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ages交联
相关语句
  ages cross-link
     Targeted AGEs and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes
     AGEs交联结构:研究防治血管硬化药物的新靶标
短句来源
  “ages交联”译为未确定词的双语例句
     Research progress of AGEs crosslinked protein breaker
     AGEs交联蛋白裂解剂的研究进展
短句来源
     Biochemical study showed that C24 could significantly increase collagen solubility(P<0.05).
     生化检测表明,C24能够显著增加糖尿病大鼠尾胶原溶解性(P<0.05),裂解体内AGEs交联结构。
短句来源
     Design, Synthesis and Screening of the Compounds Reversing Arterial Stiffening of Aging and Diabetes Based on AGEs Cross-link
     基于AGEs交联结构逆转血管硬化化合物的设计、合成和生物活性评价
短句来源
     We designed new drugs reversing arterial stiffening in aging and diabetes targeted AGEs crosslinks.
     本文以AGEs交联为靶点,进行逆转老年性和糖尿病型血管硬化药物的研究。
短句来源
     Animal model studies and preliminary clinical trials have revealed that AGEs-inhibitors and the cross-links breakers, such as ALT-711, can reduce the severity of pathological changes of advanced glycosylation at several stages, especially the AGEs breaker can reverse stiffening of body tissues, organs and vessels, thus offering new therapeutic approaches for glucose-derived complications of diabetes and ageing.
     动物模型和临床前实验表明AGEs抑制剂以及AGEs交联结构裂解剂 ,如ALT 711,可以从不同的阶段打断AGEs的形成 ,特别是AGEs裂解剂能够逆转或软化由AGEs造成的组织、器官以及血管的硬化 ,因而有希望成为一类新型治疗药物 ,用于治疗糖尿病和衰老过程中由于AGEs引发的各种并发症
短句来源
  相似匹配句对
     AGEs have a tendency to polymerize.
     AGEs具有高度交联性。
短句来源
     Research progress of AGEs crosslinked protein breaker
     AGEs交联蛋白裂解剂的研究进展
短句来源
     Crosslinking of Polypropylene
     聚丙烯的交联
短句来源
     Radiation crosslinking of pdytetrafluoroethylene
     聚四氟乙烯的辐射交联
短句来源
     These results suggest that AGEs may play a certain role in pathogenic process by E.
     结果提示AGEs可能对E .
短句来源
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Glucose and other reducing sugars react non-enzymatically with proteins, leading to the formation of advanced glycosylation end products (AGEs) and AGE-derived protein cross-linking. The accumulations of AGEs contribute to the pathological events leading to diabetic and aging complications. Animal model studies and preliminary clinical trials have revealed that AGEs-inhibitors and the cross-links breakers, such as ALT-711, can reduce the severity of pathological changes of advanced glycosylation at several stages,...

Glucose and other reducing sugars react non-enzymatically with proteins, leading to the formation of advanced glycosylation end products (AGEs) and AGE-derived protein cross-linking. The accumulations of AGEs contribute to the pathological events leading to diabetic and aging complications. Animal model studies and preliminary clinical trials have revealed that AGEs-inhibitors and the cross-links breakers, such as ALT-711, can reduce the severity of pathological changes of advanced glycosylation at several stages, especially the AGEs breaker can reverse stiffening of body tissues, organs and vessels, thus offering new therapeutic approaches for glucose-derived complications of diabetes and ageing.

葡萄糖和其他还原糖与蛋白的非酶糖基化反应导致晚期糖基化终产物 (advancedglycosylationendproducts,AGEs)以及由AGEs引发的蛋白交联物的形成 ,这是糖尿病和衰老过程中引起并发症的主要原因。动物模型和临床前实验表明AGEs抑制剂以及AGEs交联结构裂解剂 ,如ALT 711,可以从不同的阶段打断AGEs的形成 ,特别是AGEs裂解剂能够逆转或软化由AGEs造成的组织、器官以及血管的硬化 ,因而有希望成为一类新型治疗药物 ,用于治疗糖尿病和衰老过程中由于AGEs引发的各种并发症

AIM To establish a rapid method for screening advanced glycation end product(AGE) cross links breaker in vitro. METHODS The AGE cross links were prepared by incubating glycated bovine serum albumin (AGE BSA) with the rat tail tendon collagen coated on 96 well enzyme linked immunosorbent assay (ELISA) plate. The remained AGE cross links after reacted with testing compounds were quantitated by a novel ELISA with polyclonal antibody against BSA. Each step of ELISA experiment was optimized. RESULTSThe...

