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精神分裂症患者
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  schizophrenia
    METHODS:41 patients with schizophrenia were randomly divided to receive risperidone( n =21) in a dose of 4~6 mg/d for 8 weeks or chlorpromazine( n =20)in a dose of 350~600 mg/d for 8 weeks.
    方法:将精神分裂症患者41例随机分成2组,21例予利培酮4~6mg/d,po治疗,20例予氯丙嗪350~600mg/d,po治疗,8周后进行对照研究。
短句来源
    This article reports on electrocardiogram(ECG) of 376 cases schizophrenia using clozapine per os. The result showed the rate of abnormal ECG is 80.0% (301 cases),the male 76.9% (220 cases)and the female 90.0% (81 cases). The difference between male and female is significance(X2= 7.33, P<0.01).
    本文观察了376例口服氯氮平的精神分裂症患者的心电图改变,发现心电图异常改变的301例,发生率80.0%,其中男性286例中有220例(76.9%),女性90例中有81例(90.0%),女性心电图异常改变发生率明显高于男(x2=7.33,P<0.01);
短句来源
    AIM: To approach the relationship between the metabolism of clozapine in the body of patients with schizophrenia and polymorphisms of 2964 locus in cytochrome P450 1A2 (CYP1A2) for the reasonable use of clozapine.
    目的 :探讨氯氮平在精神分裂症患者体内代谢和细胞色素P4 5 0 1A2 2 964位点多态性关系 ,指导临床对不同患者合理使用氯氮平。
短句来源
    Methods 198 inpatients with Schizophrenia were untreated or stopped antipsychotics beyond 3 months,were randomly chosen.
    方法随机选择198例未曾治疗或停药3个月以上的精神分裂症患者,分别接受利培酮、氯丙嗪治疗。
短句来源
    Clozapine levels in plasma and its therapeutic effects in 18 patients with schizophrenia
    氯氮平在18例精神分裂症患者中的血药浓度及其疗效
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  “精神分裂症患者”译为未确定词的双语例句
    Results:The blood glucose level was higher in group clozapine than other two groups(P<0.01),but no changes in group chlorderazin and Risperidone before and after drug treatment(P>0.05).
    结果:氯氮平组的精神分裂症患者治疗后血糖较治疗前明显升高(P<0.01),氯丙嗪和利培酮组治疗后血糖无明显变化(P>0.05)。
短句来源
    Results Compared with the normal persons,both the levels of serum LP0 and SOD were obvi. ously higher(P<0.05,P<0.01)and GPX low-er(P
    结果精神分裂症患者血清LPO含量和SOD活性均明显高于正常人(P<0.05,P<0.01),GPX活性明显低于正常人(P<0.01);
短句来源
    OBJECTIVE: To evaluate the influence of smoking and sex on the clinical pharmacokinetics of clozapine and its metabolite norclozapine after oral administration of fix dose (6 mg·kg -1 ) of clozapine to 30 schizophrenic patients (10 smokers, 20 non smokers).
    目的:研究30例精神分裂症患者服用固定剂量(6mg·kg-1)的氯氮平达稳态后的药动学,以及吸烟与性别对药动学的影响。
短句来源
    CONCLUSION: The genotype and allele of -1438G/A of 5-HT2A receptor gene can be the predictors to risperidone efficacy.
    结论:精神分裂症患者5-HT2A受体-1438G/A的基因型和等位基因可以作为利培酮临床疗效的预测因子。
短句来源
    RESULTS:The t 1/2 of absorbtive phase, t 1/2 of clearance phase and clearance rate were 0.68,13.09,and 0.057 L/h respectively .
    结果 :精神分裂症患者吸收相半衰期为 0 .6 8h ,清除相半衰期为 13.0 9h ,清除率为 0 .0 5 7L/h。
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  schizophrenia
Alterations in components of glutamatergic system and glutamate metabolizing enzymes are considered with reference to mental disorders such as senile dementia of Alzheimer's type and schizophrenia.
      
