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近曲肾小管上皮细胞
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  renal proximal tubular cells
     Replication of a model of injury to human renal proximal tubular cells induced by hypoxia/reoxygenation
     人近曲肾小管上皮细胞缺氧/复氧损伤模型的建立
短句来源
     Objective To replicate a new model of injury to human renal proximal tubular cells ( HK 2) induced by hypoxia/reoxygenation.
     目的建立一种新的人近曲肾小管上皮细胞HK2缺氧/复氧损伤模型。
短句来源
     Objective To investigate the role of postasphyxial-serum of neonate in inducing injury of human renal proximal tubular cells(HK-2 cells).
     目的研究窒息新生儿血清在诱导人近曲肾小管上皮细胞(HK-2)损伤中的作用。
短句来源
  “近曲肾小管上皮细胞”译为未确定词的双语例句
     Real - time PCR, which run on ABI Prism 7000, was used to examine the expressions of NF - κB, IKKβ mRNA in HK-2 cell.
     ABI Prism 7000荧光定量PCR检测染铅近曲肾小管上皮细胞中NF-κB、IKKβmRNA的表达。
短句来源
     Methods:(1)Human renal proximal tubular cell (HK-2 cell) was used astarget cell .
     方法:(1)以人近曲肾小管上皮细胞(HK-2)为研究对象。
短句来源
     Conclusion FFAs can induce the phenotypic transformation of renal tubular epithelial cells into mesenchymal cells.
     结论在FFAs作用下,体外培养的正常人近曲肾小管上皮细胞发生上皮向间叶的表型转化。
短句来源
     Objective To investigate the correlations among the expressions of nuclear factor kppa B( NF - κB), inhibitor of kppa B kinase beta mRNA (IKKβ mRNA) and the lead damage of proximal renal tubular cell(HK - 2).
     目的研究铅对近曲肾小管上皮细胞真核转录因子κB(NF-κB)、真核转录因子κB抑制因子激酶βmRNA(IKKβmR NA)表达的影响,探讨其与铅致近曲肾小管上皮损伤的可能关系。
短句来源
     Methods Human renal proximal tubular cell(HK-2 cell) was used as target cell. The experiment was designed as:control group, asphyxia group ,and pyrrolidine dithiocarbamate (PDTC)blocking group.
     方法以人近曲肾小管上皮细胞(HK2)为研究对象,实验共分为对照组、窒息组和吡咯烷二硫氨基甲酸(PDTC)干预组。
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     The CB was mainly expressed in proximal convoluted tubular epithelial cells and was less in golmerulus, distal convoluted tubule and collecting duct.
     CB主要在小管上皮细胞内表达;
短句来源
     Results For operation group,The CB expressed chiefly in proximal convoluted tubular epithelial cells and was poor in golmerulus,distal convoluted tubule and collecting duct.
     结果CB主要在小管上皮细胞内表达;
短句来源
     Light microcopy of kidney revealed morphological changes of the group mainly in the epithelial cells of proximal tubules.
     小管上皮细胞空泡变性及细胞内线粒体出现丢失。
短句来源
     Results Cadmium ions could enter the epithelial cells of renal proximal convoluted tubules.
     结果镉离子可进入到小管上皮细胞内。
短句来源
     Culture and Identification of Newborn Pig's Renal Tubular Epithelial Cells in vitro
     新生猪小管上皮细胞的体外培养与鉴定
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  renal proximal tubular cells
The role of renal proximal tubular cells in diabetic nephropathy
      
The morphological and morphometrical changes in the renal proximal tubular cells of the salmonOncorhynchus gorbuscha during spawning migration are described for the first time.
      
First, the toxicity of the model conjugate S-(1,2-dichlorovinyl)-L-cysteine (DCVC) is blocked both in vivo and in isolated, renal proximal tubular cells by aminooxyacetic acid, an inhibitor of PLP-dependent enzymes.
      
Moreover, exposure of renal proximal tubular cells to propargylglycine, a suicide substrate for PLP-dependent enzymes that catalyze γ-elimination reactions, blocked the toxicity of DCVHC.
      
cDDP inhibits the Na+-coupled uptake of methyl-α-d-glucopyranoside (MGP) in renal proximal tubular cells in primary culture.
      
