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慢性丙型肝炎病毒
相关语句
  chronic hepatitis c virus
     Effect of IL-12 on lymphoproliferative response in individuals with chronic hepatitis C virus infection
     IL-12对慢性丙型肝炎病毒感染者淋巴细胞增殖的影响
短句来源
     Enhanced ability of peripheral invariant natural killer T-cells to produce IL-13 in chronic hepatitis C virus infection
     慢性丙型肝炎病毒感染者外周血恒定型自然杀伤T细胞分泌IL-13的能力增强
短句来源
     Treatment of chronic hepatitis C virus infection via antioxidants: Results of a phase I clinical trial
     抗氧化剂治疗慢性丙型肝炎病毒感染:I期临床试验结果
短句来源
     Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection
     单一干扰素治疗年轻慢性丙型肝炎病毒感染者的疗效
短句来源
     To inquire the relationship between chronic hepatitis C virus(HCV)infection and type 2 diabetes.
     探讨慢性丙型肝炎病毒(HCV)感染与Ⅱ型糖尿病发病的关系。
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  “慢性丙型肝炎病毒”译为未确定词的双语例句
     Results At the end of treatment and of follow-up period, the negative rates of HCVRNA among patients with genotype Ⅱ were 45.45% (15/33) and 27.27%(9/ 33), while the normalization rates of alanine aminotransferase were 63.64%(21/33) and 33.33%(11/33), respectively;
     结果 治疗结束及随访结束时,33例慢性丙型肝炎病毒基因Ⅱ型患者中,HCV RNA阴转率为45.45%(15/33)和27.27%(9/33),ALT的复常率分别为63.64%(21/33)和33.33%(11/33);
短句来源
     Methods Polymerase chain reaction restriction fragment length polymorphisms(PCR-RFLP) method was used to detect HincⅡ polymorphism of the LDL-R gene in 84 patients infected with HCV and 72 healthy blood donors.
     方法采用聚合酶链反应结合限制性片段长度多态性(PCR-RFLP)的方法,对84例慢性丙型肝炎病毒(HCV)感染者和72名健康献血员进行LDL-R基因HincⅡ多态性检测。
短句来源
     Methods Clinical data of 189 hepatitis C patients who were hospitalized from July 2001 to July 2004 were surveyed retrospectively.
     方法对2001年7月-2004年7月间189例住院慢性丙型肝炎病毒(HCV)感染患者的临床资料进行回顾性分析。
短句来源
     Background/Aims: To investigate the relationship between T lymphocyte subsets, serum levels of IL-2, sIL-2R and HCV RNA proliferation state.
     目的:探讨慢性丙型肝炎病毒感染患者HCV RNA增殖状态与T细胞亚群功能及血浆中IL-2和SIL-2R活性的关系。
短句来源
     Objective To clarify the significance of antibodies to hypervariable region 1(HVR 1) of hepatitis C virus (HCV) in chronic HCV-infected patients.
     目的 探讨慢性丙型肝炎病毒 (HCV)感染者血清中抗高变区 1 (HVR1 )抗体的多型性及其临床意义。
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  相似匹配句对
     Chronic hepatitis C in children: clinical and pathological features and HCV RNA in serum and liver tissues
     慢性肝炎病毒核酸的分布特征
短句来源
     Diagnosis and treatment of chronic hepatitis C infection
     慢性肝炎病毒感染的诊断和治疗
短句来源
     THE CORRELATIVE MECHANISM FOR THE CHRONICITY OF HCV INFECTION
     肝炎病毒感染慢性化的相关机制
短句来源
     Hepatitis C virus(HCV)is an important cause of chronic liver disease.
     肝炎病毒感染是导致慢性肝病的重要原因。
短句来源
     An Epidemiological Study on the Rate of Becoming Chronic in HCV Infection
     肝炎病毒感染后慢性转化率的流行病学研究
短句来源
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  chronic hepatitis c virus
Renal involvement in patients with chronic hepatitis C virus infection
      
There is an increasing recognition of the association between chronic hepatitis C virus (HCV) infection and glomerular diseases.
      
The primary therapy for patients with chronic hepatitis C virus (HCV) infection is interferon.
      
At the current time, therapy for patients with chronic hepatitis C virus with normal ALT levels should be based on results from a liver biopsy and preferably in the context of a clinical trial.
      
Early identification and consideration for antiviral treatment of chronic hepatitis C virus (HCV) is an important component in reducing morbidity and mortality.
      
