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调控细胞增殖     
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  control cell proliferation
     With regard to gene expression zinc functions mechanistically at several levels,recent interest has focused especially on the involvement of zinc in DNA transcription through the activity of transcription factors which contain specific zinc-finger regions which bind to DNA and in conjunction with other families of transcription factors,control cell proliferation,differentiation and cell death.
     近年来,有关锌对基因表达的影响主要集中于转录水平,即锌通过影响转录因子(含有锌指域)的活性进而调控细胞增殖、分化及细胞死亡。
短句来源
  regulate cell proliferation
     Cell-cell interactions regulate cell proliferation and differentiation and play an important control role in the development, maturing, aging, and illness. Protein-protein interactions and protein-nucleic acid interactions are essential elements of cell-cell interaction.
     调控细胞增殖与分化的细胞间相互作用在生物发育、成熟、衰老和疾病发生等方面发挥重要作用,蛋白质-蛋白质和蛋白质-核酸之间的相互作用是细胞相互作用的物质基础。
短句来源
     Nuclear Factor-KB (NF-KB) is an ubiquitous transcription factor and regulates the expression of several genes involved in inflammatory and immune responses, positively regulate cell proliferation and apoptosis.
     核因子-kB(NF-kB)作为一类转录因子,在调控细胞增殖和凋亡相关基因的信号传导中起到关键作用,近年来与肿瘤细胞凋亡的关系日益受到重视。
短句来源
     There was a significant positive correlation between the expression of Decorin and p16 staining intensity, a significant negative correlation between that of p16 and PCNA Conclusion: We concluded that Decorin might regulate cell proliferation by controlling the expression of p16. There was a relationship between breast cancer cells'proliferative status and lymph nodes metastasis.
     p16的染色强度与PCNA的表达有明显的负相关。 结论 :Decorin可能通过调节p16的表达来调控细胞增殖 ;
短句来源
     In early tooth development,LMO4 might regulate cell proliferation. In late tooth development,it might participate in the ameloblast differentiation.
     LMO4与Shh信号分子表达范围邻近,在牙胚发育早期可能调控细胞增殖,晚期可能参与成釉细胞的分化。
短句来源
  modulating cell proliferation
     takes part in the carcinogenesis and development of the tumors by modulating cell proliferation,influencing cell migration.
     并通过调控细胞增殖,影响细胞迁移,参与肿瘤的发生发展。
短句来源
     Conclusion:P53 palys a role in modulating cell proliferation and promoting astroglioma tumorigenesis.
     结论:提示P53蛋白在调控细胞增殖、促成脑星形胶质细胞瘤的生成中具有一定作用。
短句来源
  regulation of cell proliferation
     The sphingolipid metabolites ceramide(Cer), sphingosine(Sp), and sphingosine 1-phosphate(S1P) play important roles in the regulation of cell proliferation, survival, and apoptosis.
     鞘磷脂衍生物神经酰胺(Cer)、鞘氨醇(Sp)及 1 磷酸鞘氨醇(S1P)在调控细胞增殖、存活及凋亡中发挥着重要作用。
短句来源
     Recent study indicates that microRNA are closely related to the oncogenesis additional to its biological function in the regulation of cell proliferation,differentiation and death.
     近年来研究发现,m iRNA除了具有调控细胞增殖、死亡、细胞分化、个体发育等生物学功能以外,与肿瘤的发生也有着密切的关系。
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      control cell proliferation
    The mechanisms by which steroid hormones control cell proliferation remain a major challenge for future research.
          
    It is postulated that loci with control cell proliferation are present on chromosomes 12, 14, and 17.
          
    These results suggest that the progression of RTE cells to neoplasia is associated with a series of changes in regulatory pathways that control cell proliferation.
          
    They arise through the stepwise, progressive disruption of cellular signalling cascades which control cell proliferation, survival and differentiation.
          
    Small Ras GTPases control cell proliferation, differentiation, cellular growth and apoptosis, with cell-specific expression in the kidney.
          
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      regulate cell proliferation
    Insulin-like growth factor type 1 (IGF-1) belongs to the peptide hormones which regulate cell proliferation and differentiation as well as angiogenesis.
          
    Sonic hedgehog and Indian hedgehog are both expressed by the urothelium of the fetal prostate anlage, where they regulate cell proliferation and differentiation and play a role in prostate ductal budding.
          
