颈浸润癌的可能性在1.5~2.7%之间,而锥切检查无漏诊浸润癌。5例有脉管内浸润,8例有阴道断端残留癌,术后都作了放射治疗,至今健在(5~15年)。尽管手术范围有所不同,但无因本病死亡,5年存活率为99.79%。基于本组489例的经验,建议以扩大全子宫手术作为Ⅰ_a 期宫颈癌的治疗方法。

Ultrastructural studies on effect of HpD on carcinoma cell line were reported. A clonal cell line of cervical carcinoma (CC-801) was used. In group of 16UUUUUUUUUg/ml HpD,the matrices of some mitochondria were decreased in density 2 minutes after light exposure and swollen mitochondria with translucent matrices and slightly aggregated nuclear chromatin appeared 5 mins later. 30 mins after irradiation, these degenerative changes became pronounced and cisterna of rough endoplasmic reticulum dilated with swollen...

Ultrastructural studies on effect of HpD on carcinoma cell line were reported. A clonal cell line of cervical carcinoma (CC-801) was used. In group of 16UUUUUUUUUg/ml HpD,the matrices of some mitochondria were decreased in density 2 minutes after light exposure and swollen mitochondria with translucent matrices and slightly aggregated nuclear chromatin appeared 5 mins later. 30 mins after irradiation, these degenerative changes became pronounced and cisterna of rough endoplasmic reticulum dilated with swollen nuclei.1 h after irradiation, the swollen mitochondria showed a balloon structure without cristae,endoplasmic reticulum became more dilated and plasma membrane was broken and whole ended with necrosis.SEM revealed that the cells became slightly swollen 2 mins after irradiation, membrane vesicles developed and microvilli reduced in their number 10 mins after irradiation and then the vesicles appeared broken from thtir appendages and only residues remained on the surface.90 mins after irradiation,some cells were broken into debris wlth differents sizes.We suggest that mitochondria may be the earliest target for photosensitizing effect and other cellular changes are the secondary effect.

应用血卟啉衍生物(HpD)作用于人宫颈鳞癌细胞,当剂量为16μg/ml再光照2分钟后,透射电镜下即出现线粒体基质的灶性空化,5分钟后线粒体肿胀,核基质凝聚。光照10分钟再持续作用30分钟,上述改变更加明显,又出现粗面内质网扩张及核肿胀;60分钟后线粒体嵴呈球状嵴消失,内质网呈现空泡样结构,细胞膜裂解。扫描电镜下于光照2分钟后细胞肿大;10分钟后表面绒毛减少,泡状突起增加,有的断裂呈指状突;90分钟细胞裂解成大小不等的团块。作者认这线粒体是HpD光敏作用最早的靶细胞器,其他改变可能是线粒体损伤导致的继发效应。

The present article with the use of clinical follow-up date, analysed the specimens of 180 cases of radical hysterectomy of the early cervical squamus cell carcinoma.There were 24 cases of carcinoma in situ (13.3%), 53 cases of carcinoma in situ with gland extensive (29.5%) , 65 cases of early invasive carcinoma (IA) (36.1%), 38 cases of invasive carcinoma (IB) (31.1%). The focuses of this series mainly showed multiple central growth (89.4%), while simple central growth was rare. So clinical multiple point biopsies...

The present article with the use of clinical follow-up date, analysed the specimens of 180 cases of radical hysterectomy of the early cervical squamus cell carcinoma.There were 24 cases of carcinoma in situ (13.3%), 53 cases of carcinoma in situ with gland extensive (29.5%) , 65 cases of early invasive carcinoma (IA) (36.1%), 38 cases of invasive carcinoma (IB) (31.1%). The focuses of this series mainly showed multiple central growth (89.4%), while simple central growth was rare. So clinical multiple point biopsies raised the diagnostic positiveness of carly carcinoma. The depth of infiltration of the early invasive carcifioma was less than 5mm, and usually appeared in the forms of buds, drops, masses, or in a confluent multifocal mixed form of infiltration (63%). Clinically, carcinoma was preferably treated as invasive carcinoma. The simple invasion forms were relatively rare, and the cancer focus was less than 1mm, and should be treated as carcinoma in situ. In case of the interstitial vascular infiltration (in the cancer focus), the incidence of invasive cancer was about 3.2 times as that of the early invasive cancer. The dePth of its infiltration was proportional to that of the vascular infiltration. It was shown that lymph node metastasis was a dangerous sign, even if the depth of infiltration was less that 3mm. Therefore, to choose proper method of treatment and strengthen the immune function of the body were the key points to improve the prognosis

本文对180例早期宫颈鳞癌标本结合临床随访资料进行了分析。癌灶主要为多中心性生长(89.4%),故临床活检多点取材,可提高早期癌检出率。早浸癌浸润的深度在5mm以内,以舌状、滴状与团状或融合状多灶混合型浸润为多见(63%)。癌灶问质内有脉管浸润者,浸润癌比早浸癌增高3.2倍。其浸润深度与脉管浸润成正比,并提示了有淋巴结转移,即使浸润深度小于3mm者,也具有危险性。选择适当的治疗方法和增强机体免疫功能是改善预后的关键。

 
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