Purpose To study the expression of human papilloma viruses 16 and 18 (HPV16/18) DNA and the cell cycle proteins of p16~ Ink4a and Rb in cervical adenocarcinoma and the influence of HPV16/18 infection on expressions of p16~ Ink4a and Rb protein.
Epidermodysplasia verruciformis - associated human papillomaviruses ( EV HPV) are a group of double stranded small DNA viruses, composed mainly of HPV-5, 8, 9, 12, 14, 15, 17, 19-25, 36-38,47, 49, et al.
疣状表皮发育不良相关性人乳头瘤病毒(epidermodysplasia verruciformis-associated human papillomavirus,EV HPV)是一组双链环状小DNA病毒,主要包括HPV-5、8、9、12、14、15、17、19-25、36-38、47、49等。
Involvement of the human papillomavirus (HPV) gene E2 and transcription factor NF-κB in the regulation of MMP-9 transcription has been shown in some model systems and types of malignant tumors.
Three other viruses - Epstein-Barr virus, human papilloma virus, and human herpesvirus-8 - are implicated in benign and malignant proliferative diseases of the gastrointestinal tract.
Expression of the STAT1 gene belonging to the group of interferon-regulated genes was analyzed in cervical tumors and cell lines harboring the genome of human papilloma viruses (HPV) of so-called high risk group.
In conclusion, these data demonstrate that the STAT1 gene is expressed in an individual and specific manner both in HPV-positive cervical tumors and cell lines harboring transforming genes of these viruses.
Involvement of the human papillomavirus (HPV) gene E2 and transcription factor NF-κB in the regulation of MMP-9 transcription has been shown in some model systems and types of malignant tumors.
The present work was mainly designed to reveal a possible role of the HPV gene E2 and transcription factor NF-κB in the induction of MMP-9 expression in SCC.
Using human papillomavirus type 16 (HPV16) E7 as an antigen and Heat Shock Protein 70 as adjuvant, we constructed a DNA vaccine by linking HSP70 gene to E7C91G/gene.
Human papillomavirus type-16 infection is associated with a significant portion of squamous carcinoma of the head and neck, particularly for the oropharynx and for those lacking the other risk factors of tobacco and alcohol.