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大鼠甲状腺     
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  rat thyroid
     Cloning of Rat Thyroid Hormonr Receptor β1 cDNA and Its Expression in E.coli.
     大鼠甲状腺激素受体β1 cDNA克隆及其在E.coli.中的表达
短句来源
     Morphometric comparative study on 131 Ⅰ and 132 Ⅰ injury of rat thyroid gland
     ~(131)Ⅰ与~(132)Ⅰ对大鼠甲状腺损伤的形态计量学比较研究
短句来源
     Autoradiographic Observation on distribution of ~(99m)Tc-MIBI in rat thyroid
     应用放射自显影术观察~(99m)Tc-MIBI在大鼠甲状腺内的动态分布
短句来源
     Morphometric study on late effect of 131 Ⅰ、 132 Ⅰ on rat thyroid gland(Study on gland level)
     ~(131)Ⅰ ~(132)Ⅰ致大鼠甲状腺损伤远期效应的形态计量学研究(腺体水平研究)
短句来源
     Changes in three dimensional stereological parameters of rat thyroid glands at 20 months after injection of 131 Ⅰ and 132 Ⅰ were determined by using image analysis and morphometric methods.
     应用图像分析技术和形态计量学方法,测量了131Ⅰ、132Ⅰ注入后20月大鼠甲状腺组织损伤体视学参数的变化。
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  the thyroid
     In this experiment ~(125)I-T_3,in the thyroid gland of rats injected with NaF was much lower than that in control groups;
     注射 NaF 的大鼠甲状腺~(125)I—T_3明显低于对照组;
短句来源
     Effect of iodine on the thyroid apoptosis and expressions of bax,bcl-2 mRNA in rats
     碘对大鼠甲状腺细胞凋亡及bax、bcl-2基因mRNA表达的影响
短句来源
     COMPARISON OF THE BIOLOGICAL EFFECTS OF ~(125)I AND ~(131)I ON THE THYROID GLAND IN RAT
     ~(125)I和~(131)I对大鼠甲状腺损伤的生物效应比较
短句来源
     Influence of Zinc Deficiency and Effects of Zinc Replenishment on the Thyroid Hormone of Rats Model
     缺锌及补锌对大鼠甲状腺激素的影响
短句来源
     Pathological changes and i nfiltration of lymphocyte were observed in the thyroid tissue of rats. Serum Tg- Ab, TPO-Ab, TT3 and TT4 were detected by the method of radioimmuoassay (RIA).
     观察大鼠甲状腺组织的病理改变和炎细胞浸润程度,用放射免疫分析法检测血清中Tg鄄Ab、TPO(甲状腺过氧化物酶)鄄Ab和甲状腺激素(TT3、TT4)水平。
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  rat thyroid gland
     Morphometric comparative study on 131 Ⅰ and 132 Ⅰ injury of rat thyroid gland
     ~(131)Ⅰ与~(132)Ⅰ对大鼠甲状腺损伤的形态计量学比较研究
短句来源
     Morphometric study on late effect of 131 Ⅰ、 132 Ⅰ on rat thyroid gland(Study on gland level)
     ~(131)Ⅰ ~(132)Ⅰ致大鼠甲状腺损伤远期效应的形态计量学研究(腺体水平研究)
短句来源
     Eccritic Effect of Spirulina platensis on ~(131)Ⅰ in Rat Thyroid Gland
     螺旋藻对大鼠甲状腺内~(131)碘的促排作用
短句来源
     The Changes of Rat Thyroid Gland C Cells in Acute Intestinal Radiation Sickness (AIRS)
     大鼠甲状腺C细胞在肠型放射病中的变化
短句来源
     By using immunocytochemistry, immunoelectromicroscopy and microspectrophotometry (MSP) technique , the changes of rat thyroid gland C cells in AIRS were investigated.
     应用免疫细胞化学、免疫电镜和显微分光光度计(MSP)测量等技术,对大鼠甲状腺C细胞在肠型放射病(AIRS)中的变化进行了观察。
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  “大鼠甲状腺”译为未确定词的双语例句
     (ResultsCompared) to the control group,maleic dialdehyde(MDA) in the rat's thyroid after CPR increased greatly(t=16.75,P<0.01),while enzyme activity of superoxide dismutase(SOD) and Na~+-K~+-ATPase declined markedly(t=6.25,8.85;P<0.01).
     结果与对照组相比,复苏后大鼠甲状腺组织中MDA含量明显增高(t=16.75,P<0.01),SOD及Na+-K+-ATPase活力显著降低(t=6.25、8.85,P<0.01);
短句来源
     The Effect of Microwave on Thyroid Gland and T_3、T_4 in Blood Serum
     微波辐照对大鼠甲状腺及血清T_3、T_4的影响
短句来源
     IGF-1 and IGF-1 receptor expression in thyrocytes of aging rat
     IGF-1及其受体在老年大鼠甲状腺细胞表达的研究
短句来源
     When per gram 131I dose is less than 60μCi, the normal thyroid function is obtained.
     在一定131I剂量范围内(每克甲状腺组织131I剂量≤60μCi), 大鼠甲状腺整体功能可以维持正常,即大鼠甲状腺存在维持功能正常的131I剂量耐受范围。
短句来源
     Enlargement of thyroid,brain and liver,atrophy of thymus and spleen,were found in 10 mg·kg~(-1)and/or 50 mg·kg~(-1)groups;
     10 mg·kg~(-1)和*或50 mg·kg~(-1)MBI 导致雌雄大鼠甲状腺、脑、肝脏重量明显升高,胸腺、脾脏重量显著下降;
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  rat thyroid
Effect of long-term injection of high doses of potassium iodide on iodine metabolism in rat thyroid gland
      
