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急性白血病的
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  acute leukemia
     Relationship between the Expression of ERK1 and Cyclin D1 and Acute Leukemia
     ERK1、cyclin D1的表达与急性白血病的关系研究
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     Expression and Clinical Significance of Cyclin Kinase Inhibitor P21~(WAF1) and P27~(KIP1) in Children with Acute Leukemia
     细胞周期蛋白依赖激酶抑制因子P21~(WAF1)、P27~(KIP1)在急性白血病的表达及其意义
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     Clinical and Laboratory Studies in Acute Leukemia with 11q23/MLL Rearrangements
     伴有11q23/MLL基因重排急性白血病的临床和实验研究
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     A clinical and laboratory study of 11 cases of t(6;11)(q27;q23) acute leukemia
     11例伴t(6;11)(q27;q23)急性白血病的临床和实验研究
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     Expression of Survivin, bcl-2, mdr1 in Childhood Acute Leukemia and Its Clinical Significance
     Survivin、bcl-2、mdr1在儿童急性白血病的表达及其与临床关系的研究
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  acute leucocythemia
     Research Progress in the Treatment of Acute Leucocythemia With Traditional Chinese Medicine
     中医药治疗急性白血病的研究进展
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     The article expounded the progress in the treatment of acute leucocythemia with TCM from some aspects,such as diagnosis and treatment based on overall analysis of symptoms and signs combined with chemotherapeutics for inducement and relaxation, alleviating the noxious effect,specific prescription and specific medicine and experiment research,and so on.
     从辨证论治联合化疗诱导缓解、减轻化疗毒副作用、专方专药及实验研究等方面对中医药治疗急性白血病的研究进展进行了文献综合评述。
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     Clinical and experimental studies on five cases of acute myeloid leukemia with translocation t(16;21)(p11;q22)
     5例伴有t(16;21)(p11;q22)急性白血病的临床和实验研究
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     Conclusions The study indicates that P21~(WAF1) and P27~(KIP1) had a lower expression in the pediatric patients with leukemia,which might contribute to the pathogenesis and the progress of the leukemia.
     结论P21WAF1、P27KIP1低表达参与急性白血病的发生发展;
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     Expression of SDF-1α and Its Receptor CXCR4 in Acute Leukemias and Their Relationship with Extramedullary Infiltration
     基质细胞衍生因子-1α及其受体CXCR4在急性白血病的表达及与髓外浸润的关系
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     The clinical studies of mdr1 and CD_( 34)expressions and their correlation in AL and MDR
     多药耐药基因1和CD_(34)在急性白血病的表达及相关性的临床研究
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     Genotype and Cell Origin of Acute Leukemias Associated with Expression of CD7 Antigen
     伴有CD7抗原表达的急性白血病的基因表型和细胞来源
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  acute leukemia
A study of the relationship between expression level of TRF1 protein and telomerase activity in human acute leukemia
      
Objective: To study the expression level of TRF1 (telomeric repeat binding factor 1) protein in human acute leukemia and relationship between expression level of TRF1 protein and telomerase.
      
Results: Bone marrow tissues of 20 acute leukemia patients were studied, 11 healthy donors' bone marrows were taken as a control.
      
The expression level of TRF1 protein was significantly higher (P>amp;lt;0.01) in normal bone marrow ((2.217±0.462) μg/μl) than that of acute leukemia patients ((0.754±0.343) μg/μl).
      
It was confirmed that the activity of telomerase in normal bone marrow was lower than that of acute leukemia patients ((0.125±0.078) μg/μl vs (0.765±0.284) μg/μl, P>amp;lt;0.01).
      
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This report deals with the study of lymphocyte blastogenesis micro-method in some children diseases related to the function of cellular immunity with 49 normal children as control.

本文应用微量淋巴细胞转化试验探讨小儿一些疾病中有关细胞免疫的功能状态。正常儿童49例为对照组。测定细菌性肺炎14例,病毒性肺炎31例,发现病毒性肺炎的淋巴细胞转化率低于细菌性肺炎和正常对照组。急性白血病11例,发现化疗期明显低于间歇期,但二者均低于正常对照组。小儿肾脏疾病19例,急性期低于恢复期,二者均低于正常对照组。本文对所得结果进行了分析和讨论。

Haptoglobin (Hp) phenotypes were determined in 221 leukemia patients and 969 healthy controls in Guangdong.An increased frequency of Hp1 allele in patients (age 0-54) was found,and the relative risk ratio of individuals with Hp 1-1 suffered from leukemia is 1.9,suggesting that Hp1 allele may be related to leukemia in this area.An increased frequency of Hp1 allele was revealed in 83 acute granulocytic leukemia (AGL) patients and 57 acute lymphocytic leukemia (ALL) patients,but not in 59 chronic granulocytic leukemia...

