Under high moisture for a moment, the amount of absorption of moisture and the flowability of the granule was measured and the appearance was observed as to determine the nature of resistant to moiture of the granules.
RESULTS The components had good linear relation and their average recoveries were 99.86% for CPZ and 100.44% for SBT respectively. S isomer in CPZ,T 1551B and other related substances were seperated well. The quality character of CPZ made by solvent crystallization or lyophilization method was also studied.
According to Huang Wen-k'uei's method, we separated an oxytocic ingredient from Kwang-Ti-lung.It was a faintly yellow, hygroscopic, needle crystal, and its content in Kwang-Ti-lung was about 0.2 per cent. The crystal at the concentration of 1:250000 produced a progressive rise on the tonus of isolated uterine horns of rats or guinea pigs, and at the concentration of 1:83000, a spastic contraction was apparent. The solution of crystal by intravenous injection to the pregnant or non-pregnant anaesthetized ra...
1-(2′-Hydroxyethyl)-2-methylimidazole (Ⅲ)and its hydrochloride was found to be effective against L. icterohaemorrhagiae infection in golden hamster animal model. Ⅲ. HCl named as "Methimidel" has been effectively used in clinical therapy.Twenty-seven derivatives of Ⅲ were prepared in our laboratory. Most esters of Ⅲ and all organic salts were shown to have significant effect against L. icterohaemorrhagiae in vivo, but the latter were shown to be nonhydroscopic whereas other are.
A new technology of formulation and procedure for choline magnesium trisalicylate, which absorbs easily moisture to become rapidly strong solid and solves in alcohol and water, was developed. It was very difficult to use choline magnesium trisalicylate for processing tablet with wetting granulating procedure. The above problems had been solved by adding a small amount of paraffinum as antihumid agent. The qualities of the tablet comply with those of Ch. P. (1990). In forty minutes, the releasing profile of ...