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   star蛋白 在 畜牧与动物医学 分类中 的翻译结果: 查询用时:0.402秒
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star蛋白
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  star protein
    HCG Acutely Regulating Testosterone's Biosynthesis by Increasing the Expressing of StAR Protein
    HCG通过StAR蛋白快速调节睾酮的合成
短句来源
    The results indicated that in the testes of piglets, StAR protein were expressed in Leydig cells of pig testes from l-5th week.
    实验结果表明:在1~5周龄,StAR蛋白主要在仔猪睾丸的间质细胞中表达;
短句来源
    The expression level of StAR protein was lower in 1th and 3rd week piglets but higher in 2rd and 4th week;
    其中1周龄、3周龄StAR蛋白的表达水平较低;
短句来源
    the expression level of StAR protein in 5 th week was higher than that in 1th and 3rd week,but lower than that in 2rd, 4th week.
    2、4周龄StAR蛋白的表达水平较高,5周龄StAR蛋白的表达水平低于2、4周龄,但比1、3周龄高。
短句来源
    The results of this experiment were as shows :(1)Both of hCG and 8-Br-cAMP could enhance both the expression level of StAR protein and that of its mRNA,increase active ERK1/2 clearly depending on stimulating time. However,the effect of 8-Br-cAMP is faster than that of hCG.
    结果表明:hCG、8-Br-cAMP均能使StAR蛋白、mRNA和P-ERK1/2的水平随刺激时间的延长逐渐增加,8-Br-cAMP作用的速度较hCG更快,增幅也更明显;
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  “star蛋白”译为未确定词的双语例句
    hCG Regulating the Expression of StAR through ERK1/2 Pathway
    hCG通过ERK1/2调节睾丸间质细胞StAR蛋白的表达
短句来源
    (3) The levels of both protein and mRNA of StAR were increased by HCG in 2hours.
    (4)在2h内,HCG增加了StAR蛋白和mRNA的表达。
短句来源
    Leydig cells from 2-3 week old piglets were used to study the mechanism of hCG regulating Steroidogenic acute regulatory protein(StAR).
    以2-3周龄的仔猪睾丸间质细胞为试验材料,研究了hCG在快速调节期对StAR蛋白表达的调节机制。
短句来源
    The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner mitochondrial membranes, is mediated by the sieroidogenic acute regulatory protein (StAR).
    大量的研究表明,类固醇合成快速调节蛋白(STAR)是调节类固醇合成的限速因子,因此,我们首先研究了StAR蛋白在仔猪睾丸中的表达。
短句来源
    The results showed that in the (acute) period, HCG could increase the concentration of testosterone by promoting StAR expression.
    这表明在快速反应期,HCG通过促进StAR蛋白的表达,增强睾酮的生物合成。
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  star protein
While appending the inhibitor of Protein Kinase A (PKA) to Leydig cells in culture, the expression level of StAR protein, mRNA and the activity of ERK1/2 began to drop significantly, but the level of StAR mRNA could still be detectable.
      
While appending the inhibitor of MAPK (PD98059), the expression level of StAR protein and mRNA declined significantly.
      
These results infer that at the beginning of hCG stimulation, hCG increases the level of StAR protein by cAMP-PKA.
      
With prolonged stimulating time, hCG increases the level of StAR protein through cAMP-PKA-ERK1/2.
      
Hormonal regulation of steroidogenic acute regulatory (StAR) protein messenger ribonucleic acid expression in the rat ovary
      
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Leydig cells from 23 week old piglets were collected to study the mechanism of HCG regulating testosterone synthesis. Some precursors including cholesterol(5 mg/mL), pregnenolone(500(ng/mL),) dehydroepiandrosterone (500ng/mL), androstenedione (500ng/mL)and 22 R-Hydroxycholesterol(3 μg/mL) was added into these cultivating bottles and cocultivated with Leydig cells for 48 hours. Then, certain concentrations of HCG were added to each bottle and go on cultivating up to 2hours.The concentrations of testosterone and...

