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二羟基维生素
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  dihydroxyvitamin
    Synthesis of an Optically Active Intermediate of A ring for 19 Nor 1α,25 Dihydroxyvitamin D 3
    光学活性的19-失碳-1α,25-二羟基维生素D_3 A环关键中间体的合成
短句来源
    Cell differentiation and down regulation of nm23 gene expression in HL-60 cells induced by 1,25 dihydroxyvitamin D_3
    1,25-二羟基维生素D_3诱导HL-60细胞分化并下调nm23基因的表达
短句来源
    Objective To investigate the differentiation induction effect of 1,25 dihydroxyvitamin D 3 on leukemia cell line HL 60 and its mechanisms.
    目的 观察 1,2 5 二羟基维生素D3 [1,2 5 (OH) 2 D3 ]对白血病细胞株HL 6 0的诱导分化作用并探讨其机制。
短句来源
    Objective To study the prophylactic effects of 1,25 dihydroxyvitamin D 3 on type 1 diabetes.
    目的 探讨 1,2 5 -二羟基维生素 D3 对环磷酰胺促发的 NOD鼠 1型糖尿病的预防作用。
短句来源
    RT PCR was performed for TNF α,IFN γ and IL 10.Results The incidence of diabetes in the 1,25 dihydroxyvitamin D 3 group was 17% which was obviously less than 67% in control group (P<0.05),and the degree of insulitis in the test group was also less than in the control group.
    结果  1,2 5 -二羟基维生素 D3 处理组糖尿病发病率为 17% ,明显低于对照组 6 7% (P<0 .0 5 ) ,且胰岛炎严重程度也明显减轻。
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  “二羟基维生素”译为未确定词的双语例句
    EFFECT OF 1α, 25-DIHYDROXY-VITAMIN D_3 ON DIFFERENTIATION AND PROLIFERATION OF A HUMAN MYELOID LEUKEMIA CELL LINE
    1α,25二羟基维生素D_3对人早幼粒白血病细胞(HL—60)的诱导分化作用
短句来源
    The Inductive Effects of 1, 25-Dihydroxy-vitamin D_3 on Nerve Growth Factor in L929 Cell
    1,25二羟基维生素D_3对L929细胞神经生长因子的诱导作用
短句来源
    Objective To clarify the molecular mechanism of periodontal tissue remodeling during orthodontic tooth movement by investigating the effects of 1,25-(OH)2D3 on the expression of ODF and OCIF in human periodontal ligament cells (HPDLCs).
    目的观察1,25-二羟基维生素D3[1,25-(OH)2D3]对体外人牙周膜细胞(HPDLC)破骨细胞分化因子(ODF)mRNA及破骨细胞发生抑制因子(OCIF)mRNA表达的影响,探讨正畸牙周组织改建的分子机制。
短句来源
    The Synthesis of A - Ring Synthon for 19 - Nor - 1a, 25 - Dihydroxyvitamin D_3
    19-失碳-1α,25-二羟基维生素D_3A环合成子的合成
短句来源
    STUDY ON DE-C-RING 1α,25-DIHYDROXYVITAMIN D_3 ANALOGUS—I THE SYNTHESIS OF TWO NOVEL CHIRAL D-RING SYNTHON WITH GEM-DIMETHYL GROUP
    失-C-环1α,25-二羟基维生素D_3类似物的研究——I两个含偕二甲基的手性D环合成子的合成
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  dihydroxyvitamin
It has been reported that Dexamethasone (Dex), an active glucocorticoid (GC) analogue, synergizes the stimulatory effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on osteoblast differentiation in the mouse fibroblastic cell line NIH3T3.
      
Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA a
      
The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D3 on dendritic cells.
      
The Atlas Array technology may facilitate the elucidation of complex pharmacological process of 1,25-dihydroxyvitamin D3 on dendritic cells.
      
Since 1αOhase can locally convert 25-hydroxyvitamin D into 1α,25-dihydroxyvitamin D (1,25(OH)2D), an active metabolite of vitamin D, it is suggested that local production of 1,25(OH)2D by macrophages may promote atherosclerotic calcification.
      