Effect of enhanced bromide intake on the concentration ratio I/Br in the rat thyroid gland
      
Different tissue responses for iodine and iodide in rat thyroid and mammary glands
      
Interaction of bromine with iodine in the rat thyroid gland at enhanced bromide intake
      
High bromide intake affects the accumulation of iodide in the rat thyroid and skin
      
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  the thyroid
Primary thyroglossal duct carcinoma should conform to the following criteria: localization of the carcinoma to a clearly demonstrable thyroglossal duct cyst or tract; clinically or histologically confirmed absence of carcinoma of the thyroid gland.
      
The thyroid status of animals also influenced the balance of protein synthesis.
      
Physiological and Morphological Specific Features of the Formation of the Thyroid Status in the Aboriginal and Migrant Populatio
      
Special attention was given to the thyroid system parameters of the aborigines 17 to 40 years old living in the urban area and not involved in the traditional life style.
      
The indigenous population of the Extreme North and migrants were shown to have marked functional adaptive hyperplasia of the thyroid gland and diffuse goiter in 15% of cases.
      
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  thyroid of rat
Histological changes in thyroid of rat under the acute exposure of O-chloro-benzylidine malononitrile
      
  rat thyroid gland
Effect of long-term injection of high doses of potassium iodide on iodine metabolism in rat thyroid gland
      
Effect of enhanced bromide intake on the concentration ratio I/Br in the rat thyroid gland
      
Interaction of bromine with iodine in the rat thyroid gland at enhanced bromide intake
      
Effects of propylthiouracil (PTU) administration on the synthesis and secretion of thyroglobulin in the rat thyroid gland: A qua
      
Cytochemical demonstration of cholinesterase in follicle cells and parafollicular (C-) cells of the rat thyroid gland
      
更多          


The authors have established amethod for testing the thyroid func-tion of rats and made a study of thyroidfunction of normal rats. In this arti-cle, the method and result of the studyare reported. The thyroidal ~(125)I uptake: 50 maleand female normal Wistar rats about200 grams in weight were chosen forthis study. Less than 1 microcurie ofcarrier free ~(125)I was administered toeach rat by intraperitoneal injection.At the time of injection, an equalamount of ~(125)I solution was placedin a small rubber dish...

