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奥硝唑
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  ornidazole
     Results LD 50 of Ornidazole is 1073.96 mg/kg.
     结果 奥硝唑LD50 为 10 73.96mg/kg .
短句来源
     RESULTS:The linear concentration range of ornidazole was6.0~18.0μg/ml(r=0.9997)and the average recovery was99.80%(RSD=0.75%, n=5).
     结果:奥硝唑检测浓度在6.0~18.0μg/ml范围内线性关系良好(r=0.9 997),平均回收率为99.80%(RSD=0.75%,n=5)。
短句来源
     RESULTS:There was a good linear correlation within a range of6.0~18.0μg/ml(r=0.9997)of ornidazole concentration,the average recovery was100.19%(RSD=0.66%,n=5).
     结果:奥硝唑检测浓度在6.0~18.0μg/ml范围内线性关系良好(r=0.9997),平均回收率为100.19%(RSD=0.66%,n=5)。
短句来源
     Results:The average recove ries of ornidazole were 98.62%,RSD=0.52%(n=4) and ketoconazole were 98.98%,RSD=0 .21%(n=4),respectively.
     奥硝唑的平均回收率为98.62%,RSD=0.52%(n=4); 酮康唑的平均回收率为98.98%,RSD=0.21%(n=4)。
短句来源
     Results ①There was good liner relationship between the concentrations of ornidazole and their peak areas in the ranges of 0.00101~0.022 mg/ml(r=0.9999),The average recovery was 100.09%(n=5 RSD=0.59%);
     结果①奥硝唑的浓度与峰面积0.00101~0.022mg/ml范围内线性关系良好(r=0.9999),平均回收率为100.09%(n=5),RSD=0.59%;
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  orinidazole
     Conclusion Orinidazole is effective and safe for treament of anaerobic infec tion.
     结论 奥硝唑治疗口腔颌面部急性厌氧菌感染安全有效 ,不良反应少 ,优于同类药物甲硝唑。
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  “奥硝唑”译为未确定词的双语例句
     RESULTS The linear range was 1.0×10~(-6)-2.0×10~(-4) mol·L~(-1) with the RSD of 3.52%.
     结果奥硝唑浓度在1.0×10-6~2.0×10-4mol. L-1范围内与其荧光强度呈良好的线性关系,RSD=3.52%,检出限达1.09×10-7mol.
短句来源
     5 mol l-1 to 1.0×10? 3 mol l-1 with a detection limit of 9.0×10?
     此传感器可用于奥硝唑的测定,对奥硝唑的线性响应范围为9.0×10-6到1.0×10-3 mol l-1,检测下限为8×10-6 mol l-1。
短句来源
     Results The absorption spectrums and the contrations have good liner relationship in the range of 0.04~0.4 μg(r=0.9999). The average recovery and RSD were 99.76% and 0.47%(n=5).
     结果奥硝唑在0.04~0.40μg范围内峰面积与浓度呈良好的线性关系(r=0.9999),平均回收率为99.76%,RSD为0.47%(n=5)。
短句来源
     Following intravenous separate administration of(S)-and(R)-ornidazole(54 mg/kg), t_(1/2) were estimated to be 2.19 and 3.23 h,AUC were 138.40 and 203.09 μg·h/mL,and CL were 0.08 and 0.05 L/h for(S)-and(R)-enantiomers,respectively.
     静脉注射给药后,左旋、右旋奥硝唑的t1/2分别为2.19和3.23h,AUC分别为138.40和203.09μg. h/mL,CL分别为0.08和0.05 L/h。
短句来源
     Result There were no evident changes in apparent,PH,content and absorption curves within 6h.
     结果在0~6h内,溶液外观、pH值和紫外吸收光谱基本不变化,头孢匹胺与奥硝唑的含量没有明显的变化。
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  ornidazole
Cerebrospinal fluid concentrations of metronidazole, tinidazole and ornidazole in rabbits
      
The penetration of metronidazole, tinidazole and ornidazole into the cerebrospinal fluid (CSF) of rabbits was determined using a bioassay based on the antibacterial activity of the drugs.
      
The activity of niridazole was compared to that of chemically related compounds (metronidazole, ornidazole, tinidazole).
      
Pharmacokinetics of ornidazole in neonates and infants after a single intravenous infusion
      
The single dose pharmacokinetics of ornidazole has been evaluated in 12 neonates or infants (aged 1 to 42 weeks) after the infusion of 20 mg/kg over 20 min.
      
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Objective:To evaluate the efficacy and safety of o rn idazole tablet in the treatment of acute anaerobic infection and vaginalis trich omoniasis.Methods:In this random double-blind double-dummy control clinical tr ial,121 patients with acute anaerobic infections and 80 patients with vaginalis trichomoniasis were treated with ornidazole tablet or tinidazole tablet for 3~1 0 days,with the dose of 500 mg twice daily by mouth,the stomatological patients were received the dose of 500 mg·d~(-1),qd and double dosis...

Objective:To evaluate the efficacy and safety of o rn idazole tablet in the treatment of acute anaerobic infection and vaginalis trich omoniasis.Methods:In this random double-blind double-dummy control clinical tr ial,121 patients with acute anaerobic infections and 80 patients with vaginalis trichomoniasis were treated with ornidazole tablet or tinidazole tablet for 3~1 0 days,with the dose of 500 mg twice daily by mouth,the stomatological patients were received the dose of 500 mg·d~(-1),qd and double dosis at the first tim e.Results:In the treatment of acute anaerobic infections,the total effec tive rate,bacterial clearance rate and adverse reaction rate of ornidazole and tinidazole were 98.4%,(96.2%,)11.5% and 85%,90.7%,28.3% resp ecti vely,the adverse reactions were generally mild and well tolerated.The significan t differences of total effective rate and adverse reaction rate between two grou ps were observed.In the treatment of vaginalis trichomoniasis,the total effectiv e rates of two groups were 100%.Conclusion:Ornidazole is an effective and safe drug for treating acute anaerobic infections and vaginalis trichomoniasis,the adverse reaction rate is less compared with tinidazole.

