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呼吸道上皮细胞     
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  airway epithelial cells
     Transfection of Dominant Negative MyD88 Decreases IL-8 Production in Bacteria-infected Airway Epithelial Cells
     MyD88缺去突变基因转染降低病原菌感染的人呼吸道上皮细胞IL-8的分泌
短句来源
     Involvement of MAPKs and NF-κB pathways in Pseudomonas pyocyanin-induced interleukin-8 expression by human airway epithelial cells
     绿脓菌素激活MAPKs、NF-κB信号通路诱导呼吸道上皮细胞IL-8表达
短句来源
     Objective To investigate the effects of oxygen free radicals on release of enogenous active molecules of cultured canine airway epithelial cells(CAEC),such as nitric oxide (NO),endotheline 1(ET 1),prostaglandin E 2(PGE 2) and theromboxane(TXA 2).
     目的探讨氧自由基对培养犬呼吸道上皮细胞合成释放小分子活性物质一氧化氮(NO),内皮素1(ET1),前列腺素E2(PGE2])和血栓烷素(TXA2)的影响。
短句来源
     Protease-activated receptor-2 induced activation of airway epithelial cells in asthma
     蛋白酶激活受体-2介导的呼吸道上皮细胞活化在哮喘中的作用
短句来源
     Four hours after airway epithelial cells incubating with colitoxix(LPs), the content of ET 1, TXA 2 and PGE 2 in the clear liquid of cultared airway epithelial cells were measured.
     方法大肠杆菌内毒素(LPS)与培养小牛呼吸道上皮细胞孵育4小时后,测定培养呼吸道上皮细胞上清液中ET-1、TXA2、PGE2的含量。
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  airway epithelial cell
     Effect of FIP200 on Adhesion and Migration of Human Airway Epithelial Cell Stimulatied by Fibronectin
     FIP200对呼吸道上皮细胞细胞粘附迁移的影响
短句来源
     Conclusion Airway epithelial cell play an important role in resident local inflammation partly through signals of IL 6 and IL 8 in zymosan induced inflammation.
     结论 在接受酵母菌多聚糖刺激时,呼吸道上皮细胞可能通过激活IL 6和IL 8信号通路释放IL 6和IL 8,从而参与气道疾病的发生。
短句来源
     The effects of zymosan on airway epithelial cell line(A549)
     酵母菌多聚糖对呼吸道上皮细胞系A549的作用
短句来源
     DNA Damage and Apoptosis of Human Airway Epithelial Cell Lines Caused by Cigarette Smoke Extract
     香烟烟雾提取物对人呼吸道上皮细胞DNA损伤和凋亡的影响
短句来源
     To explore the new gene therapeutic strategies for airway inflammation,plasmid expressing dominant negative myeloid differentiation protein(MyD88 DN) was constructed and transfected into human airway epithelial cell lines A549 and SPCA-I. The cells were challenged with M.tuberculosis,P.
     本实验通过构建突变M yD 88真核表达质粒(M yD 88 DN),转染人呼吸道上皮细胞株A 549及SPC-A-1,探讨其对病原菌感染上皮细胞IL-8表达的影响。
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  respiratory epithelial cells
     UNSCHEDULED DNA REPAIR SYNTHESIS IN HUMAN FETAL RESPIRATORY EPITHELIAL CELLS
     人胚呼吸道上皮细胞非时序DNA合成
短句来源
     In order to study and compare the difference in DNA repair synthesis induced by chemical carcinogens in human respiratory epithelial cells and fibroblast cells, nasophar-yngeal and tracheobronchial epithelial cells and fibroblast cells were treated with dire carcinogen 4-nitroquinoline-1-oxide (4-NQO) and indirect carcinogen benzo(a) pyrene (BaP). The unscheduled DNA synthesis(UDS) of cells was assessed using autoradiography.
     为研究和比较化学致癌物对人呼吸道上皮细胞和纤维母细胞的损伤及损伤后DNA修复合成的差异,作者用直接致癌物4-硝基喹啉-1-氧化物(4-NQO)和间接致癌物3,4-苯并芘(BaP)处理人胚鼻咽、气管上皮细胞和纤维母细胞,用放射自显影术测定这3种细胞的非时序脱氧核糖核酸合成(UDS)。
短句来源
     FIP200 antisense oligodeoxynucleotides(ODNs)were transfected into human respiratory epithelial cells by the actionic lipid method.
     方法通过纤连接蛋白(FN)诱导培养呼吸道上皮细胞增殖,以FIP200反义寡核苷酸(ODN)经脂质体转染细胞;
短句来源
  respiratory epithelium
     A STUDY OF E CADHERIN EXPRESSION ON RESPIRATORY EPITHELIUM OF SMOKING MICE
     吸烟小鼠呼吸道上皮细胞上皮钙粘附素表达的研究
短句来源
     The dynamic expression of E cadherin(E cd) on respiratory epithelium of smoking mice with different duration was examined by immunofluorescence, and underwent a quantitative analysis through microphotometry.
     通过免疫荧光法检测不同吸烟时间小鼠呼吸道上皮细胞上皮钙粘附素(Ecadherin,Ecd)表达的动态变化,并采用显微荧光光度术进行定量分析。
短句来源
     The results suggest that the dynamic expression of E cd plays an important role in the process of injury and repair on respiratory epithelium.
     提示,Ecd表达的动态变化在呼吸道上皮细胞损伤与修复过程中起重要作用
短句来源
     The results showed that after the first smoking, the E cd expression on respiratory epithelium apparently down regulated compared with normal control (P<0 01). It decreased to the lowest during 4 to 6 weeks, then up regulated gradually.
     结果表明,首次吸烟1h后呼吸道上皮细胞Ecd表达与正常对照组比较明显下调(P<001),46W后降到最低水平。
短句来源
     Conclusions It is suggested that pulmonary sclerosing hemangioma is an epithelial neoplasm derived from primitive respiratory epithelium capable of differentiating toward pneumocytes or Clara cells.
     结论 SH可能起源于多潜能的原始呼吸道上皮细胞 ,它具有向肺泡上皮细胞、Clara细胞分化的能力。
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      airway epithelial cells
    In this review, we will discuss the advances and limitations of these nonviral vectors in gene delivery, particularly to airway epithelial cells.
          
