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精神分裂症
相关语句
  schizophrenia
    Schizophrenia And Humoral Medium
    精神分裂症与体液介质
短句来源
    Schizophrenia treated with metoclopramide in 17 patients
    甲氧氯普胺治疗精神分裂症17例
短句来源
    A preliminary study of efficacy of risperidone on treating schizophrenia and clinical application of PANSS
    维思通治疗精神分裂症疗效与PANSS应用的初步研究
短句来源
    Analysis of Antipsychotics Used for Schizophrenia in44Hospitals in Guangdong Province During the Pe-riod2000~2002
    2000年~2002年广东地区44家医院抗精神分裂症药物应用分析
短句来源
    METHODS:60 patients with schizophrenia were randomly allocated to receive 2 mg,4 mg,or 6 mg risperidone for 8 weeks.
    方法:将60例精神分裂症住院患者随机分成2,4,6mg三组,给予利培酮口服治疗8周,开放性对照3组间的疗效、不良反应。
短句来源
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  “精神分裂症”译为未确定词的双语例句
    Meta-analysis of comparative study in treatment of negative symptom between risperidone and other antipsychotics.
    维思通与其它抗精神病药物治疗精神分裂症阴性症状对照研究的Meta分析
短句来源
    A positive correlation between SOD activity and total BPRS scores was found (r=0.588,P< 0.05).
    研究发现精神分裂症病人红细胞SOD活性改变与BPRS总分呈正相关(γ=0.588,P<0.05)。
短句来源
    Itsuggested that the atrophy degeneration ofschizophrenic patients' brain tissues were caused bythe long - term exitement of the brain dopamine,not by antipsychotics.
    因此推测,精神分裂症病人脑组织萎缩变性是病人脑多巴胺长期亢盛导致脑组织萎缩性改变,而不是长期应用拮抗剂--抗精神病药物所致。
短句来源
    Methods one hundred patients with schizophenia were treated with risperidone or clozapine who were selected randomly from Hebei Mental Health Center. (2002.6.1-2003.6.1)aged from18-65.Using home-made questionaire.
    方法随机抽取2002年6月1日 -2003年6月1日间在河北省精神卫生中心住院、年龄18~65岁、符合CCMD -3精神分裂症诊断标准、分别接受利培酮、氯氮平治疗的100例患者 ,用自制调查表进行调查患者治疗前后血糖、血脂的变化 ,用BPRS评定疗效。
短句来源
    Predictors of haloperdol induced acute akathisia in schizophrinia.
    氟哌啶醇治疗精神分裂症所致急性静坐不能的预测因素
短句来源
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  schizophrenia
Alterations in components of glutamatergic system and glutamate metabolizing enzymes are considered with reference to mental disorders such as senile dementia of Alzheimer's type and schizophrenia.
      
The molecular pathways for mental development, common forms of autisms, schizophrenia, and affective disorders have yet to be elucidated.
      
MicroRNA in schizophrenia: Genetic and expression analysis of miR-130b (22q11)
      
MiR-130b expressed in the brain and potentially targeting MECP2 is located in the susceptibility locus for schizophrenia (22q11).
      
Genetic association analysis of 300 schizophrenia and 316 normal control individuals revealed no statistically significant association of any of the miR-130b allelic variants with schizophrenia.
      
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  schizopherenia
Association, if any, of these allelic variants with schizopherenia has been tested using a case-control approach.
      
Speculation as to the psychic and biochemical relationship between celiac syndrome and schizopherenia suggests a basis for additional research.
      


Experiments were conducted on fiftymale rabbits to identify the concomi-tant changes both of the EEG and thebehavior as an epileptic pattern causedby the adminstration of Coriaria Lac-tone and to find out an adequate doseof this drug to induce a high frequencyof epileptic seizure with a low mor-tality rate. Coriaria Lactone, manufactured bythe pharmaceutical laboratory of Si-chuan Medical College, is an activeconstituent of Loranthus on Coriariasinica Maxim, a medicinal herb, whichhas long been known having...