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In order to investigate variation in hepatitis C virus (HCV) nonstructural 5b (NS5b) nucleotide sequence and the relationship with interferon treatment, cDNA containing in this region were obtained by reverse transcription polymerase chain reaction from the sera of 4 HCV RNA positive asymptomatic chronic carriers and 9 chronic hepatitis C patients. The cDNA were then directly analysed by polymerase chain reaction directed sequencing. Compared with three published HCV type Ⅱ/1b sequences (HCV J, HC C2 and...

In order to investigate variation in hepatitis C virus (HCV) nonstructural 5b (NS5b) nucleotide sequence and the relationship with interferon treatment, cDNA containing in this region were obtained by reverse transcription polymerase chain reaction from the sera of 4 HCV RNA positive asymptomatic chronic carriers and 9 chronic hepatitis C patients. The cDNA were then directly analysed by polymerase chain reaction directed sequencing. Compared with three published HCV type Ⅱ/1b sequences (HCV J, HC C2 and HCV BDS), the homology of HCV was lower in the patients with chronic hepatitis C (93.52%±2.09% average), especially in nonresponders to interferon (92.70±1.90% average), than in asymptomatic HCV carriers (95.65±2.61%). In 5 patients, HCV RNA was eliminated by interferon treatment. In the remaining 4 interferon-treated HCV survived patients there were 9-48 nucleotide substitutions in HCV mutants out of 380 nucleotides, resulting 6-20 amino acids changes out of 126 amino acids. These results suggested that NS5b region variants play an important role in maintaining persistent infection and the evolution of NS5b is associated with the effect of interferon treatment.

以聚合酶链反应直接序列分析方法测定了4例无症状慢性丙型肝炎病毒(HCV)感染者,与9例接受干扰素治疗的慢性丙型肝炎患者血清中HCV非结构基因5b(NS5b)cDNA的序列。发现,与已发表的Ⅱ/1b型HCV序列相比,无症状慢性HCV感染者的HCV在核苷酸水平的同源性高于干扰素治疗有效的慢性丙型肝炎患者(95.65%±2.61%比94.35%±2.29%),后者又高于干扰素治疗无效的慢性丙型肝炎患者(92.70%±1.90%)。还发现在干扰素治疗后,治疗无效者血清中HCVNS5bcDNA序列发生明显变化,在所测定的380个核苷酸中有9~48个发生碱基替换,从而导致所编码的氨基酸中有6~20个发生突变。结果提示,HCVNS5b基因变异与病情及干扰素治疗有一定关系。变异较大者常出现明显的临床表现,且干扰素治疗可能趋势于失败。

To investigate the relationship between cellular immune function and the infection status of viruses in chronic HCV infection,peripheral blood T-lymphocyte subsets and serum levels of IL-2 and sIL-2R were determined by indirect immuno-fluorescence and ELISA in 75 patients with chronic HCV infection, of which 45 cases were HCV-RNA positive and 28 cases HCV-RNA negative. The HCV-RNA was determined by RT-PCR. It was found that the CD3+ and CD4+ T cell subsets , CD4+/CD8+ ratio and the blood levels of IL-2 of patients...

To investigate the relationship between cellular immune function and the infection status of viruses in chronic HCV infection,peripheral blood T-lymphocyte subsets and serum levels of IL-2 and sIL-2R were determined by indirect immuno-fluorescence and ELISA in 75 patients with chronic HCV infection, of which 45 cases were HCV-RNA positive and 28 cases HCV-RNA negative. The HCV-RNA was determined by RT-PCR. It was found that the CD3+ and CD4+ T cell subsets , CD4+/CD8+ ratio and the blood levels of IL-2 of patients were significantly lower than those of the controls, but the level of sIL-2 increased significantly. The T cell subsets, CD4+/CD8+ ratio and blood levels of IL-2 of HCV-RNA positive cases were significantly lower than those of the HCV-RNA negative cases. It suggests that suppression of the cell mediated immunity might be the cause of HCV persistant infection.

目的:探讨慢性丙型肝炎病毒(HCV)感染患者丙型肝炎病毒RNA(HCV RNA)增殖状态与T细胞亚群功能及血浆中IL-2和slL-2R活性的关系。方法:以间接免疫荧光法,ELISA法和RT-PCR分别检测75名慢性HCV感染患者(其中HCV RNA阳性47例,HCV RNA阴性28例)外周血T细胞亚群,IL-2及sIL-2R的水平和HCV RNA。结果:慢性HCV感染患者周围血CD3~+,CD4~+淋巴细胞亚群,CD4~+/CD8~+比值及IL-2水平均显著低于正常对照组(P<0.01),而sIL-2R明显升高(P<0.01);血清HCV RNA阳性患者T细胞亚群,CD4~+/CD8~+比值及IL-2水平显著低于HCV RNA阴性患者(p<0.01)。结论:慢性HCV感染患者的机体免疫功能紊乱。细胞免疫功能低下,HCV RNA阳性患者较阴性患者更甚,提示细胞免疫功能受抑可能是HCV持续增殖的原因。

Objective: To evaluate the efficacy of oxymatrine in treating chronic hepatitis C and its mechanism. Methods: Forty three patient were divided randomly into the treated group (20 cases) and the control group (23 cases). The treated group was given oxymatrine 600 mg per day intramuscularly, and the control group was given the general liver protective agents such as vitamins. The therapeutic course of both groups was 3 months. Results: HCVRNA of 8 in 17 cases (47 1%) of the treated group converted to negative,...

