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抗fas
相关语句
  anti-fas
     Inhibition of Apoptosis of Mouse T Cells by Anti-Fas Ribozyme
     抗Fas核酶抑制小鼠T细胞凋亡
短句来源
     Effect of mitomycin C combined with C_2-ceramide or anti-Fas monoclonal antibody in human bladder cancer cells
     丝裂霉素C与C_2-神经酰胺或抗Fas单克隆抗体联合治疗膀胱癌的体外研究
短句来源
     FasL:24h-6.18%±1.37, 96h-22.64%±2.82.The blocking of Fas-FasL interaction with anti-Fas monoclonal antibody led to significantly reduced T-cell apoptosis:22.72%±3.54 , 51.47%±3.75 without the antibody.
     FasL :2 4h 6 .18%± 1.37,96h - 2 2 .6 4 %± 2 .82。 用抗Fas单克隆抗体阻滞Fas-FasL相互作用导致明显的T细胞凋亡减少 ,百分比为 2 2 .72 %± 3.5 4 ,未加抗体的为 5 1.4 7%± 3.75。
短句来源
     Apoptosis was blocked in Jurkatbcl-2 by anti-Fas McAb treatment.
     其Jurkatbcl2能明显耐受抗Fas抗体诱导的细胞凋亡。
短句来源
     Meanwhile there is no cell clone forms in the medium which contains 10 μmol/ L RA+100 ng/ ml anti-Fas antibody.
     同时含有 10 μmol/LRA +10 0ng/ml抗Fas抗体的培养基内 ,则无细胞克隆形成。
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  “抗fas”译为未确定词的双语例句
     At the same time,the anti Fas (1 mg/L) could induce 28.8% apoptosis of SW620 cell.
     同时,抗Fas抗体(1mg/L)可最大程度地诱导28.8%的SW620细胞发生凋亡。
短句来源
     Anti Fas antibody induce apoptosis in cultured human glomerular mesangial cells
     抗Fas抗体诱导人肾小球系膜细胞凋亡
短句来源
     Results All cells were incubated with Bcl 2 ASON (17 samples) or anti Fas MoAb (8 samples) for 48 hours, and the percentage of apoptotic leukemic cells reached to (35.7±9.4)% and (39.4±8.2)% respectively.
     结果Bcl2反义脱氧寡核苷酸或抗Fas单抗分别与17例及8例小儿急淋白血病细胞培养48小时后,能各自诱导(35.7±9.4)%及(39.4±8.2)%细胞凋亡。
短句来源
     Stat3 expression level was observed by means of immunoblotting and immunobiochemistry in HL 60. Results: Lower level of Stat3 and the faster cell proliferation were determined in group Fas/130 and Fas/130f compared with the control, and the lowest was in group Fas/130f.
     结果 :转染p ED Fas/130后用抗 Fas抗体作用 6~ 8h,HL - 6 0细胞 Stat3表达下降 (P<0 .0 5 ) ,而 Fas/130 f组的 Stat3的表达下降更明显(P<0 .0 1) ;
短句来源
     Methods:CD3induced Jurkat cell line was used as the activated T cell apoptosis model,and the antisense Fas cDNA was introduced into Jurkat cells with retroviral vector.
     方法:应用CD3诱导Jurkat细胞的凋亡作为激活的T细胞凋亡模型,应用逆转录病毒载体将反义Fas转染Jurkat细胞,观察反义Fas对CD3及抗Fas单克隆抗体(单抗)对Jurkat细胞凋亡的影响。
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  相似匹配句对
     Intervention with anti-H.
     H.
短句来源
     Anti-H.
     H .
短句来源
     Inhibition of Apoptosis of Mouse T Cells by Anti-Fas Ribozyme
     Fas核酶抑制小鼠T细胞凋亡
短句来源
     Anti Fas antibody induce apoptosis in cultured human glomerular mesangial cells
     Fas体诱导人肾小球系膜细胞凋亡
短句来源
     About the FAS System
     浅谈FAS系统
短句来源
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  anti-fas
Anti-Fas antibodies that activate apoptosis of thymocytes by receptor pathway were used as a reference system.
      
At the same time, the caspase-3 inhibitor Z-DEVD-FMK abolished the ganglioside-and antibody-induced depolarization of thymocyte mitochondrial membranes by a receptor-dependent route either partly (GM1 and GT1b) or completely (anti-Fas antibodies).
      
Resistance of SKW6 cell to apoptosis induction with anti-Fas antibody upon transduction of a reverse fragment to a cDNA encoding
      
The effect of transduction with a reverse fragment to a cDNA encoding human 6A8 α-mannosidase on apoptosis induction of human B cell line SKW6 by anti-Fas antibody was tested.
      
Apoptosis-inducer of anti-Fas monoclonal antibody was used to induce apoptosis in SKW6 cells.
      
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Objective:To explore an approach to the reduction of activation induced apoptosis of T cell so as to maximize the number of CTL and enhance the tumor cytotoxicity.Methods:CD3induced Jurkat cell line was used as the activated T cell apoptosis model,and the antisense Fas cDNA was introduced into Jurkat cells with retroviral vector.Results:The expression level of Fas protein in Jurkat cells transducted with the retroviral vector was decreased.Apoptosis was reduced in antisense Fastransfected Jurkat cells after...

