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治疗途径     
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  therapy approach
     The aim of this research is to investigate the expression of MMP-7 and TIMP-1 in the cervical carcinoma and to evaluate the relationship between the expression of both MMP-7, TIMP-1 and clinicpathologic features of cervical carcinoma in order to seek new prognosis index, and new therapy approach.
     故本试验拟通过检测宫颈癌中MMP-7,TIMP-1及二者之间平衡关系的表达情况,来探寻其与宫颈癌的侵袭转移及预后的关系,以寻求新的预后判定指标及新的治疗途径
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     Objective To investigate the changes of TNF-α in reperfusion host received graft liver transfected with short hairpin RNA(shRNA)targeting Interleukin 1 receptor associated kinase-4 (IRAK-4)gene through portal vein during cold ischemia period or in vivo after portal vein was inoscu- lated to explore effective gene therapy approach and the possibility of IRAK-4 as genetherapy target for liver ischemia/reperfusion injury(I/RI).
     目的通过观察活体或冷保存期离体门静脉灌注供肝转染白细胞介素-1受体相关激酶-4(IRAK-4)特异短发夹 RNA(shRNA)对再灌注后受体 TNF-α产生的影响,判断以 IRAK-4为肝移植缺血再灌注损害(I/RI)治疗靶点的可行性并探索可行的 shRNA 治疗途径
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     To obtain a better understanding of the mechanismsunderlying ASMC prolifeation after arterial injury and explore an effective therapy approach, a plasmid (pLXSN/ATR),which expresses antisense thrombin receptor (ATR) mRNA directed against the sequences of translation initiationregion, thrombin cleavage and binding sites of the thrombin receptor, was constructed and transfected into thecultured RASM.
     为进一步阐明血管损伤后平滑肌细胞增生的机理及探索有效治疗途径,针对凝血酶受体基因中一段包括转录起始点,翻译起始点,凝血酶结合和切割位点的序列作为靶序列,构建了凝血酶受体反义RNA重组表达载体pLXSN/ATR,并将其导入凝血酶刺激的动脉平滑肌细胞。
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     The currently accepted outcome showed that TGF-β could adjust the biological action of epithelium healing through different signal transduction passageway. And the new therapy approach has been experimented that blocking the negative action of Smad signaling at gene level in order to exert adequately the positive effect of accelerating cell proliferation,promoting stroma forming and inducing cell migration. It is significative in clinical treatment of all kinds of corneal wound.
     研究发现:TGF-β可通过不同的信号传导通路调控修复上皮层细胞的生物学行为,为充分发挥TGF-β促进细胞增殖、细胞外基质形成、诱导细胞移行的正效作用,学者们尝试在基因水平上阻断负相调控通路-Smad信号传导通路的作用,这为临床上治疗各种原因引起的角膜创伤开辟了新的治疗途径
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     Conclusion For the recurrent cases after embolotherapy of balloon, such as too huge or small fistulas, and treatment difficultly via artery, if combined with different agents and therapy approach, satisfactory result will be obtained.
     结论对颈动脉海绵窦瘘球囊栓塞后复发,瘘口过大、过小、动脉途径治疗困难等情况应用不同材料及治疗途径可取得良好的治疗效果。
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  therapeutic approach
     Objective In order to study the pathogenesis of human papillomavirus(HPV) and seek for a therapeutic approach of the diseases caused by HPV, the construction of HPV18 E6E7 antisense RNA expressing recombinants was studied.
     目的 为了探讨人乳头瘤病毒 (HPV)的致病机理和寻找由HPV所致疾病的治疗途径 ,研究了HPV1 8型E6E7反义RNA表达重组体的构建。
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     Nuclear factor KB-a new therapeutic approach?7
     核因子KB:一种新的治疗途径?
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     The present clinical data indicates that the IL1ra may offer a novel therapeutic approach to ocularinnammation.
     结论:临床资料显示IL-1ra对眼部炎症可能提供一种新的治疗途径
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     ObjectiveTo investigate a better therapeutic approach for proximal ureter stones (PUS) by extracorporeal shock wave lithotripsy(ESWL)in order to improve the clinical curative efficacy.
     【目的】探讨体外冲击波碎石术(ESWL)治疗输尿管上段结石的较佳治疗途径,以提高临床疗效。
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     PLV is a relatively new therapeutic approach to acute lung injury(ALI) and acute respiratory distress syndrome(ARDS).
     部分液体通气是急性肺损伤和急性呼吸窘迫综合征相对新型的治疗途径
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  therapeutic approaches
     This experiment had offered theoretical evidence for further study of multiple sclerosis (MS) on pathogenesis and given the clues for searching new effective therapeutic approaches of MS,
     为深入研究多发性硬化(MS)的发病机理及探索新的有效治疗途径提供了理论依据。
     This experiment had offered theoretical evidence for further study of multiple sclerosis (MS) on pathogenesis and given the clues for searching new effective therapeutic approaches of MS.
     为深入研究多发性硬化 (MS)的发病机理及探索新的有效治疗途径提供了理论依据。
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     It has been shown that NOS/NO system and HO/CO system are closely associated with the occurrence and development of ischemic cerebral injury, furthermore, they also have complicated interactions with each other. Understanding their mechanisms of action will help explore the clinical therapeutic approaches of cerebral ischemic injury.
     研究表明,NOS/NO系统和HO/CO系统均与缺血性脑损伤的发生发展密切相关,而且两者之间还存在着错综复杂的相互作用,对其作用机制的深入了解有助于探索缺血性脑损伤的临床治疗途径
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     The study of the mechanisms of nerve growth factors for promoting neuroplasicity may provide novel therapeutic approaches for the treatment and rehabilitation of stroke, Alzheimer's disease, and peripheral nerve injury, and it may facilitate the development of the therapeutic drugs.
     对神经生长因子促进神经可塑性的机制进行研究,可能为卒中、Alzheimer病以及周围神经损伤等疾病的治疗和康复提供新的治疗途径,并促进相关治疗药物的开发。
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     Therapeutic approaches to down-regulate TGF-3 level under high glucose conditions provide one strategy to inhibit the progression of diabetic nephropathy.
     在高糖条件下下调TGF-β信号的治疗途径为我们提供了一个抑制DN发生、发展的策略。
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  therapeutic options
     Conclusions:The increase in serum levels of sEselectin ,sICAM1 and sIL2R was related to the inflammation development in psoriasis. It was also demonstrated that sEselectin serum level positively correlated with the severity of psoriasis. The authors suggest that these findings could be used as indicators to assess the severity of the disease, to investigate new therapeutic options and to predict the prognosis of the disease.
     结论 : 血清sE selectin、sICAM 1、sIL 2R升高与银屑病炎症形成有关 ,sE selectin水平与疾病严重程度密切相关 ,可作为评估银屑病严重程度的客观指标 ,对寻找新的治疗途径、预测疾病转归也具有一定的意义
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      therapy approach
    It also appears that no cancer gene therapy approach can be applied universally, but rather we will see treatments that show effectiveness in only a particular type of tumor.
          