Objective: To evaluate the efficacy of oxymatrine in treating chronic hepatitis C and its mechanism. Methods: Forty three patient were divided randomly into the treated group (20 cases) and the control group (23 cases). The treated group was given oxymatrine 600 mg per day intramuscularly, and the control group was given the general liver protective agents such as vitamins. The therapeutic course of both groups was 3 months. Results: HCVRNA of 8 in 17 cases (47 1%) of the treated group converted to negative, while in 18 cases of the control group, the negative conversion only took place in 1 patient (5.6%), the negative conversion rate was significantly higher in the treated group than that in the control group (P<0 05). The normalization rates of serum alanine transaminase (ALT) of the treated group after 1 month and 2 months treatment was higher than that of the control group, but after 3 months treatment, the normalization rates of the two groups were not different significantly. Plasma level of soluble interleukin 2 receptor and serum level of collagen type Ⅳ in the treated group were lowered significantly after treatment, but in the control group, there were no significant change, the difference between the two groups was significant (P<0 01,P<0 05). Conclusion: Oxymatrine is effective in inhibiting proliferation of HCV, antagonisting liver fibrosis and regulating immune reaction of the host, so it could be a safe, effective durg in treating chronic hepatitis C.

目的 :初步探讨氧化苦参碱治疗慢性丙型病毒性肝炎的效果及其机制。方法 :43例慢性丙型肝炎病毒(HCV)感染患者随机分为治疗组 (2 0例 )和对照组 (2 3例 )。治疗组给予氧化苦参碱每日 60 0mg肌肉注射 ,对照组给予维生素类一般护肝药物 ,疗程均为 3个月。结果 :治疗组可统计病例 1 7例中血清HCVRNA转阴 8例(47 1 % )、对照组可统计病例 1 8例中血清HCVRNA转阴 1例(5 6% ) ,两组转阴率比较有显著性差异 (P <0 0 5 )。治疗组治疗第 1、2个月末血清丙氨酸转氨酶(ALT)复常率均高于对照组(均为P <0 0 5 ) ,但治疗结束时两组复常率间无显著性差异。治疗组治疗后血浆可溶性白介素 2受体(SIL 2R)水平和血清IV型胶原(IV CL)水平较治疗前显著下降(分别为P <0 0 1、P <0 0 5 ) ,对照组治疗前后SIL 2R和IV CL水平无显著性差异 (均为P >0 0 5 )。治疗组血浆SIL 2R水平和血清IV CL水平下降值显著高于对照组 (分别P <0 0 1 ,P <0 0 5 )。结论 :氧化苦参碱有抑制H...

目的 :初步探讨氧化苦参碱治疗慢性丙型病毒性肝炎的效果及其机制。方法 :43例慢性丙型肝炎病毒(HCV)感染患者随机分为治疗组 (2 0例 )和对照组 (2 3例 )。治疗组给予氧化苦参碱每日 60 0mg肌肉注射 ,对照组给予维生素类一般护肝药物 ,疗程均为 3个月。结果 :治疗组可统计病例 1 7例中血清HCVRNA转阴 8例(47 1 % )、对照组可统计病例 1 8例中血清HCVRNA转阴 1例(5 6% ) ,两组转阴率比较有显著性差异 (P <0 0 5 )。治疗组治疗第 1、2个月末血清丙氨酸转氨酶(ALT)复常率均高于对照组(均为P <0 0 5 ) ,但治疗结束时两组复常率间无显著性差异。治疗组治疗后血浆可溶性白介素 2受体(SIL 2R)水平和血清IV型胶原(IV CL)水平较治疗前显著下降(分别为P <0 0 1、P <0 0 5 ) ,对照组治疗前后SIL 2R和IV CL水平无显著性差异 (均为P >0 0 5 )。治疗组血浆SIL 2R水平和血清IV CL水平下降值显著高于对照组 (分别P <0 0 1 ,P <0 0 5 )。结论 :氧化苦参碱有抑制HCV增殖 ,抗肝纤维化及调节宿主免疫反应的作用 ,可能成为治疗慢性HCV感染安全而有效的药物。

 
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