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谷胱甘肽过氧化物酶基因
相关语句
  glutathione peroxidase gene
     Effect of selenium on human myocardial glutathione peroxidase gene expression
     硒对人心肌谷胱甘肽过氧化物酶基因表达影响的研究
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  “谷胱甘肽过氧化物酶基因”译为未确定词的双语例句
     Forty eight clones were sequenced,including 16 new genes,10 glutathione-s-transferase genes,5 glutathione peroxidase genes,2 catalase genes,3 hydroxysteroid dehydrogenase genes,4 tyrosine kinase genes,1 thyroid peroxidase-like protein gene,3 genes for cellulose,1 cAMP responsive element binding protein gene and 3 shell biomineralization related genes.
     选取含插入片段大小不同的48个克隆测序,其中有16个新基因,10个谷胱甘肽转移酶的基因,5个谷胱甘肽过氧化物酶基因,2个过氧化氢酶基因,3个羟基类固醇脱氢酶基因,4个酪氨酸激酶基因,1个类甲状腺过氧化物酶蛋白基因,3个纤维素酶基因,1个cAMP效应元件结合蛋白基因,3个贝壳生物矿化相关蛋白的基因。
短句来源
     THE INFLUENCE OF SELENIUM ON THE EXPRESSION OF GLUTATHIONE PEROXIDASE IN PATIENTS WITH RHEUMATIC HEART DIS EASE
     硒对风湿性心瓣膜病病人谷胱甘肽过氧化物酶基因表达的影响
短句来源
     Radish Phospholipid Hydroperoxide GlutathionePeroxidase Gene Structure and UpstreamRegulatory Sequence Analysis
     萝卜磷脂氢谷胱甘肽过氧化物酶基因结构及其调控序列分析(英文)
短句来源
     THE EFFECT OF POLYSACCHARIDE KRESTIN ON PEROXIDASE GENE EXPRESSION IN MACROPHAGES
     云芝多糖对巨噬细胞谷胱甘肽过氧化物酶基因表达的影响
     In the study genomic organization and the upstream regulatory sequence analysis of this gene was presented.
     此前的研究表明,萝卜磷脂氢谷胱甘肽过氧化物酶基因(RsPHGPx)编码一个有生理功能的过氧化物酶,并且RsPHGPx基因的表达可能受发育和环境胁迫信号的复杂调控.
短句来源
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  相似匹配句对
     STUDY ON GLUTATHIONE PEROXIDASE
     谷胱甘肽过氧化物酶的研究
短句来源
     DETERMINATION OF GLUTATHIONE PEROXIDASE IN RICE SEEDLINGS
     水稻谷胱甘肽过氧化物酶的测定法
短句来源
     Biosynthesis of Glutathione
     谷胱甘肽的生物合成
短句来源
     THE EFFECT OF POLYSACCHARIDE KRESTIN ON PEROXIDASE GENE EXPRESSION IN MACROPHAGES
     云芝多糖对巨噬细胞谷胱甘肽过氧化物酶基因表达的影响
     Effect of selenium on human myocardial glutathione peroxidase gene expression
     硒对人心肌谷胱甘肽过氧化物酶基因表达影响的研究
短句来源
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  glutathione peroxidase gene
Expression of the glutathione peroxidase gene lacking its 3' untranslated region
      
The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to
      
An oxygen responsive transcription factor regulating human glutathione peroxidase gene (GPx) through two oxygen responsive elements (ORE1 and ORE2) has been purified and characterized by sequence-specific DNA affinity chromatography.
      
Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury.
      
Molecular cloning of human plasma glutathione peroxidase gene and its expression in the kidney.
      
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The biological functions of Se are mediated through selenoproteins with Se as selenocysteine.It is known that specific insertion of selenocysteine into proteins is directed by the UGA codon.In eukaryotes,co transtational insertion of selenocysteine into selenoproteins necessitated the participation of the selenocysteine insertion sequence (SECIS),an element lying in the 3' untranslated region (UTR) of selenoprotein mRNAs.Based on computer folding studies,the putative SECIS elements found in the 3'UTR of the...

The biological functions of Se are mediated through selenoproteins with Se as selenocysteine.It is known that specific insertion of selenocysteine into proteins is directed by the UGA codon.In eukaryotes,co transtational insertion of selenocysteine into selenoproteins necessitated the participation of the selenocysteine insertion sequence (SECIS),an element lying in the 3' untranslated region (UTR) of selenoprotein mRNAs.Based on computer folding studies,the putative SECIS elements found in the 3'UTR of the 15 glutathione peroxidase (GPx)cDNAs were compared,which contained three conserved features:AUGA A(G)AA GA.Predicted secondary structures for the 15 SECIS elements belong to the form Ⅰ group(the unparied AAA nucleotides lie in the apical loop)or the form Ⅱ group (the unparied AAA form a bulge in the 5'arm).The 3'UTR of cytoplasmic GPx,human plasma GPx and Schistosoma mansoni GPx contain the form Ⅰ SECIS,while the 3'UTR of phospholipid hydroperoxide GPx,plasma GPx(rat,mouse and bovine)and human giGPx contain the form Ⅱ SECIS.