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Objective To study the effects of low density lipoprotein (LDL) on human proximal tubular epithelial cells (HK 2), and further examine the effects of HK 2 activated by LDL on phenotypic changes in human renal interstitial fibroblasts (RIFB). Methods 3H thymidine incorporation and direct cell counting were performed to detect cell proliferation. Message RNA and protein of α smooth muscle actin (α SM actin) were analyzed by Northern and Western blot. Fibronectin or laminin levels were determined using...

Objective To study the effects of low density lipoprotein (LDL) on human proximal tubular epithelial cells (HK 2), and further examine the effects of HK 2 activated by LDL on phenotypic changes in human renal interstitial fibroblasts (RIFB). Methods 3H thymidine incorporation and direct cell counting were performed to detect cell proliferation. Message RNA and protein of α smooth muscle actin (α SM actin) were analyzed by Northern and Western blot. Fibronectin or laminin levels were determined using an inhibition enzyme linked immunosorbant assay. After exposed to LDL activated HK 2 conditioned media (CM), total collagen synthesis or collagen Ⅲ mRNA expression was measured by proline incorporation or RT PCR in primary cultures of RIFB. Results Incubation of HK 2 with LDL (100~500 μg/ml) for 72 hours stimulated HK 2 proliferation. mRNA expression, protein synthesis of α SM actin and secretory fibronectin level were up regulated by LDL at a concentration of 250 μg/ml. When exposed to CM from LDL treated HK 2, thymidine incorporation rate was not changed in RIFB, but α SM actin production was significantly enhanced. CM from LDL treated HK 2 also showed the stimulated proline incorporation and secretion of fibronectin or laminin. Expression collegen Ⅲ mRNA was up regulated by CM from LDL treated HK 2 cells. Conclusion The results indicate that LDL stimulates HK 2 cells proliferation, phenotypic changes and fibronectin synthesis. Human proximal tubular epithelial cells activated by LDL modulate the phenotype and matrix production in RIFB.

目的 观察低密度脂蛋白 (LDL)对近曲肾小管上皮细胞 (HK 2 )的作用 ;探讨经LDL活化的HK 2对肾间质成纤维细胞 (RIFB)生物学表型的影响。方法 用3H TdR掺入和细胞计数法评价细胞增殖 ;Northern和Western杂交方法检测α 平滑肌肌动蛋白 (α SM actin) ;间接竞争抑制酶联免疫吸附法测定纤粘连蛋白和层粘连蛋白含量 ;3H 脯氨酸掺入法测定细胞总胶原成分的合成 ;逆转录聚合酶链反应法观察Ⅲ型胶原mRNA表达。结果 LDL(10 0~ 5 0 0 μg/ml)能够促进HK 2细胞增殖 2 2~3 8倍 ,并上调α SM actinmRNA表达 ,使其蛋白质合成增加 1 2~ 2 4倍 ,并促进纤粘连蛋白分泌。LDL刺激的HK 2条件培养液对RIFB的DNA合成无影响 ,但可显著上调细胞内α SM actin的蛋白合成 ;LDL(2 5 0 μg/ml或 5 0 0 μg/ml)刺激的HK 2条件培养液能够促进RIFB总胶原成分的合成、使细胞分泌纤粘连蛋白和层粘连蛋白增加、并能够显著上调Ⅲ型胶原mRNA表达。结论 LDL具有促进HK 2增殖、表型转化和纤粘连...

目的 观察低密度脂蛋白 (LDL)对近曲肾小管上皮细胞 (HK 2 )的作用 ;探讨经LDL活化的HK 2对肾间质成纤维细胞 (RIFB)生物学表型的影响。方法 用3H TdR掺入和细胞计数法评价细胞增殖 ;Northern和Western杂交方法检测α 平滑肌肌动蛋白 (α SM actin) ;间接竞争抑制酶联免疫吸附法测定纤粘连蛋白和层粘连蛋白含量 ;3H 脯氨酸掺入法测定细胞总胶原成分的合成 ;逆转录聚合酶链反应法观察Ⅲ型胶原mRNA表达。结果 LDL(10 0~ 5 0 0 μg/ml)能够促进HK 2细胞增殖 2 2~3 8倍 ,并上调α SM actinmRNA表达 ,使其蛋白质合成增加 1 2~ 2 4倍 ,并促进纤粘连蛋白分泌。LDL刺激的HK 2条件培养液对RIFB的DNA合成无影响 ,但可显著上调细胞内α SM actin的蛋白合成 ;LDL(2 5 0 μg/ml或 5 0 0 μg/ml)刺激的HK 2条件培养液能够促进RIFB总胶原成分的合成、使细胞分泌纤粘连蛋白和层粘连蛋白增加、并能够显著上调Ⅲ型胶原mRNA表达。结论 LDL具有促进HK 2增殖、表型转化和纤粘连蛋白分泌的作用。LDL活化的HK 2能够调节RIFB生物学表型、促进细胞外基质产生。