    This article describes an equine-assisted experiential therapy approach and presents treatment outcomes in 31 participants in an equine-assisted, experiential therapy program.
          
    As a result, to be clinically applicable, the CI therapy approach to rehabilitation will likely require a paradigm shift in the delivery of physical rehabilitation services.
          
    A gene therapy approach to treatment of autoimmune disease
          
    It is argued that this gene therapy approach may be viewed as an adjunct to chemotherapeutic drugs, which may allow not just viral suppression, but also immune restoration.
          
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      therapeutic approach
    Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.
          
    The positive clinical response obtained supports that autologous dendritic cell-based immunotherapy is a promising therapeutic approach for refractory gallbladder cancers.
          
    This fact underlines the necessity for a more effective diagnostic and therapeutic approach to patients with clinically suspected PE.
          
    Partial liquid ventilation using PFCs is a relatively new therapeutic approach for the treatment of acute lung injury (ALI) and ARDS.
          
    For logistic and financial reasons however, not all patients with acute myocardial infarction can benefit from this therapeutic approach in spite of the high density of health care in Germany.
          
    更多          
      therapeutic approaches
    The pathogeneses of endogenous inflammatory diseases and therapeutic approaches are discussed.
          
    Thus, downregulation of Bcl-2 and Bcl-xL can potentially be used to improve therapeutic approaches to advanced cancer.
          
    They will also review presymptomatic testing of hereditary cancers, and the application of expression profiling to identify patients likely to benefit from particular therapeutic approaches.
          
    This article explains the basics of alveolar physiology and the therapeutic approaches derived from it.
          
    In Europe, severe sepsis with at least two organ failures or septic shock are indicative for adjunctive therapeutic approaches utilizing activated protein c (Xigris?).
          
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      therapeutic options
    It is very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic options available, especially for the lesion arising in the anal canal.
          
    The use of pCPS in resuscitation is indicated in circulatory arrest if further therapeutic options seem promising.
          
    Using the clinical presentation as an example the diagnostic and therapeutic options of the opsoclonus-myoclonus syndrome are discussed.
          
    The basis of first line therapy is the understanding of the pathophysiology of myocardial ischemia, the clinical symptoms, the diagnostic tools and the preclinically available therapeutic options.
          
    Therapeutic options, including volume control, clearance of uremic toxins, correction of acid base disturbances and temperature control, are improved.
          
    更多          


    22 cases of intrathoracic hydatid cysts were treated with prazi quantel and divided into 2 groups: Group Ⅰ with 120-150 mg/kg was given preoperatively, the mortality of the protoscoleces in the enueleated intact cyst was 43.1%; Group Ⅱ was given 210 mg/kg, being 64.2%. Besides, praziquantel was not given in a control group 9.2% (P<0.01). The protoscoleces were injected into the peritoneal cavities of mice. The growth rate of secondary cystic formation in the groups with praziquantel was 25%, while in the control...

