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卵巢癌手术
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  operation of ovarian cancer
     Objective To evaluate the clinical significance of the serum CA125 level before and after operation of ovarian cancer.
     目的 分析卵巢癌手术前后测定血清CA125水平的临床意义。
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  “卵巢癌手术”译为未确定词的双语例句
     Results:23 of 24 specimens((95.83%)) can be evaluated by ATP-TCA,the sensitive rates of ATP-TCA was 91.30% for TAX,86.96% for GEM,65.22% for ADM,47.83% for TPT and 21.74% for DDP,respectively.
     结果:24例上皮性卵巢癌手术标本中,ATP-TCA可评价率95.83%,所测标本对药物的体外敏感率依次为泰素91.30%,吉西他滨86.96%、多柔比星65.22%、拓扑替康47.83%、顺铂21.74%。
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     Expression of Survivin mRNA was significantly correlated with cancer stage classification (P<0.05),but negatively related with pathological type,histological grade,and lymph node metasatasis (P>0.05).
     腹水或腹腔冲洗液中SurvivinmRNA的阳性表达与卵巢癌手术病理分期有关(P<0.05),与病理类型、组织分级和淋巴转移无明显相关性(P>0.05)。
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     Clinical Significance of Combined Determination of the Changes of Serum NO, TGF-α and TNF Levels After Operation in Patients with Ovarian Cancer
     卵巢癌手术治疗前后血清NO、TGF-α和TNF联检的临床意义
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     Objectives: To study the potential molecular mechanism of the chemosensitive difference between human ovarian epithelial and germ cell tumor by testing the expression of p53(mutation),Bcl-2,Topo Ⅱα in paraffin embedded tissue from human ovarian tumor.
     采用组织芯片,免疫组化技术,同时对人上皮性卵巢癌和生殖细胞性卵巢癌手术标本中p53(突变型),Bcl-2,Topo Ⅱ α蛋白的表达情况进行检测,了解这三种与肿瘤化疗敏感性有关的蛋白在这两种对化疗敏感性不同的卵巢癌中的表达情况,初步探讨上皮性卵巢癌和生殖细胞性卵巢癌化疗敏感性差异的分子机理。
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     Anterior-posterior views of thepelvis and abdomen were obtained routinely withycamera dunng 18~24 hour after the application ofantibody. The results of RII were compared with thefindings in operation or CT examination. Sensitivity indiagnosis was 100%(13 /13), specificity was94%(16 /17) and metastatic foci sensitivity was63 %(10/16).
     结果:卵巢恶性肿瘤RII的阳性检出率为100%(13/13),卵巢癌手术、化疗后无复发和卵巢及其他良性病变的阴性预测率为94%(16/17),肿瘤转移灶的检出率为63%(10/16)。
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     The Technological Improvements of Cytoreductive Surgery in Advanced Epithelial Ovarian Cancer
     晚期卵巢癌减瘤手术技术的改进
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     operation.
     手术治疗。
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     Technology of surgery navigation
     手术导航技术
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     CISPLATIN REGIMENS WITH SURGERY IN THE TREATMENT OF ADVANCED OVARIAN CANCER
     顺氯氨铂联合化疗配合手术治疗晚期卵巢癌
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     Immunotherapy for ovarian cancer
     卵巢癌的免疫治疗
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Human Ovary Embryo Carcinoma (OEC) removed surgically have been transplanted into nude mi-

本文利用卵巢癌手术标本建立体外细胞系及裸鼠移植瘤(OEC)。将来自同一病人的脾淋巴细胞体外经重组人类白细胞介素2活化为LAK细胞。裸鼠体内进行的Winn氏中和试验结果表明,L-AK细胞能有效地抑制自体恶性肿瘤在裸鼠体内的成瘤现象。

adioimmunoimaging (RI I) assay with  ̄(99m)Tc la-beled anti-CEA monoclonal antibody was performedin 31 patients with suspected primary or reccurrentmaligment ovarian tumor. The radiation dose ragingirom 920MBq to 110MBq(1mgIgG) was administeredi.v for each patient. Anterior-posterior views of thepelvis and abdomen were obtained routinely withycamera dunng 18~24 hour after the application ofantibody. The results of RII were compared with thefindings in operation or CT examination. Sensitivity indiagnosis was 100%(13...

