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   反义治疗组 的翻译结果: 查询用时:0.481秒
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反义治疗组
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  antisense experimental group
    METHODS: There were 7 groups in our study, normal control group, c-erbB-2 sense experimental group, c-raf-1 sense experimental group, c-erbB-2 antisense experimental group, c-raf-1 antisense experimental group, whole-dose experimental group, half-dose experimental group.
    方法:实验分成7组:正常对照组、c-erbB-2正义治疗组、c-raf-1正义治疗组、c-erbB-2反义治疗组、c-raf-1反义治疗组、全剂量联合治疗组和半剂量联合治疗组。
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    Results The growth inhibitory rate in sense experimental group and antisense experimental group was 7.6% and 71.2%,respectively. The tumor response rate of antisense experimental group was 22.7%.
    结果 反义治疗组与正义治疗组的抑瘤率分别为 71.2 %和 7.6% ,反义治疗组肿瘤缩小率为 2 2 .7% ,与正义治疗组相比较有显著性差异。
短句来源
    c erbB 2 expression decreased about 61.0% in the antisense experimental group.
    RT -PCR结果显示反义治疗组c erbB 2表达水平降低约 61.0 %。
短句来源
    Results:The growth inhibitory rate in sense experimental group and antisense experimental group were 6.8% and 68.1%,respectively,the tumor response rate of antisense experimental group was 16.7%.
    结果 :反义治疗组与正义治疗组的抑瘤率分别为 6 8.1%和 6 .8% ,反义治疗组肿瘤缩小率为 16 .7% ,与正义治疗组相比较有明显的差别。
短句来源
    Methods: There were 3 groups in our study: normal control group,c-raf-1 sense oligodeoxynucleotides(SODN) experimental group,and c-raf-1 antisense experimental group.
    方法:实验分3组:正常对照组、c-raf-1正义治疗组、c-raf-1反义治疗组
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  “反义治疗组”译为未确定词的双语例句
    Results: In the ASODN experimental group and SODN group,the OD-value were 0.272 and 1.307 respectively(P<0.05) 72h after transfection;
    结果:反义治疗组与正义治疗组比较:转染72h OD值分别0.272与1.307(P<0.05);
短句来源
    METHODS: There were 7 groups in our study, normal control groupⅠ, c-erbB-2 sense mixed lipofectin (Lip) group Ⅱ, bcl-2 sense mixed Lip group Ⅲ, c-erbB-2 antisense mixed Lip groupⅣ, bcl-2 antisense mixed Lip group Ⅴ, whole-dose bcl-2 and c-erbB-2 antisense mixed Lip group Ⅵ, half-dose bcl-2 and c-erbB-2 antisense mixed Lip group Ⅶ.
    结果:实验组与对照组比较,S期(DNA合成期)有逐渐延长的趋势,其中bcl-2反义寡核苷酸与c-erbB-2反义寡核苷酸+脂质体(半剂量)联合组最为明显。 从细胞形态学观察:反义治疗组观察到线粒体肿胀、凋亡等现象,而bcl-2反义寡核苷酸与c-erbB-2反义寡核苷酸+脂质体(半剂量)联合组最为典型。
短句来源
    2. The changing of histopathological characteristics and ultrscrostructure of tumor tissues in tree different groupsUnder microscope quite a lot tumor cell degeneration and necrosis were observed in tumor nodules given TANKl-ASODN.
    3组肺癌组织中均有表达hTERT mRNA的阳性肿瘤细胞。 对照组、正义组肿瘤细胞胞浆染色阳性程度高,反义治疗组肿瘤细胞呈现弱阳性表达,阳性细胞,l加kyrase反义寡核酸抑制人肺癌细胞系生长作用的基础研究分布较稀少。
短句来源
    C6 gli oma cells were implanted into the cutis of 36 nude mice. Ten days later, the nude mice were randomly divided into three groups and were treated with SON, AON and normal saline respectively.
    在裸鼠接种C6脑胶质瘤细胞株后10天,随机将动物分成正义治疗组(c-myb SON组)、反义治疗组(c-myb AON组)和对照组,每组12只。
短句来源
    Results (1) All the animals of control groups, bearing parental C6 glioma, were died of tumor around 2 weeks after tumor injection, while those of the therapeutic groups treated by antisense IGF 1mRNA, kept alive beyond 80 days with the completely disappearing of the tumor mass.
    结果  (1)颅内种植肿瘤后 ,反义治疗组肿瘤不断减小至 8周后几乎完全消失 ,动物生存期超过 80天的观察期 ,对照组均因肿瘤增大在 2周前后死亡 ;
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This study was aimed at the level and implication of e xpression of c-myb and bcl-2 proteins in C6 glioma. The therapeutic effect of oncogene c-myb antisense oligodeoxynucleotide on C6 glioma in nude mice was studied. C6 gli oma cells were implanted into the cutis of 36 nude mice.Ten days later, the nude mice were randomly divided into three groups and were treated with SON, AON and normal saline respectively.Three mice of every group were killed at 4 days, 8 da ys, 12 days and 16 days after treatment, respectively.The...

