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底物蛋白
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  substrate proteins
     This system can facilitate understanding of how eukaryotic Hsp70 and Hsp90 work together as essential components of a process that alters the conformations of substrate proteins to states that respond in signal transduction.
     这个系统可以帮助理解在真核细胞中,Hsp70和Hsp90怎样联合作用,改变底物蛋白构象,以及怎样应答信号作用。
短句来源
     Glycogen synthase kinase-3(GSK-3),a multifunctional serine-threonine kinase, has played an important role in glycogen metabolism and is known to occupy a central stage in many cellular physiological events by phosphorylation of multifold substrate proteins,including Wnt and Hedgehog signal transduction pathways.
     糖原合成酶激酶-3(glycogen synthase kinase-3,GSK-3)是一个多功能的丝氨酸/苏氨酸蛋白激酶,不仅参与肝糖代谢过程,而且还参与Wnt和Hedgehog信号通路,通过磷酸化多种底物蛋白来调节细胞的生理过程。
短句来源
     Establishment of HSP90 Overexpressing Cell Line and Analysis of the Binding Ability of HSP90 with Substrate Proteins
     HSP90高表达细胞系的建立及其对底物蛋白结合能力的影响
短句来源
     Objective:To investigate the interactions between Bcl-2 protein,a new target for anticancer agents,and its substrate proteins.
     目的:探讨抗肿瘤药物新靶点Bcl-2蛋白与底物蛋白的相互作用。
短句来源
     Hsp70 are monomeric proteins that bind to unfolded, mainly hydrophobic segments of substrate proteins, in an ATP-regulated manner.
     Hsp70是单体蛋白,主要结合非自然折叠的蛋白,依赖于ATP/ADP的形式变换,使得这些底物蛋白正确折叠。
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  “底物蛋白”译为未确定词的双语例句
     HSP90 binding abilities with substrate protein HSP70, Raf-1 were observed by HSP90 coimmunoprecipitation.
     通过免疫共沉淀方法,观察HSP90表达与底物蛋白HSP70、Raf-1的结合情况。
短句来源
     Skp2, a member of the substrate-recognition subunit of SKP1 Cullin F box(SCF) ubiquitin ligase complex, is required for the G1-S transition.
     Skp2是细胞从G1期进入S期的必需因子,是SKP1 Cullin F box(SCF)复合体中DNA复制所必须的一种F-box蛋白,在泛素化过程中负责对底物蛋白的识别和泛素化降解。
短句来源
     heparin completely inhibited 43kD and 66kD polypeptide phosphorylation and also induced 39.4kD polypeptide phosphorylation.
     肝素能完全抑制43kD和66kD底物蛋白磷酸化,肝素还增加39.4kD底物磷酸化。
短句来源
     Although the transforming mechanisms of P210BCR-ABL may involve a number of signal pathways, the fundamental andprimary signal trigger is not others but the aberrant PTK activity of P210BCR-ABL, which catalyzes the phosphorylation of tyrosine residues in specific sites of p210BCR-ABL itself and a host of substrates.
     P210~(BCR-ABL)导致CML发生的分子病理机制涉及多个信号通路,但最原始的信号启动因素则是过高的PTK活性催化P210~(BCR-ABL)自身和底物蛋白上特定位点的酪氨酸残基(tyrosine residue,Tyr)过度磷酸化所致。
短句来源
     The optimum reaction conditions were determined as follows:E/S 3000 U/g,substrate concentration 6 %,pH 7.5,temperature 45 ℃,and reaction time 3 h.
     在单因素分析的基础上采用正交实验对水解条件进行优化,得出最适酶解条件为:酶加量3000 U/g底物蛋白,底物浓度6%,pH值7.5,温度45℃,水解时间3h。
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  相似匹配句对
     Identification of Substrates of Protein Kinase C at 1-Cell Fertilized Eggs in Mouse
     小鼠受精卵中蛋白激酶C底物的鉴定
短句来源
     Studies on the Substrate of Protein Kinase C in Leukemia Leucocytes
     白血病细胞中蛋白激酶C底物的研究
短句来源
     Western blotting tested the expressed proteins.
     蛋白表达。
短句来源
     MLL protein;
     MLL蛋白;
短句来源
     concentration of substrates;
     底物浓度;
短句来源
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  substrate proteins
Electrostatic Interactions Play a Critical Role in Mycobacterium tuberculosis Hsp16.3 Binding of Substrate Proteins
      
The nature of the interactions between Hsp16.3 and the denatured substrate proteins was investigated.
      
A working model for Hsp16.3 binding to its substrate proteins is proposed.
      
Its main purpose is to discuss the ability of chaperonins (and that of some chaperones) to interact directly with substrate proteins in the course of their folding and thus accelerate the ratelimiting steps of that process.
      
Experimental data supporting the notion that the structure and functional properties of GroEL are not optimal for an effective folding of many of its substrate proteins is discussed.
      