adioimmunoimaging (RI I) assay with  ̄(99m)Tc la-beled anti-CEA monoclonal antibody was performedin 31 patients with suspected primary or reccurrentmaligment ovarian tumor. The radiation dose ragingirom 920MBq to 110MBq(1mgIgG) was administeredi.v for each patient. Anterior-posterior views of thepelvis and abdomen were obtained routinely withycamera dunng 18~24 hour after the application ofantibody. The results of RII were compared with thefindings in operation or CT examination. Sensitivity indiagnosis was 100%(13 /13), specificity was94%(16 /17) and metastatic foci sensitivity was63 %(10/16). The serum CA_(125) in this study appearedto be correlated with the results of RII. However. in 2patients with nomial serum CA_(125) titers RII revealedtrue positive.The preliminary clinical results of RII with ̄(99m)Tc-MAb showed that RII is a promising methodfor the detection of malignant ovarian tumors.

应用放射性核素锝( ̄(99m)Tc)标记抗癌胚抗原(CEA)单克隆抗体(McAb)放射免疫显像(RII),对13例卵巢恶性肿瘤、4例卵巢癌手术、化疗后无复发的病人以及13例卵巢及盆腔内其他良性病变的病人,在注射标记抗体后第18、24小时进行盆腹腔前后位平面显像观察。结果:卵巢恶性肿瘤RII的阳性检出率为100%(13/13),卵巢癌手术、化疗后无复发和卵巢及其他良性病变的阴性预测率为94%(16/17),肿瘤转移灶的检出率为63%(10/16)。提示: ̄(99m)Tc-CEA-McAb的RII对卵巢恶性肿瘤的定性、早期诊断有一定意义。

Splicing variants of CD 44 molecules (CD 44 v) has been known to be involved in malignant transformation and metastasis of different types of human tumors. However, their status as well as role(s) in ovarian cancers are still in dispute. In this study, CD 44 expression patterns in normal ovarian epithelium,benign ovarian tumors and ovarian cancers were checked immunohistochemically using a series of monoclonal antibodies (MAbs) against the epitopes of standard form of CD 44 (CD 44...

Splicing variants of CD 44 molecules (CD 44 v) has been known to be involved in malignant transformation and metastasis of different types of human tumors. However, their status as well as role(s) in ovarian cancers are still in dispute. In this study, CD 44 expression patterns in normal ovarian epithelium,benign ovarian tumors and ovarian cancers were checked immunohistochemically using a series of monoclonal antibodies (MAbs) against the epitopes of standard form of CD 44 (CD 44 s) and CD 44 variant exons respectively. The results revealed that CD 44 v was negative in normal ovarian tissues; 4 out of 25 benign tumors were found with focally expressed variant exons 8 10 (v8 v10), but negative for other exons. In contrast, multiple isoforms of CD 44 v were detected in all of the ovarian cancer cell lines; among those isoforms,v7 was distinctively up regulated and commonly distributed. Our data thus suggest that expressions of CD 44 v especially v7 occur at relatively late stage of stepwised ovarian carcinogenesis which would become a new malignant biomarker and potential immunodiagnostic element for ovarian cancers.

细胞粘附因子CD44的变异型(CD44v)出现在多种肿瘤的恶性转化过程中并与这些肿瘤的转移能力密切相关。然而,CD44基因在良恶性卵巢肿瘤中的表达类型尚无定论。为此,本研究使用特异性识别CD44分子不同抗原决定簇的单克隆抗体,对正常卵巢组织以及良性和恶性肿瘤的CD44表达类型进行免疫组织化学分析。结果显示,CD44v在正常卵巢内呈阴性;25例良性肿瘤中,21例阴性,4例有灶局性变异型外显子v8-v10的表达;相反,26例卵巢癌手术切除标本和2株卵巢癌细胞系Caov3和Ovca3有多种形式的CD44v存在;其中,v7的表达明显上调。2例交界性肿瘤的表达形式与卵巢癌相似,但呈灶局阳性。本结果因而提示,CD44v尤其是v7出现在卵巢癌恶性转化的过程中;它(们)可能成为该类肿瘤新的生物标志物并在癌细胞转移中起促进作用。

 
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