    TLR signals in mast cells increase their release of IL-5, and TLR signals in airway epithelial cells enhance airway generation of proallergic cytokines.
          
    Effects of cigarette smoke extract on E-cadherin expression in cultured airway epithelial cells
          
    To investigate whether the change of E-cadherin (ECD) expression plays a role in the injury and repair of airway epithelial cells (AEC) caused by smoking, porcine AECs were cultured by using an enzyme-dispersed method.
          
    Effect of lithium on cell cycle progression of pig airway epithelial cells
          
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      airway epithelial cell
    The airway epithelial cell, which normally expresses the cystic fibrosis transmembrane conductance regulator (CFTR), directs the inflammatory response.
          
    Using a newly developed orthotopic tracheal transplant model, we have obtained evidence for an important and probably exclusive role for airway epithelial cell injury as a primary mechanism for the immunopathogenesis of the development of OAD.
          
    In this study, we investigated the effects of culturing a human airway epithelial cell line, Calu-3, in the presence of 5?mM sodium butyrate.
          
    hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3
          
    The CFBE41o- cell line was also compared with a wild-type airway epithelial cell line, 16HBE14o-, which served as model for bronchial epithelial cells in situ.
          
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      respiratory epithelial cells
    The affinity of the chicken viruses to sialoglycoconjugates of chicken intestine as well as chicken, monkey, and human respiratory epithelial cells exceeds that of the duck viruses.
          
    Recent evidence indicates that viral infection plays a role in the initial damage of the respiratory epithelial cells and staphylococcal colonization ensues.
          
    Moxifloxacin and Ciprofloxacin Protect Human Respiratory Epithelial Cells against Streptococcus pneumoniae, Staphylococcus aureu
          
    Here we show that moxifloxacin and ciprofloxacin accumulate approximately 7- to 10-fold in primary human respiratory epithelial cells, derived from nasal polyps and grown in 3-dimensional vesicles.
          
    The results suggest that intracellular accumulation of moxifloxacin and ciprofloxacin is important for the protection of respiratory epithelial cells from the cytotoxic effects of major respiratory tract pathogens.
          
    更多          
      respiratory epithelium
    NA promotes viral penetration of sialic acid-rich mucin that bathes and protects respiratory epithelium through which the virus must spread and replicate.
          
    Furthermore, since the respiratory mucosa reacts in a uniform manner to an inflammatory stimulus, the result of this penetration study is valid for inflammatory diseases in any area lined with respiratory epithelium.
          
    Serotonin-and bombesin-immunoreactive (IR) PNECs were observed as solitary cells or clusters of cells at the base of ciliated epithelium on the dilated apical parts of primary septa where incoming air first arrives, and in the respiratory epithelium.
          
    Serotonin-IR PNECs were predominantly present in the ciliated epithelium while bombesin-IR PNECs were found in the ciliated and respiratory epithelium.
          
    placebo because the anatomic structure of the cilia of the sperm cells and of the respiratory epithelium cells is similar.
          
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    The type and number of epithelial cells of respiratory tract in rats were studied with tech-nique of ~3H-TdR incorporation.Wistar rats were injected with ~3H-TdR solution in 7.4×10~4Bq/g ofbody weight.The labelled and unlabelled basal and mucous cells of trachea and branchi were counted onthe sections for calculation of the labelling indexes(LI)of both type of cells.The results showed that fortrachea and branchi the LI of basal ceils were 0.0052 and 0.0198,and the LI of mucous ceils were0.0014 and 0.0047,respectively.The...

