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原位凝胶
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  in situ gel
    Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration
    石杉碱甲鼻用原位凝胶的制备及其经鼻脑靶向性评价
短句来源
    In vivo Distribution and Pharmacokinetics of Dexamethasone Sodium Phosphate Thermosensitive in situ Gel Following Intratympanic Injection
    鼓室注射地塞米松原位凝胶的体内分布及药动学研究
短句来源
    Rheological properties of sucrose acetate isobutyrate in situ gel
    乙酸异丁酸蔗糖酯原位凝胶流变学性质的研究
短句来源
    The purpose of this paper was to develop a thermosensible in situ gel including ribavirin(RBVR) for intranasal administration.
    本论文以利巴韦林(RBVR)为模型药物,对鼻用温敏型原位凝胶进行了研究。
短句来源
    The effects of huperzine A tablets and its in situ gel with different doses on the dysmnesia of acquiredlearning, retention and reappearance of memory in mice and the dysmnesia of acquired learning in rats were investigated.
    考察了石杉碱甲片及不同剂量原位凝胶对记忆获得障碍、记忆巩固不良和记忆再现障碍小鼠及记忆获得障碍大鼠的影响。
短句来源
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  in situ forming gel
    Pharmacokinetics of nitrendipine biodegradable microspheres and in situ forming gel
    尼群地平可生物降解微球和原位凝胶的药物动力学
短句来源
    Objective To study the pharmacokinetic characters of nitrendipine biodegradable microspheres and in situ forming gel.
    目的研究尼群地平可生物降解微球和原位凝胶在家兔体内的药物动力学特征。
短句来源
    Methods After muscular injection administration of a single dose of nitrendipine biodegradable microspheres,in situ forming gel(test formulation A and B)and nitrendipine solution(reference formulation C) to each of three healthy rabbits,the plasma concentrations of the active drugs at different times were observed by HPLC and the plasma concentration-time curves of these formulations were obtained.
    方法采用HPLC法,测定3只健康家兔肌注尼群地平微球及原位凝胶(分别为受试制剂A、B)和尼群地平溶液(参比制剂C)后不同时间点的血药浓度,绘制药时曲线,计算药物动力学参数及相对生物利用度。 结果家兔肌注相当于尼群地平30 mg的制剂A、B和C后,血浆中尼群地平的tmax分别为3、1和1 h;
短句来源
    Conclusions Comparing with nitrendipine solution,nitrendipine biodegradable microspheres and in situ forming gel had longer action time in rabbits,but their relative bioavailabilities were lower.
    结论尼群地平可生物降解微球和原位凝胶与尼群地平溶液相比,在家兔体内具有更长的作用时间,但相对生物利用度较低。
短句来源
  “原位凝胶”译为未确定词的双语例句
    The development of injectable biodegradable in-situ forming gel implants based on PLA/PLGA, SAIB, organic gel or PLA/PLGA-PEG triblock copolymers as carriers, including their characteristics , drug release mechanism, preparation and application, was reviewed.
    综述以聚乳酸/聚乳酸-乙醇酸共聚物(PLA/PLGA)、醋酸-异丁酸蔗糖酯(SAIB)、有机凝胶和PLA/PLGA与PEG的三嵌段共聚物为载体的注射型原位凝胶植入剂的研究进展,包括其特性、释药机制、制备和应用。
短句来源
    Diffusion behaviors of drugs in thermosensitive in situ gels
    温度敏感原位凝胶中药物的扩散行为
短句来源
    Study on Nitrendipine In-situ Forming Gel and Biodegradable Microspheres
    尼群地平原位凝胶及可生物降解微球的研究
短句来源
    Determination of cyclosporine in ophthalmic situ-forming gel with HPLC
    高效液相色谱法测定环孢霉素眼用原位凝胶的含量
短句来源
    Development of Injectable Biodegradable In-situ Forming Gel Implants
    注射型原位凝胶植入剂的研究进展
短句来源
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  in situ gel
The expression of human SOD protein in the transgenic plants was shown by in situ gel staining assay.
      
Rapid detection of a fungal Poly (3-hydroxybutyrate) depolymerase using a new in situ gel activity staining technique
      
A mucoadhesive in situ gel delivery system for paclitaxel
      
The objective of this study was to develop an in situ gel delivery system containing paclitaxel (PTX) and mucoadhesives for sustained and targeted delivery of anticancer drugs.
      
In vitro dissolution method for evaluation of buprenorphine in situ gel formulation: A technical note
      
更多          
  in situ forming gel
In Vivo Properties of an In Situ Forming Gel for Parenteral Delivery of Macromolecular Drugs
      
Iversen, In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs, Pharm.
      
  in situ-forming
In situ-Forming Pharmaceutical Organogels Based on the Self-Assembly of L-Alanine Derivatives
      
In Situ-Forming Oleogel Implant for Rivastigmine Delivery
      
First report on the efficacy of L-alanine-based in situ-forming implants for the long-term parenteral delivery of drugs.
      