Experiments were conducted on fiftymale rabbits to identify the concomi-tant changes both of the EEG and thebehavior as an epileptic pattern causedby the adminstration of Coriaria Lac-tone and to find out an adequate doseof this drug to induce a high frequencyof epileptic seizure with a low mor-tality rate. Coriaria Lactone, manufactured bythe pharmaceutical laboratory of Si-chuan Medical College, is an activeconstituent of Loranthus on Coriariasinica Maxim, a medicinal herb, whichhas long been known having beneficialeffect on some form of psychosis intraditional Chinese medicine and wasrecently demonstrated effective for thetreatment of schizophrenia by psychia-trists in our and other hospitals. Anepileptic-like convulsion was usuallyfound in those patients using the drugas a cure. In our previous experimentsthe effects of Coriaria Lactone onbehavior and EEG of the rabbit wereobserved.It was found that the Coria-ria Lactone caused convulsion andEEG changes which were much thesame as those of the epileptic patients,and there seemed to be a dose-depen-dent effect. These findings raised thepossibility of inducing epileptic seizureby Coriaria Lactone. In our present work,further observa-tions were made. Thus, when theexperimental animal was conscious andunrestrained the EEG of the animalwas recorded by telemetric methodwhich made the simultaneous observa-tion of both EEG and behavior seizurespossible. The fifty rabbits, weighing2.0-2.8 kg, were divided arbitrarilyinto four groups, three of which weredesigned for testing the optimum dosageand the remaining one for examiningthe possibility that conventional anti-epileptics, sodium phenobarbital, couldantagonize the effects induced by theoptimum dosage. The results were: 1. In group of 2mg/kg dosage therewas no effect. In group of 3mg/kg dosage the effect was significant: therate of seizure was 100%, i.e. all theanimals tested in this group had aseizure, with a death rate of 13.3%,whereas in group of 4mg/kg dosagethe death rate was 66.7% which muchhigher than that of the former group(P<0.01 ) though the rate of seizure(100% ) was the same. From thesedata it showed that 3 mg/kg could bethe optimum dosage of Coriaria Lac-tone for inducing an epileptic seizure. 2. The seizure revealed by EEG re-cording and behavior observation (insome cases cinematograph was taken)showed typical epileptic characteris-tics. On the other hand, this CoriariaLactone-caused seizure was antagonizedby preinjection of sodium phenobarbital(50mg/kg) 2 hours before the injectionof Coriaria Lactone. Thereby, it wasshown from both the obverse and thereverse sides that Coriaria Lactonewas an effective agent for inducingepileptic seizure. 3. Repeated injections of Coriaria Lac-tone (3mg/kg ) induced correspondingrepeated seizures when the dosage usedand the time interval chosen weresuitable. This suggested that the accu-mulation action of Coriaria Lactonewas not significant in the body. Although a researcher in his experi-ment may observe the behavior and EEGrecord separately, we think it best torecord both the indices at the sametime because antiepileptic drugs affectthe behavior and EEG of epilepsyseizure differently. Some drugs havea depressant effect on EEG seizurewhile others do not affect the beha-vioral seizure. Still some others justact in the reverse manner. In our pre-sent experiment we observed both thebehavioral and EEG seizure patternsby Coriaria Lactone at the same time. In our investigation an easy andeffective model of animal was offered.

本文报告以家兔作为实验动物,用马桑内酯造成癫痫模型。所用方法简便可靠。本模型可用于探索马桑内酯治疗精神分裂症的作用机理,也可用于探索癫痫发生机理及筛选抗癫痫药物。

Owing to lack of highly sensitive spectrophotometer at present,medium voltagepaper electrophoresis was used in the determination of γ-aminobutyric acid in humancerebrospinal fluid.The method was proved to be successful.First of all,a powderwas prepared from the CSF by means of freezing and drying,so that the GABA perunit volume of CSF was concentrated.The standard curve of GABA showed a goodcorrelation between its optical density and concentration,obtainig a straight lineranging from 0.50-8.00μg,the recovery...

Owing to lack of highly sensitive spectrophotometer at present,medium voltagepaper electrophoresis was used in the determination of γ-aminobutyric acid in humancerebrospinal fluid.The method was proved to be successful.First of all,a powderwas prepared from the CSF by means of freezing and drying,so that the GABA perunit volume of CSF was concentrated.The standard curve of GABA showed a goodcorrelation between its optical density and concentration,obtainig a straight lineranging from 0.50-8.00μg,the recovery rate was 94.5±2.3%.From our study of11 normal subjects and 31 Schizophrenia patients,it is indicated that both the sensi-tivity and reproducibility of this method are worth recommending.

本文采用冰冻干燥浓缩脑脊液,用纸上电泳法分离γ-氨基丁酸与谷氨酸。测定了正常健康人11名与精神分裂症病人31名的脑脊液中γ-氨基丁酸与谷氨酸含量。本法回收率,灵敏度及重现性均较好,用于临床检验是简便可行的。

The relationship between schizophrenia and humoral medium was studied by many investigators for many years. These study results were reviewed as follows: 1. No change in immunological levels between schizophrenia patients and normals was found by most of investigators, but a few of investigators showed that immunity of schizophrenia patients were different from that of normals. 2. The activity of monoamine oxidase(MAO) and it's catalysing catabolite levels have significant diffence between schizophrenia and...

The relationship between schizophrenia and humoral medium was studied by many investigators for many years. These study results were reviewed as follows: 1. No change in immunological levels between schizophrenia patients and normals was found by most of investigators, but a few of investigators showed that immunity of schizophrenia patients were different from that of normals. 2. The activity of monoamine oxidase(MAO) and it's catalysing catabolite levels have significant diffence between schizophrenia and normals. Catabolites of MAO include dopamino, 5—hydroxytryptamine and norepiaephiae et al. 3. Humoral substance like opioid peptides was likly to relate to schizophrenia.

很多医学科学工作者对精神分裂症与体液介质的关系己经研究多年,其情况大概有下列几个方面。 1.大部分人在研究精神分裂症与免疫能力的关系时没有发现精神分裂症病人与正常人有什么不同,但少数研究人员认为精神分裂症病人的免疫力与正常人有所不同。 2.大多数的研究主要集中于单胺氧化酶及其代谢产物方面,精神分裂症病人的单胺氧化酶话性及其摧化代谢产物水平与正常人有明显的不同。单胺氧化酶的代谢产物主要有多巴胺,5—羟色胺及去甲肾上腺素等。 3.另外,类鸦片样多肽物质也几乎也与精神分裂症有关。

 
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