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去势对照组
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  ovariectomized control group
     METHODS:Fifty SD female rats were divided into 5 groups of 10 rats each:normal control group,ovariectomized control group,PEM group,estrogen group and PEF+estrogen group.
     方法:3月龄SD雌性大鼠50只(体质量200~230g),随机分为正常对照组、去势对照组、脉冲电磁场组、雌激素组、脉冲电磁场+雌激素组(每组10只)。
短句来源
     To investigate the preventive effects of pulsed electromagnetic fields(PEMFs) with specific parameters on osteoporosis,thirty 3-month old female Sprague-Dawley rats were randomly divided into three different groups: normal control group(SHAM group),ovariectomized control group(OVX group),pulsed electromagnetic fields exposing group(PEMFs group),each group had 10 rats. Rats in the SHAM group received the dorsal switch operation,and the other two groups were ovariectomized bilaterally;
     为检验脉冲电磁场对去卵巢大鼠骨质疏松模型的预防效果,用30只质量180-220 g 3月龄雌性未孕SD大鼠去势建立骨质疏松模型,并随机分成正常对照组(SHAM)、去势对照组(OVX)、脉冲电磁场(PEMFs)组,每组10只,其中SHAM组作假手术,不切除卵巢,其余2组做双侧卵巢切除术;
短句来源
  intact control group
     Methods: 24 male New Zealand white rabbits were divided randomly into three groups: intact control group ( n =8,sham castration ), hypotestosteronemia group ( n =8,castration ) and testosterone replacement group ( n =8,castration +testosterone undecanoate intramuscular injection,14mg/kg).
     方法 :选择健康雄性新西兰白兔 2 4只随机分成三组 :假去势对照组、低睾酮血症组 (去势 )及睾酮替代组 (去势 1周后加用长效十一酸睾酮单次肌注 ,14mg kg) ,每组 8只。
短句来源
     Aim To investigate the effect of estradiol on inhibition of neointimal proliferation after rat carotid artery balloon injury. Methods Eight-ten week-old S-D rats were divided into intact control group (n=7), gonadectomized control group (n=7) and estradiol (n=7,gonadectomization)group in each sex.
     为探讨雌二醇对去势大鼠颈总动脉球囊损伤后内膜增生的影响 ,选择 8- 10周S -D大鼠 ,雌性、雄性各 2 1只 ,各分三组 :非去势对照组 (n =7)、去势对照组 (n =7)和实验组 (n =7,去势 +雌二醇 )。
短句来源
  intact control
     Methods Eight to ten-week-old SD rats (male,n=21,female,n=21) were divided into intact control(n=7),gonadectomy control(n=7) and estradiol (n=7, gonadectomy)groups in each sex.
     方法8~10wkSD大鼠雌性 (n=21)、雄性 (n=21) ,各分3个组 :非去势对照组 (n=7) ,去势对照组 (n=7) ,实验组 (n=7 ,去势 +雌二醇 )。
短句来源
     Methods: 24 male New Zealand white rabbits were divided randomly into three groups: intact control group ( n =8,sham castration ), hypotestosteronemia group ( n =8,castration ) and testosterone replacement group ( n =8,castration +testosterone undecanoate intramuscular injection,14mg/kg).
     方法 :选择健康雄性新西兰白兔 2 4只随机分成三组 :假去势对照组、低睾酮血症组 (去势 )及睾酮替代组 (去势 1周后加用长效十一酸睾酮单次肌注 ,14mg kg) ,每组 8只。
短句来源
     Methods 24 male SD rats weighed (320±20) g were randomly divided into orchidectomized control(ORX)group (given with maize oil), low dose DHT (LD-DHT, 0.6 mg·kg -1·d -1) group, high dose DHT (HD-DHT, 6.0 mg·kg -1·d -1) group, and intact control (INT) group (given with maize oil), each group included 6 rats.