The authors have established amethod for testing the thyroid func-tion of rats and made a study of thyroidfunction of normal rats. In this arti-cle, the method and result of the studyare reported. The thyroidal ~(125)I uptake: 50 maleand female normal Wistar rats about200 grams in weight were chosen forthis study. Less than 1 microcurie ofcarrier free ~(125)I was administered toeach rat by intraperitoneal injection.At the time of injection, an equalamount of ~(125)I solution was placedin a small rubber dish of 0.3cm indiameter. This was used as a standard. It was measured by the external neckcounting technique. Fundamentally,the technique consisted in placing theanimal thyroid region under a scintil-lation detector using 5×5cm NaI(TI)scintillation crystal in a properlyshielded enclosure and the ~(125)I activitywas determined by a scaler (ModelGN 104) 4,6,24h after the injection of~(125)I. A collimator with upper hole5cm in diameter was used. The areacovered was a circle of approximately2.5cm in diameter. Counting was donewith the rat lying on its back withthe neck hyperextended, and the colli-mator touching the skin overlying thethyroid gland. After the external measurements werecompleted, the animals were killedand the two lobes of the thyroid glandwith intact isthmus were freed fromthe adjacent tissues and counted in atube in a scintillation well type counter(Model FH 408). Standard ~(125)I wasalso counted in 0.5ml saline in thewell type counter and the thyroidalradioactivity in vitro was also expres-sed as percentage of administereddose. This technique enables thyroidal ~(125)Imeasurement to be made with accu-racy and reproducibility in the rat. Invivo thyroid ~(125)I determination hasbeen compared against in vitro thyroid~(125)I determination in 20 rats undervarious levels of ~(125)I activity in verygood agreement with correspondingdetermination (r=+0.97). The thyroiduptake percent in control rats was38.5±11.1%(24h) and the uptake percentof dose/mg tissue was 1.78±0.6%.The maximal thyroid radioiodine up-take occurred in 24h. Serum thyroxine (T_4) concentration:The serum samples were assayed by acompetitive protein binding assay. Themean serum concentration of T_4 in 40rats was 5.56±1.24μg/100ml (3.4-8.5 μg/100ml). Serum triiodothyronine (T_3) and thy-rotropin (TSH) concentration: Theserum samples were assayed by radio-immunoassay. The mean serum concen-tration of T_3 in 26 rats was 58.8±22.6ng/100ml and the TSH was 2.2±0.6μIU/ml (43 rats). The quantity of ~3H-Leucine incor-porated into the thyroid protein wasdetermined in 35 rats which recieveda single intraperitoneal injection of 0.5microcurie DL-Leucine-4, 5-~3H pergm body weight and the animals werekilled 36h later. The radioactivity ofthyroid tissue was determined by aliquid scintillation system(Model FJ-353). The mean value of incorporationwas 143.7±51.8cpm per mg. The authors believe that the appli-cation of thyroid function tests report-ed here may be useful in the study oftoxicology and other subjects.

本文报告正常大鼠甲状腺功能状态的测定方法,计有甲状腺吸碘百分率,单位重量甲状腺吸碘百分率,~3H—亮氨酸掺入量,血清甲状腺素(T_4),血清三碘甲状腺原氨酸(T_3),和血清促甲状腺素(TSH)六项指标。并讨论了这些指标的意义及其可靠性。

The thyroid function in 90 rats givenN, N'-Methylene-Bis (2-Amino-5-Sulf-hydryl)-1, 3, 4-thiadiazole (018) wasstudied. The chemical was given toanimals per oral daily(500ppm mixedin diet) for 110 days. The percentthyroid radioiodine uptake, percentuptake per milligram, ~3H-Leucine in-corporation into thyroid protein, serumThyroxine (T_4), and serum thyrotropin(TSH) concentration were tested. The results showed that significantimpairment of thyroid function wasobserved in rats. The main manifesta-tions were that...

The thyroid function in 90 rats givenN, N'-Methylene-Bis (2-Amino-5-Sulf-hydryl)-1, 3, 4-thiadiazole (018) wasstudied. The chemical was given toanimals per oral daily(500ppm mixedin diet) for 110 days. The percentthyroid radioiodine uptake, percentuptake per milligram, ~3H-Leucine in-corporation into thyroid protein, serumThyroxine (T_4), and serum thyrotropin(TSH) concentration were tested. The results showed that significantimpairment of thyroid function wasobserved in rats. The main manifesta-tions were that the percent of thyroidradioiodine uptake and T_4 concentra-tions lowered. The average level of uptake percentin "018" group was 28.1% (on 40th day),while the level in normal group was46.8%. the average level of thyroiduptake percent per milligram was low-ered to 0.26, while the level of normalgroup was 1.66(P<0.05). The serumT_4 concentration also lowered. Theaverage level of serum T_4 in "018"group was 4.12μg/dl, while the normallevel was 6.04μg/dl(on 80th day). The weight of thyroid in "018" groupincreased. Meanwhile, the quantity of~3H-Leucine incorporated into the thy-roid protein decreased. The maximalthyroid radioiodine uptake occurredin 4 or 6h(it occurred in 24h in normalrats). These findings, therefore, show-ed that this chemical considerablyimpaired the iodothyronine formationand that the biosynthesis of thyroglo-bulin was inhibited.

