Results The expression of COX-2 mRNA was not detectable in SW480 colon cancer cells. NS-398 (75 μmol/L) inhibited the cells proliferation and induced apoptosis in colon cancer cell lines. The ratio of cells in G1 phase was increased from 37.9% to 48.6 % , and the ratio of cells in S phase was decreased from 58.1% to 44.9%.
Methods Two colon cancer cell lines (SW1116 and Colo -320) were treated with the DNA methyltransferase (DNMT) inhibitor, 5-aza-2′-deoxycytidine (5-aza-dC) and/or the histone deacetylase (HDAC) inhibitor, trichostatin A(TSA)or sodium butyrate(NaBu).
Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.
Methods Two colonic cancer cell lines (SW1116 and Colo 320) were treated with the DNA methyltransferase (DNMT) inhibitor, 5 aza 2′ deoxycytidine (5 aza dC) or/and the histone deacetylase (HDAC) inhibitor, trichostatin A(TSA) or sodium butyrate.
Results: A genfibinib-resistant human colon carcinoma cell line HT-29/ZD has been established successfully, with the RI being 26.67. The doubling times of HT-29/ZD and HT-29 cells were 33.25 and 37.7 h, respectively.
Objective: To study the expression of the inducible nitric oxide synthase (iNOS) gene and the effects of tumor necrosis factor- α (TNF-α) and interferon- γ (IFN-γ)on proliferation of the continuous cultured human colon cancer cell line CCL229.
Estradiol exhibited a concentration-dependent biphasic growth effect on a mouse colon cancer cell line (MC-26).
PAC1 is expressed on the HCT8 human colon cancer cell line and is coupled to the activation of both intracellular cAMP and Ca2+ with consequent stimulation of growth.
Both ELISA and fluorescence-activated cell sorting (FACS) reactions were inhibited with Fuc-GM1or H4-II-E but not with the structurally related ganglioside GM1 or Fuc-GM1-negative colon cancer cell line LS-C.
One of the CTL clones was able to kill an HLA-A2+ colon cancer cell line harbouring mutant TGFβRII.