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氨基茚
相关语句
  aminoindan
     Objective:To synthesize 1 aminoindan.
     目的 :合成 1 氨基茚
短句来源
     Methods:1 Aminoindan was synthesized from 3 phenylpropionyl chloride by three unite reaction.
     方法 :以苯丙酰氯为初始原料 ,经 3步反应合成 1 氨基茚
短句来源
     Conclusion:1 Aminoindan is syhthesized in this route with the yield of 39.2%.
     结论 :该法合成了 1 氨基茚 ,收率达 39.2 %。
短句来源
  “氨基茚”译为未确定词的双语例句
     Synthesis of 1-aminoindan
     1-氨基茚的合成
短句来源
     Effects of Aminoxyacetic Acid (AOA) and 2-Aminoindan-2-phosphonic Acid (AIP) on the Activities of Some Enzymes Induced by Methyl Jasmonate in Tobacco Calli
     氨基茚磷酸(AIP)和氨基氧乙酸(AOA)对茉莉酸甲酯诱导的烟草一些酶活性的影响
短句来源
     Objective To study the expression of mGluR1a ( metabotropic glutamate receptor 1a) and the effects of AIDA ( 1-aminoindan-1 , 5-dicarboxylic acid) in mechanically injured cortical neuron in vitro. Methods The cortical neurons of mouse fetus ( 15-16 days old) were cultured in vitro for seven days.
     目的研究体外培养小鼠脑皮层神经元机械性损伤后代谢型谷氨酸受体1a(metat-ropicglutamatereceptor1a,mGluR1a)的表达规律及其选择性拮抗剂1-氨基茚-1,5-二羧酸(1-aminoindan-1,5-dicarboxylicacid,AIDA)的保护作用。
短句来源
     R-(+)-N-propargyl-1-aminoindan hydrochloride(i. e.Rasagiline,a new medicine for curing parkinsonism) was synthesized from 1-ind anone by condensation,reduction,resolution,catalytic hydrogenation,etc. .
     以1-茚酮为原料,经缩合、还原、拆分、催化氢化得R-1-氨基茚,再与3-溴丙炔反应,经成盐合成雷莎吉兰盐酸盐.
短句来源
  相似匹配句对
     Synthesis of 1-aminoindan
     1-氨基的合成
短句来源
     Objective:To synthesize 1 aminoindan.
     目的 :合成 1 氨基
短句来源
     AMINO-SILICONE SOFTENER
     氨基聚硅酮柔软剂
短句来源
     Synthesis of Aminopolysiloxane
     氨基聚硅氧烷的合成
短句来源
     Synthesis of 1,3-indandione
     1,3-二酮的合成
短句来源
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  aminoindan
A preparative procedure has been developed for the synhtesis of 1-aminoindan-1,5-dicarboxylic acid which is a new group I metabotropic glutamate receptor antagonist.
      
The article describes a general procedure for synthesizing hydantoins of the indan series, which makes it possible to obtain bioisosteric analogs of 1-aminoindan-1,5-dicarboxylic acid, a group I metabotropic glutamate receptor antagonist.
      
(2S)-α-ethylglutamic acid (EGlu; 1 mM), an antagonist of group II mGluRs, but not (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; 1 mM), an antagonist of group I mGluRs, antagonized the 1S,3R-ACPD-induced effect.
      
Finally, a structurally related drug, 4-methoxy-5-methyl-aminoindan (MMAI), produced dose-dependent reductions in behavioral activity that are similar to the effects of fenfluramine.
      
MMAI (5-methoxy-6-methyl-2-aminoindan) is a nonneurotoxic, highly selective neuronal serotonin (5-HT) releasing agent.
      
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Objective:To synthesize 1 aminoindan.Methods:1 Aminoindan was synthesized from 3 phenylpropionyl chloride by three unite reaction.The end up of reaction was determined by TLC.Results:The structure of the interesting compound was confirmed by MS,purity measured by GS MS was 97.8%?Conclusion:1 Aminoindan is syhthesized in this route with the yield of 39.2%.

目的 :合成 1 氨基茚。方法 :以苯丙酰氯为初始原料 ,经 3步反应合成 1 氨基茚。由TLC确定每步反应终点。结果 :目标化合物结构经MS确证 ,纯度经GS MS测定达 97.8%。结论 :该法合成了 1 氨基茚 ,收率达 39.2 %。

Objective To study the expression of mGluR1a ( metabotropic glutamate receptor 1a) and the effects of AIDA ( 1-aminoindan-1 , 5-dicarboxylic acid) in mechanically injured cortical neuron in vitro. Methods The cortical neurons of mouse fetus ( 15-16 days old) were cultured in vitro for seven days. Mechanical injury was caused by plastic tip piercing the cortical neuronal culture in the injury group, while the control group underwent all the same managements except for the mechanical injury. Immunohistochemical...