    Sonic hedgehog and Indian hedgehog are both expressed by the urothelium of the fetal prostate anlage, where they regulate cell proliferation and differentiation and play a role in prostate ductal budding.
          
    Abundant evidence has indicated that protein tyrosine kinases (PTKs) convey signals from G protein-coupled receptors (GPCRs) to regulate cell proliferation, migration, adhesion, and potentialy cellular transformation.
          
    Research focused on deciphering the biochemical mechanisms that regulate cell proliferation and function has largely depended on the use of tissue culture methods in which cells are grown on two-dimensional (2D) plastic or glass surfaces.
          
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      modulating cell proliferation
    Regulation of intracellular Ca2+ in breast cancer may be important in modulating cell proliferation, differentiation, apoptosis, and cytotoxicity, as well as contributing to mechanisms of action of anticancer agents.
          
    The aim of this review is to present and discuss new findings implicating NHE1 activation as a central signaling event activated by stress conditions and modulating cell proliferation and death.
          
    Previous studies showed that the hormone relaxin acts on human breast cancer MCF-7 cells in vitro by modulating cell proliferation and promoting cell differentiation toward a duct epithelial phenotype.
          
    These results are compatible with a role forvestigial in modulating cell proliferation.
          
    Interactions between tumor cells and their substratum influence cancer progression by modulating cell proliferation and survival.
          
    更多          
      regulation of cell proliferation
    Most cell adhesion proteins contain modules similar to epidermal growth factor (EGF) and also their repeats, which determine the involvement of these proteins in regulation of cell proliferation, differentiation, and apoptosis.
          
    Induced changes were analyzed in the expression of several transcriptional factors involved in the regulation of cell proliferation and apoptosis.
          
    All these data suggest that the telomerized cells preserved the normal mechanisms of regulation of cell proliferation.
          
    Research in recent years indicates that PKCζ plays a pivotal role in the regulation of cell proliferation.
          
    Furthermore, the research on the molecular mechanism ofp15 in regulation of cell proliferation shows thatp15 can inhibit the growth of some kinds of tumor cells, andp15 is the mediator of TGF-β-induced cell arrest.
          
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    proliferaton of nomal animal cells is a controllable process. on the contrary. proliferaton of cancer cells can't be controlled. Recent discovery of polypeptide growth factors, oncongenes and oncongenic proteins is helpful for us to understand these procss. Based on these research results, hypothesis that the cell growth is regulated by cell growth stimulators and cell growth inhibitors was put forward in this paper. the known experimental results have proved the rationality of hypothesis, which predicates that...

    proliferaton of nomal animal cells is a controllable process. on the contrary. proliferaton of cancer cells can't be controlled. Recent discovery of polypeptide growth factors, oncongenes and oncongenic proteins is helpful for us to understand these procss. Based on these research results, hypothesis that the cell growth is regulated by cell growth stimulators and cell growth inhibitors was put forward in this paper. the known experimental results have proved the rationality of hypothesis, which predicates that we can design some experiments to look for some unknown controlling substances. At the same time, the hypothesis will prpbably provide us a new way to treat cancer.

    正常动物细胞的增殖是一个可控的过程,而恶性肿瘤细胞则可不受控制地生长。多肽类生长因子、致癌基因和致癌蛋白关系的新发现有助于阐明这些过程。本文基于这些研完成果,提出了通过促进细胞生长和抑制细胞生长的两大类物质调控细胞增殖的假设。已有的实验结果初步证实假设的合理性,这预示着可设计一些实验来寻找未知的调控细胞增殖的物质。这一假设的提出,为治疗癌症提供了新途径。

    The biochemical basis of pericyte loss in early diabetic retinopathy is still an open question. In studies on the mechanism by which retinal peri-cytes degenerate, we first established a bovine retinal capillary pericyte (BRCP) cell line. Subcultured BRCP grown in high (10-40mmol/L) glucose media were used as an experimental model. We found that high concentrations of glucose suppress the mitotic rate and cell birth rate of cultured BRCP. High concentrations of glucose inhibit myo-inositol transport and result...