     方法24只SD雄性大鼠,随机分为去势对照组(ORX)、去势低剂量二氢睾酮(LD-DHT)、去势高剂量组(HD-DHT)和正常对照组(INT),每组6只。
短句来源
     Aim To investigate the effect of estradiol on inhibition of neointimal proliferation after rat carotid artery balloon injury. Methods Eight-ten week-old S-D rats were divided into intact control group (n=7), gonadectomized control group (n=7) and estradiol (n=7,gonadectomization)group in each sex.
     为探讨雌二醇对去势大鼠颈总动脉球囊损伤后内膜增生的影响 ,选择 8- 10周S -D大鼠 ,雌性、雄性各 2 1只 ,各分三组 :非去势对照组 (n =7)、去势对照组 (n =7)和实验组 (n =7,去势 +雌二醇 )。
短句来源
     Results Neointimal areas and ratios of intimate/media,in male,in subgroup estradiol were less than those in the intact control significantly(all P <0 01),and those in the gonadectomized control(all P <0 05).
     结果 雄性试验组内膜面积、内膜面积 /肌层面积 ,均显著比非去势对照组减小 (均 P<0 .0 1 ) ,比去势对照组减小 (均 P<0 .0 5) ;
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  “去势对照组”译为未确定词的双语例句
     The apoptosis rates and expression levels of Fas and FasLmRNA were higher than those of the OVX control group in the two concentrations (10-3 μmol/L,10-2 μmol/L)(allP<0.01).
     与去势对照组相比,E2在10-3μmol/L、10-2μmol/L浓度时凋亡率及Fas、FasL基因的表达增高(均P<0.01)。
短句来源
     Result The apoptosis of OVX+E2 group was higher in the two most concentration(10^-3umol/l,10^-umol/l)(both P<0.01),when the expressions of Fas,FasL mRNA were higher(Fas:both P0.01;FasL: both P0.01).
     结果:E2在浓度(10^-3umol/l、10^-2umol/l)时凋亡率高于去势对照组(均P<0.01),且Fas、FasL 基因的表达升高(Fas:均P<0.01;FasL:均P<0.01)。
     In 3, 6, 9, 12 days after treatment the plasma LH levelof T_4 in the 7.5 μg group was significantly lower as compared with the control(P<0.05), but T_4 in the 2. 5μg and 5. 0μg groups were not (P>05).
     结果表明血浆LH含量与去势对照组相比,7.5μg组的第3、6、9天明显低(P<0.05),2.5和5.0μg组各天则无差异(P>0.05)。
短句来源
     Comb weight in the sham group was infinitely higher than other groups(P<0.01); Compared to OVX group, the values of AKP, BGP and strACP in serum in OVX-IP98 group was decreased(P<0.05) and sham group, but values of AKP, BGP and strACP were tendency to increase in OVX-Gn group compared to OVX-IP98 group(p<0.05);
     IP98治疗组血清AKP、BGP、StrACP水平比去势对照组显著降低(P<0.05),也低于假手术组,但Ge治疗组血清AKP、StrACP比IP98有增高的趋势(P>0.05),而BGP则显著高于OVX+IP98组(P<0.05);
短句来源
     Forty 3-month-old female SD rats were divided into 5 groups randomly:imitate surgery control groups(SHAM),ovariectomized control groups(OVX1),ovariectomized plus exercise training groups(OVX2),ovariecto-mized treated groups with PEMFs (OVX3), and ovariectomized treated groupswith PEMFs and exercise training(OVX4).
     本文以3月龄雌性SD大鼠(40只)为研究对象,随机分为5组:假手术对照组(SHAM),去势对照组(OVX1),运动组(OVX2),低频脉冲电磁场(PEMFs)治疗组(OVX3),运动结合PEMFs治疗组(OVX4),每组8只。
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  intact control group
All groups, including the intact control group, had significantly lower CaCl2 preferences than did the TPTX group given vehicle.
      