This study was aimed at the level and implication of e xpression of c-myb and bcl-2 proteins in C6 glioma. The therapeutic effect of oncogene c-myb antisense oligodeoxynucleotide on C6 glioma in nude mice was studied. C6 gli oma cells were implanted into the cutis of 36 nude mice.Ten days later, the nude mice were randomly divided into three groups and were treated with SON, AON and normal saline respectively.Three mice of every group were killed at 4 days, 8 da ys, 12 days and 16 days after treatment, respectively.The levels of c-myb and Bcl-2 proteins expression in the three groups were observed by the S-P immunohi stochemical method. The results showed the expression of c-myb and bcl-2 protein s was significantly decreased in the AON group, compared with that in the SON and control groups (P<0.05). These data suggest that c-myb and bcl-2 proteins may play an important role in malignant glioma, and c-myb gene and bcl-2 gene may be involved in the tumorigenesis and development of glioma.

为探讨c-myb和bcl-2基因在C6脑胶质瘤细胞中的表达及其作用,作者采用c-myb反义硫代寡核苷酸(AON)进行裸鼠的体内试验。在裸鼠接种C6脑胶质瘤细胞株后10天,随机将动物分成正义治疗组(c-myb SON组)、反义治疗组(c-myb AON组)和对照组,每组12只。分别于治疗后第4、8、12、16天各处死动物3只,切取脑胶质瘤标本,用S-P免疫组化法观察c-myb和bcl-2蛋白的表达情况。结果:c-myb AON组c-myb蛋白和bcl-2蛋白阳性表达率与c-myb SON组和对照组比较,均有显著性差异(P<0.05)。从而提示c-myb蛋白和bcl-2蛋白可能与C6脑胶质瘤的发生、发展有关。

Objective This study was to discuss the exact role of IGF 1 in the development of glioma and to filtrate an effective target for the gene therapy of the brain tumors. Methods An antisense IGF 1 mRNA strategy was performed into the rat C6 glioblastom cells with the liporfecamine assay. A further study was followed by setting up a rodent animal model (Wistar rat) bearing C6 glioma, through which the different biologic characters between the gliomas with and without antisense IGF 1 mRNA were analyzed by pathological...

Objective This study was to discuss the exact role of IGF 1 in the development of glioma and to filtrate an effective target for the gene therapy of the brain tumors. Methods An antisense IGF 1 mRNA strategy was performed into the rat C6 glioblastom cells with the liporfecamine assay. A further study was followed by setting up a rodent animal model (Wistar rat) bearing C6 glioma, through which the different biologic characters between the gliomas with and without antisense IGF 1 mRNA were analyzed by pathological observation as well as MRI scanning, etc. Results (1) All the animals of control groups, bearing parental C6 glioma, were died of tumor around 2 weeks after tumor injection, while those of the therapeutic groups treated by antisense IGF 1mRNA, kept alive beyond 80 days with the completely disappearing of the tumor mass. (2) Compared with the control groups, it was found that a relative increase of apoptotic cells and mononuclear lymphocytes accompanied with a decrease of IGF 1 expression and cell proliferative potential around the tumor site of therapeutic groups.Conclusions The complete regression of glioma in this experiment indicates that antisense IGF 1 strategy, might be a sound therapeutic modality against brain tumors, however, the mechanism of this strategy based not only on the antisense mediated inhibition of IGF 1 expression but also on the antisense mediated enhancement of immune response of the lost.