Objective To study the expression of mGluR1a ( metabotropic glutamate receptor 1a) and the effects of AIDA ( 1-aminoindan-1 , 5-dicarboxylic acid) in mechanically injured cortical neuron in vitro. Methods The cortical neurons of mouse fetus ( 15-16 days old) were cultured in vitro for seven days. Mechanical injury was caused by plastic tip piercing the cortical neuronal culture in the injury group, while the control group underwent all the same managements except for the mechanical injury. Immunohistochemical examination was made on these neurons at 10, 30 minutes,1 ,3,6, 12, 24 and 72 hours after injury. At the same time, the data were collected to detect the activity of lactate dehydro-genase ( LDH). A1DA was added to the wells in the AIDA treated group 30 minutes before injury so that the end concentration of AIDA reached 20 μmol/L Ca2+ level in neurons was detected with laser scanning confocal microscopy. Results There was weak expression of mGluR1a in neurons in the control group, with the positive particles distributing in the neuronal cytoplasm, cyto-membrane and dendrites. While in the injury group, there was widespread expression of mGluR1a positive neurons from 10 minutes to 24 hours after injury and distribution of the positive particles mainly in the cytoplasm around the nucleus 10 minutes after injury. Neurons were rarely alive 72 hours after injury, with weak expression of mGluR1a. The concentration of LDH reached (80.5±21.9) U/L in the control group but that in the injury group increased significantly 30 minutes after injury (P < 0.05). However, the concentration of LDH at the 3rd and 6th hours in the injury group showed insignificant statistical difference compared with control group (P>0. 05). The concentration of LDH decreased significantly 12-72 hours after injury in the AIDA treated group compared with that of the injury group alone (P < 0. 05 ). Ca2+ level was decreased significantly in AIDA treated group than that in control group, with statistically significant difference (P < 0.05). Conclusions Expression of mGluR1a increases significantly in mechanically injured cortical neurons of mouse in vitro, and its selective mGluR1a antagonist AIDA has obvious neuropro-tective effects after neuronal trauma.

目的研究体外培养小鼠脑皮层神经元机械性损伤后代谢型谷氨酸受体1a(metat-ropicglutamatereceptor1a,mGluR1a)的表达规律及其选择性拮抗剂1-氨基茚-1,5-二羧酸(1-aminoindan-1,5-dicarboxylicacid,AIDA)的保护作用。方法孕15-16d昆明种小鼠胚胎脑皮层神经元体外培养7d,以微量移液器塑料滴头在培养孔内划割,造成机械性损伤,伤后不同时间点(10,30min、1,3,6,12,24,72h)行神经元免疫组化染色,并留取培养液上清,检测乳酸脱氢酶(lactatedehydrogenase,LDH)活性;对照组除不划伤神经元,其他处理同损伤组。AIDA处理组在损伤前30min,每孔加入AIDA使其终浓度为20μmol/L,其余步骤同前,激光扫描共聚焦显微镜检测AIDA处理前后神经元细胞内Ca2+含量变化。结果mGluR1a在正常神经元中表达呈弱阳性,染色颗粒分布于胞浆、胞膜及突起;机械性损伤后10min起,mGluR1a表达明显增强,胞核周围胞浆内染色明显加深,持续至伤后24h,神经元突起中也有明显表达,伤后72h,存活神经元数量明...

目的研究体外培养小鼠脑皮层神经元机械性损伤后代谢型谷氨酸受体1a(metat-ropicglutamatereceptor1a,mGluR1a)的表达规律及其选择性拮抗剂1-氨基茚-1,5-二羧酸(1-aminoindan-1,5-dicarboxylicacid,AIDA)的保护作用。方法孕15-16d昆明种小鼠胚胎脑皮层神经元体外培养7d,以微量移液器塑料滴头在培养孔内划割,造成机械性损伤,伤后不同时间点(10,30min、1,3,6,12,24,72h)行神经元免疫组化染色,并留取培养液上清,检测乳酸脱氢酶(lactatedehydrogenase,LDH)活性;对照组除不划伤神经元,其他处理同损伤组。AIDA处理组在损伤前30min,每孔加入AIDA使其终浓度为20μmol/L,其余步骤同前,激光扫描共聚焦显微镜检测AIDA处理前后神经元细胞内Ca2+含量变化。结果mGluR1a在正常神经元中表达呈弱阳性,染色颗粒分布于胞浆、胞膜及突起;机械性损伤后10min起,mGluR1a表达明显增强,胞核周围胞浆内染色明显加深,持续至伤后24h,神经元突起中也有明显表达,伤后72h,存活神经元数量明显减少,mGluR1a染色呈弱阳性。对照组LDH活性为(80.5±21.9)U/L,损伤后30min,LDH活性较对照组明显增加(P<0.05),3,6h时与对照组相比,差异无统计学意义(P>0.05),伤后12-72h,LDH活性较对照组明显增强(P<0.05)。伤后12-72h,AIDA处理组LDH活性较单纯损伤?

R-(+)-N-propargyl-1-aminoindan hydrochloride(i. e.Rasagiline,a new medicine for curing parkinsonism) was synthesized from 1-ind anone by condensation,reduction,resolution,catalytic hydrogenation,etc..The chemical structure of the target compound was confirmed by assay of the melting point,NMR,MS and optical activity.

以1-茚酮为原料,经缩合、还原、拆分、催化氢化得R-1-氨基茚,再与3-溴丙炔反应,经成盐合成雷莎吉兰盐酸盐.产物经熔点,质谱,核磁共振谱及旋光测定得以确定.

 
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