In addition, bioginseng increased the concentration of thyroid-stimulating hormone by 14.5% compared with the intact control group.
      
Rats with THX did not differ from the intact control group on any of these measurements.
      
The cancellous bone volume of the proximal tibia was significantly decreased by 6-wk post-HX compared with the intact control group.
      
The mean MIP in the intact control group was 84 mm Hg.
      
  intact control
The thresholds of pain sensitivity in the rats of all strains were significantly lower saline injected animals than in the intact control, just as the level of dopamine in the hippocampus of KM rats.
      
In eyestalk intact control animals, the ecdysteroids increased significantly in the hemolymph, from 11.26 ng/ml at the beginning of the experiment to 89.68 ng/ml by 68 days (7 days before moulting).
      
Radiological, histological, histomorphometrical, microradiographic and oxytetracycline-fluorescence studies of the osteotomized and intact control femora were performed.
      
Thioridazine (12.5 μM)-treated glioma cells costained with PI and Hoechst 33342 revealed a red fluorescence of fragmented nuclei in treated cells and a blue fluorescence of intact control nuclei.
      
After 4 and 24 h, spinal cords were removed and ATP, glucose, and lactate were analyzed by a bioluminescence approach in serial sections and compared to a laminectomized (intact control), hemisected-only or hemisected vehicle-injected control group.
      
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Effects of the thyroxine on the release of pituitary luteinizing hormone andresponsiveness of anterior pituitary to LHRHa have been studied in the 200--250gorchidectomized rats. In 3, 6, 9, 12 days after treatment the plasma LH levelof T_4 in the 7.5 μg group was significantly lower as compared with the control(P<0.05), but T_4 in the 2. 5μg and 5. 0μg groups were not (P>05). Pituitaryresponsiveness to 100 μg/100g body weight LHRHa were larger than that of 500μg/100 g body weight in all groups. The elevation...

Effects of the thyroxine on the release of pituitary luteinizing hormone andresponsiveness of anterior pituitary to LHRHa have been studied in the 200--250gorchidectomized rats. In 3, 6, 9, 12 days after treatment the plasma LH levelof T_4 in the 7.5 μg group was significantly lower as compared with the control(P<0.05), but T_4 in the 2. 5μg and 5. 0μg groups were not (P>05). Pituitaryresponsiveness to 100 μg/100g body weight LHRHa were larger than that of 500μg/100 g body weight in all groups. The elevation of plasma LH concentrationafter iv LHRHa in normol, castrated, T_4 2.5μg and 5.0μg groups became significantat 15th min, while in the 7. 5 μg group the elevation was delayed to 60th min. Theweight and LH content of anterior pituitary grand did not show obvious differenceamong all groups (P>0.05). These data indicate that 7.5μg T_4 has a suppressiveeffect on the pituitary LH release and responsiveness to LHRHa in the orchidec-tomized rats.

本文观察了雄性去势大鼠注射T_4后对血浆和垂体组织LH含量的影响及垂体对不同剂量的LHRHa的反应性。结果表明血浆LH含量与去势对照组相比,7.5μg组的第3、6、9天明显低(P<0.05),2.5和5.0μg组各天则无差异(P>0.05)。各组对100ng/100克体重LHRHa的反应比对500ng的要大,T_4 7.5μg组对LHRHa最大反应出现的时间比2.5和5.0μg组的推迟60min。垂体重量和LH含量各组无差异(P>0.05)。结果提示:7.5μg T_4对雄性去势大鼠的LH分泌和对垂体的LHRHa反应均显示抑制作用。

The effects of some cytokines produced mainly by mono-macrophage system cells on mechanism of estrogen-deficiency induced bone loss have attracted a widespread attention. To investigate the changes of IL-1, TNFa and IL-6 secretion, 20 female Wistar rats, weighing 183±12g, were randomly divided into ovariectomized group (OVX) and sham-operated group, and sacrificed at 26 weeks after operation.Serum estradiol was determined by radioimmunoassay. IL-1, TNFa and IL-6 activities released from lipopolysaccharide-stimulated...

The effects of some cytokines produced mainly by mono-macrophage system cells on mechanism of estrogen-deficiency induced bone loss have attracted a widespread attention. To investigate the changes of IL-1, TNFa and IL-6 secretion, 20 female Wistar rats, weighing 183±12g, were randomly divided into ovariectomized group (OVX) and sham-operated group, and sacrificed at 26 weeks after operation.Serum estradiol was determined by radioimmunoassay. IL-1, TNFa and IL-6 activities released from lipopolysaccharide-stimulated spleen macrophages were determined by MTT method.IL-1 secretion from LPS-stimulated spleen macrophages in OVX rats was significantly higher than that in sham-operated rats. Simultaneously, TNFa and IL-6 were also increased, though not significantly.The results suggest that IL-1, TNFa and IL-6 increases were closely related with estrogen deficiency,and the significant increase in IL-1 secretion may be a major characteristic during the relative slow period of bone loss after ovariectomy.

