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myc蛋白     
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  myc protein
     There was a remarkable correlation between the TUNEL positive neurons and the gray scale of c myc protein in both groups ( r = 0.92 in the experimental group, r = 0.84 in the sham group, P <0.01).
     TUNEL阳性细胞数和c -myc蛋白灰度具有明显的相关性 (实验组r=0 .92 ,对照组r =0 .84 ,P <0 .0 1)。
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     Results:C myc mRNA positive rate in 29 cases of benign and 7 cases of malignant adrenal pheochromocytomas were 27.5%(8/29) and 71.5%(5/7) C myc protein's expression rate of benign and malignant pheochromocytomas were 31.0%(9/29) and 71.4%(5/7).
     结果 :原位杂交结果显示 :C mycmRNA在良性肾上腺嗜铬细胞瘤中表达率为 2 7.5 % (8 2 9) ,而在恶性肾上腺嗜铬细胞瘤中为 71.4(5 7) (P <0 .0 5 ) ; 免疫组化结果显示 :C myc蛋白表达率分别为 31.0 % (9 2 9)和 71.4% (5 7) (P <0 .0 5 ) ;
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     TGF β 1 could significantly stimulate thymidine uptake and increased C myc protein expression in GNM cell lines, while TGF β 1 inhibited cell proliferation and decreased C myc protein expression in TSCCa cell lines;
     TGF β1可促进GNM细胞3 H TdR掺入率 ,同时GNM细胞中C myc蛋白表达明显上调 ; 而TGF β1可抑制TSCCa细胞的增殖 ,TGF β1作用于TSCCa细胞后C myc蛋白表达水平开始下降 ,并与TGF β1有剂量依赖关系。
短句来源
     BACKGROUND & OBJECTIVE: The latest researches showed that myc protein could up-regulate the expression of human telomerase reverse transcriptase (hTERT), multidrug resistance gene 1(MDR1), multidrug resistance-related protein (MRP) in some kinds of tumors, and hTERT is correlated with efficiency of anti-tumor chemotherapy.
     背景与目的:已证实myc蛋白可上调某些肿瘤中人端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)、多药耐药基因(multidrug resistance gene,MDR1)、多药耐药相关蛋白(multidrug-resistance-related protein,MRP)mRNA的表达,hTERT与化疗疗效有关。 阐明肺癌中myc、hTERT与多药耐药相关基因的内在关系,可为治疗提供更多思路。
短句来源
     The results showed that the positive rate of P62 c myc protein expression was 63 55% (68/107). The over expression of P62 c myc protein related negatively with survival. 94.00% of the cases with overexpression of P62 c myc protein survived ≤5 years, 65.00% survived >5 years-<10 yeras, and 21.62% survived ≥10 years.
     结果显示:P62c-myc蛋白表达阳性率为63.55%(68/107),对生存时间≤5年、>5年~<10年和≥10年者,其P62c-myc蛋白表达阳性率分别为94.00%(47/50),65.00%(13/20)和21.62%(8/37);
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  myc
     Relationship between apoptosis and cell proliferation and expression of Rb, bcl 2 and c myc proteins in human breast cancer
     乳腺癌中凋亡与细胞增殖及Rb、bcl-2、c-myc蛋白表达的关系
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     P53,Cmyc expressions of 47 mice with leukemia were significantly higher than those of control group(P<0.05).
     47只白血病小鼠P53、C myc蛋白阳性表达率均比正常对照组高(P<0.05);
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     Results:The rates of positive immunostaining of cyclin D1,P53 and c myc in gastric carcinoma were 32.75% ,25.40% and 52.38%,respectively.
     结果 :63例胃癌中cyclinD1、P53及c myc蛋白染色阳性率分别为 32 .75 %、2 5 .40 %及 52 .38% ;
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     Methods After treatment of HepG 2 cells with 0~1.5 g/L matrine for 3 d, the protein expressions of AFP, PCNA, wp53, Rb, N ras and c myc were detected with immunocytochemical method, mRNA expressions of wp53, c myc with in situ hybridization;