The molecular pathways for mental development, common forms of autisms, schizophrenia, and affective disorders have yet to be elucidated.
      
MicroRNA in schizophrenia: Genetic and expression analysis of miR-130b (22q11)
      
MiR-130b expressed in the brain and potentially targeting MECP2 is located in the susceptibility locus for schizophrenia (22q11).
      
Genetic association analysis of 300 schizophrenia and 316 normal control individuals revealed no statistically significant association of any of the miR-130b allelic variants with schizophrenia.
      
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In order to examine the cytogenetic effects of clozapine on thirty schizophrenics, 13 males, 17 females, mean age 35 ± SD 7(21-52 ) yr with 400-500 mg/d in acute stage and average maintaining dose of 178 +++++++++++++++++40 mg/d for mean duration of 2.9 +++++++++++++++++ 0.5 yr (2-4.5 yr), the chromosomal aberrations have been studied. The chromosomes were prepared from the peripheral blood. The preliminary results suggested that the schizophrenic group had higher(P<0.05)frequencies of chromosomal aberrations...

In order to examine the cytogenetic effects of clozapine on thirty schizophrenics, 13 males, 17 females, mean age 35 ± SD 7(21-52 ) yr with 400-500 mg/d in acute stage and average maintaining dose of 178 +++++++++++++++++40 mg/d for mean duration of 2.9 +++++++++++++++++ 0.5 yr (2-4.5 yr), the chromosomal aberrations have been studied. The chromosomes were prepared from the peripheral blood. The preliminary results suggested that the schizophrenic group had higher(P<0.05)frequencies of chromosomal aberrations than those of normal controls(n = 30).The type of chromosomal aberrations, mainly, are chromosomal break, dicentromeric chromosome and ring chromosome.

用外周血培养制备染色体,观察30例长期服用国产氯氮平的精神分裂症患者染色体畸变率,以此检测氯氮平的遗传效应。与30例正常对照组相比初步认为服氯氮平患者体内染色体畸变率较高(P<0.05)。染色体畸变类型主要为染色体断裂、双着丝粒和环形染色体等。讨论了引起畸变的各种原因。

The clozapine levels in plasma were measured during the treatment of 18 male schizophrenic inpatients. A positive linear correlation was found between plasma clozapine levels and the doses given. However, the individual variation were so great that the relationship was not significant between the plasma levels and the clinical efficacy or the abnormal changes of EEG or ECG induced by the drug. Nevertheless, the measurement of plasma clozapine levels has potential significance for those with poor therapeutic...

The clozapine levels in plasma were measured during the treatment of 18 male schizophrenic inpatients. A positive linear correlation was found between plasma clozapine levels and the doses given. However, the individual variation were so great that the relationship was not significant between the plasma levels and the clinical efficacy or the abnormal changes of EEG or ECG induced by the drug. Nevertheless, the measurement of plasma clozapine levels has potential significance for those with poor therapeutic effect and serious side effects to clozapine.

系统检测18例服氯氮平的精神分裂症患者血浆药物浓度。结果表明,血药浓度和服药剂量呈正相关;而不同患者血药浓度的个体差异很大。血药浓度和临床疗效以及脑、心电图异常改变均无明显联系。初步讨论了血药浓度检测的临床意义,认为对于某些疗效较差或药物副反应较重的患者,血药浓度测定具有临床参考价值。

Seyenteen patients with schizophrenia were treated with metoclopramide 225-675 mg/d. The results showed that 9 patients (53%) were effective on metoclopramide, but the side effect was more than other drugs. In 7 patients(41%), cyanosis were - discovered after using metoclopramide. In addition, many extrapyramidal symptoms and poor appetite were consequent on taking metoclopramide. It is necessary to consider whether it may be used as an effective antipsychotic.

作者使用甲氧氯普胺(metoclopramide)225-675mg/d治疗精神分裂症患者17例,结果有效9例(53%)。我们发现此药副作用多,服药后出现紫绀7例(41%),并较多出现锥体外系反应及食欲减退,该药是否能作抗精神病药推广应用值得考虑。

 
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