AIM To establish a rapid method for screening advanced glycation end product(AGE) cross links breaker in vitro. METHODS The AGE cross links were prepared by incubating glycated bovine serum albumin (AGE BSA) with the rat tail tendon collagen coated on 96 well enzyme linked immunosorbent assay (ELISA) plate. The remained AGE cross links after reacted with testing compounds were quantitated by a novel ELISA with polyclonal antibody against BSA. Each step of ELISA experiment was optimized. RESULTSThe screening results of a lead compound ALT 711 and 10 new testing compounds by this established method corresponded with that by high performance liquid chromatography method and the data for ALT 711 were consistent with others′ work. CONCLUSION The established new method can be used for screening breaker of AGE cross links in vitro and with high through property.

目的 建立一种快速、体外筛选晚期糖基化终产物 (AGE)交联结构裂解剂的方法。方法 以牛血清白蛋白 (BSA)与葡萄糖孵育形成AGE BSA ,并与包被于 96孔酶标板上的大鼠尾胶原蛋白交联制备AGE BSA 胶原交联结构 ,药物作用一定时间后 ,采用以抗BSA为抗体的ELISA方法检测BSA残留量 ,以此评价裂解剂的裂解强度。并对ELISA全程条件进行了优化。结果 BSA与葡萄糖孵育 3~ 4个月后 ,在Ex/Em( 395 / 4 6 0nm)下出现特异性荧光 ,SDS电泳显示 6 8.0ku的BSA已转化为分子量大于6 8.0ku蛋白质 ,表明已形成AGE BSA ;AGE BSA可与鼠尾胶原蛋白形成特异性的交联结构 ,最强特异性结合的包被量为每孔 0 .0 1~ 0 .1μg。最理想的封闭液为Pierce公司的SuperBlock封闭缓冲液。用新建立的ELISA方法对先导化合物苯基 4 ,5 二甲基噻唑氯嗡盐 (ALT 711)及新合成 10种裂解剂进行了体外裂解效应的评价 ,ALT 711结果与文献报道基本一致 ;本方法筛选的结果与高效液相以小分子二羰基化合物为底物的筛选方法结果趋势一致。结论此...

目的 建立一种快速、体外筛选晚期糖基化终产物 (AGE)交联结构裂解剂的方法。方法 以牛血清白蛋白 (BSA)与葡萄糖孵育形成AGE BSA ,并与包被于 96孔酶标板上的大鼠尾胶原蛋白交联制备AGE BSA 胶原交联结构 ,药物作用一定时间后 ,采用以抗BSA为抗体的ELISA方法检测BSA残留量 ,以此评价裂解剂的裂解强度。并对ELISA全程条件进行了优化。结果 BSA与葡萄糖孵育 3~ 4个月后 ,在Ex/Em( 395 / 4 6 0nm)下出现特异性荧光 ,SDS电泳显示 6 8.0ku的BSA已转化为分子量大于6 8.0ku蛋白质 ,表明已形成AGE BSA ;AGE BSA可与鼠尾胶原蛋白形成特异性的交联结构 ,最强特异性结合的包被量为每孔 0 .0 1~ 0 .1μg。最理想的封闭液为Pierce公司的SuperBlock封闭缓冲液。用新建立的ELISA方法对先导化合物苯基 4 ,5 二甲基噻唑氯嗡盐 (ALT 711)及新合成 10种裂解剂进行了体外裂解效应的评价 ,ALT 711结果与文献报道基本一致 ;本方法筛选的结果与高效液相以小分子二羰基化合物为底物的筛选方法结果趋势一致。结论此方法可用于体外筛选AGE交联裂解化合物 ,并具有高通量的特点

· The effect of lens protein glycosylation in cataract formation and development has long been concerned about. By summarizing the concept of glycosylation, glycosylation of lens crystallin, enzymes and receptors, we attempted to conduct a systematic review of the effect of glycosylation on age-related cataract and diabetic cataract. The preventive strategies to glycosylation, such as advance glycation end product and cross-linking inhibitors, were also summarized to offer an effective and feasible guideline...

· The effect of lens protein glycosylation in cataract formation and development has long been concerned about. By summarizing the concept of glycosylation, glycosylation of lens crystallin, enzymes and receptors, we attempted to conduct a systematic review of the effect of glycosylation on age-related cataract and diabetic cataract. The preventive strategies to glycosylation, such as advance glycation end product and cross-linking inhibitors, were also summarized to offer an effective and feasible guideline for clinical therapy of cataract.·

晶状体蛋白质糖基化在白内障发生、发展中起的作用已被长期关注。本综述从糖基化的概念、晶状体蛋白的糖基化、晶状体酶和受体的糖基化3方面,系统论述了糖基化的作用机制及其在年龄相关性和糖尿病性白内障形成中的重要作用,并介绍了抑制糖基化的方法,如AGEs形成抑制剂、AGEs交联阻断剂,这些具有针对性的治疗方法为白内障的治疗提出了有效可行的指导依据。

 
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