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大鼠产生
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  rats caused
     Objective: To observe the changes of nephrotoxicity on rats caused by LDXG (龙胆泻肝丸),TZS (导赤散) and Caulis Aristolochiane Manshuriensis decoction.
     目的 :比较单味关木通及其复方龙胆泻肝丸、导赤散对大鼠产生的肾毒性反应及严重程度。
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  rats developed
     RESULTS : At 3 to 5 weeks after myocardial infarction, rats developed CHF. This was evidenced by a marked increase in left ventricular end-diastolic pressure (LVEDP) with mean values of 23 to 26 mmHg, by a 30 % to 40 % reduction in left ventricular dp/dtmax and by a more than 10 % decrease in mean arterial pressure (MAP) as compared to sham-operated rats.
     结果:心肌梗死3-5周后,大鼠产生慢性心衰,与假手术大鼠相比,慢性心衰大鼠左心室舒张末期压(LVEDP)显著升高,其均值为23-26mmHg,心肌收缩力(左心室dp/dt_(max))降低30%-40%,平均动脉压(MAP)降低大于10%。
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     Results: (1)The rats developed CPP with amphetamine 2.0 mg·kg~ -1 and the vanished CPP could be rekindled by hydrocortisone 10 mg·kg~ -1;
     结果:(1)苯丙胺2·0mg·kg-1可使大鼠产生条件性位置偏爱效应,氢化可的松10mg·kg-1可使已消失的条件性位置偏爱效应重现;
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     Results The rats developed hyperalgesia after CCI and IT SB203580 administration significantly increased MWT in a dose dependent manner.
     结果 CCI后大鼠产生了机械痛敏,鞘内注射SB203580剂量依赖性地提高了MWT。
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     Nicotine was subcutaneously administrated to rats 6 times a day for 9 days, and the doses of nicotine were gradually increased from 0.5 to 4.0 mg·kg -1 . The rats developed physical dependence. Naloxone 4 mg·kg -1 (sc) could precipitate nicotine abstinence syndrome, in these rats, with signs same as those precipitated by mecamylamine 1 mg·kg -1 (sc).
     大鼠连续9d递增皮下注射烟碱后产生依赖,皮下注射阿片受体拮抗剂纳洛酮(4mg·kg-1)可使烟碱依赖大鼠产生明显的戒断症状,并与美加明激发的戒断症状十分相似。
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  rats to produce
     Complete or Fragment of Aβ_42 Vaccine with Aluminum Adjuvant Effectively Induced Rats to Produce Specific Antibody
     铝佐剂Aβ_(42)及其亚单位疫苗可有效诱导大鼠产生特异性抗体
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     Conclusions1) Obstruction of pancreatic duct and injecting Na TC into it induces rats to produce AHNP.
     结论1)结扎胰胆管末端,然后于胰胆管内缓慢注射药物5%牛磺胆酸钠().lml/kg,能诱导S干大鼠产生可靠的AHNP模型。
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  “大鼠产生”译为未确定词的双语例句
     SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonists
     SR141716A诱导大鼠产生与CB1受体激动剂相反的行为模式(英文)
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     However, the dose of Ace + Caf + Bul at 300 + 35 + 52.5 mg/kg resulted in sedation in rats.
     剂量至(300+35+52.5)mg/kg,对大鼠产生镇静作用。
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     injection of NDMA at doses of 1,2, 3,5,10, 30, 50 mg/kg respectively, the production of O 6- mG in the DNA of rats displayed obvious dose-response relationship as well as cell and organ specificity.
     分别给大鼠一次腹腔注射NDMA 1,2,3,5,10,30,50mg/kg,5小时后大鼠产生O~6—mG具有明显的剂量反应关系以及器官和细胞特异性。
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     METHODS Adenine was given to rats at a dose of 250 mg·kg-1·d-1 ig for 21 d.
     方法通过ig腺嘌呤250mg·kg-1·d-1,连续21d,使大鼠产生类似于人的CRF症状。
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     The maximal doses of propofol and thiopental in the experiment weretested on 12 other separate animals for possible anaesthetic effects. Results Propofol (0.2mg/Kg、2mg/Kg) and thiopental (5mg/Kg) significantlysuppressed the increase in the discharges of NSRN induced by CAO (P<0.05)and the doses of propofol, 2mg/Kg and thiopental, 5mg/Kg did not produceanesthetic effects on the rats.
     结果 异丙酚(0.2mg/Kg、2mg/Kg)及硫喷妥钠(5mg/Kg)能明显抑制 CAO引起的 NSRN 放电频率的增加(P<0.05),且异丙酚(2mg/Kg)、硫喷妥钠(5mg/Kg)未能对大鼠产生麻醉作用。
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  rats caused
The administration of 99mTc-AA with PPA in rats caused an increase of the uptake of 99mTc-AA at 120?min in the investigated organs compared to the administration of 99mTc-AA alone.
      
Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyrid
      
The efficacy of these rods implanted alone or in combination in relieving chronic pain in rats caused by the ligation of the sciatic nerve of their right hind limbs was studied.
      
Oral application of 700 mg/kg salicylic acid to pregnant and nonpregnant female rats caused an increase of serum Mg2+ and a decrease of serum Ca2+ concentration.
      
For example, folate deprivation decreased erythrocyte folate; folate supplementation to the Ni-supplemented rats caused a larger increase in erythrocyte folate concentration than did folate supplementation to the Ni-deprived rats.
      
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  rats developed
Both groups initially developed a similar increase in blood pressure but only the 2K-1C rats developed myocardial hypertrophy after 2-4 weeks.
      
In DDC group, 3 out of 50 rats developed cancer and 4 developed atypical hyperplasia of hronchial epithelium within 35 to 40 days.
      
At 4th and 8th week after constriction of the abdominal aorta, rats developed significant left ventricular hypertrophy.
      
Rats developed characteristic myocardial subcellular degeneration and increased cardiac mitochondrial volume density when copper depleted, despite lack of overt cardiac hypertrophy, hypertension, or anemia.
      
DOCA-salt hypertensive rats developed hypertension, hypertrophy, perivascular and interstitial fibrosis, endothelial dysfunction, and prolongation of the cardiac action potential duration within 4 wk.
      
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  rats to produce
The following drugs were administered to male Sprague-Dawley rats to produce general anesthesia: phenobarbital (250 mg/kg), hexobarbital (200 mg/kg), chloral hydrate (350 mg/kg), ketamine (150 mg/kg), urethane (1.2 g/kg), halothane and ether.
      
High fat diet (8?weeks) and deoxycorticosterone acetate (DOCA; 40?mg?kg-1, s.c.) were administered to rats to produce hypercholesterolemia and hypertension (mean arterial blood pressure >amp;gt;120?mmHg) respectively.
      
Tumour cells from a squamous carcinoma (approximately 2.5×105) were injected intraportally into a syngeneic strain of rats to produce liver metastases 14 days later.
      
To determine the map location of this gene, a single F344.rnu/rnu (athymic nude congenic Fischer rat) male congenic rat was bred with 3 LEW/N (NIH stock Lewis rat) female rats to produce F1 progeny.
      
A suspension of bacteria of the same strain was mixed with a sufficient amount of serum from the immunized rats to produce agglutination.
      
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Tachyphylaxis to ephedrine has been studied on the cat's nictitating membranes, the cat's and the rat's blood pressure. In the course of the development of tachyphylaxis to ephedrine in cats, it was found that: (1)the cumulative effect(probit) of ephedrine on nictitating membranes could be plotted linearly against its cumulative dose(log)(Fig.3), (2)the responses of nictitating membranes to supramaximal electrical stimuli on the cervical sympathetic nerve diminished, and (3) both the pressor and the nictitating...

Tachyphylaxis to ephedrine has been studied on the cat's nictitating membranes, the cat's and the rat's blood pressure. In the course of the development of tachyphylaxis to ephedrine in cats, it was found that: (1)the cumulative effect(probit) of ephedrine on nictitating membranes could be plotted linearly against its cumulative dose(log)(Fig.3), (2)the responses of nictitating membranes to supramaximal electrical stimuli on the cervical sympathetic nerve diminished, and (3) both the pressor and the nictitating membrane responses to intravenous noradrenaline increased. Tachyphylaxis to the pressor effect of ephedrine in rats was found to be easily induced by repeated intravenous doses of 8mg/kg each at short intervals(Fig.6).After the development of tachyphylaxis to ephedrine in rats,the dose-pressor-response curve of tyramine was depressed (Fig.7), while that of noradrenaline was not altered significandy. In cats pretreated with reserpine (2.5—5mg/kg), the response of nictitating membranes was depressed significantly at the dose of 2.5mg/kg on the dose-response curve of ephedrine (Fig.4). On the contrary, the dose-pressor-response curves in reserpinized cats and rats were elevated at the last and maximal dose of ephedrine (12.5mg/kg in cats; 8mg/kg in rats) in comparing with controls in which the response to the last dose had been depressed due to the development of tachyphylaxis (Fig. 5,9). In rats pretreated with reserpine in different schedules (5mg/kg, 3—4 hours previously; 1mg/kg daily for 5 days and 7mg/kg daily for 2 days), the development of tachyphylaxis tended to be delayed and the pressor effect of the first dose of ephedrine was potentiated especially during the acute influence of a 5mg/kg dose of reserpine. Bilateral adrenalectomy made no significant difference in the results of some of the above experiments (Fig.9, Tab.4). Infusion of noradrenaline in the beginning of the rat experiments could also potentiate the pressor effect of ephedrine, but unlike reserpinization, it hastened the development of tachyphylaxis in most cases. If noradrenaline was infused after tachyphylaxis, it could partially restore the pressor effect of ephedrine injected during the infusion (Fig.8). After cocaine(2.5mg/kg, i.v.), the dose-pressor-response curve was depressed and the development of tachyphylaxis hastened (Fig.10). These results would suggest the coexistence of two important factors in the development of tachyphylaxis to ephedrine: (1) tachyphylaxis to the direct action of ephedrine is due to saturation of receptors; (2) tachyphylaxis to the indirect action of ephedrine is due to depletion of catechol amines.

