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原始乳腺癌
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  “原始乳腺癌”译为未确定词的双语例句
     Immortalization of cultures derived from primary breast carcinoma by ectopic expression of human telomerase reverse transcriptase and its significance
     端粒酶永生化原始乳腺癌组织来源细胞及其意义
短句来源
     Background and purpose:Most breast cancer cell lines were derived from malignant pleural fluid or other tissues that metastasized from breast carcinoma.
     背景与目的:乳腺癌细胞系大部分来源于乳腺癌转移所致的胸水或非原始乳腺癌组织来源,与真正的乳腺癌的生物学性状有很大差异。
短句来源
     We aimed to establish immortalized cultures derived from primary breast cancer by introducing hTERT and determine the gene profile of hTERT-transfected cultures. Methods:hTERT was introduced into breast tumor cultures with a puromycin-resistant retroviral construct,pBABE-hTERT-puro.
     方法:通过重组逆转录病毒pBABE-hTERT-puro将hTERT基因导入原始乳腺癌组织来源的细胞,建立稳定表达hTERT的永生乳腺癌细胞。
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  相似匹配句对
     Chemoprevention of breast cancer
     乳腺癌的药物预防
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     Breast cancer in older women
     老年人乳腺癌
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     f mutated by nitrous acid, the bio-activity of the bacterium T.
     f菌和原始T .
短句来源
     Immortalization of cultures derived from primary breast carcinoma by ectopic expression of human telomerase reverse transcriptase and its significance
     端粒酶永生化原始乳腺癌组织来源细胞及其意义
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     Original Sense of Jewelry
     首饰的原始意识
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  primary breast tumor
Remarkably, increased Cyr61 protein expression was observed in greater than 50% of primary breast tumor lysates that were progesterone receptor (PR) + but estrogen receptor negative.
      
Results: Primary breast tumor ALDH1A1 and ALDH3A1 levels were highly predictive of their respective levels in paired metastatic breast tumors present in axillary lymph nodes (r2=0.80 and 0.85, respectively).
      
The current tumor was apparently a metastasis from this primary breast tumor.
      
We found that BMP-2 is expressed in primary breast tumor tissue samples and in breast cancer cell lines.
      
In the present study, we demonstrate, using restriction fragment length polymorphism (RFLP) analysis at the L-myc proto-oncogene (chromosome 1p32), a frequent loss of heterozygosity in primary breast tumor DNAs (55 out of 152 informative tumor DNAs).
      
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Background and purpose:Most breast cancer cell lines were derived from malignant pleural fluid or other tissues that metastasized from breast carcinoma.Breast carcinogenesis is under represented due to the significant distinction of biological characteristics between cancer cell lines and primary breast cancers.Few primary breast tumors spontaneously developed into immortal cell lines.Overexpression of human telomerase reverse transcriptase(hTERT) in normal epithelial cells led to immortalization.We aimed to...

Background and purpose:Most breast cancer cell lines were derived from malignant pleural fluid or other tissues that metastasized from breast carcinoma.Breast carcinogenesis is under represented due to the significant distinction of biological characteristics between cancer cell lines and primary breast cancers.Few primary breast tumors spontaneously developed into immortal cell lines.Overexpression of human telomerase reverse transcriptase(hTERT) in normal epithelial cells led to immortalization.We aimed to establish immortalized cultures derived from primary breast cancer by introducing hTERT and determine the gene profile of hTERT-transfected cultures.Methods:hTERT was introduced into breast tumor cultures with a puromycin-resistant retroviral construct,pBABE-hTERT-puro.Real-Time RT-PCR was used to analyze the expression level of hTERT after transfection.The upregulated gene profile was determined with microarray techniques.Results:hTERT was stably over expressed,at least 1 400-fold in hTERT-transfected cells compared to pBABE-puro transfected cultures.These ectopic over-expressions led to immortalization of transfected cultures,which could undergo at least 40-50 passages.Microarray analysis further confirmed the over-expression of hTERT in transfected cultures and demonstrated that 22 genes were up-regulated due to over-expression of hTERT.No down-regulated genes were observed cross all cultures.Conclusions:Over-expression of hTERT led to immortalization of breast tumor primary cultures and up-regulated certain genes.

背景与目的:乳腺癌细胞系大部分来源于乳腺癌转移所致的胸水或非原始乳腺癌组织来源,与真正的乳腺癌的生物学性状有很大差异。而仅部分细胞系直接由乳腺癌原代细胞在体外培养条件下成为永生化的细胞系,过表达人端粒酶逆转录酶(hTERT)可使正常人上皮细胞永生化。本研究将通过hTERT转染入原始乳腺癌组织来源的细胞建立永生化乳腺癌细胞系,并研究过表达hTERT对其他基因表达的影响。方法:通过重组逆转录病毒pBABE-hTERT-puro将hTERT基因导入原始乳腺癌组织来源的细胞,建立稳定表达hTERT的永生乳腺癌细胞。再利用微阵列技术检测乳腺癌细胞中hTERT诱导的基因表达改变。结果:Real-Time RT-PCR证实hTERT转染后的乳腺癌细胞中hTERT过度并稳定表达,为转染前表达量的1400倍以上,并使得被转染的细胞永生化,可以传40~50代以上。微阵列结果进一步证实hTERT在转染后的细胞中过表达,另外,有22个基因在转染后的乳腺癌细胞中上调,未观察到所有细胞株中均下调的基因。结论:过表达hTERT可导致乳腺癌原代细胞的永生化,并对部分基因有上调作用。

 
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