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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
Identification of scavenger receptor SR-BI as a high density lipoprotein receptor.
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Identification of scavenger receptor SR-B1 as a high density lipoprotein receptor.
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Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology.
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In vivo evidence that SR-BI is a functional high density lipoprotein receptor under feedback control.
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Hepatic high-density lipoprotein receptors: Roles in lipoprotein metabolism and potential for therapeutic modulation
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| | In order to study the formation of cholesterol gallstone through rabbit model which was induced by high cholesterol diet (HCD), we investigated the high density lipoprotein receptor (HDLr) activities of hepatocytes, total bile acids and cholesterol of common duct bile at 1 week(1w), 2 weeks(2w), 3 weeks (3w)and 4 weeks(4w) in comparison with those of a control group respectively. The results were as follows: ①The HDLr Bmax decreased and the kd value increased significantly (1w group vs control group, P ... | | 采用高胆固醇膳食诱发兔胆囊胆固醇结石模型,分别对高胆固醇膳食后1、2、3、4周及对照组高密度脂蛋白受体( H D Lr)活性,胆汁中胆汁酸及胆固醇变化进行了研究。结果发现:①高胆固醇膳食后1周肝细胞 H D Lr Bm ax 明显增大而 Kd 值明显变小,与对照组相比有显著性差异( P< 0.05),2周组两者降至对照组水平,3周及4周组 Bm ax 明显变小而 Kd 值明显增大,有显著性差异( P< 0.05),②1周组胆汁中总胆汁酸含量增加,2周组与对照组相近,3周组胆汁酸含量减少( P> 0.05),4周组则明显减少( P< 0.05);③随着高胆固醇膳食进食时间增加,胆汁中胆固醇含量持续增加,3周组及4周组与对照组有显著性差异( P< 0.05)。成石中肝细胞 H D Lr 活性及胆汁中胆汁酸含量均表现为先升后降,提示肝细胞 H D Lr 活性下降可能引起 肝细胞摄取用于胆汁酸合成的底物减少,并可能在胆囊结石形成中起重要作用。 | | 文摘来源 | | Aim In an effect to study further the anti-atherogenic effects of human plasma HDL, the HDL receptor activity on liver plasma membranes of cholesterol fed As rabbits injected with HDL was investigated. Methods HDL receptor activity was detected by the method of enzyme linked immunosorbent receptor assay (ELISA) and the levels of serum, liver and bile lipids of As rabbits were also determined. Results The results of lipid measurement showed that human plasma HDL could not decrease the level of... | | 为了研究高密度脂蛋白对抗动脉粥样硬化的作用机理,采用酶联免疫受体分析法对注射高密度脂蛋白的动脉粥样硬化家兔肝细胞膜高密度脂蛋白受体活性进行了检测。结果表明,人血浆高密度脂蛋白虽不能降低高脂饲养的家兔血脂含量,但可显著降低其肝脏脂质水平和显著升高胆囊胆汁脂质水平。受体分析发现,高脂对照组动物肝细胞膜高密度脂蛋白受体Kd值显著降低,而高密度脂蛋白试验组动物Kd值未见明显变化,但Bmax却显著降低。提示长期高脂饲养有使动脉粥样硬化模型动物肝细胞膜高密度脂蛋白受体Kd值显著降低的作用。 | | 文摘来源 | | High-density lipoprotein receptor plays a very important role in the mechanism of reverse transportation of cholesterol.To identify the molecular biology mechanism antiatherosclerosis effect of aerobic exercise,we use the technique of RT-PCR to study the effect of aerobic exercise on gene expression of high-density lipoprotein receptor,that is class B type I scavenger receptor (SR-BI), in ApoE-deficient mice.The results indicated that aerobic exercise inhibits the progress of atherosclerotic lesions is rela... | | 高密度脂蛋白受体是胆固醇的代谢和转运机制中的关键环节 ,为了探讨有氧运动预防AS的发生和控制AS斑块进展的分子机制 ,本项目采用RT -PCR等方法研究了有氧运动对ApoE基因缺陷小鼠高密度脂蛋白受体SR -BI基因表达的影响。实验结果提示 ,有氧运动对AS斑块进展的抑制作用与组织SR -BI表达上调有关 ,有氧运动对SR -BI基因表达的影响涉及一个负反馈调节机制。 | | 文摘来源 | |   | | << 更多相关文摘 |
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