    The biochemical basis of pericyte loss in early diabetic retinopathy is still an open question. In studies on the mechanism by which retinal peri-cytes degenerate, we first established a bovine retinal capillary pericyte (BRCP) cell line. Subcultured BRCP grown in high (10-40mmol/L) glucose media were used as an experimental model. We found that high concentrations of glucose suppress the mitotic rate and cell birth rate of cultured BRCP. High concentrations of glucose inhibit myo-inositol transport and result in decreased intracellular myo-inositol content. This inhibition can be partially reversed by sorbinil, an aldose reductase inhibitor (ARI). Myo-inositol is a precursor of inositol phospholipids (IPLs), whose metabolism is responsible for a number of signal transduction processes. Phosphoinositidase (Plase) cleaves the phos-phodiester bond of phosphotidylinositol 4,5 diphosphate (PIP2) to produce two second messengers, inositol trisphosphate (IP3) and diacylglycerol (DG). Further experiments showed that IP3 and DG synergistically activate BRCP proliferation in vitro. High concentrations of glucose altered the formation of both IPLs and inositol phosphate esters (IPEs) in an organ culture of retinal micro-vessels. This alteration can be reversed by adding either high concentrations of myo-inositol or ARI to the medium. Plase activity was attenuated to 82% or 55% when glucose in the growth medium was increased from 5 to 15 or 30 mmol/L, respectively. When IPLs from BRCP were analyzed by HPLC and TLC, we observed the reduction of three IPLs, including the substrate of Plase, PIP2. The reduced levels of IPLs were restored by adding either free myo-inositol or ARI to the high-glucose medium. These findings suggest that the alteration in IPL metabolism in BRCP may be related to insufficient myo-inositol or to an activated sorbitol pathway under high glucose conditions. The supplementation of either inositol or ARIs may be used as in vitro therapy for the treatment of "diabetic pericytes".

    在高浓度葡萄糖条件下(模拟糖尿病条件)培养视网膜毛细血管周细胞,由于调控细胞增殖的第二信使——肌醇磷脂代谢产物减少,使周细胞增殖活力降低。在高葡萄糖条件下,周细胞内肌醇水平下降、山梨醇通路被激活;外加肌醇或阻断山梨醇通路则可使异常的肌醇磷脂代谢得到不同程度的纠正,周细胞增殖活力亦随之回升。提示外加肌醇和阻断山梨醇通路是防止糖尿病周细胞衰亡的有效体外治疗。

    Changes of (Na~+-K~+)-ATPase activity,cAMP and fibronectin (FN) content and cellsurface microvilli were studied cytochemically,immunocytochemically and scanning elec-tron microscopically on human stomachGlandular carcinoma (SGC-7901) cells trea-ted with NaBT(2.5mM). It was found that NaBT not only inhi-bited cell growth but also remarkably decrea-sed the activity of cell surface (Na~+-K~+)-ATPase of SGC-7901 cells.Note worthy wasthat,in comparison with the untreated tumorcells,the increase of the intensity of...

    Changes of (Na~+-K~+)-ATPase activity,cAMP and fibronectin (FN) content and cellsurface microvilli were studied cytochemically,immunocytochemically and scanning elec-tron microscopically on human stomachGlandular carcinoma (SGC-7901) cells trea-ted with NaBT(2.5mM). It was found that NaBT not only inhi-bited cell growth but also remarkably decrea-sed the activity of cell surface (Na~+-K~+)-ATPase of SGC-7901 cells.Note worthy wasthat,in comparison with the untreated tumorcells,the increase of the intensity of intracel-lular cAMP and FN immunofluorescence inNaBT-treated tumor cells was striking.More-over,in contrast to untreated tumor cells,the cell surface of NaBT-treated tumor cellsshowed more smooth and fewer microvilliunder SEM. That NaBT may induce differentiation ofSGC-7901 cells through inhibition of (Na~+-K~+)-ATPase activity and modulation of cel-lular cAMP and FN content was discussed.

    应用兔抗纤维粘(连)蛋白(FN)抗体和兔抗3t,5,环腺苷酸(cAMP)特异性抗体,并用羊抗兔IgG荧光抗体,在荧光显微镜下观察丁酸钠对人胃腺癌SGC一7901细胞系的纤维粘(连)蛋白(FN)和cAMP水平的变化。实验结果表明丁酸钠有增强SGC一7901细胞内纤维粘(连)蛋白(FN)和c.~MP水平的作用;应用电镜细胞化学和扫描电镜的技术方法,观察到人胃腺癌SGC一7901细胞在丁酸钠作用下膜表而(Na+一K+)一ATP酶活性明显下降;微绒毛明显减退,膜表面较光滑。这可能说明丁酸钠通过抑制(Na~一K+)一ATP酶活性,提高了细咆内cAMP水平,调控细胞的增殖和分化。

     
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