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蛋白
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Nine women of second trimester pregnancy were induced aborted by intramuscular injection of Trichosanthin.It was found that HPL declined rapidly,and fell to 63% at the 8th hourand to 34% at the 12 th hour after injection respectively.The HCG declinedto 50% at the 24 th hour.The syncytiotrophoblast had already degenerated within 12 hours after injection and became aggravated progressively.There were apparent coagula-tive necrosis of syncytiotrophoblast at 24 hours.But no obstruction in inter-villous spaces with...

Nine women of second trimester pregnancy were induced aborted by intramuscular injection of Trichosanthin.It was found that HPL declined rapidly,and fell to 63% at the 8th hourand to 34% at the 12 th hour after injection respectively.The HCG declinedto 50% at the 24 th hour.The syncytiotrophoblast had already degenerated within 12 hours after injection and became aggravated progressively.There were apparent coagula-tive necrosis of syncytiotrophoblast at 24 hours.But no obstruction in inter-villous spaces with fibrin could be observed.However,fibrinous obstructionin intervillous spaces did not take place until 24 hours.The fibrin deposited mainly on the surface of more severely degeneratedsyncytiotrophoblast and gradually increased in amount and finally the inter-villous spaces were thrombosed.The above mentioned lesions were especially conspicuous at the chorionnear the decidua basalis.

通过对肌注天花粉后不同时间取的血液和胎盘组织的研究,观察到了胎盘合体滋养叶细胞坏死与纤维蛋白阻塞绒毛间隙的动态过程。阐明了肌注天花粉首先引起胎盘合体滋养叶细胞坏死,而纤维蛋白阻塞绒毛间隙是合体滋养叶细胞坏死的结果。

Electron microscopic studies of placental tissues from ten cases were presented. Three specimens were taken from full-term normal placentas and seven from placentas of pre-eclamptic patients at term. The ultrastructure of chorionic villi of both normal and pre-eclamptic placentas was examined. The difference between the normal and pathological structures revealed in our work and that of the other authors were analyzed, and suggested that the proliferation of cytotrophoblastic cells of the placental villi in...

Electron microscopic studies of placental tissues from ten cases were presented. Three specimens were taken from full-term normal placentas and seven from placentas of pre-eclamptic patients at term. The ultrastructure of chorionic villi of both normal and pre-eclamptic placentas was examined. The difference between the normal and pathological structures revealed in our work and that of the other authors were analyzed, and suggested that the proliferation of cytotrophoblastic cells of the placental villi in the pre-eclamptic placenta was probably the effect of tissue anoxia. On the free surfaces of syncytial cells, fibrous deposition was sccn and the basal membrane of these cells was thickened. In the tissues where the fibrous deposition was prevalent, there were changes in the structure of syncytial cells, and reduction in organcllcs and microvilli. On the fetal side, changes in the endothelial cells such as cellular swelling, reduction of organcllcs, increase in intracellular filaments and shortage of sinocytosis were shown. All of these changes mentioned above, may affect the function of normal nutrient exchanges in the placenta.

本文观察了10例(3例正常足月与7例先兆子癇)胎盘的超微结构,对正常足月胎盘绒毛与先兆子癇胎盘绒毛的超微结构进行了描述。复习有关文献并从正常和病理方面与有关研究资料进行了初步的对比分析。从两者结构方面存在的差别,提示先兆子癇胎盘绒毛细胞滋养层细胞增生,为缺氧的结果。在合体细胞游离面有纤维蛋白样物质沉着处,基底膜往往同时增厚。凡有纤维蛋白样物质沉着的地方合体细胞有改变,细胞器减少,微绒毛减少。胎儿毛细血管内皮细胞肿胀,胞质内细胞器减少,原纤维增多,胞饮减少。这些改变可能使胎盘运输的功能和物质交换量受到影响。

The intrauterine foreign bodies used in a series of our experiments were made of stain-

取四种异物(不锈钢、塑料、铜丝、硅胶)置于兔子宫内,观察异物对胚泡着床、宫腔内环境及子宫内膜局部组织的形态学的影响。结果:(1)凡四种不同异物所在处均无胚泡着床,(2)子宫腔洗液中蛋白氮、白细胞计数及其分类、免疫反应与血凝因子的变化无统计学意义,但发现蛋白氮含量与中性粒细胞成正相关;(3)经显微镜、扫描电镜、透射电镜观察,见内膜表面腺体的分泌物增多,形成之屏障覆盖于内膜表面。内膜表面有糜烂及溃疡面,并伴有白细胞浸润;(4)偶见内膜坏死、出血。提示异物抗生育的作用在于阻碍胚泡着床,而影响胚泡着床的原因则在于异物对局部引起的机械性压迫或刺激的组织反应。

 
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