本文对于猫瞬膜,猫及大鼠血压对麻黄碱的快速耐受性进行了系統研究。在猫对麻黄碱快速耐受性产生过程中发现:(1) 麻黄碱对瞬膜的积累作用(机率)与积累剂量(对数)呈直线关系,(2) 瞬膜对电刺激交成神经的反应减弱,(3) 血压及瞬膜对静脉注射去甲腎上腺素的反应增加。与其他实驗动物相似,大鼠連续注射麻黄碱8毫克/公斤,其升压作用也易于产生快速耐受性。大鼠血压对麻黄碱产生快速耐受性后,酪胺的剂量反应曲线被压低,但去甲腎上腺素的曲线并无显著改变。猫预先注射利血平后,其瞬膜对麻黄碱的剂量反应曲线中部(2.5毫克/公斤)被压低。在猫和大鼠的剂量-升压反应曲线中,最大也卽最后一剂麻黄碱(猫:12.5毫克/公斤;大鼠:8毫克/公斤)的反应由于快速耐受性而有所降低;但用利血平后可使这个反应较对照組显著升高。大鼠预先用不同剂量利血平后,麻黄碱快速耐受性的产生趋于延緩;并且第一剂麻黄碱的升压作用,特别是在注射利血平5毫克/公斤,3—4小时后,有增强现象。切除腎上腺对上述結果似无影响。预先灌注去甲腎上腺素也可增强第一剂麻黄碱的升压作用,但与利血平化不同,对多数大鼠,反可促进快速耐受性的产生。大鼠产生快速耐受性后,灌注去甲腎...

本文对于猫瞬膜,猫及大鼠血压对麻黄碱的快速耐受性进行了系統研究。在猫对麻黄碱快速耐受性产生过程中发现:(1) 麻黄碱对瞬膜的积累作用(机率)与积累剂量(对数)呈直线关系,(2) 瞬膜对电刺激交成神经的反应减弱,(3) 血压及瞬膜对静脉注射去甲腎上腺素的反应增加。与其他实驗动物相似,大鼠連续注射麻黄碱8毫克/公斤,其升压作用也易于产生快速耐受性。大鼠血压对麻黄碱产生快速耐受性后,酪胺的剂量反应曲线被压低,但去甲腎上腺素的曲线并无显著改变。猫预先注射利血平后,其瞬膜对麻黄碱的剂量反应曲线中部(2.5毫克/公斤)被压低。在猫和大鼠的剂量-升压反应曲线中,最大也卽最后一剂麻黄碱(猫:12.5毫克/公斤;大鼠:8毫克/公斤)的反应由于快速耐受性而有所降低;但用利血平后可使这个反应较对照組显著升高。大鼠预先用不同剂量利血平后,麻黄碱快速耐受性的产生趋于延緩;并且第一剂麻黄碱的升压作用,特别是在注射利血平5毫克/公斤,3—4小时后,有增强现象。切除腎上腺对上述結果似无影响。预先灌注去甲腎上腺素也可增强第一剂麻黄碱的升压作用,但与利血平化不同,对多数大鼠,反可促进快速耐受性的产生。大鼠产生快速耐受性后,灌注去甲腎上腺素可部分地恢复麻黄碱的升压作用。预先静脉注射可卡因2.5毫克/公斤可压低麻黄碱的剂量反应曲线。以上一系列实验資料提示麻黄碱快速耐受性的形成由于两种重要因素:(1) 麻黄碱直接作用的快速耐受性是由于受体的饱和,(2) 麻黄碱间接作用的快速耐受性是由于介质的耗竭。

HEDP has now been widely used in electroplating industry as a new complexing-agent to replace cyanides. In this study, the toxicity of HEDP was assessed in animals by means of radionuclide tracing method. The absorption rate of 99mTc-HEDP P. 0. within 24 hours was about 20%. Most of the HEDP absorbed was concentrated in bony tissue, only a small fraction was distributed in other organs.The biological half-time of 99mTc-HEDP was 13.75 hours. Thus 2.86 days were required to excrete 95% of the P. 0. dose of HEDP....

