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电迷宫
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  electric maze
    Millimeter microwave radiation can cause decreased learning capacity and memory of the matured offspring. They need more training and appeared to have more erroneous frequency than the control group irt order to get the stipulated criteria in conditional reflex test of Y-type electric maze.
    毫米波辐射可导致成熟后仔鼠的学习及记忆能力降低,表现在Y型电迷宫条件反射实验中,需要较对照组鼠更多训练次数和错误次数才能达到规定标准。
短句来源
    The test of learning capacity and memory of adult offspring were employed on Y-type electric maze. The quantity of M-R and its affinity to ligand, the contents of monoamine transmitter and AVP in the brain of the fetuses at term and adult offspring were measured by using RBA, HPLC-ECD and RIA separately.
    用电迷宫对子鼠进行学习记忆功能测试,分别用RBA、HPLC-ECD、RIA法对子鼠脑M-胆碱能受体(M-R)、单胺递质和精氨酸加压素(AVP)进行测定。
短句来源
    The electric maze indicator had positive correlation with P3-like potentials.
    正常大鼠类P3与电迷宫条件反射有相关性。
短句来源
    Methods Two month old BALB/c mice were separately irradiated by millimeter wave with frequencies of 37.4 ~60 GHz at power densities of 1~8 mW/cm 2 for 2 h daily from 6th to 15th day of gestation. The test of learning capacity and memory of the adult offspring was employed on Y type electric maze. The contents of monoamine transmitter in the brain of the fetuses at term,adult offspring were measured by using HPLC ECD.
    方法用37.4~60GHz、功率密度1~8mW/cm2的毫米波,在小鼠怀孕6~15d时进行2h/d辐射,用电迷宫对子鼠进行学习记忆功能测试,用高效液相色谱电化学检测(HPLCECD)对子鼠脑单胺递质进行测定。
短句来源
    Aim: The present study was undertaken to assess the cognitive function in vascular dementia animal and to know the correlation between the P3 potential and the electric maze test.
    目的:判断血管性痴呆(VD)动物的认知功能,并了解类P3电位与动物电迷宫指标之间的相关性。
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    The neurological deficit (I1h、I2h、I3h、R1h、R4h、R8h、R24h)was measured by Longa’s method and the ability of learning and remembrance after reperfusion 24h was measured by Y-labyrinth. The immunohistochemistry staining and TUNEL reaction were used to facilitate the quantities of Survivin、fas/fas-L and HSP-70 protein and apoptosis in the brain tissus.
    并在缺血(ischemia,I)和再灌注(reperfusion,R)I/R后不同时间点(I1h、I2h、I3h、R1h、R4h、R8h、R24h)对大鼠进行神经体征的观察,记录动物神经行为缺陷计分,通过Y-电迷宫测试缺血再灌注24h后大鼠学习、记忆能力。
短句来源
    RESULTS:(1)The neurological score and the study- remembrance score(N represents number of time when the rat learn standardization ,A/10 represents rate of retention of memory ) after ischmia 3 hours and reperfusion 24h (I 3h / R 24h) was 0, 47.5±7.1, 0.91±0.08 in the sham operation;
    结果:(1)缺血3h再灌注24h后神经功能缺陷计分及Y-电迷宫测试大鼠学习记忆能力(N代表学会标准时的训练次数;A/10代表记忆保持率): Sham组: 0分,N为47.5±7.1 , A/10为0.91±0.08;
短句来源
    Methods With the administration of L ω nitro L arginine(L NA) into bilateral hippocami,the rat model with disorders of learning and memory abilities was established.
    方法 大鼠双侧海马注入N ω 硝基 L 精氨酸 (L NA)建立学习记忆障碍模型 ,注完L NA后再给大鼠腹腔内注射尼莫地平 ,用Y型电迷宫进行学习记忆能力测试。
短句来源
    CONCLUSION: Hypoxic Preconditioning can protect the ischemia brain on reperfusion injury , reduce the neurological deficit and promote rehabilitation of learning and remembrance of rats .
    缺血3h再灌注24h后神经功能缺陷计分及Y-电迷宫测试大鼠学习记忆能力,HP+I/R组优于I/R组,差异有统计学意义(p<0.05)。 结论:低氧预适应可减轻局灶性缺血再灌注脑损伤,减少大鼠脑缺血再灌注后的脑细胞凋亡和神经功能缺失,提高动物学习记忆能力和损伤后神经功能恢复。
短句来源
    RESULTS:Latencies of the P3-like potentials were not obviously influenced by different lead parameters.
    方法:采用正常大鼠测定听觉类P3、电迷宫条件反射,观察3种导联、两种声强、两种平均叠加次数对P3的影响,比较类P3与电迷宫结果的关系。
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In this article mice were irradiated with 36.11 GHz millimeter microwave at power density 7.2mW/cm~2 for 2 hours daily from the 6th to 15th day of gestation. We evaluated the following listed item with postnatal psychophysiological markers of the litter. The findings showed that: under the low power density millimeter microwave radiation, the litters appeared to have no alteration of physiological markers of pinna detachment, eye opening, testes descent, vaginal opening as well as early reflex makers of surface...