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Changes in the contents of soluble proteins and free amino acids, the synthesis of protein, and proteolytic activity during senescence of mung bean cotyledons were investigated in this study. The results are as follows:From day 1 to day 7 after germination, the contents of soluble proteins markedly decreased while the contents of total free amino acids increased from day 1 to 5 and then declined (Fig. 1). It is worth noting that the patterns of change in individual amino acids were not the same. The complexity...

Changes in the contents of soluble proteins and free amino acids, the synthesis of protein, and proteolytic activity during senescence of mung bean cotyledons were investigated in this study. The results are as follows:From day 1 to day 7 after germination, the contents of soluble proteins markedly decreased while the contents of total free amino acids increased from day 1 to 5 and then declined (Fig. 1). It is worth noting that the patterns of change in individual amino acids were not the same. The complexity of different free amino acids implied that the components played different roles in regulating the senescence of mung bean cotyledons.The incorporation of ~3H-leucine into protein showed that the rate of protein synthesis increased after the onset of senescence and reached the top by the 4th day (Fig. 2). Analysis of ribosomal population and calculation of the ratio of polysomes to total ribosomes (P/T) revealed a similar trend to that of ~3H-leucine incorporation (Fig. 3 , Table 2 ). All these results suggested that the synthesis of protein was active during the early staage of senescence of mung bean cotyledons.The activity of leucine aminopeptidase decreased from day 1 to day 7.However, the caseolytic activity of mung bean cotyledons increased rapidly during the early stage of senescence and decreased sharply after day 5 (Fig. 5). Thus, it may be concluded that the loss of soluble proteins during early senescence can be ascribed to accelerated hydrolysis by endopeptidases and the slowdown of protein synthesis was mainly responsible for the decline of soluble proteins during late senescence.

萌发绿豆子叶自然衰老过程中可溶性蛋白质含量一直下降;从衰老开始到衰老前期,总游离氨基酸含量明显上升;但游离氨基酸各组分在子叶衰老期间的变化趋势并不相同。~3H-亮氨酸掺入蛋白质试验和多聚核糖体的相对量及其与总核糖体的比值(P/T)测定都证明在子叶衰老前期有蛋白质的新合成。子叶衰老期间。氨肽酶活性明显降低;而以酪蛋白为底物的蛋白水解酶活性却急剧上升,承担着催化蛋白质降解的主要功能。

In this paper, the quantity of insulin receptors and the receptor tyrosine kinase activity and its endogenous substrates were comparatively studied in K-562 cells before and after transformation. It was shown that following transformation, the quantity of insulin receptor and the insulin-stimulated tyrosine kinase activity were reduced distinctly, and the endogenous substrate, a 67KD protein for the receptor tyrosine kinase disappeared. These results indicate that the insulin receptor tyrosire (?)inale and its...

In this paper, the quantity of insulin receptors and the receptor tyrosine kinase activity and its endogenous substrates were comparatively studied in K-562 cells before and after transformation. It was shown that following transformation, the quantity of insulin receptor and the insulin-stimulated tyrosine kinase activity were reduced distinctly, and the endogenous substrate, a 67KD protein for the receptor tyrosine kinase disappeared. These results indicate that the insulin receptor tyrosire (?)inale and its endogenous substrate may play an important role in the insulin-controlled porliferation of K-562 cell.

对丁酸钠转化前后的人红白血病细胞林K-562的表面胰岛素受体数量、胰岛素受体酪氨酸蛋白激酶活性及细胞内源性底物进行了研究。结果表明:丁酸钠转化后的K-562细胞酪氨酸蛋白激酶活性降低,胰岛素受体数量减少,K-562细胞酪氨酸蛋白激酶的内源性底物,分子量为67KD—底物蛋白在转化后消失。说明该底物及胰岛素受体酪氨酸蛋白激酶在胰岛素调控的K-562细胞的增殖中起重要作用。

In this paper, the tyrosine protein kinase activity of insulin receptor and its endogenous substrates were investigated on the human leukemia cell line K-562 differentiated by sodium butyrate. The results showed that the tyrosine protein kinase activities and number of insulin receptors in differentiated, cells were reduced. An endogenous substrate for tyrosine protein kinase disappeared in differentiated cells. This study provides a powerful clue not only for eliciting the mechanism of cell growth and carcinogenesis...

In this paper, the tyrosine protein kinase activity of insulin receptor and its endogenous substrates were investigated on the human leukemia cell line K-562 differentiated by sodium butyrate. The results showed that the tyrosine protein kinase activities and number of insulin receptors in differentiated, cells were reduced. An endogenous substrate for tyrosine protein kinase disappeared in differentiated cells. This study provides a powerful clue not only for eliciting the mechanism of cell growth and carcinogenesis but also for the therapy of leukemia.

本文对丁酸钠诱导分化的人白血病细胞株K-562细胞的胰岛素受体酪氨酸蛋白激酶性及细胞内源性底物进行了研究。结果表明,诱导分化后的细胞酪氨酸蛋白激活酶活性降低,胰岛素受体数量减少,酪氨酸蛋白激酶的一底物蛋白在分化后消失。该研究结果及其在该方面的进一步研究有可能为白血病发病机制的阐明以及为临床治疗白血病开辟靳途径提供一些有价值的线索。

 
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