     方法  0~ 1 5g/L苦参碱作用HepG2 细胞 3d ,免疫组化检测AFP、PCNA、wp5 3、Rb、N ras、c myc蛋白的表达 ,原位杂交法检测wp5 3、c mycmRNA的表达 ,真彩色图像定量分析检测结果 ,Microsoft-Excel软件统计学处理结果 ;
短句来源
     P53,Cmyc expressions of 23 mice without leukemia didn't have difference with control group(P>0.05).
     23只未形成白血病的实验组小鼠P53、C myc蛋白阳性表达率均与正常对照组无显著差异(P>0.05).
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  myc gene
     ② The expressions of bcl 2 and c myc gene in SHG 44 cells were decreased after the treatment of 100 μmol/L NDGA with the elapse of time, indicating a close association with cell apoptosis.
     ②经NDGA处理细胞后 ,出现SHG 44细胞bcl 2、c myc蛋白表达水平降低 ,且随着作用时间的延长 ,这种趋势更加明显 ,与细胞凋亡的发生密切相关 ;
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     mixed type group ( χ 2 =6.497, P <0.05). The positive rates of c myc gene protein in the different stages of squamous cell carcinoma group (21 cases) were 100.0%(9/9) in stage I, 85.7%(6/7) in stage Ⅱ, and 60.0%(3/5) in stage Ⅲ repectively.
     2 1例鳞癌标本 , 级 , 级 , 级中 c- myc蛋白的阳性率分别为 1 0 0 .0 % (9/9) ,85 .7% (6 /7) ,6 0 .0 % (3 /5 ) .
短句来源
     Results The expression of c myc gene was high in acute myelogenous leukemia, it had statistical difference between two group of patients (P<0 01).
     结果白血病组 c- m yc蛋白表达较非白血病组明显增高 ,两者呈显著性差异 (P<0 .0 1)。
短句来源
     Objective To explore the effect of oxidative stress on neuronal apoptosis and c myc expression and the role of c myc gene in promoting neuronal apoptosis after traumatized brain injury (TBI) in rats.
     目的 探讨氧化应激对脑损伤后神经细胞凋亡和c -myc蛋白表达的影响及c -myc基因在脑损伤神经细胞凋亡中的作用。
短句来源
     METHODS: From translation initiation region of second extron of c myc gene, oligonucleotides were synthesized and modified with phosphorothioate. Rabbit lens were treated with galactose and c myc ASODN and the effects of c myc ASODN on the level of c Myc protein expression and the cell cycle of LEC induced by galactose were detected by flow cytometry.
     方法 :人工合成与c myc基因第二外显子翻译起始区序列互补的寡核苷酸并磷酸化修饰 ,用半乳糖和c mycASODN处理体外培养的兔晶状体 ,流式细胞术检测c mycA SODN对半乳糖诱导的LEC中c Myc蛋白表达水平及细胞周期的影响 .
短句来源
  “myc蛋白”译为未确定词的双语例句
     EXPRESSION OF HPV_(16) E_6mRNA,P~(53),P~(21)~(ras) AND C-MYC PROTEIN IN HUMAN CERVICAL CANCEROUS TISSUES
     人子宫颈癌中的HPV_(16)E_6mRNA、p~(53)、P~(21)~(ras)和c-myc蛋白表达
短句来源
     The Significance of HPV_(16)E_6mRNA、P~(21ras) andc-myc Protein Expression in Cervical Cancerous
     HPV_(16)E_6mRNA、P~(21ras)和c-myc蛋白在子宫颈鳞癌中表达的意义
短句来源
     There was a significant correlation between telomerase activity and the expression of hTERT and c-myc protein (r=0.761,P<0.001;r=0.654,P<0.001;r=0.486,P<0.001,respectively).
     HCC癌组织中端粒酶活性、hTERT及c-myc蛋白阳性表达率两两均呈显著正相关(r=0.761,P<0.001;r=0.654,P<0.001;r=0.486,P<0.001)。
短句来源
     Results:A higher detection rate of HPV16E6DNA,E6protein and p53protein were found in invasive cervical carcinoma which c - myc positive expression rate was significantly lower than chronic cervicitis.
     结果:浸润性宫颈癌HPV16 E6 DNA及其蛋白、p53蛋白阳性率明显高于慢性宫颈炎组,c-myc蛋白阳性率则明显低于慢性宫颈炎组,p53蛋白阳性率与HPV16 E6 DNA的检出率之间无负相关关系。
短句来源
     Results The expression rate of C-myc protein in control group and injury after 3h and 6h was 7.41±3.25%? 15.25±6.85% and 17.51±7.78% respectively.
     结果对照组和伤后3h、6h每组大鼠C-myc蛋白阳性表达百分率分别为:7.41±3.25%、15.25±6.85%和17.51±7.78%。
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  myc protein
A decrease in the HL-60 native c-myc protein level wasalso observed with 100 μg/ml of modified antisense ODN, but not with thesense ODN control, by immunoblot analysis.
      