In this article mice were irradiated with 36.11 GHz millimeter microwave at power density 7.2mW/cm~2 for 2 hours daily from the 6th to 15th day of gestation. We evaluated the following listed item with postnatal psychophysiological markers of the litter. The findings showed that: under the low power density millimeter microwave radiation, the litters appeared to have no alteration of physiological markers of pinna detachment, eye opening, testes descent, vaginal opening as well as early reflex makers of surface righting, air righting, auditory startle. In these test, we also found no obvious effect on swimming endurance of matured offspring. The body weight of offspring decresed temporarily but it showed no difference between radiation and control group one week later. Millimeter microwave radiation can cause decreased learning capacity and memory of the matured offspring. They need more training and appeared to have more erroneous frequency than the control group irt order to get the stipulated criteria in conditional reflex test of Y-type electric maze.These results indicate that exposure to millimeter microwave radiation at low power density on the postimplantation embryos may result in subtle long-term neurophysiologic alteration.

本文用频率36.11GHz,功率密度为7.2mW/cm~2的毫米波,在小鼠怀孕6—15天时进行2小时/天的照射,用生后精神生理学指标进行分析。结果发现,未见导致胎仔生后耳廓张开、睁眼、睾丸下降、阴唇张开等生理指标的改变,也未使表面翻正、姿态纠正、听觉惊愕等早期反射指标发生变化,成熟仔鼠的游泳耐力亦未受明显影响。但可导致出生三天内的脍仔体重降低,一周后照射组胎仔体重与对照组无明显差别。毫米波辐射可导致成熟后仔鼠的学习及记忆能力降低,表现在Y型电迷宫条件反射实验中,需要较对照组鼠更多训练次数和错误次数才能达到规定标准。实验证明,低功率密度毫米波照射植入后期胚胎可引起仔鼠精细的精神生理学方面的改变。

The Sprague-Dawley rats withpostnatal 3 d were collected.The hypetpheny-lalaninemia was induced by intraperitoneal in-jection with phenylalanine.Fluorospec-trophotometry was applied to quantive determination of norepinephrine(NE),dopamine(DA)and serotonin(5-HT)in the cerebralcortex and its synaptosome of the rats. Beha-vior in the rats was observed by Y-maze learn-ing.The results showed that compare withthe control,the contents of NE,DA and 5-HT were decreased over 38.6%~67.4% inthe cortex of the hyperphenylalaninemic...