作者测试了二巯基敌枯双对大鼠甲状腺功能的损害。表现为:甲状腺吸碘率降低,吸碘曲线高峰提前,血清T_4含量降低,甲状腺~ H-亮氨酸掺入量降低,甲状腺重量明显增加。并认为该农药主要是影响了甲状腺激素合成机理。

The morphological process of form-ing a new follicle and goitre bythe induction of N, N'-methylene-bis(2-amino-5-sulfhydryl-1, 3, 4-thiadi-azole) in rats is described in thispaper. The formation of a new fol-licle went through five consecutivestages: hyperplasia of the originalfollicular epithelia, formation ofthe solid bud, formation of the sol-id follicular cell nest, formation ofthe vesicular follicular cell nest,and formation of the secondary fol-licle. The morphological process of form-ing a goitre could...

The morphological process of form-ing a new follicle and goitre bythe induction of N, N'-methylene-bis(2-amino-5-sulfhydryl-1, 3, 4-thiadi-azole) in rats is described in thispaper. The formation of a new fol-licle went through five consecutivestages: hyperplasia of the originalfollicular epithelia, formation ofthe solid bud, formation of the sol-id follicular cell nest, formation ofthe vesicular follicular cell nest,and formation of the secondary fol-licle. The morphological process of form-ing a goitre could be divided intofour periods: (1) the primary hyper-plastic period, from the 1st to 10th-days, mainly showing an activehyperplasia of the original follicu-lar cells leading to form a lot ofhyperplastic patches, solid buds, anda few solid and vesicular follicularcell nests, an active proliferation ofthe cells of connective tissue andcapillary endothelium, a decrease ofcapillary ATPase activity and thenucleus staining of the proliferativefollicular cells, and an increase inthe weight of the thyroid; (2) theperoid of immature structural recon-struction, from the 11th to 20thdays, being characterized by disap-pearance of the greater part of theoriginal structure of the thyroidand its replacement by solid and ve-sicular follicular cell nests withoutcellular proliferation of stroma andfollicular epithelium, and no incre-ase in the weight of the thyroid;(3) the secondary hyperplastic pe-riod, from the 21st to 40th days,showing once again more vigoroushyperplasia of the parenchyma andstroma, decrease of ATPase activityand reappearance of the stained nu-clei, and considerable increase in theweight of the thyroid; (4) the periodof mature structural reconstruction,from the 41st to 80th days, beingcharacterized by the structure of thethyroid consisting mainly of the uni-form and small follicles which weremore mature with monolayer epitheli-um of high cuboidal or low column-ar cells without proliferation of par-enchyma and stroma, the appearanceof a few large follicles with huge amount of colloid and flat epithelium,and no increase in the weight of thethyroid. At this point the parenchymatous goitre seen in the subchronicor chronic experiments was formed. The mechanism of the for mation ofthe goitre has been discussed. It issuggested that the N, N'-methylene-bis(2-amino-5-sulfhydryl-1, 3, 4-thiadia-zole) injures the rough endoplasmicreticulum of the follicular cells, anddecreases the synthesis of thyroglobu-lin, so that the synthesis of thyro-xin becomes deficient. Therefore, theblood level of thyroxin decreases.Thisstimulates the pituitary to secretemore thyrotrophin (TSH) and causesits increase in blood. The increasedTSH then stimulates a proliferationof the thyroid to produce the goitre.

本文报告二巯基敌枯双所致大鼠甲状腺肿的形态发生。新形成的继发滤泡起源于原滤泡上皮。其发生过程经历了原滤泡上皮增生复层化,实心芽形成,实心滤泡细胞团形成,空心滤泡细胞团形成以及继发滤泡形成5个阶段。由滤泡上皮增生发展到甲状腺肿,经历了原发增生期、非成熟性改建期、继发增生期以及成熟性改建期4个时期。本文对甲状腺肿形成的机理作了简要讨论。

 
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