In this study, we investigated the effect of adrenomedullin(ADM) on renal tubulointerstitial lesion Plasma ADM concentration was measured in 26 glomerulonephritis patients with tubulointerstitial lesion by radioimmunoassay, and collagen synthesis and secretion of HK 2 cells were determined by 3H proline incorporation and radioactivity in medium As compared with normal subjects, plasma ADM was increased by 120% ( P <0 01) in patients with mild tubulointerstitial lesion,and by 220% ( P <0 01)...

In this study, we investigated the effect of adrenomedullin(ADM) on renal tubulointerstitial lesion Plasma ADM concentration was measured in 26 glomerulonephritis patients with tubulointerstitial lesion by radioimmunoassay, and collagen synthesis and secretion of HK 2 cells were determined by 3H proline incorporation and radioactivity in medium As compared with normal subjects, plasma ADM was increased by 120% ( P <0 01) in patients with mild tubulointerstitial lesion,and by 220% ( P <0 01) in those with severe lesion, which was more prominent than in mild lesion ( P <0 01); ADM had no effect on resting HK 2 cells, but could inhibit the TGF β1 induced collagen synthesis and secretion This study suggested that besides diuretic and natriuretic actions, ADM can also inhibit renal tubular cells collagen synthesis and secretion stimulated by TGF β1 Plasma ADM increase in glomerulonephritis patients with tubulointerstitial lesion may be a compansative protection

为探讨肾上腺髓质素 (ADM)在肾小管间质病变中的作用 ,采用放射免疫法测定了 2 6例合并小管间质病变的原发性肾小球肾炎病人血浆ADM水平 ,并在培养的人近曲肾小管上皮细胞系 (HK 2 )观察了ADM对胶原合成和分泌的影响。结果表明 ,小管间质轻度病变组和重度病变组血浆ADM水平较对照组分别增加了 1 2倍和 2 2倍 (P <0 0 1) ,其中间质重度病变组较轻度病变组血浆ADM水平高出 0 5倍 (P <0 0 1) ;ADM对静止的HK 2细胞胶原合成和分泌无明显影响 ,但能够抑制TGF β1刺激的胶原合成和分泌 (P <0 0 1)。提示合并小管间质病变的原发性肾小球肾炎病人血浆ADM水平升高 ,可能为一种代偿性的保护作用。

[Objective] To roundly observe the pathological damages of DNY on kidney and testis of rats. [ Methods ] DNT were dissolved in vegetable oils. SD rats were divided into 0,5,16,50 mg/kg four groups. DNT were poured into rat s stomach through mouth once a day for 13 weeks, and observe the pathological changes of kidney and testis after the rat was killed. [Results] The kidney and testis of rats have different damages. The epithelial cell of renal tubule edema and interstitial tissue of kidney congestion showed...

[Objective] To roundly observe the pathological damages of DNY on kidney and testis of rats. [ Methods ] DNT were dissolved in vegetable oils. SD rats were divided into 0,5,16,50 mg/kg four groups. DNT were poured into rat s stomach through mouth once a day for 13 weeks, and observe the pathological changes of kidney and testis after the rat was killed. [Results] The kidney and testis of rats have different damages. The epithelial cell of renal tubule edema and interstitial tissue of kidney congestion showed obvious dose - response relationship with DNT contents. The testis interstitial edema, reproductive cells of convoluted somniferous tubules and sperm were decreased in 50mg/kg group. [Conclusion] DNT could cause some damage on kidney and testis of rats.

[目的]全面观察二硝基甲苯(DNT)对大鼠肾脏和睾丸的病理损害情况。[方法]用二硝基甲苯以食用植物油为溶剂分为0、5、16、50 mg/kg剂量组给大鼠经口灌胃,每日1次,连续13周,宰杀后取其肾脏、睾丸观察病理改变。[结果]大鼠肾脏、睾丸有不同程度的损伤,其中近曲肾小管上皮细胞水肿、肾间质淤血与DNT各剂量间呈显著正相关性。50 mg/kg组大鼠睾丸间质水肿、精曲小管各级生殖细胞及精子数量减少。[结论]表明DNT对大鼠肾脏和睾丸有一定的毒作用。

 
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