    The type and number of epithelial cells of respiratory tract in rats were studied with tech-nique of ~3H-TdR incorporation.Wistar rats were injected with ~3H-TdR solution in 7.4×10~4Bq/g ofbody weight.The labelled and unlabelled basal and mucous cells of trachea and branchi were counted onthe sections for calculation of the labelling indexes(LI)of both type of cells.The results showed that fortrachea and branchi the LI of basal ceils were 0.0052 and 0.0198,and the LI of mucous ceils were0.0014 and 0.0047,respectively.The labelling of both type of cells indicates that both of them are thecarcinogenesis related cells with capabitity of mitosis.

    本文利用~3H-TdR 掺入技术研究大鼠呼吸道上皮细胞的标记类型和数量。大鼠腹腔注射7.4×10~4Bq/g(体重)~3H-TdR6小时后,制片计数气管和支气管上皮标记及非标记的基底细胞和粘液细胞,计算出标记指数。结果表明,气管及支气管基底细胞标记指数分别为0.0052和0.0198,粘液细胞标记指数分别为0.0014和0.0047,说明两类细胞都是具有分裂能力的癌形成相关细胞。

    In order to study and compare the difference in DNA repair synthesis induced by chemical carcinogens in human respiratory epithelial cells and fibroblast cells, nasophar-yngeal and tracheobronchial epithelial cells and fibroblast cells were treated with dire carcinogen 4-nitroquinoline-1-oxide (4-NQO) and indirect carcinogen benzo(a) pyrene (BaP). The unscheduled DNA synthesis(UDS) of cells was assessed using autoradiography. The frequency of UDS showed clear dose dependency in all cell types treated with 4-NQO,...

    In order to study and compare the difference in DNA repair synthesis induced by chemical carcinogens in human respiratory epithelial cells and fibroblast cells, nasophar-yngeal and tracheobronchial epithelial cells and fibroblast cells were treated with dire carcinogen 4-nitroquinoline-1-oxide (4-NQO) and indirect carcinogen benzo(a) pyrene (BaP). The unscheduled DNA synthesis(UDS) of cells was assessed using autoradiography. The frequency of UDS showed clear dose dependency in all cell types treated with 4-NQO, but UDS occurred 3.0 and 2.4 times more frequently in the tracheobronchial and nasopharyngeal epithelial cells than in the fibroblast cells, respectively. After treatment with BaP, the frequency of UDS showed clear dose dependency only for both epithelial cell types, not for the fibrolast cells. 8.6 and 3.0 times more UDS were in tracheobronchial and nasopharyngeal epithelial cells than in fibroblast cells, respectively. These results indicatet that thenasop haryng response of human respiratory epithelial cells to some DNA damaging agents is different from that of fibroblast cells. The respiratory epithelial cells are more sensitive to damage by chemical carcinogens than fibroblast cells and are the chief target cells of chemical carcinogens.

    为研究和比较化学致癌物对人呼吸道上皮细胞和纤维母细胞的损伤及损伤后DNA修复合成的差异,作者用直接致癌物4-硝基喹啉-1-氧化物(4-NQO)和间接致癌物3,4-苯并芘(BaP)处理人胚鼻咽、气管上皮细胞和纤维母细胞,用放射自显影术测定这3种细胞的非时序脱氧核糖核酸合成(UDS)。用4-NQO处理后,这3种细胞的UDS均呈明显的剂量依赖(dose dePendency)关系,但气管和鼻咽上皮细胞UDS平均分别是纤维母细胞的3.0和2.4倍。用BaP处理后,气管和鼻咽上皮细胞UDS呈现明显的剂量依赖关系,而纤维母细胞未见这种关系。气管和鼻咽上皮细胞的UDS平均分别是纤维母细胞的8.6和3.0倍。

    Granule membrane protein-140(GMP-140),IL-1,TNF and EC-PMN adhesion were measured after cultured airway epithelial cell exposured to xanthine and xanthine oxidase for 4 hours.Oxygen free radicals enhence epithelial-leukocyte adherence,stimulate epithelial cells to express GMP-140 and secrete IL-1,TNF.IL-1,TNF may be involved in oxygen radicals promoting ECPMN adhesion.

    为研究氧自由基对呼吸道上皮细胞-中性粒细胞粘附作用的影响及其机制,本文用培养的犬呼吸道上皮细胞与黄嘌呤+黄嘌呤氧化酶共同孵育4小时后,测定上皮细胞-中性粒细胞粘附率、GMP-140分子表达及上清液中IL-1、TNF含量,发现氧自由基可明显促进上皮-中性粒细胞粘附及GMP-140表达,同时还具有刺激IL-1及TNF分泌的作用,说明氧自由基促进白细胞与上皮细胞粘附作用与其促进IL-1、TNF生成有关。

     
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