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自分泌作用
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  autocrine function
     Study on hCG Autocrine Function of JAR Cell
     滋养细胞肿瘤JAR细胞株hCG自分泌作用的研究
短句来源
     Objective: To study the autocrine function of vascular endothelial growth factor(VEGF) and its receptors Flt-1 and KDR/Flk-1 in the proliferation,differentiation,and mineralization of growth plate chondrocytes of neonatal rat.Methods: Growth plate cartilages were sampled from 10 neonatal rats of day 1 to day 2,and the expressions of VEGF and its receptors Flt-1 and KDR/Flk-1 were examined by immunohistochemical staining and reverse transcriptase polymerase chain reaction.
     目的:探讨血管内皮生长因子(VEGF)在鼠生长板软骨细胞增殖、分化和矿化过程中的自分泌作用。 方法:新生鼠(1~2d)10只,切取干骺部软骨组织,采用免疫组织化学方法(5只)和RT-PCR方法(5只),检测VEGF及其受体Flt-1和KDR/Flk-1在胫骨生长板中的表达。
短句来源
     Objective: To study the autocrine function of vascular endothelial growth factor (VEGF) in rat osteoblast.
     目的: 探讨血管内皮生长因子(VEGF)在鼠成骨细胞中的自分泌作用
短句来源
     Autocrine function of VEGF in osteoblast of proximal tibia of neonatal rat
     VEGF在新生鼠胫骨上端成骨细胞中自分泌作用的研究
短句来源
     Acting as an important factor of angiogenesis,VEGF might play an important autocrine function during osteoblast differentiation.
     作为一种重要的血管性因子,VEGF的自分泌作用方式在成骨细胞的分化中起重要作用。
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  “自分泌作用”译为未确定词的双语例句
     The recent studys found the spetific receptors of VEGF (VEGFR1, FLT-1; VEGFR2, KDR) also exit in the tumor cells, which indicated that VEGF acted in an autocrine manner in some tumor cell lines and some tumors.
     最近的相关研究发现肿瘤细胞亦表达VEGF特异性受体(VEGFR1,FLT-1;VEGFR2,KDR),提示VEGF在肿瘤存在自分泌作用方式。
短句来源
     Our results indicate that human myeloma cell lines,KM2 and KM3,proliferate by the IL—6 autocrine mechnism,while TNF promotes this au-tocrine.
     我们的结果提示,人骨髓瘤细胞系KM_2、KM_3存在IL-6自分泌增殖机制,而TNF 可加强这种自分泌作用
短句来源
     Objective To explore the effect of autocrine vascular endothelial growth factor(VEGF) on the apoptosis of MCF-7 and its possible mechanisms.
     目的研究血管内皮细胞生长因子(VEGF)对乳腺癌细胞株MCF-7的凋亡及凋亡相关基因survivin和bcl-2表达的影响,探讨VEGF自分泌作用抑制肿瘤细胞凋亡的机制。
短句来源
     TGFβ produced by proliferative and dysplastic bile duct cells, CC cells and stomal myofibroblasts might stimulate the TGFβR on myofibroblasts, resulted in proliferation of the myofibroblasts and its collagen production through autocrine and paracrine secretion, and resulted in the stromal difference between CC and HC.
     结论 增生、不典型增生胆管或CC细胞与间质肌成纤维细胞产生的TGFβ可能通过旁分泌与自分泌作用于肌成纤维细胞的TβR ,刺激后者增生、生成胶原 ,造成HC与CC的间质差异。
短句来源
     Conclusions: TGFα but not EGF might be synthesized locally, acting on the granulosa cells in an autocrine fashion through EGFR in granulosa cells.
     结论:卵巢局部产生EGFs是TGFα而非EGF,TGFα通过自分泌作用于EGFR;
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  相似匹配句对
     Since the interacting coping theory and its model were put forward by R.
     R.
短句来源
     After R.
     R.
短句来源
     Study on hCG Autocrine Function of JAR Cell
     滋养细胞肿瘤JAR细胞株hCG分泌作用的研究
短句来源
     Autocrine function of VEGF in osteoblast of proximal tibia of neonatal rat
     VEGF在新生鼠胫骨上端成骨细胞中分泌作用的研究
短句来源
     ANTISECRETORY EFFECTS OF BERBERINE
     小蘖碱的抗分泌作用
短句来源
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  autocrine function
This endothelium-derived bradykinin can exert an autocrine function by stimulating endothelial B2-receptors with a subsequent increase in [Ca2+]i and nitric oxide formation.
      
The growth factors are synthesized by the neural crest cells and therefore are likely to have autocrine function.
      
Autocrine function within the epithelium and endothelium also is possible because these cells express both Fas and Fas ligand.
      
Endothelial cells co-express the precursor, the converting enzyme and the receptor, thus implying autocrine function of endothelin.
      
In addition, adipocytes secrete TNF and also express TNF receptors consistent with an autocrine function.
      
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Dysregulated cytokines play an important role in the malignant proliferation of myeloma cells.Inthis article,effcts of IL—6,IL—1 and TNF on the proliferation of human myeloma call lines,KM2 and KM3 were studies.Both KM2 and KM3 can constitutively secrete IL- 6 for their ownproliferation.Anti—IL—6 monoclonal antibody can inhibit their proliferation.And this inhibi- tion could be reversed by exogecic IL—6.Either IL—6 or TNF enhances the proliferation ofKM2 and KM3,while IL—1 does not.Adding TNF in the culture...