真核生物将硒代半胱氨酸插入蛋白质必需硒代半胱氨酸插入元件(SECIS)的参与,后者位于硒蛋白mRNA的3′非翻译区.采用RNA折叠程序对15个谷胱甘肽过氧化物酶基因进行计算机处理发现,其可能的SECIS中都具有3段保守碱基AUGA-A(G)AA-GA.根据A(G)AA位于顶环或者顶环上游5′臂的突环上,可将SECIS分为Ⅰ型和Ⅱ型结构

A novel radish RsPHGPx cDNA, which encodes a functional phospholipid hydroperoxide glutathione peroxidase (PHGPx) protein, was identified in the previous work. In the study genomic organization and the upstream regulatory sequence analysis of this gene was presented. Southern blot analysis showed that RsPHGPx gene existed in radish genome in manner of single copy. Moreover, a 3.3 kb genomic DNA fragment of RsPHGPx gene was isolated by combination of common PCR and genome-walking method. Sequence analysis on...

A novel radish RsPHGPx cDNA, which encodes a functional phospholipid hydroperoxide glutathione peroxidase (PHGPx) protein, was identified in the previous work. In the study genomic organization and the upstream regulatory sequence analysis of this gene was presented. Southern blot analysis showed that RsPHGPx gene existed in radish genome in manner of single copy. Moreover, a 3.3 kb genomic DNA fragment of RsPHGPx gene was isolated by combination of common PCR and genome-walking method. Sequence analysis on this genomic fragment demonstrated that RsPHGPx gene consists of seven exons separated by six introns, and suggested that a short 5'-flanking sequence immediately before the exon 1 should be the putative RsPHGPx promoter region, which is proceeded by the upstream neighboring biotin synthase gene. Cis-acting elements search showed that the putative promoter contains elements responsive to hormones (eg. E-Box and W-Box), abiotic stresses (eg. MYB and MYC binding sites), and light (BoxⅡ and I-Box), etc. Northern blot analysis indicated that the expression of RsPHGPx was subjected to up-regulation of chilling and down-regulation of ABA and successive illumination (in etiolated seedlings), implying the regulatory roles of some predicted elements. However the up-regulation effect of herbicide paraquat, which can induce oxidative stress, suggested the presence of some unknown elements in the promoter region. This is the first report on gene structure and upstream regulatory sequence analysis in reported plant PHGPx genes, which will be a prerequisite to understand regulatory mechanism of PHGPx gene expression in plants.

磷脂氢谷胱甘肽过氧化物酶(PHGPx)是谷胱甘肽过氧化物酶(GPx)家族的重要一员,是目前已知能直接保护生物膜免受过氧化损伤的唯一酶类.此前的研究表明,萝卜磷脂氢谷胱甘肽过氧化物酶基因(RsPHGPx)编码一个有生理功能的过氧化物酶,并且RsPHGPx基因的表达可能受发育和环境胁迫信号的复杂调控.要深入了解该基因的表达调控机制首先必须阐明RsPHGPx基因的结构及其上游调控序列.DNA印迹表明萝卜RsPHGPx基因以单拷贝的形式存在于基因组中.以基因组DNA为模板,通过常规PCR与染色体步行相结合的方法克隆到了一段3.3kb长的RsPHGPx基因组序列.分析发现,该基因由7个外显子和6个内含子组成,所有内含子的剪切位点均符合真核生物GT-AG规则.另外还发现该基因的上游基因是生物素合成酶基因;位于RsPHGPx基因上游的调控序列只有不足300bp.这些结构特征与拟南芥AtGPX3基因极其相似.顺式作用元件的数据库搜索发现RsPHGPx基因的上游调控序列含有多个响应激素(如E-Box和W-Box)、胁迫(如转录因子MYB和MYC的结合位点)和光(如BoxⅡ和Ⅰ-Box)信号的元件.RNA印迹分析表明...