目的 :评价奥硝唑片治疗由厌氧菌所致的感染及滴虫所致阴道炎的临床疗效及其安全性。方法 :采用多中心随机双盲双模拟平行对照研究方法 ,试验组口服奥硝唑 ,对照组口服替硝唑 ,共观察厌氧菌感染 12 1例(外科 60例 ,口腔科 61例 ) ,妇科阴道毛滴虫感染 80例 ,奥硝唑 5 0 0mg ,bid ;口腔科奥硝唑 5 0 0mg ,qd ,首剂加倍。疗程 3~ 10d。结果 :奥硝唑与替硝唑治疗急性厌氧菌感染总有效率分别为 98.4 %及 85 % (P <0 .0 5 ) ,细菌清除率分别为 96.2 %及 90 .7% (P >0 .0 5 ) ;治疗滴虫性阴道炎的总有效率均为 10 0 %。奥硝唑和替硝唑的不良反应发生率分别为 11.5 %及 2 8.3 % (P <0 .0 5 )。结论 :奥硝唑片治疗急性厌氧菌感染和滴虫性阴道炎安全有效 ,不良反应少 ,优于同类药物替硝唑。

Objective:To evaluate the clinical effection of ornidazole treating suppurative periodontitis and pericoronitis.Methods:The volunteers who were tested a pus anaerobe culture blood and urine routine.Liver and kidney function before and after treatment respectively took fills in order by double blind and double imitation and uncover the blind after all data was statistically analyzed.Results:There are no obvious difference in number,sex age kind of disease infection type.Total dosage course curative effect was...

Objective:To evaluate the clinical effection of ornidazole treating suppurative periodontitis and pericoronitis.Methods:The volunteers who were tested a pus anaerobe culture blood and urine routine.Liver and kidney function before and after treatment respectively took fills in order by double blind and double imitation and uncover the blind after all data was statistically analyzed.Results:There are no obvious difference in number,sex age kind of disease infection type.Total dosage course curative effect was 100% in test group and 68.75% in control group ( P <0.05).The rate of anaerobe elimination was 93.33% in test group and 84.62% in control group.The cure rate of anaerobe was 16.66% in test group and 10% in control group ( P >0.05).The harmful reaction appeared only one in test group and three cases in control group.The laboratory findings was basically no change before and after treatment both in two groups( P >0.05).Conclusions:It is effective and safe to treat stomatologic infection with ornidazole pill. [

目的 :评价奥硝唑片剂治疗牙周及冠周化脓性感染的临床效果。方法 :采用双盲双模拟法将受试药 ,对照药按顺序发放给受试者 ,使用前后各查一次厌氧菌培养 ,血、尿常规及肝肾功能。全部病例观察表验收后揭盲。结果 :受试组和对照组参加人数、性别、年龄、病情、感染类型 ,总用药量 ,疗程均无明显差异 (P >0 .0 5 )。牙周炎、冠周炎 ,受试组治疗有效率 10 0 % ,对照组为 6 8.75 % ,治疗效果优于对照组 (P >0 .0 5 )。细菌清除率受试组为 93.33% ,对照组为 84.6 2 % (P >0 .0 5 )。厌氧菌临床治愈率受试组为 16 .6 6 % ,高于对照组 10 % (P >0 .0 5 )。出现不良反应受试组 1例 ,对照组 3例 (P >0 .0 5 )。实验室结果两组治疗前后基本无变化 (P >0 .0 5 )。结论 :奥硝唑片剂治疗口腔感染是安全有效的。

Objective To evaluate the effect of Ornidazole on the treatment of periodontitis and pericoronitis.Methods 30 periodontitis and pericoronitis patients were treated by the tabeles of Ornidazole,and 30 patients treated by Tinidazole served as control group.the clinical effection and the rate of killing anaerobic bacteria were observed.Results The effective rate was 83.3% in rest group and 73.3% in control group respectively.There were no significant differences between two groups(P>0.05).Conclusion Ornidazole...

Objective To evaluate the effect of Ornidazole on the treatment of periodontitis and pericoronitis.Methods 30 periodontitis and pericoronitis patients were treated by the tabeles of Ornidazole,and 30 patients treated by Tinidazole served as control group.the clinical effection and the rate of killing anaerobic bacteria were observed.Results The effective rate was 83.3% in rest group and 73.3% in control group respectively.There were no significant differences between two groups(P>0.05).Conclusion Ornidazole shows obvious therapeutic effects on infection with anaerobic bacteria.

目的 评价奥硝唑治疗口腔厌氧菌感染疾病的效果。方法 选择口腔厌氧菌感染疾病患者 60例。以替硝唑为对照组 ,采用双盲法 ,对其临床疗效和细菌清除率进行比较。结果 奥硝唑总有效率 83 .3 % ,细菌清除率 91.7% ;替硝唑总有效率 73 .3 % ,细菌清除率 88.4% ,二者间无显著性差异 (P >0 .0 5 )。结论 奥硝唑治疗口腔厌氧菌感染疾病效果显著。

 
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