Dysregulated cytokines play an important role in the malignant proliferation of myeloma cells.Inthis article,effcts of IL—6,IL—1 and TNF on the proliferation of human myeloma call lines,KM2 and KM3 were studies.Both KM2 and KM3 can constitutively secrete IL- 6 for their ownproliferation.Anti—IL—6 monoclonal antibody can inhibit their proliferation.And this inhibi- tion could be reversed by exogecic IL—6.Either IL—6 or TNF enhances the proliferation ofKM2 and KM3,while IL—1 does not.Adding TNF in the culture system for 48 hours,onecould find the IL—6 bioactivity elevated.Our results indicate that human myeloma cell lines,KM2 and KM3,proliferate by the IL—6 autocrine mechnism,while TNF promotes this au-tocrine.

细胞因子的异常表达对骨髓瘤细胞的恶性增殖起重要作用。本文研究了IL-6、IL-1及TNF 对人骨髓瘤细胞系增殖的影响。KM_2、KM,均能分泌IL-6,以维持自身的增殖。培养体系中加入抗IL-6抗体可抑制瘤细胞的增殖,这种抑制作用可通过加入重组IL-6而逆转.在培养体系中加入重组IL-6和TNF 均可促进KM_2、KM_3的增殖,而IL-1无此作用。培养体系中加入TNF 培养后,上清中IL-6活性增高。我们的结果提示,人骨髓瘤细胞系KM_2、KM_3存在IL-6自分泌增殖机制,而TNF 可加强这种自分泌作用

The expression of insulin-like growth factor Ⅰ(IGF-Ⅰ)gene was studied in both normaland diabetic rat eyes via in situ hybridization. The results revealed the regional expression of IGF-Ⅰgenein the rat eyes. The expression of IGF-Ⅰ mRNA in the internal nuclear layer and ganglion cell layer isstrong, in choroid, retinal pigment epithelium and external nuclear layer is moderate, in sclera is weakin degree a nd no such mRNA is detected in the cornea. The abundance of IGF-Ⅰ mRNA in diabetic eyetissues is significantly(P<...

The expression of insulin-like growth factor Ⅰ(IGF-Ⅰ)gene was studied in both normaland diabetic rat eyes via in situ hybridization. The results revealed the regional expression of IGF-Ⅰgenein the rat eyes. The expression of IGF-Ⅰ mRNA in the internal nuclear layer and ganglion cell layer isstrong, in choroid, retinal pigment epithelium and external nuclear layer is moderate, in sclera is weakin degree a nd no such mRNA is detected in the cornea. The abundance of IGF-Ⅰ mRNA in diabetic eyetissues is significantly(P< 0. 05 or P≤0.01 ) higher than that in normal eye. These findings suggestthat(1) functionally, the eye ball be considered to be an “IGF-Ⅰ paracrine-autocrine system”, and(2)the high expression of IGF-Ⅰ indicate its initiation of diabetic retinopathy and its promotion of the pro-gression of the lesion.

用原位杂交技术对正常及糖尿病大鼠眼组织的胰岛素样生长因子Ⅰ基因(insulin-likegrowthfactor-Ⅰ,IGF-Ⅰ)进行了研究。IGF-Ⅰ基因在眼组织的表达呈区域性,视网膜内核层及神经节细胞表达最强;脉络膜、视网膜色素上皮细胞及外核层次之;巩膜最弱,角膜未见表达信号。糖尿病眼组织IGF-Ⅰ基因表达显著增强(P<0.05或P≤0.01)。结果表明:整个眼球组织形成了一个IGF-Ⅰ旁分泌、自分泌作用系统;糖尿病眼组织IGF-Ⅰ基因高表达预示IGF-Ⅰ可诱发并加速糖尿病视网膜病变的发生发展。

To evaluate the role of interleukin 6 and tumor necrosis factor in pathogenesis of acute leukemia,the autocrine and induction of interleukin 6 and tumor necrosis factor in acute leukemia cells and the effect of recombinant tumor necrosis factor and interleukin 6 on proliferation and differentiation of leukemia cells were observed in this studies. The results indicated that both tumor necrosis factor and interleukin 6 participated in leukemia blasts and regulation of growth in autocrine form and inducing differentiation....

To evaluate the role of interleukin 6 and tumor necrosis factor in pathogenesis of acute leukemia,the autocrine and induction of interleukin 6 and tumor necrosis factor in acute leukemia cells and the effect of recombinant tumor necrosis factor and interleukin 6 on proliferation and differentiation of leukemia cells were observed in this studies. The results indicated that both tumor necrosis factor and interleukin 6 participated in leukemia blasts and regulation of growth in autocrine form and inducing differentiation. Futherly, tumor necrosis factor appeared the effect of inhibition of growth on acute leukemia cells,but interleukin 6 showed promotion of growth to leukemia cells. It is suggested that this effect of tumor necrosis factor and interleukin 6 on leukemia cells play an important role in pathogenesis of acute leukemia.

通过诱导急性白血病肿瘤细胞自分泌白细胞介素6和肿瘤坏死因子,利用急性白血病原代肿瘤细胞和肿瘤细胞系HL-60和K562,分别观察了IL-6和TNFα对急性白血病细胞的调控作用。结果发现,急性白血病细胞存在着IL-6和TNFα的自分泌作用,而TNFα和IL-6对白血病细胞则有诱导分化作用;进一步研究发现,TNFα对急性白血病细胞株还可呈现生长抑制作用;而IL-6则可表现为生长促进作用。IL-6和TNFα对急性白血病细胞的这种凋控在白血病的发病和免疫调控治疗中将有意义。

 
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