磷脂氢谷胱甘肽过氧化物酶(PHGPx)是谷胱甘肽过氧化物酶(GPx)家族的重要一员,是目前已知能直接保护生物膜免受过氧化损伤的唯一酶类.此前的研究表明,萝卜磷脂氢谷胱甘肽过氧化物酶基因(RsPHGPx)编码一个有生理功能的过氧化物酶,并且RsPHGPx基因的表达可能受发育和环境胁迫信号的复杂调控.要深入了解该基因的表达调控机制首先必须阐明RsPHGPx基因的结构及其上游调控序列.DNA印迹表明萝卜RsPHGPx基因以单拷贝的形式存在于基因组中.以基因组DNA为模板,通过常规PCR与染色体步行相结合的方法克隆到了一段3.3kb长的RsPHGPx基因组序列.分析发现,该基因由7个外显子和6个内含子组成,所有内含子的剪切位点均符合真核生物GT-AG规则.另外还发现该基因的上游基因是生物素合成酶基因;位于RsPHGPx基因上游的调控序列只有不足300bp.这些结构特征与拟南芥AtGPX3基因极其相似.顺式作用元件的数据库搜索发现RsPHGPx基因的上游调控序列含有多个响应激素(如E-Box和W-Box)、胁迫(如转录因子MYB和MYC的结合位点)和光(如BoxⅡ和Ⅰ-Box)信号的元件.RNA印迹分析表明RsPHGPx基因的表达受到脱落酸(ABA)和连续光照(在黄化苗中)处理的负调控,受到冷胁迫(4℃)的正调控,这暗示了预测的顺式作用元件的调控作用.然而,除草剂paraquat对该基因表达的正调控作用,暗示了某些与氧化胁迫相关的未知元件的存在.这些结果进一步印证了RsPHGPx基因的表达受发育和环境胁迫信号复杂调控的推测.这是迄今为止首个关于植物PHGPx基因结构和上游调控序列的系统报道,为今后全面认识植物PHGPx基因的表达调控机制奠定了必要基础.

The study was conducted to investigate the effects of vitamin C polyphosphate on transcription activity of antioxidase gene in mice liver. 24 male mice(3-4 weeks old)with an initial body weight of 16-22 g were randomly divided into four groups. These were fed with 35% vitamin C polyphosphate supplementation at the dosages of 0, 500, 2 500 and 5 000 mg/kg of the diet, respectively for 4 weeks. In order to evaluate transcription activity of liver antioxidase gene, livers were collected to detect the mRNA of superoxide...

The study was conducted to investigate the effects of vitamin C polyphosphate on transcription activity of antioxidase gene in mice liver. 24 male mice(3-4 weeks old)with an initial body weight of 16-22 g were randomly divided into four groups. These were fed with 35% vitamin C polyphosphate supplementation at the dosages of 0, 500, 2 500 and 5 000 mg/kg of the diet, respectively for 4 weeks. In order to evaluate transcription activity of liver antioxidase gene, livers were collected to detect the mRNA of superoxide dismutases(SOD), catalase(CAT)and glutathione peroxidase(GSH-Px)by RT-PCR. Results showed that vitamin C polyphosphate had significant effects on transcription activity of antioxidase gene in mouseliver. The CAT mRNA in the groups supplemented with vitamin C polyphosphate at 2 500 and 5 000 mg/kg were significantly higher than that of control group. The SOD mRNA in the groups supplemented with vitamin C polyphosphate at 2 500 mg/kg were higher than that of the control group, and the 5 000 mg/kg group were higher than those of other three groups. The GSH-Px mRNA in the groups supplemented with vitamin C polyphosphate at 5 000 mg/kg was notably higher than those of other three groups. These results suggest that vitamin C polyphosphate can improve the transcription activity of the antioxidase gene in mouse liver, while the requirement for vitamin C polyphosphate to improve transcription activities of the antioxidase gene varies.

为研究维生素C多聚磷酸酯对小鼠肝脏脂质抗氧化物酶基因转录的影响,将24只3-4周龄、体重为16-22g的健康雄性小鼠随机分为4组,分别在饵料中添加0、500、2500和5000mg/kg的35%维生素C多聚磷酸酯,喂食4周后取其肝脏,用Trizol法抽提总RNA,利用RT-PCR方法对小鼠肝脏超氧化物歧化酶基因、过氧化氢酶基因和谷胱甘肽过氧化物酶基因的mRNA进行分析。结果表明,维生素C多聚磷酸酯对小鼠肝脏抗氧化物酶基因的转录有显著性影响(P<0·05)。维生素C多聚磷酸酯添加量为2500和5000mg/kg的两组,过氧化氢酶基因的mRNA水平明显高于对照组;维生素C多聚磷酸酯添加量为2500和5000mg/kg的两组超氧化物歧化酶基因的mRNA水平明显高于对照组,其中5000mg/kg组的mRNA水平明显高于其它三组;维生素C多聚磷酸酯添加量为5000mg/kg组,谷胱甘肽过氧化物酶基因的转录活性明显高于其它三组(P<0·05)。研究结果表明:高剂量的维生素C多聚磷酸酯能促进小鼠抗氧化物酶基因的转录活性,但促进不同抗氧化物酶基因转录所需的维生素C多聚磷酸酯的量不同。

 
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