Leydig cells from 23 week old piglets were collected to study the mechanism of HCG regulating testosterone synthesis. Some precursors including cholesterol(5 mg/mL), pregnenolone(500(ng/mL),) dehydroepiandrosterone (500ng/mL), androstenedione (500ng/mL)and 22 R-Hydroxycholesterol(3 μg/mL) was added into these cultivating bottles and cocultivated with Leydig cells for 48 hours. Then, certain concentrations of HCG were added to each bottle and go on cultivating up to 2hours.The concentrations of testosterone and cAMP were measured by radioimmunoassay, but the level of steroidogenic acute regulatory(StAR) protein and mRNA were measured by immmunoblotting and RT-PCR respectively. The results were as follows: (1) HCG increased not only the production of testosterone, but also the concentration of cAMP of cells;(2) Although the conversion from cholesterol to testosterone could significantly be promoted, the conversion from other precursors to testosterone were not affected significantly .(3) The levels of both protein and mRNA of StAR were increased by HCG in 2hours.The results showed that in the (acute) period, HCG could increase the concentration of testosterone by promoting StAR expression.

以2~3周龄长白仔猪睾丸间质细胞为材料研究HCG对睾酮合成的快速调节作用。结果表明:(1)在2h内,对照组间质细胞分泌睾酮的量为(3.25±0.28)ng/mL,而HCG(浓度为50IU/mL)处理组睾酮的浓度为(8.79±0.54)ng/mL,增幅为4.54ng/mL,二者差异极显著(P<0.01);(2)在2h内,对照组细胞内cAMP的浓度为(13.13±1.12)pmol/mL,而处理组cAMP的浓度为(39.22±2.38)pmol/mL,二者之间差异极显著(P<0.01);(3)加入前体物后,胆固醇对照组睾酮浓度为(3.81±0.45)ng/mL,处理组睾酮浓度为(27.13±1.27)ng/mL,处理组睾酮的浓度明显高于对照(P<0.05),其它几种前体对照组与处理组差异不显著(P>0.05)。(4)在2h内,HCG增加了StAR蛋白和mRNA的表达。这表明在快速反应期,HCG通过促进StAR蛋白的表达,增强睾酮的生物合成。

GCs were obtained from the ovaries of activity of DES-treated immature rats and cultured in serum-free medium. FSH receptor occupancy lesded to phosphorylation/activation of p38 MAPK in time-dependent manner. Phosphorylated p38 MAPK by FSH was observed within 5 min and reached the highest level at 30 min. Moreover, such activation was protein kinase A-dependent as indicated by the results using specific inhibitors.Interestingly.inhibition of p38 MAPK acitivity with SB203580 augmented estradiol production at...

GCs were obtained from the ovaries of activity of DES-treated immature rats and cultured in serum-free medium. FSH receptor occupancy lesded to phosphorylation/activation of p38 MAPK in time-dependent manner. Phosphorylated p38 MAPK by FSH was observed within 5 min and reached the highest level at 30 min. Moreover, such activation was protein kinase A-dependent as indicated by the results using specific inhibitors.Interestingly.inhibition of p38 MAPK acitivity with SB203580 augmented estradiol production at the same time (p<0.01). RT-PCR data showed that inclusion of SB203580 in the FSH-stimulated FSH-induced STAR mRNA Production, while decreased the FSH-stimulated P450arom mRNA expression of STAR in mitochondria than FSH treatment alone.

利用乙烯雌酚(DES)处理23日龄SD大鼠,分离卵巢颗粒细胞(GC)进行无血清培养。结果表明,FSH(50ng/m1)处理GC,可迅速激活有丝分裂原蛋白激酶(p38MAPK),FSH处理5min便可观察到磷酸化的p38MAPK;FSH处理30min,磷酸化的p38MAPK水平达到最高;向培养液中加入H89(蛋白激酶A抑制剂,10μM),则显著抑制了FSH对p38MAPK的激活作用,提示这种激活作用依赖于蛋白激酶A(PKA)。用SB203580(p38MAPK抑制剂,20μM)抑制p38MAPK激活,则进一步提高了FSH对孕酮和甾体生成快速调节蛋白(StAR)的诱导作用,同时降低了FSH对雌激素生成的促进作用(p<0.01)。RT-PCR结果显示:抑制p38MAPK活性后,FSH对StARmRNA刺激作用明显增强,但对细胞色素P450芳香化酶(P450arom)mRNA的诱导作用却减弱了(p<0.05)。激光共聚焦和蛋白印迹结果显示:在GC中,StAR蛋白主要分布在线粒体中;与对照组相比,FSH显著提高了StAR的荧光强度和蛋白水平;抑制p38MAPK活性则增强了FSH对StAR蛋白表达...