A clone that expressed the v-myc protein was propagated to the end of its life span, with periodic cryogenic storage of the progeny.
      
Molecular analysis showed that the infinite life span cells are, indeed, derived from the cells used for transfection, and that they continue to express the v-myc protein.
      
We further examined the effect of FR901228 on c-myc protein, which is one of the main hTERT transcription activators.
      
FR901228 repressed c-myc protein only in the absence of CHX, and depended on the enhancement of de novo protein synthesis.
      
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  myc
Such are the suggested effects on telomerase of Myc, p53, Waf1, protein kinases B and C, Wnt5A, TGFβ, WT1, and estrogens.
      
However, Myc, p53, WT1, estrogens, protein kinases B and C, and TGFβ can also directly influence telomerase independently of the G1-S checkpoint mechanism.
      
To study some additional factors necessary for such transformation, c-myc and N-rasAsp12 were consecutively introduced into REF52 cells by retroviral infection, and the cell cultures obtained were analyzed.
      
The proliferating-cell gene cluster included MET, VIM, MYC, TOP2A, PCNA.
      
In pCI.ori-neo, chromosomal ori was from the human c-myc locus.
      
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  myc gene
Silencing of c-myc gene expression using enzymatically and chemically synthesized siRNAs
      
The expression of c-myc gene was found pronouncedly reduced by Western blot analysis.
      
However, the inhibition of PTPase activity may block the induction oftnf-β gene and c-myc gene transcription by IL-2 and ultimately results in cell death.
      
HeLa cells overexpressing Bcl-2 partly resist As2O3 induced apoptosis, which might be relative to preventing the cells from As2O3 caused G2/M block, downregulation of c-myc gene expression and inhibition of viral gene expression was also noted.
      
CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins.
      
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  myc genes
The regulation of c-myc protein, product of c-myc/genes, was studied in four glioma cell lines by Northern blot, pulse-chase dot blot, immunoblot and immunoprecipitation analyses.
      
However, cells without DMs were also present in which the c-myc genes were found integrated into any of several distinct chromosomes (mainly 7q+, 4 and 4q+, and 1).
      
When only cells with integrated genes were present, this cell line was still highly tumorigenic indicating that the localization of the c-myc genes in DMs was not required for these cells to be tumorigenic in nude mice.
      
In accordance with immunohistochemical findings, in situ hybridization demonstrated a significant level of expression of PDGF-B, PDGF-A receptor, PDGF-B receptor, and c-myc genes in proliferating intimal cells of the thoracic and abdominal aortas.
      
Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of β-actin, EGFR, c-cerbB2, MTS1, k-ras, RB, BRCA1, cyclin E, and c-myc genes.
      
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The expression of C-myC oncogene was studied at the protein level incells obtained from 10 patients with leukemia. Expression of C-myConcogene in 4 patients without remission was much higher than thatin other 3 patients with remission. 2 cases was examined who had beenremission in clinic and in amount of bone marrow blast cells but whoseexpression of C-myC and the amount of C-myC positive cell was stillkeeped at high level. They had relapse after lmonth. this data suggestedthat expression of C-myC oncogene in...

The expression of C-myC oncogene was studied at the protein level incells obtained from 10 patients with leukemia. Expression of C-myConcogene in 4 patients without remission was much higher than thatin other 3 patients with remission. 2 cases was examined who had beenremission in clinic and in amount of bone marrow blast cells but whoseexpression of C-myC and the amount of C-myC positive cell was stillkeeped at high level. They had relapse after lmonth. this data suggestedthat expression of C-myC oncogene in protein level could predictwhether leukemia relapse in future as more susceptible indicater thanthat in the bone marrow morphology. In other hand amount of C-myCpositive cells in bone marrow of all 10 cases was more than that ofblast cells, suggesting that some leukemic cells which can not bedetectable in morphology of cells can be detected.

