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Three cases of bilateral exophthalmos in adult male rhesus monkeys between the ages of 6-8 years are reported. The proptosis with periorbital edema and stretching of the upper eyelids ranged from 8 to 13.5mm. There was slight paraplegia in 2 cases at the early stage. Serum levels of T3, T4, T3/T4 and T3 uptake (MAA) were 395-508ng/dl, 3.8-5.85 μg/dl, 71-134, 0.773 -0.901, respectively. T3 suppressibilities were normal in all cases. B-scan ultrasonographies did not show neoplastic space-occupying orbital lesion... Three cases of bilateral exophthalmos in adult male rhesus monkeys between the ages of 6-8 years are reported. The proptosis with periorbital edema and stretching of the upper eyelids ranged from 8 to 13.5mm. There was slight paraplegia in 2 cases at the early stage. Serum levels of T3, T4, T3/T4 and T3 uptake (MAA) were 395-508ng/dl, 3.8-5.85 μg/dl, 71-134, 0.773 -0.901, respectively. T3 suppressibilities were normal in all cases. B-scan ultrasonographies did not show neoplastic space-occupying orbital lesion in globes and orbits. During intramuscular administration with dexamethason (5 mg/day) for 10 days in 2 cases, the proptosis were rapidly decreased to normal or near normal. The weights of thyroid glands of 2 cases were 0.7 and 1.5g. 本文报告了三例年龄为6—8岁的雄性恒河猴的双侧性突眼症。眼眶周围水肿,上眼睑明显外翻,突眼度为8—13.5mm。其中两例在病程早期有轻度的截瘫。血清T_3、T_4水平及T_3/T_4和T_3摄取(MAA)分别为395—508ng/dl、3.8—5.88μg/dl、71—134和0.773—0.910。甲状腺24小时和48小时吸碘率分别为25.0—37.8%和18.1—22.8%。T_3抑制试验正常。B型超声波检查未见球内和眶内占位性病变。其中两例以地塞米松(5mg/只/日)治疗10天后,眼球突出度迅速下降。 剖检两例,甲状腺重量分别为0.7和1.5克。镜检,部分甲状腺滤泡内胶质淡染或空虚,上皮细胞有乳头状增生和间质内淋巴细胞浸润。眼外肌水肿,变性和肌纤维溶解,细胞吞噬和淋巴细胞浸润。股四头肌显示淋巴细胞浸润和肌纤维变性。这些结果表明,恒河猴可自发毒性弥漫性甲状腺肿,即Graves氏病。 Our research shows that the positive response to both the TRH stimulation test and the T3 inhibition test can be similar in the diagnosis of Graves' ophthalmopathy in either the hyperthyroid or euthyroid state. Since the TRH stimulation test is safe and time saving with little side effect, we believe it can replace the T3 inhibition test. In Graves' ophthalmopathy with a euthyroid state, the two tests overlap each other by 20 per cent. When one of the tests is negative, the other should be performed. When the... Our research shows that the positive response to both the TRH stimulation test and the T3 inhibition test can be similar in the diagnosis of Graves' ophthalmopathy in either the hyperthyroid or euthyroid state. Since the TRH stimulation test is safe and time saving with little side effect, we believe it can replace the T3 inhibition test. In Graves' ophthalmopathy with a euthyroid state, the two tests overlap each other by 20 per cent. When one of the tests is negative, the other should be performed. When the two analyses are used in combination the positive test rate will rise. 本文证明TRH兴奋试验与T_3抑制试验在Graves氏病眼征(甲亢与甲功正常)中的阳性率是相似的。由于TRH兴奋试验省时间、安全、副作用小,临床上可以代替T_3抑制试验。在甲功正常的Graves氏病眼征中,两个试验彼此有交叉(20%)。当一个试验阴性时,应再作另一个试验。若将两个试验结合起来,可提高阳性诊断率。 Allotypic differences of C4, particularly C4 null alleles (C4QO), was investigated in patients with Gravea' disease and compared with those in 89 normal blood donors. C4 allotyping technique was according to 4th International Worshop for the Genetics of Complement and established in our laboratory. Advanced thin layer densitometry was employed for detecting C4QO. Significantly increased frequencies of C4A QO (0.364) and C4BQO (0.216) in Graves' patients were found as compared with 0.169 for C4A QO and 0.073... Allotypic differences of C4, particularly C4 null alleles (C4QO), was investigated in patients with Gravea' disease and compared with those in 89 normal blood donors. C4 allotyping technique was according to 4th International Worshop for the Genetics of Complement and established in our laboratory. Advanced thin layer densitometry was employed for detecting C4QO. Significantly increased frequencies of C4A QO (0.364) and C4BQO (0.216) in Graves' patients were found as compared with 0.169 for C4A QO and 0.073 for C4BQO in normal controls. Similar results were also obtained by fur ther analysis of differnent C4QO phenotypes. 依照我室仿第四届国际补体专题讨论会推荐的方法建立的技术程序,并辅以先进的薄层扫描,对44例份Graves氏病人及89例份正常人的EDTA血浆的C4别型,特别是C4QO的情况进行了检测与对比,发现Graves氏病人的C4QO基因频率(C4AQO为0.364,C4BQO为0.216)较正常人(C4AQO为0.169,C4BQO为0.073)显著增高,进一步分析不同的C4QO表型,情况亦然。
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