Implantable drug delivery systems (IDDS) are long-term acting controlled release systems,administered subcutaneously through surgically implantation or injection via a syringe.The recently developed IDDS are reviewed and the advantages,the drawbacks and the prospects for application are analyzed.The reverse thermosensitive biodegradable injectable implant in situ is of remarkable potential of application in effective and long-term drug delivery.

体内植入型药物释放系统为一类经手术植入体内或皮下,或经穿刺导入皮下的控制释药制剂,适用于靶向给药或长期给药。本文根据系统植入形式和释药机制的不同,将植入型药物释放系统进行了分类,并对各种植入药物体系的特点和存在的问题作了评述。反向温敏型注射式原位凝胶植入系统是一类最具潜力的长期释药系统,可实现药物的长期、安全、有效释放,具有广泛的应用前景。

The effects of huperzine A tablets and its in situ gel with different doses on the dysmnesia of acquiredlearning, retention and reappearance of memory in mice and the dysmnesia of acquired learning in rats were investigated. Theresults showed that huperzine A in situ gel with the doses of 17.5, 35 and 70μg/kg(qd for 7d) could significantly amelioratethe impaired memory of the above-mentioned mice. The effect of huperzine A in situ gel of 70μg/kg dose group was slightlybetter than tablets of equidose and ameliorated...

The effects of huperzine A tablets and its in situ gel with different doses on the dysmnesia of acquiredlearning, retention and reappearance of memory in mice and the dysmnesia of acquired learning in rats were investigated. Theresults showed that huperzine A in situ gel with the doses of 17.5, 35 and 70μg/kg(qd for 7d) could significantly amelioratethe impaired memory of the above-mentioned mice. The effect of huperzine A in situ gel of 70μg/kg dose group was slightlybetter than tablets of equidose and ameliorated the dysmnesia of acquired learning in rats as well.

考察了石杉碱甲片及不同剂量原位凝胶对记忆获得障碍、记忆巩固不良和记忆再现障碍小鼠及记忆获得障碍大鼠的影响。结果显示,17.5、35和70μg/kg的石杉碱甲原位凝胶(日服1次,连续7d)对上述记忆损伤小鼠均有明显改善作用,70μg/kg的石杉碱甲原位凝胶药效略优于同剂量片剂,且对东莨菪碱所致大鼠记忆获得障碍也有一定疗效。

Objective To investigate the absorption and distribution of DSP (Dexamethasone sodium phosphate)-loaded thermosensitive in situ gel following IT(intratympanic injection) in guinea pig and provide rationale for clinical application. Methods DSP-loaded thermosensitive in situ gel was prepared by using poloxamer 407 as matrix. The HPLC assays for the determination of DSP and dexamethasone (Dex) in perilymph (PL), cerebrospinal fluid (CSF) and plasma were developed, respectively. DSP-loaded gel and solution were...

Objective To investigate the absorption and distribution of DSP (Dexamethasone sodium phosphate)-loaded thermosensitive in situ gel following IT(intratympanic injection) in guinea pig and provide rationale for clinical application. Methods DSP-loaded thermosensitive in situ gel was prepared by using poloxamer 407 as matrix. The HPLC assays for the determination of DSP and dexamethasone (Dex) in perilymph (PL), cerebrospinal fluid (CSF) and plasma were developed, respectively. DSP-loaded gel and solution were administered after IT or IV (intravenous injection). PL, CSF and plasma were collected periodically. The concentrations of DSP and Dex were measured by HPLC, and were used to estimate in vivo distribution and pharmacokinetic parameters of Dex in the inner ear. Results The AUC (area under curve) and t_ 1/2 of Dex in PL following IT DSP-loaded gel were 593.7-and 28.6-fold higher than those following Ⅳ DSP solution. Moreover, DSP-loaded gel following IT extended the mean residence time(MRT) by nearly 5 times, compared with the solution. After IT, the concentration levels of Dex in CSF and plasma were much lower than that in PL. Conclusion DSP thermosensitive in situ gel following IT has significant cochlea-oriented and sustained-release effect.

目的研究鼓室注射(intratympanicinjection,IT)地塞米松磷酸钠(DSP)温度敏感原位凝胶的体内分布特征,探讨载药凝胶经圆窗膜吸收的规律,为其临床应用提供理论依据。方法制备DSP温度敏感原位凝胶。建立在外淋巴(perilymph,PL)、脑脊液(cerebrospinalfluid,CSF)和血中DSP及地塞米松(Dex)的HPLC测定方法。经鼓室注射DSP凝胶,并与溶液剂相比较,测定药物的体内分布和在PL中的药代动力学参数。结果鼓室注射DSP原位凝胶,Dex在内耳组织的局部生物利用度显著提高,AUC是静脉注射溶液的593.7倍;药物作用时间明显延长,同鼓室注射溶液相比,t1/2高28.6倍,MRT增加了近5倍。而且,当采用鼓室注射时,药物在体内其他部位分布甚少,在血和CSF中的浓度均远远低于PL。结论经鼓室给药的DSP原位凝胶对耳蜗具有明显的定位释药作用和缓释效果。

 
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