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There were no changes in prostate structure throughout the study period in either the patients or the controls.
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| | Light microscopy,transmission electron microscopy,and in situ cell death detection were carried out successively before and after castration in canine.The result revealed that the process of the morphological changes following castration could be divided into two phases,the fresh apoptotic phase and the stale apoptotic phase.Not only apoptosis but also atrophy and necrosis could be observed in prostatic tissue after castration.These three morphological changes were present on the prostatic stromal cells jus... | | 采用光镜、电镜、原位末端标记法,连续观察去势前后犬前列腺的病理学改变。去势后犬前列腺的病理改变可划分为新鲜凋亡期和陈旧凋亡期。去势不仅导致前列腺细胞的凋亡病变,还引起萎缩、坏死病变。此三种病变在前列腺上皮和基质内都存在,共同构成了去势晚期前列腺结构和功能的高度损害。 | | 文摘来源 | | Objectives:Zinc plays an important role in the structure and function of prostate.This research is to evaluate efficacy of dignosis of prostate cancer(PCa) and BPH with zinc. Methods:This research included 30 cases of BPH(mean age 62.4) and 12 cases of Pca(mean ages 65.5),whose serum zinc concentration was measured. Results:The mean serum zinc concentration of BPH and PCa patients were (204.32±109.04) μmol/L and (97.65±63.16) μmol/L( P <0.01) respectively.The differences of the prostate structure and fu... | | 目的:微量元素锌对前列腺的结构与功能有着重要的影响,并可成为诊断前列腺疾病的一项重要检测手段。方法:本研究选择30例良性前列腺增生病人,平均年龄62.4岁;12例前列腺癌病人,平均年龄65.6岁,测定其血清锌含量。结果:血清锌平均浓度良性前列腺增生组为(204.32±109.04)μmol/L,前列腺癌组为(97.65±63.16)μmol/L,二者差异显著(P<0.01)。结论:由于前列腺增生(BPH)及前列腺癌时前列腺结构、功能的不同改变而导致血清锌的浓度差异,故测定血清锌浓度对前列腺增生与前列腺癌的鉴别诊断有一定的参考价值。 | | 文摘来源 | | Androgens are required for the structural and functional integrity of the prostate.The involvement of androgens in the pathogenesis of prostate cancer has been well docu-mented.The identification of androgen-responsive genes is essential for the molecular char-acterization of androgen action.Understanding of androgen action in the prostate may lead to novel approaches for prevention and treatment for prostate cancer. | | 雄激素是保持前列腺结构与功能完整的重要因素,也是前列腺癌发生的起始要素。因此,以雄激素应答基因为线索,研究前列腺中雄激素的作用不但有助于前列腺癌的发生与转归机制的阐明,也能为前列腺癌的预防与治疗提供新的思路。 | | 文摘来源 | |   |
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