The Sprague-Dawley rats withpostnatal 3 d were collected.The hypetpheny-lalaninemia was induced by intraperitoneal in-jection with phenylalanine.Fluorospec-trophotometry was applied to quantive determination of norepinephrine(NE),dopamine(DA)and serotonin(5-HT)in the cerebralcortex and its synaptosome of the rats. Beha-vior in the rats was observed by Y-maze learn-ing.The results showed that compare withthe control,the contents of NE,DA and 5-HT were decreased over 38.6%~67.4% inthe cortex of the hyperphenylalaninemic ratsand decreased over 51.9%~70.2%in thesynaptosome of the cortex.Y-maze learningability in the rats was decreased apparently.The results suggest that the mental retarda-tion of PKU is in close correlative with de-crease of some monoamine transmitter con-tents in the cortex and its synaptosome.

以3d龄Sprague-Dawley大鼠腹腔注射苯丙氨酸(Phe)诱导高苯丙氨酸血症,荧光法测定大脑皮层及其突触体中去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)含量;Y型电迷宫法测其学习记忆能力.结果显示:高苯丙氨酸血症大鼠大脑皮层NE、DA及5-HT含量降低38.6%~67.4%,突触体中NE、DA和5-HT含量降低51.9%~70.2%,学习记忆能力明显低于对照组.结果提示,苯酮尿症智力障碍可能与大脑皮层及其突触体中某些单胺类递质含量降低相关.

To determine the threshold of fetus injury induced by millimeter wave irradiation and to clarify the mechanism of lowering learning capacity and memory of the adult offspring, and whether these effects are of frequency-specific, two-month old BALB/c mice were separately irradiated by millimeter wave with a frequency of 60 GHz at power densities of 1-8 mW·cm 2 for 2 h daily from the 6th to 15th day of gestation. The test of learning capacity and memory of adult offspring were employed on Y-type electric...

To determine the threshold of fetus injury induced by millimeter wave irradiation and to clarify the mechanism of lowering learning capacity and memory of the adult offspring, and whether these effects are of frequency-specific, two-month old BALB/c mice were separately irradiated by millimeter wave with a frequency of 60 GHz at power densities of 1-8 mW·cm 2 for 2 h daily from the 6th to 15th day of gestation. The test of learning capacity and memory of adult offspring were employed on Y-type electric maze. The quantity of M-R and its affinity to ligand, the contents of monoamine transmitter and AVP in the brain of the fetuses at term and adult offspring were measured by using RBA, HPLC-ECD and RIA separately. The results revealed that millimeter wave irradiation at power densities of 3,5,8 mW·cm 2 lowered learning capacity and memory of adult offspring. It significantly increased Bmax in hippocampus of adult offspring. It obviously reduced the content of DA in brain of the fetuses at term and adult offspring. Irradiation at a power density of 8 mW·cm 2 significantly reduced the content of AVP in hypothalamus and pituitary gland of adult offspring. It is suggested that the threshold of fetuses injury induced by millimeter wave irradiation to pregnant mice with a frequency of 60 GHz is between the 1 mW·cm 2 and 3 mW·cm 2 . The mechanism that millimeter wave irradiation lowered learning capacity and memory of the adult offspring is closely related to a decrease of the content of AVP, DA in the hippocampus. The effect isn′t frequency-specific.

为阐明毫米波对胚胎产生损伤效应阈值及导致学习记忆功能降低的机理,明确毫米波的生物效应有无频率特异性,用60GHz、功率密度1~8mW·cm2的毫米波,在小鼠怀孕6~15d时进行2h·d1辐射。用电迷宫对子鼠进行学习记忆功能测试,分别用RBA、HPLC-ECD、RIA法对子鼠脑M-胆碱能受体(M-R)、单胺递质和精氨酸加压素(AVP)进行测定。结果如下,≥3mW·cm2的辐射导致成年子鼠学习记忆功能明显降低、成年子鼠海马区Bmax明显升高、足孕胚胎及成年子鼠脑中多巴胺(DA)含量明显降低,8mW·cm2辐射导致成年子鼠下丘脑及垂体中AVP含量明显降低。结论为:60GHz毫米波辐射导致胚胎损伤的阈值在1~3mW·cm2,其导致子鼠学习记忆功能降低与使子鼠脑中AVP、DA含量下降及海马区胆碱能神经活性降低相关,未见毫米波频率特异性效应

 
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