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In order to find out the most effective combined chemotherapeutic regime used for intestinal helminths, this study was designed and carried out. 441 patients were divided into two major groups. The First group,one part of this group were 111 patienls (56 persons infected with Ascaris and 102 with hookworms) treated with albendazole 300mg/d× 1 plus pyrantel 150mg Bid. Three weeks and 5 months after treatment, the total negative rates were 73.9%and 61.3%, in which the negative rates of Ascaris 3 weeks and 5 months... In order to find out the most effective combined chemotherapeutic regime used for intestinal helminths, this study was designed and carried out. 441 patients were divided into two major groups. The First group,one part of this group were 111 patienls (56 persons infected with Ascaris and 102 with hookworms) treated with albendazole 300mg/d× 1 plus pyrantel 150mg Bid. Three weeks and 5 months after treatment, the total negative rates were 73.9%and 61.3%, in which the negative rates of Ascaris 3 weeks and 5 months after treatment were 98.2% and 81.5%, while hookworm, 92.2% and 94.7%. Another part of first group were 109 patients (95 Ascaris, 96 hookworm and 98 Trichuris infections) treated with the same drugs mentioned above and oxantel 225mg Bid in addition.The negative rates of these patients treated after 3 weeks and 5 months were 70.6% and 67.0%, in which the negative rates of Ascaris were 98.9% and 88.3% , while hookworm, 92.7% and 90.1% and Trichuris 87.8% 95.8%. The second group,one part of this group were 120 patients(44 Ascaris and 107 hookworm infections) treated with albendazole of 600mg/d×l. After treatment the total negative rates of this part were 75.8%and 56.7%, in which the negative rates of Ascaris 100% and 88.6%, hookworm 88.8% and 79.6%. Another part of the second group has 101 cases (91 Ascaris, 88 hookworm and 95 Trichuris cases) treated with albendazole 600mg/d×1 plus oxantel 225mg Bid. The total negative rates obtained at same time as mentioned above were 72.3% and 50.5%, in which the negative rates of Ascaris were 94.5% and 86.9%, hookworm 84.1% and 86.2%, and Trichuris 93.7% and 93.3%.The egg reduction rates of all of these groups reached 90~100%. These drugs in combined use had no obvious side effects at all. These results suggested that combined chemotherapy for intestinal helminths is successful not only for the efficacy obtained in short period (3 weeks), but also in longer period (5 months) especially in hookworm and Trichuris infections. 441例线虫感染者分成两大组。甲组:其中111人感染蛔虫56人.钩虫102人,应用丙硫咪唑300mg顿服及噻嘧啶300mg分两次服,治后3周及5月复查,全阴转率73.9%及61.3%,其中蛔虫阴转率98.2%及81.5%,钩虫92.2%及94.7%;另有109人感染蛔虫95人、钩虫96人及鞭虫98人,用上述两药外加酚嘧啶450mg分两次服,治后全阴转率70.6%及67.0%,其中蛔虫98.9%及88.3%,钩虫92.7%及90.1%,鞭虫87.8%及95.8%。乙组:其中120人感染蛔虫44人,钩虫107人,用丙硫唑咪600mg顿服,全阴转率75.8%及56.7%,蛔虫100.0%及88.6%,钩虫88.8%及79.6%;另有101人感染蛔虫91人、钩虫88人,鞭虫95人,用丙硫咪唑600mg顿服及酚嘧啶450mg分两次服,治后全阴转率72.3%及50.5%,蛔虫94.5%及86.9%,钩虫84.1%及86.2%,鞭虫93.7%及93.3%。虫卵减少率各组均达90%以上至100%。各药配伍均未见明显副反应。 Prostaglandin F2α ( PGF2α ) in the brain cortex was measured in mice which were devided into 3 groups, ie sham operation group, cerebral ischemia group and reperfusion after cerebral ischemia group, treated with saline or clonidine ( 0 .15~1 .Omg/kg ) , respectively. The results showed that the PGF2α level in the ischemia group treated with saline was higher than sham operation group, but the PGF2α level in reperfusion group was the highest in all groups. Compared with saline, clonidine decreased the PGF2α levels... Prostaglandin F2α ( PGF2α ) in the brain cortex was measured in mice which were devided into 3 groups, ie sham operation group, cerebral ischemia group and reperfusion after cerebral ischemia group, treated with saline or clonidine ( 0 .15~1 .Omg/kg ) , respectively. The results showed that the PGF2α level in the ischemia group treated with saline was higher than sham operation group, but the PGF2α level in reperfusion group was the highest in all groups. Compared with saline, clonidine decreased the PGF2α levels either in the ischemia group or the reperfusion group significantly . This may be useful to attenuate the brain lesion caused by PGF2α . 将小鼠分为假手术组、脑缺血组和脑缺血后重灌流组三大组,其中后两大组分别又分为生理盐水组、可乐定0.15mg/kg组和可乐定1.0mg/kg组三小组,测定大脑皮质PGF_(2α)含量。结果表明,脑缺血3min可使小鼠脑皮质PGF_(2α)含量显著升高(从平均7.1pg/mg上升到20.4pg/mg),而缺血后重灌流则使PGF_(2α)含量更加升高。与生理盐水组相比,可乐定0.15mg/kg或1.0mg/kg都可显著降低缺血组及缺血后重灌流组小鼠脑皮质PGF_(2α)含量,这有助于减轻缺血及重灌流时PGF_(2α)对脑组织的损害作用。 Using a standardized 24-hr recall method, baseline dietary surveys were done in a total of 813 workers and farmers of Beijing and Guangzhou in autumn of 1983—84 and spring of 1985-86 under the PBC-US cooperative study on CVD epidemiology. A common food table was used to estimate the nutrients intake. The relationship between nutrition factors and serum lipids within population was studied by multiple regression analyses adjusted for age, sex, occupation (workers or farmers), body mass index and alcohol intake.... Using a standardized 24-hr recall method, baseline dietary surveys were done in a total of 813 workers and farmers of Beijing and Guangzhou in autumn of 1983—84 and spring of 1985-86 under the PBC-US cooperative study on CVD epidemiology. A common food table was used to estimate the nutrients intake. The relationship between nutrition factors and serum lipids within population was studied by multiple regression analyses adjusted for age, sex, occupation (workers or farmers), body mass index and alcohol intake. For each subject, the mean intake of nutrients in 6 days (3 in autumn and 3 in spring) was used as independent variables, and the mean serum lipids from two measurements was taken as dependent variable. Results showed that the Keys "dietary lipid score" was positively associated with TC and HDL-C, and specifically, saturated fatty acid within Beijing group and dietary cholesterol within Cuangzhou group were positively associated with serum TC. Saturated and monounsaturated fatty acids were found to he related positively and carbohydrates negatively to HDL-C. 本文应用中美心血管病流行病学合作研究在北京和广州35~54岁工人农民中进行心血管病基线调查时的膳食调查813例资料,对比分析北京和广州工农男女共八个组的营养素摄入量和血脂水平,并在北京和广州两大组人群内分析有关营养因素和血脂的关系。结果表明,在控制年龄、性别、工农、体重指数及饮酒量等混杂变量的条件下,“膳食脂质分值”与血清总胆固醇及高密度脂蛋白胆固醇均呈显著正关联,饱和脂肪酸在北京人群内、膳食胆固醇在广州人群内与血清总胆固醇呈显著正关联。饱和及单不饱和脂肪酸与高密度脂蛋白胆固醇呈正关联,而碳水化合物则呈负关联。未见上述各营养素与血清甘油三酯有显著关联。
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