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例老年性精神分裂症患者
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  senile schizophrenics
     Methods Fifty-eight senile schizophrenics were randomly divided into: risperidone group(n=30,mean dosage 2.70±1.21mg/d) and perphenazine group (n=28,mean dosage 16.30±3.95mg/d) for 8 weeks.
     方法 将58例老年性精神分裂症患者随机分为利培 酮治疗组(研究组)30例和奋乃静治疗组(对照组)28例,疗程8w。 利培酮平均治疗剂量2.70±1.21mg·d-1,奋乃静平均治 疗剂量16.30±3.95mg·d-1。
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     B,9cases;
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Objective To explore the curative effect and safety of risperidone in the treatment of senile schizophrenics. Methods Fifty-eight senile schizophrenics were randomly divided into: risperidone group(n=30,mean dosage 2.70±1.21mg/d) and perphenazine group (n=28,mean dosage 16.30±3.95mg/d) for 8 weeks. The efficacy and side effects were assessed by the Positive and Negative Symptoms Scale(PANSS) and Treatment Emergent Symptoms Scale(TESS) before treatement and at end of 8th week. Results At the end of 8th week...

Objective To explore the curative effect and safety of risperidone in the treatment of senile schizophrenics. Methods Fifty-eight senile schizophrenics were randomly divided into: risperidone group(n=30,mean dosage 2.70±1.21mg/d) and perphenazine group (n=28,mean dosage 16.30±3.95mg/d) for 8 weeks. The efficacy and side effects were assessed by the Positive and Negative Symptoms Scale(PANSS) and Treatment Emergent Symptoms Scale(TESS) before treatement and at end of 8th week. Results At the end of 8th week ,the scores of PANSS in both groups decreased significantly compared with pre-treatment(P<0.01), effective rates were 70.0% in risperidone group and 71.4% in perphenazine group, which showed no significant difference(P>0.05);. TESS showed that risperidone had best fewer and milder side effects than perphenazine did(P<0.01). Conclusion Risperidone has better efficacy and compliance and higher safety in the treatment of senile patients with schizophrenia.

目的 探讨利培酮对老年性精神分裂症患者的疗效与安全性。方法 将58例老年性精神分裂症患者随机分为利培 酮治疗组(研究组)30例和奋乃静治疗组(对照组)28例,疗程8w。利培酮平均治疗剂量2.70±1.21mg·d-1,奋乃静平均治 疗剂量16.30±3.95mg·d-1。在治疗前及治疗第8w末采用阳性与阴性症状量表、副反应量表评定疗效与副反应。结果 治 疗第8w末,两组阳性与阴性症状量表评分较治疗前均显著降低(P<0.01),研究组有效率70.0%,对照组71.4%,两组疗效 差异无显著性(P>0.05);副反应量表评分:研究组42.3±16.5分,对照组65.6±20.4分,利培酮的不良反应较奋乃静少而 轻,差异有极显著性(χ2=10.273,P<0.01)。结论 利培酮治疗老年性精神分裂症疗效好、依从性好、安全性高。

 
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