Haptoglobin (Hp) phenotypes were determined in 221 leukemia patients and 969 healthy controls in Guangdong.An increased frequency of Hp1 allele in patients (age 0-54) was found,and the relative risk ratio of individuals with Hp 1-1 suffered from leukemia is 1.9,suggesting that Hp1 allele may be related to leukemia in this area.An increased frequency of Hp1 allele was revealed in 83 acute granulocytic leukemia (AGL) patients and 57 acute lymphocytic leukemia (ALL) patients,but not in 59 chronic granulocytic leukemia (CGL) patients.The levels of serum Hp tested after chemotherapy were more significantly decreased in AGL and ALL with Hp 2-2 or Hp 2-1 than before,but not in Hp 1-1.An unsignificantfy changed level of serum Hp was observed in CGL with Hp 2-2 or Hp 2-1 or Hp 1-1 before and after chemotherapy.The results suggested a relationship between Hp1 allele and acute leukemia in this area.Hp phenotypes of 45 healthy mothers and their leukemic children were determined.The frequencies of homozygotes and hetrozygotes given birth by homozygous or hetrozygous mothers were distributed essentially as expected.In addition,an increased frequency of Hp1 allele was found in 159 heptocarcinoma patients,suggesting that Hp1 allele may be also related to some other tumors besides leukemia.

本文报告广东地区0—54岁白血病病人Hp~1频率显著高于正常人,其相对危险率为1.9,提示这一地区Hp~1基因与白血病发生有关。急粒和急淋组Hp~1频率显著高于正常人,慢粒组则与正常人无显著差异。化疗后的急拉和急淋组Hp2-2型和Hp2-1型Hp平均含量较化疗前显著降低,Hp1-1型则降低不显著;慢粒组三类Hp平均含量化疗前后无明显变化。提示Hp~1基因可能与急性白血病发生有关。具有Hp纯合子或杂合子正常母亲的白血病子女中,纯合子与杂合子的比例符合预期比例,提示在白血病病人家庭中Hp的遗传方式无异常。还观察到,肝癌中Hp~1频率亦显著增高,提示Hp~1基因除与白血病有关外,还可能与其他某些肿瘤的发生有关。

By means of inicrospectropliotometry, the nuclear DNA content and nuclear area of leukemic cells were observed in 5 patients with acute leukemia and 2 patients with acute mosiocytic leukemia by treatment of HOAP. The results indicated that the nuclear DNA content of acute leukemic cells was significantly higher than the normal monocytcs. Their nuclear DNA contents were increased progressively with the nuclear area. It was positive correlation between them. But it was power function negative correlation between...

By means of inicrospectropliotometry, the nuclear DNA content and nuclear area of leukemic cells were observed in 5 patients with acute leukemia and 2 patients with acute mosiocytic leukemia by treatment of HOAP. The results indicated that the nuclear DNA content of acute leukemic cells was significantly higher than the normal monocytcs. Their nuclear DNA contents were increased progressively with the nuclear area. It was positive correlation between them. But it was power function negative correlation between the nuclear DNA content Per unit area (DNA/n2) and nuclear area.The nuclear DNA content was decreased and the nuclear area was increased in varying degrees, in 2 patients with acute monocytic leukemia by treatment of HOAP for a week. The number of large nucleus cells was increased, DNA content was toward to normal distribution ni one case with complete remission.

利用显微分光光度计法观察5例急性白血病细胞核DNA含量与核面积变动的关系及经HOAP治疗的2例急性单核细胞白血病的细胞核DNA含量及核面积变动与治疗的关系。 结果指出急性白血病细胞DNA含量较正常单核细胞为高,有明显差异,它们的细胞核DNA总含量随核面积的增加呈递增状态,两者呈正相关。饶有兴趣的是细胞核单位面积的DNA(DNA/u~2,F)与核面积(A)之间呈幂函数负相关。 二侧急单经HOAP治疗一周后,细胞核DNA含量有不同程度的下降,但核面积均有不同的增大。完全缓解的一例,大核细胞数目增多,DNA含量趋向正态分布。

 
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