本文检测10例白血病C-myC癌基因在蛋白质水平上的表达,发现4例不缓解白血病的C-myC阳性细胞百分比以及C-myC总的表达量明显高于缓解期病人的表达,2例病人临床及骨髓象已达缓解,但C-myC蛋白阳性细胞百分数及C-myC蛋白总表达量仍维持高水平表达,分别于28天及37天复发。这提示,C-myC蛋白的表达水平是预示白血病复发的更敏感的指标。另外,10例白血病病人的C-myC阳性细胞百分数均较骨髓内幼稚细胞百分数为高,提示一部分形态上看来是正常的细胞,仍有C-myC的表达,这部分细胞很可能是白血病细胞。

Objective : The possibilities of inhibition of cell proliferation and induciton of its differentiation dueto Myc protein synthesis arrest by c-myc antisense in human glioblastoma cells have been explored. Methods :An antisense pentadecadeoxynucleotide complementary to the initiation codon and the next four codons of c-myc mRNA was synthesized with an automatic DNA synthesizer.Adding this c-myc antisense to BT325 cellculture, the cell number in each well was recorded daily, and the cellular levels of Myc protein,S-100...

Objective : The possibilities of inhibition of cell proliferation and induciton of its differentiation dueto Myc protein synthesis arrest by c-myc antisense in human glioblastoma cells have been explored. Methods :An antisense pentadecadeoxynucleotide complementary to the initiation codon and the next four codons of c-myc mRNA was synthesized with an automatic DNA synthesizer.Adding this c-myc antisense to BT325 cellculture, the cell number in each well was recorded daily, and the cellular levels of Myc protein,S-100 andGFAPwere immunocytochemically assayed. Results : It was found that 4 umol/L of c-myc antisenseoligodeoxynucleotide could significantly inhibit Myc protein synthesis in BT325 cells 1 h after administration,and the frank retardation of cell growth occurred at 5th day. From 2nd to 5th day, the cellular levels of S-100and GFAP obviously increased in contrast to the decreased Myc protein level, implying a tendency to differen-tiatAn irrelevant oligodeoxynucleotide of the same length(15-mer),used as contro, showed no such ef-fects , indicating that the effects of c-myc antisense was sequence-specific. Conclusjon:C-myc antisenseoligodeoxynucletide could specifically inhibit Myc protein synthesis in cultured BT325 cells, suppress prolifera-tion,and induce differentiaiton.

目的:探讨在体外c-myc反义核酸是否可通过阻断人脑胶质瘤细胞中c-myc基因的表达而抑制细胞增殖并诱导分化.方法:人工合成与c-mycmRNA起始码及其后四个密码子互补的寡聚脱氧核苷酸(简称反义核酸)片段,用它处理培养的BT325细胞,观察它对细胞增殖的影响.同时用免疫细胞化学方法检测细胞中Myc蛋白的水平以及能反映胶质瘤细胞分化的S-100和GFAP两种蛋白的水平,分析这些指标的变化.结果:发现4umol/L的c-myc反义核酸明显抑制BT325细胞的增殖和Myc蛋白的合成,且后者发生在加入反义核酸后1h,并持续24h以上,而细胞增殖受抑制要到第5日才明显.从第2日到第5日细胞中S-100和GFAP染色明显加深,反映细胞有分化趋势.用同样长度的无关序列寡聚脱氧核苷酸作对照,则未见上述变化,表明c-myc反义核酸的作用是序列特异性的.结论:c-myc反义核酸可特异地抑制BT325细胞中Myc蛋白的合成和细胞增殖,并能诱导其分化.

Two monoclonal antibodies, anti-c-myc protein and proliferating cell nuclear antigen (PCNA), were used in an immunohistoche-mical reaction to examine the colonic epithelium in normal mucosa, colitis, adenoma and carcinoma. In colitis and tumors the proportion of c-myc protein and PCNA-positive epithelial cells was higher than in normal. There exists a trend that the positive rates of c-myc protein and PCNA are progressively higher in the sequence of tubular, tubovillous and villous adenomas, al-

本文应用c-myc癌基因蛋白和增殖细胞核抗原(PCNA)免疫组织化学方法,研究了它们在正常大肠粘膜、结肠炎、腺瘤和腺癌中的表达。发现结肠炎和肿瘤c-myc蛋白和PCNA阳性率较正常粘膜高。在管状腺瘤、管状绒毛状腺瘤和绒毛状腺瘤,阳性率呈进行性增加,但没有统计学意义。c-myc蛋白和PCNA表达呈相关性。肿瘤中阳性细胞呈异质性,所以要得到可靠的研究结果应多点取材。

 
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