The partially purified rhBMP6 by heparin affinity chromatography was shown to possess bone induction activity tested by the induction of alkaline phosphatase activity in C2C12 cells.
Objective To observe in vitro the effects of platelet-rich plasma ( PRP) of different concentrations on the proliferation, differentiation, and mRNA of autologous bone marrow stromal cells(MSCs), to evaluate the bone induction effect of PRP on MSCs, and to investigate the feasibility of bone tissue regeneration by tissue engineering with the obtained optimal concentration.
CONCLUSION:Both of two materials have good biocompatibility. Bionic biphasic ceramic-like biologic active bone has heterogenous ossification ability and bionic BCBB is ineffective in bone induction.
Conclusion Bone at the interface can grow into the contained space of hollow prosthesis through holes at the wall, and form mature bone. rhBMP-2 loaded in the hollow space can obviously promote this effect and the carrier Healon GV has no negative influence but can increase bone inductive effect.
Treatment of DABM with the cyanoacrylate caused an intense inflammatory process with a foreign body reaction, and abolished bone induction and new bone formation.
Bone induction by both isograft and homograft of the mouse calvaria was observed in the diffusion chambers using HA millipore filter.
Bone induction by implantation of decalcified bone is described by many authors.
The role of periosteal bone induction was essential for the ossification of a growing gap, whereas the ossification of a simple gap proceeded equally by the endosteal and periosteal routes.
The rationale underlying this intralesional treatment was that the bone grafting material might reverse ABC expansion by promoting ossification through a bone induction mechanism.
Using decalcified bone matrix (DBM), bone matrix gelatin (BMG) and Undecalcified bone matrix(UDBM), the capacity of bone induction -was investigated respectively.the experiments were done on the adult rat skulls on which trephine defects of 8 mm in diameter were made, the implants were in form of discs of same size as the defects. BMG was found having the best bone induction capacity, while DBM the next, from the histo-pathological observation, it was suggested that during the process of resorption of BMG and...
Using decalcified bone matrix (DBM), bone matrix gelatin (BMG) and Undecalcified bone matrix(UDBM), the capacity of bone induction -was investigated respectively.the experiments were done on the adult rat skulls on which trephine defects of 8 mm in diameter were made, the implants were in form of discs of same size as the defects. BMG was found having the best bone induction capacity, while DBM the next, from the histo-pathological observation, it was suggested that during the process of resorption of BMG and DBM, bone morphogenetic Protein (BMP) was released by diffusion, which induced mesenchymal cells originating from the dura mater to differentiate into osteoblasts and form new bone repairing the bone defects
Fifty four healthy rabbits with 108 limbs were divided into 3 grops with 36 limbs in each group, made 1 cm long radius defect in each limb. Group A was implanted by decalcified homogenous bone; roup B by fresh autogenous bone and group C by fresh homogenous bone. Then 3 rabbits with 6 limbs of each group were killed in the 1st, 3, 5, 7, 10 and 13th week respectively, to compare the bone healing roentgenologically and histologically There was receptive reaction in fresh homogenous bone implantation but not demonstrated...
Fifty four healthy rabbits with 108 limbs were divided into 3 grops with 36 limbs in each group, made 1 cm long radius defect in each limb. Group A was implanted by decalcified homogenous bone; roup B by fresh autogenous bone and group C by fresh homogenous bone. Then 3 rabbits with 6 limbs of each group were killed in the 1st, 3, 5, 7, 10 and 13th week respectively, to compare the bone healing roentgenologically and histologically There was receptive reaction in fresh homogenous bone implantation but not demonstrated in decalcified homogenous bone implantation. This experiment indicated that the bone healing of implantation with decalcified homogenous bone and fresh autogenous bone were faster than fresh homogenous bone and no receptive reaction. However there was no significant difference in the bone healing between the implantation with decalcified homogenous bone and fresh autogenous bone. The new cartilage and new bone appeared in the decalcified implant rather than near the host bone. This shows that the new bone is formed probablly by bone induction. Decalcified homogenous bone is a better implant.
Sheep bone morphogenetic protein (sBMP) was chemically extracted from demineralized and gelatinized cortical bone by means of a CaCl_2-urea solvent, sBMP was isolated in quantity of 1,250mg/kg fresh bone. 5mg of the isolated protein implanted in muscle pouches of rats induced perivascular mesenchymal connective tissue cells which differentiated into cartilage by the 7th day and calcifying new bone by 21st day.
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bone induction
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