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1 α 25-dihydroxy-vitamin D3(1α 25 (OH)2 D3)induced differentiation of human promyelocytic leukaemia cells ( HL-60 ) into mature myeloid cells in vitro. The ratio of nuclei to cytoplasma decreased; Their nucleoli reduced; Cells became irrgular and extended the pseudopods. 1 α 25 (OH ) 2 D3 caused significant increase of nitroblue tetrazolium ( NBT ) reduction and α-non-specific acid esterase (α-NAE ) and acid phosphatase (ACP ) activities. These data and morphological characteristics suggest that HL-60 cells...

1 α 25-dihydroxy-vitamin D3(1α 25 (OH)2 D3)induced differentiation of human promyelocytic leukaemia cells ( HL-60 ) into mature myeloid cells in vitro. The ratio of nuclei to cytoplasma decreased; Their nucleoli reduced; Cells became irrgular and extended the pseudopods. 1 α 25 (OH ) 2 D3 caused significant increase of nitroblue tetrazolium ( NBT ) reduction and α-non-specific acid esterase (α-NAE ) and acid phosphatase (ACP ) activities. These data and morphological characteristics suggest that HL-60 cells were conclusively identified as monocytes/macrophages. The histogram of DNA distribution ahylyzed by flow cytometry demonstrated G0 + G1 phase increased and S phase increased and S phase decreased remarkably after treatment with lα, 25 ( OH ) 2 D3 as compared with untreated cells.

1α,25二羟基维生素D_3在体外可诱导HL-60细胞向单核/巨噬样细胞发展。在形态上,核/质比例减少,核仁减少,细胞变得不规则并伸出伪足;在细胞化学方面,细胞对NBT还原能力增强,α萘酚醋酸酯酶和酸性磷酸酶阳性率明显增加,细胞周期的变化是:二倍体细胞明显增多,G_0+G_1期增加和S期减少。表明在1α,25(OH)_2D_3作用下,HL-60细胞向成熟分化,细胞DNA合成受抑制。

Serum concentration of 25-hydroxyvitamin D [25(OH)D_3] in 592 Beijing normal subjects (age: O-87 years), 256 cases maternal and cord blood and 361 patients with 20 different disorders (altogether1209 subjects) were determined by competitive protein binding assay. Decreased serum levels of 25(OH)D_3 compared with normal ware observed in patients with rickets, tetany, pneumonia infantilehepatitis, bone tumor, diabetes and renal disease and increased serum levels of 26 (OH) D_3 was inpatients with Vitamin D overdose...

Serum concentration of 25-hydroxyvitamin D [25(OH)D_3] in 592 Beijing normal subjects (age: O-87 years), 256 cases maternal and cord blood and 361 patients with 20 different disorders (altogether1209 subjects) were determined by competitive protein binding assay. Decreased serum levels of 25(OH)D_3 compared with normal ware observed in patients with rickets, tetany, pneumonia infantilehepatitis, bone tumor, diabetes and renal disease and increased serum levels of 26 (OH) D_3 was inpatients with Vitamin D overdose and fatty liver. Serum values of 1,25-dihydroxyvitamin D_3 [1,25(OH)_2D_3] were detected by radioreceptor assay in35 Beijing normal subjects, 28 cases of maternal and cord blood and 68 patients (131 in total). Serumvalues of 1,25(OH)_2D_3 was lower than normal in uremic, nephrotic syndrome and osteoporotic patientsand higher than normal in pregnant women. The results show that the variations of serum 25(OH)D_3 and 1,26(OH)_2D_3 are valuble indicatorsfor diagnosis, evaluating treatment and prognosis of metabolic bone disease.

本文采用竞争性蛋白结合法(CPBA)测定1209例受检者血清25羟基维生素D_3[25(OH)D_3],其中包括0~87岁健康人592例,孕妇与新生儿256例,患者361例(20个病种);并采用放射受体法测定131例受检查者血清1,25二羟基维生素D_3[1,25(OH)_2D_3],其中健康人35例,孕妇与新生儿28例,患者68例。结果表明,血清25(OH)D_3和 1,25(OH)_2D_3水平的变化对钙磷代谢失调及代谢性骨病的诊断、评价治疗和预后有重要参考意义。

Abstract

1,25二羟基维生素D_3对L929细胞神经生长因子的诱导作用李贤慧,石育原,甄红英(白求恩医科大学分子生物学中心实验室,长春130021)随着1,25-二羟基维生素D3(1,25-(OH)2-D3)及其受体(VDR)研究的深入,发现(1,25-(O?..

 
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