目的 明确IGF 1在脑肿瘤发生发展中的作用并为基因治疗优选靶的。方法 采用Wistar大鼠C6脑胶质瘤模型进行反义IGF 1基因治疗 ,通过MRI及病理活检等手段 ,动态观察、分析各时限治疗组与对照组动物 (每组 10只 )肿瘤的差别。结果  (1)颅内种植肿瘤后 ,反义治疗组肿瘤不断减小至 8周后几乎完全消失 ,动物生存期超过 80天的观察期 ,对照组均因肿瘤增大在 2周前后死亡 ;(2 )治疗组肿瘤相对于同时限对照组者凋亡细胞、淋巴细胞浸润增加 ;IGF 1表达、细胞增殖活性有所下降。结论 反义IGF 1基因治疗能有效抑制大鼠体内胶质瘤的恶性进展 ,IGF 1表达减少使细胞增殖活性下降和免疫系统攻击增强可能是治疗组肿瘤消失的双重原因

Objective To explore the effect of c erbB 2 antisense oligodeoxynucleotides(ASODN) treatment in the human ovarian epithelial cancer transplanted subcutaneously in nude mice.Methods The model of human ovarian epithelial cancer transplanted subcutaneously was established in 15 nude mice,then divided randomly into 3 groups and different treatment was given respectively(control group,sense experimental group and antisense experimental group).The weight of nude mice and tumor volume were observed,the tumor growth...

Objective To explore the effect of c erbB 2 antisense oligodeoxynucleotides(ASODN) treatment in the human ovarian epithelial cancer transplanted subcutaneously in nude mice.Methods The model of human ovarian epithelial cancer transplanted subcutaneously was established in 15 nude mice,then divided randomly into 3 groups and different treatment was given respectively(control group,sense experimental group and antisense experimental group).The weight of nude mice and tumor volume were observed,the tumor growth inhibitory and the tumor response rate was calculated,too.c erbB 2 gene expressions were compared by RT PCR after treatment among the 3 groups.Results The growth inhibitory rate in sense experimental group and antisense experimental group was 7.6% and 71.2%,respectively.The tumor response rate of antisense experimental group was 22.7%.There was no statistically difference of nude mice weight among the 3 groups.c erbB 2 expression decreased about 61.0% in the antisense experimental group.Conclusion The results suggested that there is a positive value in the human ovarian epithelial cancer transplanted subcutaneously in nude mice treated by c erbB 2 antisense oligodeoxynucleotides,it will be a more important gene therapeutic strategy for the ovarian cancer in the future.

目的 探讨c erbB 2反义寡脱氧核苷酸 (ASODN )对人卵巢癌裸鼠皮下移植瘤的治疗作用。方法 将 15只裸鼠建立人卵巢癌皮下移植瘤模型 ,然后随机分成 3组予以不同条件处理 :对照组 (腹腔注射转染液和脂质体 ) ,正义治疗组 (腹腔注射脂质体 c erbB 2 -SODN ) ,反义治疗组 (腹腔注射脂质体 c erbB 2 -ASODN )。治疗期间定期观测裸鼠体重和肿瘤体积 ,计算抑瘤率及肿瘤缩小率。利用RT -PCR技术比较治疗后各组肿瘤组织中c erbB 2基因水平。结果 反义治疗组与正义治疗组的抑瘤率分别为 71.2 %和 7.6% ,反义治疗组肿瘤缩小率为 2 2 .7% ,与正义治疗组相比较有显著性差异。各组裸鼠体重变化无明显差异。RT -PCR结果显示反义治疗组c erbB 2表达水平降低约 61.0 %。结论 脂质体 c erbB 2 -ASODN对人卵巢癌裸鼠皮下移植瘤有一定的治疗作用 ,可能成为日后卵巢癌基因治疗的重要途径。

 
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