利用乙烯雌酚(DES)处理23日龄SD大鼠,分离卵巢颗粒细胞(GC)进行无血清培养。结果表明,FSH(50ng/m1)处理GC,可迅速激活有丝分裂原蛋白激酶(p38MAPK),FSH处理5min便可观察到磷酸化的p38MAPK;FSH处理30min,磷酸化的p38MAPK水平达到最高;向培养液中加入H89(蛋白激酶A抑制剂,10μM),则显著抑制了FSH对p38MAPK的激活作用,提示这种激活作用依赖于蛋白激酶A(PKA)。用SB203580(p38MAPK抑制剂,20μM)抑制p38MAPK激活,则进一步提高了FSH对孕酮和甾体生成快速调节蛋白(StAR)的诱导作用,同时降低了FSH对雌激素生成的促进作用(p<0.01)。RT-PCR结果显示:抑制p38MAPK活性后,FSH对StARmRNA刺激作用明显增强,但对细胞色素P450芳香化酶(P450arom)mRNA的诱导作用却减弱了(p<0.05)。激光共聚焦和蛋白印迹结果显示:在GC中,StAR蛋白主要分布在线粒体中;与对照组相比,FSH显著提高了StAR的荧光强度和蛋白水平;抑制p38MAPK活性则增强了FSH对StAR蛋白表达的诱导作用。

Leydig cells from 2-3 week old piglets were used to study the mechanism of hCG regulating Steroidogenic acute regulatory protein(StAR).The results of this experiment were as shows :(1)Both of hCG and 8-Br-cAMP could enhance both the expression level of StAR protein and that of its mRNA,increase active ERK1/2 clearly depending on stimulating time.However,the effect of 8-Br-cAMP is faster than that of hCG.(2) While appending the inhibitior of PKA(PKI) to leydig cells in culture,both of the expression level of...

Leydig cells from 2-3 week old piglets were used to study the mechanism of hCG regulating Steroidogenic acute regulatory protein(StAR).The results of this experiment were as shows :(1)Both of hCG and 8-Br-cAMP could enhance both the expression level of StAR protein and that of its mRNA,increase active ERK1/2 clearly depending on stimulating time.However,the effect of 8-Br-cAMP is faster than that of hCG.(2) While appending the inhibitior of PKA(PKI) to leydig cells in culture,both of the expression level of StAR protein and that of its mRNA began to drop significantly and the activity of ERK1/2 was inhibited but the level of StAR mRNA could still be detectable.(3) While appending the inhibitior of MAPK(PD98059),the expression level of StAR protein mRNA dropped significantly.These results inferred that at the beginning of hCG stimulating,hCG increased the level of StAR protein by cAMP-PKA.With the increase of time,hCG increased the level of StAR protein through cAMP-PKA-ERK1/2.

以2-3周龄的仔猪睾丸间质细胞为试验材料,研究了hCG在快速调节期对StAR蛋白表达的调节机制。结果表明:hCG、8-Br-cAMP均能使StAR蛋白、mRNA和P-ERK1/2的水平随刺激时间的延长逐渐增加,8-Br-cAMP作用的速度较hCG更快,增幅也更明显;加入PKI,StAR蛋白、mRNA和P-ERK1/2活性明显下降,但StAR mRNA仍然可以检测到;加入MAPK的抑制剂PD98059后,StAR蛋白、mRNA的水平均降低。由此可知,hCG在诱导StAR蛋白的表达过程中,首先通过cAMP-PKA直接调节蛋白前体蛋白向成熟蛋白的转化,随着时间的延长,通过cAMP-PKA-ERK1/2级联,磷酸化转录因子,促进StAR基因的表达。

 
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