Results In 99 cases with endometrial cancer,the positive expression rate of hMLH1 and hMSH2 was 38.3% and 60.6% respectively. It wasn't positively correlated with FIGO grade,pathological types and histologic stage.
The patient developed two consecutive vaginal tumors diagnosed as metastases of the previously diagnosed endometrial carcinoma.
To assess survival, disease-specific survival, acute and late toxicity and quality of life in patients with curable endometrial carcinoma treated with adjuvant or primary radiotherapy at the age ≥ 75 years.
Expression and significance of Smad4 and p21WAF1 in endometrial carcinoma
Objective: To investigate the expression of Smad4 and p21WAF1 in endometrial carcinoma and its clinical significance.
Methods: Immunohistochemical method was used to detect Smad4 and p21WAF1 expression in 56 cases of endometrial carcinoma.
None of the 19 endometrial neoplasms after tamoxifen therapy was of the endometrioid type: 11 were mucinous adenocarcinomas, 4 clear cell carcinomas, 2 serous-papillary carcinomas, one carcinosarcoma and one malignant Müllerian mixed tumor.
The failure of demonstrating a steroid receptor complement in endometrial neoplasms was, in general terms, an adverse prognostic sign.
Furthermore, many endometrial neoplasms are originated from the luminal and glandular surface epithelium.