Puerarin could improve the general state, improve the general state, decrease triglyceride (P <0.05), serum cholesterol (P <0.05), low density lipoprotein (P <0.05), glycosylated hemoglobin (P <0.05), and glycated low density lipoprotein (P <0.05), increase high density lipoprotein (P <0.05).
After ten weeks, the concentrations of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and C reactive protein (CRP) in each group were measured.
Before and after 2-week treatment,the serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) in the serum were determined. After 4-week treatment,TC and TG contents in the liver,and nitric oxide(NO),thromboxan B2(TXB2) and endothelin-1(ET-1) levels in the serum were measured.
MethodsFeeding with high fat feedstuff to establish the hyperlipidmia model in rats and detecting the various indexes of lipid including the total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),superoxide dismutase(SOD),malondialenhyde(MDA) and so on.
It was demonstrated that in both Huanglianjiedu decoction and berberine groups the levels of serum total cholesterol, triglycerides, apolipoprotein B and fasting blood glucose were significantly decreased, while their high density lipoproteins cholesterol and apolipoprotein AⅠlevels increased, glucose tolerance improved, and body weight reduced, as compared with those in model group. There was no significant difference of the above mentioned parameters between Huanglianjiedu decoction group and berberine group.
结果表明黄连解毒汤组和黄连素组大鼠总胆固醇、甘油三酯、载脂蛋白 B、空腹血糖水平均比模型组明显降低 ,而高密度脂蛋白 -胆固醇、载脂蛋白 A 水平显著升高 ,口服糖耐量试验改善、大鼠体重减轻 ,但黄连解毒汤和黄连素两组之间各指标无显著性差异。
METHODS: SD rats were divided into 6 groups at random and hyperlipidemia model groups were constructed by feeding with high lipid diet, the rats in each group were administrated with defined preventive drugs, TC, TG, LDL-C, HDL-C, apoA1, apoB100, whole blood viscosity and hemorheologic parameters were determined 14d after the drug administration.
Methods 95 impaired glucose regulation patients were divided into treatment group and control guoup randomly and bosseyed, the treatment group took the capsule of Xiaokekang, the control group took placebo, after 6 months treatment, observe the IGR patients’ level of serum TC、TG、HDL-C、LDL-C 、FPG、PG2H and the circs of IGR’ lapse.
In the experiments, the activities of antioxidant enzymes SOD, GSH-Px, the primary enzyme of the membrane Na+-K+-ATPase and HDL-C of rat erythrocytes were increased in the groups treated by white mulberry fruits and juice.
One-way ANOVA revealed differences in the erythrocyte suspension viscosity, total globulins, triglycerides, high density lipoprotein cholesterol (HDL Ch), plasma viscosity, and acid resistance of erythrocytes.
The statistically significant two-way interaction effects of ADH7 StyI and CYP2E1 DraI on diastolic blood pressure (P = 0.029) and on the serum high density lipoprotein level (P = 0.042) were also revealed.
Plasma triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and apoA-I concentrations were markedly increased in T0901317-treated groups.
Body mass index (BMI) and lipid profile including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride correlated with blood pressure.
In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control, whereas HDL cholesterol and triglyceride (TG) levels did not differ between the two groups.
In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control, whereas HDL cholesterol and triglyceride (TG) levels did not differ between the two groups.
High density lipoprotein (HDL) plays a central role in the removal of excess cholesterol from cells, and cholesteryl ester transfer protein (CETP) is a crucial protein involved in the regulation of HDL levels.
Effect of antiatherogenic high density lipoprotein (HDL) and apolipoprotein AI (apoAI) on production of prostaglandin E2(PGE2) by human monocyte-derived macrophages was investigated.
The liver is also the major site of uptake of3H-CLE-high density lipoprotein (HDL) (40%-45% of the injected dose) but its uptake by the liver increased only by 20% with estradiol treatment.
The thiazides hydrochlorothiazide and chlorthalidone cause an elevation of plasma triglycerides and very low density lipoprotein (VLDL) but have little effect on total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL).
A mechanism of activation of protein biosynthesis in hepatocytes was proposed as effected by the conditioned medium of nonparenchymal liver cells incubated in the presence of high density lipoproteins, cortisol, and lipopolysaccharides.
The review highlights the membrane aspect of cholesterol efflux from cell membranes to high density lipoproteins (HDL), an initial stage of reverse cholesterol transport to liver.
No such effect has been found in hamsters, but cottonseed protein may slightly elevate the percentage of serum total cholesterol carried by the high density lipoproteins.
The effect of exercise on serum high-density lipoprotein cholesterol (HDL-C ) concentration was examined in adult female rats. Fifty-two rats were divided into 4 groups: control group ( higl-fat diet ) , exercise group 1 (high-fat diet and 0.5 hr forced swimming/day ),exercise group 2 ( high-fat diet 2 hr forced swimming/day ) and exercise group 3 (high-fat diet and ;4 hr forced swimming/day). 'The rats swam in warm water (28-30℃ ) for 3 weeks (5 day/week) .The experimental diet consisted of basal diet (93%...
Carthamus Tinctorius L. is a ch- inese traditional drug for invigorating the circulation of blood and reducing stasis. It is generally believed that S- afflor Yellow(S. Y. )from Safflower is the main pharmaceutic composition of carthamus tinctorius L. In clinic, S. Y. is used to treat cornary heart diseases, arteriosclerosis, hypertension etc. Such diseases all related to lipids metabolisml. We used the biochemical method in the research of effects of S. Y. on rabbits plasma-lipids and l- iver function. Aft...
Newborn rats were injected subcutaneously momosedium glutamate(MSG). Those rats became obese.In order to reduce obesity biochemical and morphological studies were carried out on the experimetal model of obese rats by oral administration evening primrose oil(EPO).The following results were obtained: 1.Lee's index was significantly increased by MSG injection.The increases of body weight and Lee's indox in MSG rats were reduced by oral EPO.2.The levels of serum, triglyceride were significantly higher in the M ...
高密度脂蛋白
high density lipoprotein 
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