Objective:To explore an approach to the reduction of activation induced apoptosis of T cell so as to maximize the number of CTL and enhance the tumor cytotoxicity.Methods:CD3induced Jurkat cell line was used as the activated T cell apoptosis model,and the antisense Fas cDNA was introduced into Jurkat cells with retroviral vector.Results:The expression level of Fas protein in Jurkat cells transducted with the retroviral vector was decreased.Apoptosis was reduced in antisense Fastransfected Jurkat cells after antiCD3 or antiFas treatment.Conclusion:Antisense blocking of Fas expression can partially inhibit Jurkat cell apoptosis induced by antiCD3 or antiFas.

目的:探索阻断激活T细胞凋亡的途径,增加激活的T细胞数量,提高肿瘤免疫治疗的疗效。方法:应用CD3诱导Jurkat细胞的凋亡作为激活的T细胞凋亡模型,应用逆转录病毒载体将反义Fas转染Jurkat细胞,观察反义Fas对CD3及抗Fas单克隆抗体(单抗)对Jurkat细胞凋亡的影响。结果:构建一个反义Fas的逆转录病毒载体pLXSN-反义Fas,并转染Jurkat细胞,发现Jurkat细胞Fas蛋白表达量下降,并部分阻断CD3及抗Fas单抗诱导的Jurkat细胞凋亡。结论:应用反义技术阻断Fas基因表达,可部分阻断CD3及抗Fas单抗诱导的Jurkat细胞凋亡。

Aim: The aim was to clarify the role between hepatocyte Fas expression and apoptosis in hepatitis B virus related chronic liver diseases. Methods: The liver tissues were investigated by in situ immunohistochemistry and TUNEL test. ResuIts: Fas expression in hepatcyte was found in 94.7% of 38 cases with chronic hepatitis. 59.3% of 27 with liver cirrhosis, and 41.9% of 43 with hepatocellular carci- noma respectively, significantly correlated with the severity of inflammatory lesions. The nuclei stained witl. TUNEL...

Aim: The aim was to clarify the role between hepatocyte Fas expression and apoptosis in hepatitis B virus related chronic liver diseases. Methods: The liver tissues were investigated by in situ immunohistochemistry and TUNEL test. ResuIts: Fas expression in hepatcyte was found in 94.7% of 38 cases with chronic hepatitis. 59.3% of 27 with liver cirrhosis, and 41.9% of 43 with hepatocellular carci- noma respectively, significantly correlated with the severity of inflammatory lesions. The nuclei stained witl. TUNEL showed the 3'-OH end of DNA which marked impaired DNA, and also correlated positively with imflammation lesiocts. Apoptotic cells distributed mostly in the piecemeal necrotic region. ConcIusion: The CTL-Fas-apoptosis system was also involved in the mechanism of liver damage of hepatitis B. In hepatocellular carcinoma there was a relationship between the expression of Fas and p53 mutant.

目的:探讨HBV感染时的肝细胞凋亡及其参与的病理机制。方法:研究HBV相关CH38例、LC27例和HCC43例的肝组织,以抗Fas单抗检测Fas表达及以标记的核苷酸借3'未端转移酶检测DNA损伤。结果:Fas表达CH94.7%、LC59.3%、HCC41.9%,与炎症重度明显相关。DNA损伤也与炎症一致。原位展现的凋亡细胞,主要在碎屑样坏死区。结论:CTL-Fas-凋亡也是参与肝细胞损伤的重要机制。在HCC,Fas还与突变型p53的表达相关,p53基因突变使细胞生长失控而癌变;细胞生长失控可能也是激发Fas表达的信号。

Objective: This research is aimed at expression of recombinant FAS antigen and preparation of anti FAS antibodies to lay the basis for functional study of FAS system. Methods: The DNA fragment encoding outer membrane part of FAS antigen was amplified by polymerase chain reaction(PCR) method. The PCR products were directly cloned into pGEM T system. DNA Sequencing analysis revealed a correct cDNA sequence of FAS antigen. The FAS DNA fragment was recovered and inserted into pGEX KG plasmid,then...

Objective: This research is aimed at expression of recombinant FAS antigen and preparation of anti FAS antibodies to lay the basis for functional study of FAS system. Methods: The DNA fragment encoding outer membrane part of FAS antigen was amplified by polymerase chain reaction(PCR) method. The PCR products were directly cloned into pGEM T system. DNA Sequencing analysis revealed a correct cDNA sequence of FAS antigen. The FAS DNA fragment was recovered and inserted into pGEX KG plasmid,then transformed into E.coli recipient cells. The recombinant clones were induced by appropriate IPTG concentration. A high level expression of recombinant FAS and glutathione S transferase fusion protein was obtained. Results: Recombinant FAS antigen was expressed and purified;anti FAS polyclonal antibodies were prepared;anti FAS antibodies could induce the apoptosis of FAS positive U937 cells. Conclusion: Recombinant FAS antigen and anti FAS antibodies can be used to analyze the functions of FAS system.

目的:获得重组FAS抗原,用于抗体制备及进一步的功能分析。方法:用PCR技术从完整的FAScDNA克隆上扩增其编码胞外区的部分,将PCR产物直接克隆到pGEM-T载体系统,DNA序列分析证实序列完全正确;用EcoRⅠ和SalⅠ将FAS胞外区片段切出,定向克隆到经同样酶切处理的pGEX-KG表达载体,转化大肠杆菌,经优化IPTG的诱导条件,获得了FAS胞外区与谷胱甘肽-S-转移酶的融合蛋白高效表达;用亲合层析法从细菌粗提物中纯化了GST-FAS融合蛋白,免疫家兔制备了抗FAS抗体。结果:用重组FAS为免疫原制备的抗体能诱导U937细胞产生细胞凋亡。结论:重组FAS抗原和制备的抗体能用于对FAS系统的功能研究

 
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