HEDP has now been widely used in electroplating industry as a new complexing-agent to replace cyanides. In this study, the toxicity of HEDP was assessed in animals by means of radionuclide tracing method. The absorption rate of 99mTc-HEDP P. 0. within 24 hours was about 20%. Most of the HEDP absorbed was concentrated in bony tissue, only a small fraction was distributed in other organs.The biological half-time of 99mTc-HEDP was 13.75 hours. Thus 2.86 days were required to excrete 95% of the P. 0. dose of HEDP. Therefore, a slight accumulation would occur when successive doses were given at intervals of less than 24 hours.The LD60 of HEDP P. 0. was at the level of 2.05g/kg in mice and 1.69g/kg in rats, implying that HEDP is a compound of low toxioity, graded according to our national standard.After prolonged P. O. administration with larger dose of HEDP, the rats developed metabolic disturbance of calcium and phosphate. The histopathologio and roent-genologic findings were similar to that of rachitis, and subsequently, the growth and development of bone and dental matrix were delayed or retarded.In conclusion, the threshold dose of HEDP causing chronic intoxication was equivalent to 160 mg/kg/day, and the safety subthreshold dose 40mg/kgdaily.

我们以放射性核素示踪法和环境毒理学实验方法,研究了消除电镀含氰废水污染环境的代用品——络合剂羟基乙叉二膦酸二钠盐(HEDP)在动物体内的毒物动力学及其毒性作用。结果表明HEDP经消化道的吸收率约为20%,主要分布在骨胳系统,生物半衰期为13.75小时。HEDP急性毒性实验结果提示它属于低毒类化学物质。HEDP在实验动物体内有轻度蓄积作用,以较高剂量HEDP给动物长期染毒后,可引起机体钙、磷代谢的紊乱,形成一系列佝偻病样骨、齿组织脱钙的组织病理学和X线表现,最后导致骨、齿生长发育迟缓或停滞。HEDP对大鼠产生慢性毒作用的阈剂量为每日160mg/kg,阈下安全剂量为每日40mg/kg。

Schizandrol A is one of the active constituents isolated from the ethanol extract of the dried fruit of Schizandra chinensis Baill(Fructus schizandras). Intraperitoneal injection of a dose of 1/10 LD_(50) of schizandrol A in mice prolonged the sleeping time induced by pentobarbital or barbital. In doses of 1/50 LD_(50), schizandrol A decreased the mice spontaneous motor activity (SMA). Schizandrol A also enhanced the inhibiting effects of chlorpromazine, reserpine and pentobarbital, and antagonisted the stimulating...

Schizandrol A is one of the active constituents isolated from the ethanol extract of the dried fruit of Schizandra chinensis Baill(Fructus schizandras). Intraperitoneal injection of a dose of 1/10 LD_(50) of schizandrol A in mice prolonged the sleeping time induced by pentobarbital or barbital. In doses of 1/50 LD_(50), schizandrol A decreased the mice spontaneous motor activity (SMA). Schizandrol A also enhanced the inhibiting effects of chlorpromazine, reserpine and pentobarbital, and antagonisted the stimulating effects of amphetamine and coffeine on SMA in mice. The ID_(50s) of schizandrol A on tonic convulsion induced by electric shock (MES), metrazol, nicotine and hydrastine were 55, 51, 58, and 82 mg/Kg respectively, and those on foot shock aggression and isolated aggression in mice were 99 mg/Kg and 35 mg/Kg. The specific avoidance-blocking activity produced by neuroleptics was also produced by schizandrol A in rats. When schizandrol A was given at higher doses to rats, catalepsy was observed which could be prevented by prior intraventricular injection of dopamine. These experimental results indicate that schizandrol A posseses extensive inhibiting effects on the CNS which is charateristic for neuroleptics.

醇甲为五味子仁乙醇提取物中主要有效成分之一。腹腔注射明显延长小鼠戊巴比妥钠及巴比妥钠的睡眠时间,减少小鼠自主活动,并加强利血平及戊巴妥钠对自主活动的抑制作用,对抗咖啡因、苯丙胺对自主活动的兴奋作用。醇甲对抗MES、戊四唑、菸碱及北美黄连碱的强直性惊厥,抑制小鼠由电刺激或长期单居引起的激怒行为,对大鼠回避性条件反射及二级条件反射有选择性抑制作用,大剂量使大鼠产生木僵,该木僵可被脑室注射DA所对抗。从实验结果看来,醇甲有广泛中枢抑制作用,并且有安定药的作用特点。

 
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