    22 cases of intrathoracic hydatid cysts were treated with prazi quantel and divided into 2 groups: Group Ⅰ with 120-150 mg/kg was given preoperatively, the mortality of the protoscoleces in the enueleated intact cyst was 43.1%; Group Ⅱ was given 210 mg/kg, being 64.2%. Besides, praziquantel was not given in a control group 9.2% (P<0.01). The protoscoleces were injected into the peritoneal cavities of mice. The growth rate of secondary cystic formation in the groups with praziquantel was 25%, while in the control group, being 70%(P<0.01). We believe that praziquantel is provided with protoscolicidal effects and that preoperative praziquantel may be benifieial for tile recurrence of hydatid cyst after operation.

    本文报告了用国产吡喹酮治疗22例胸内包虫病的临床和实验结果,旨在探讨该药对胸内包虫病的疗效问题,寻求非手术治疗的途径。实验部分采用对手术摘除的包虫标本进行分析检查的方法:一方面分别观察服药组和对照组(未服药)的原头蚴死亡率,并用这些原头蚴接种子对包虫易感的动物小白鼠腹腔内,观察继发囊肿的生长率,以此评定药物对原头蚴的作用;另一方面借助光学及电子显微镜,观察生发层的形态和改变,作为评定药效的参考指标。结果表明。吡喹酮具有杀伤包虫囊肿内原头蚴的作用。为此考虑,吡喹酮作为术前用药,可能对防止原头蚴手术野的污染而继发囊肿有所裨益。

    In an effort to evaluate the possible effect of cryopreserved autologous bone marrow infusions in man,11 patients with cancer were treated with high-dose chemotherapy or large-field radiotherapy followed by an infusion of cryopreserved autologous bone marrow harvested before the treatment. The result indicated that cryopreserved autologous bone marrow infusions hastened hematopoietic recovery in the patients who had received the above mentioned treatment, and the effect could be beneficial to the patients. The...

    In an effort to evaluate the possible effect of cryopreserved autologous bone marrow infusions in man,11 patients with cancer were treated with high-dose chemotherapy or large-field radiotherapy followed by an infusion of cryopreserved autologous bone marrow harvested before the treatment. The result indicated that cryopreserved autologous bone marrow infusions hastened hematopoietic recovery in the patients who had received the above mentioned treatment, and the effect could be beneficial to the patients. The methods of harvesting autologous bone marrow cryopreservation and determination of cell vitality were described and discussed. It may be concluded that the procedure is safe for clinical trial. It seems to be a promising approach that may offer hope to cancer patients who have failed to respond to conventional therapeutic modalities.

    本文报道了11例恶性肿瘤患者,大剂量化疗或大面积(全身)放射治疗后,使用冷冻保存的自身骨髓对加速造血功能恢复的初步效果。回输冷冻保存的自身骨髓,对受药物或射线抑制的造血系统有促进恢复和重建造血功能之效应。讨论了14例患者自身骨髓采取、冷冻保存和活性测定的方法,证明临床使用是安全可靠的。自身骨髓输注,对常规治疗无效的患者提供了新的治疗途径,但尚处于试验阶段,需累积更多的病例资料才能加以肯定。

    The cryoprobe soaked in liquid nitrogen is a new cryother- apic instrument with metallic material as its cold storage.It is provided with the advantages of simplicity,convenience and wide adaptation.In the clinic,it has been used effectively for the cryoextraction of cataract,cryoblock of fissures in retinal detachment.A new and effective therapeutic way was found in the treatment of herpes simplex keratitis,blepharal nevi,infl- amentory granuloma on palpebra and ocular hemangiomata.In this article,a rather...

    The cryoprobe soaked in liquid nitrogen is a new cryother- apic instrument with metallic material as its cold storage.It is provided with the advantages of simplicity,convenience and wide adaptation.In the clinic,it has been used effectively for the cryoextraction of cataract,cryoblock of fissures in retinal detachment.A new and effective therapeutic way was found in the treatment of herpes simplex keratitis,blepharal nevi,infl- amentory granuloma on palpebra and ocular hemangiomata.In this article,a rather detailed discussion has been held about the history of cryotherapy and various kinds of methods in the trea- tment of the ophthalmic field by means of cryoprobe soaked in liquid nitrogen.

    浸冷式液氮冷刀,系用金属材料为储冷装置的新式冷冻治疗器械。它具有设备简单、使用方便和适应症广等优点。在临床上用于白内障冷冻摘出术和视网膜脱离冷凝封闭裂孔术,效果可靠,为单纯疱疹性角膜炎、睑缘痣、眼睑炎性肉芽肿和眼部血管瘤的治疗,找到了一条新的、有效的治疗途径。本文从冷冻治疗的历史回顾,浸冷式液氮冷刀治疗各种眼病的方法和疗效等方面,作了较为详尽的讨论。

     
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