Human serum HDL isprepred with supercentrifugation, which is degreased with alcohol/ether(3/1V/V),chro-matogrphyed with Sephacryl S-200 and DEAE-52 to obstain purified ApoA Ⅰ,which isverified to be unique belt by gel electrophosis.
The results have shown that the concentration of hCG β in postmenopausal women is much higher than that in premenopausal women ( P <0.001). Correspondingly, triglyceride (TG) is elevated ( P < 0.05). High density lipoprotein cholesterol (HDL C) and HDL C/LDL C ratio are decreased ( P <0.001, P <0.01).
ATP-binding cassette transporter A1 (ABCA1) is an important membrane transporter for cholesterol and lipids, it promotes overloaded cholesterol to efflux from cells to ApoA-I and package into high-density lipoprotein, which process involved in revise cholesterol transfer.
Trimethylpropylmethyl-fluorophosphatase (somanase, EC 3. 1. 8. 2. ) was purified from toad serum (Bufo bufo garagrizanes), which catalyzes the hydrolysis of O-1, 2, 2trimethylpropylmethyl-fluorophosphate (soman)─a high toxic chemical warfare agent. The somanase was found to be present in a form combined with high-density lipoprotein(HDL).
Blood samples were collected before the experiment and 45 days, 75 days and 105 days after the experiment from all the rabbits for measurement of serum total cholesterol (TC),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG), high-density lipoprotein cholesterol(HDL-C) respectively.
The results show that SFPS at each dose of the 3 groups can inhabit the total cholesterol, triglyceride and low-density lipoprotein cholesterol, even reduce their contents, and can increase the content of high-density lipoprotein cholesterol.
One-way ANOVA revealed differences in the erythrocyte suspension viscosity, total globulins, triglycerides, high density lipoprotein cholesterol (HDL Ch), plasma viscosity, and acid resistance of erythrocytes.
The statistically significant two-way interaction effects of ADH7 StyI and CYP2E1 DraI on diastolic blood pressure (P = 0.029) and on the serum high density lipoprotein level (P = 0.042) were also revealed.
Plasma triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and apoA-I concentrations were markedly increased in T0901317-treated groups.
Body mass index (BMI) and lipid profile including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride correlated with blood pressure.
In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control, whereas HDL cholesterol and triglyceride (TG) levels did not differ between the two groups.
CETP thus plays a potential pro-atherogenic role by moving CE from HDL into pro-atherogenic VLDL and LDL particles, thereby lowering atheroprotective HDL cholesterol.
Mean serum high-density lipoprotein cholesterol (HDL-c) levels were decreased significantly from 1982-1983 to 1997-1999, with the changes from -13.2% to -38.6% in males and from -9.8% to -21.7% in females.
The ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDL-c) increased dramatically during this period because of a concurrent decline in the levels of HDL-c and the increase in the levels of TC.
Similar trends were observed in the mean serum triglyceride (TG) and the mean serum low-density lipoprotein cholesterol (LDL-c) levels, both in females and males.
Mean serum high-density lipoprotein cholesterol (HDL-c) levels were decreased significantly from 1982-1983 to 1997-1999, with the changes from -13.2% to -38.6% in males and from -9.8% to -21.7% in females.
The ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDL-c) increased dramatically during this period because of a concurrent decline in the levels of HDL-c and the increase in the levels of TC.
In macrophages obtained in acute phase of inflammation (24 h), degradation of 125I-labeled native low density lipoprotein (NLDL) was 4-fold increased and degradation of 125I-labeled acetylated LDL (AcLDL) was 2-3-fold decreased.
Mean serum high-density lipoprotein cholesterol (HDL-c) levels were decreased significantly from 1982-1983 to 1997-1999, with the changes from -13.2% to -38.6% in males and from -9.8% to -21.7% in females.
The ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDL-c) increased dramatically during this period because of a concurrent decline in the levels of HDL-c and the increase in the levels of TC.
We evaluated the efficacy of alternate-day dosing of atorvastatin in comparison with the standard one-daily dose on total cholesterol, low and High-density lipoprotein (LDL and HDL) and triglycerides.