20只雌性大鼠分为切除双侧卵巢组(假去势组)和假性切除对照组(假去势组)。术后第26周末,取各组大鼠脾脏制备巨噬细胞,用MTT法检测其在细菌脂多糖刺激下IL-1、TNFa和IL-6分泌水平。结果表明,大鼠去势后第26周末,脾脏巨噬细胞的IL-1分泌水平显著高于假去势对照组(P<0.05)TNFa和IL-6分泌水平亦较假去势对照组增加,但无显著性差异。此提示脾脏巨噬细胞IL-1、  TNFa和IL-6分泌水平的改变与雌激素减少密切相关,有可能在骨质疏松的骨丢失相对缓慢时期以IL-1分泌增多为主要特征。P<0.0l,*P<0.05;两组n=103讨论主要由单核巨噬细胞系来源的细胞分泌的IL-1、TNFa和IL-6是近年来逐渐被认识的几种具有激素样作用的活性物质,在体液和骨髓微环境中通过自分泌或旁分泌与骨代谢密切相关m。雌激素减少致骨转换率加快,骨吸收超过骨形成,骨量减少。在此过程中,破骨细胞数量增多和活性增强已得到证实。在破骨细胞生成、增生、分化、成熟过程及活化过程中,IL-1、TNFa和IL-6发挥重要作用。雌激素抗骨吸收的作用据推测就是抑制了IL-1、TNFa和IL-6及某些参与骨吸收...

20只雌性大鼠分为切除双侧卵巢组(假去势组)和假性切除对照组(假去势组)。术后第26周末,取各组大鼠脾脏制备巨噬细胞,用MTT法检测其在细菌脂多糖刺激下IL-1、TNFa和IL-6分泌水平。结果表明,大鼠去势后第26周末,脾脏巨噬细胞的IL-1分泌水平显著高于假去势对照组(P<0.05)TNFa和IL-6分泌水平亦较假去势对照组增加,但无显著性差异。此提示脾脏巨噬细胞IL-1、  TNFa和IL-6分泌水平的改变与雌激素减少密切相关,有可能在骨质疏松的骨丢失相对缓慢时期以IL-1分泌增多为主要特征。P<0.0l,*P<0.05;两组n=103讨论主要由单核巨噬细胞系来源的细胞分泌的IL-1、TNFa和IL-6是近年来逐渐被认识的几种具有激素样作用的活性物质,在体液和骨髓微环境中通过自分泌或旁分泌与骨代谢密切相关m。雌激素减少致骨转换率加快,骨吸收超过骨形成,骨量减少。在此过程中,破骨细胞数量增多和活性增强已得到证实。在破骨细胞生成、增生、分化、成熟过程及活化过程中,IL-1、TNFa和IL-6发挥重要作用。雌激素抗骨吸收的作用据推测就是抑制了IL-1、TNFa和IL-6及某些参与骨吸收的细胞因子的分泌[5]?

Objective:To investigate effect of tamoxifen on estradiol inhibition neointimal proliferation after rats carotid common arteries injury. Method:Eight~ten weeks old gonadectomized rats were divided into groups of male (n=21)and female(n=21),in which consists of three subgroups:gonadectomized control (n=7),estradiol (n=7),tamoxifen (n=7). Rats were killed two weeks after their common carotid artery arteries were injured with F 2.0 PTCA balloon catheter.Left and right carotid common arteries were...

Objective:To investigate effect of tamoxifen on estradiol inhibition neointimal proliferation after rats carotid common arteries injury. Method:Eight~ten weeks old gonadectomized rats were divided into groups of male (n=21)and female(n=21),in which consists of three subgroups:gonadectomized control (n=7),estradiol (n=7),tamoxifen (n=7). Rats were killed two weeks after their common carotid artery arteries were injured with F 2.0 PTCA balloon catheter.Left and right carotid common arteries were measured. Data were analysed with t test,P< 0.05 considered to be significant.Result: Neointimal areas,ratios of intima/media in estradiol subgroups all were less than those of control subgroups (all P< 0.05 ), those of tamoxifen subgroups all were similar to those of control subgroups(all P> 0.05 ).Conclusion: Estradiol inhibited neointimal proliferation after rats carotid common artery injury.Tamoxifen antagonized effect of estradiol,suggested that estradiol inhibited neointimal proliferation by estrogen receptor.

目的 :探讨他莫昔芬对雌二醇抑制大鼠颈总动脉球囊损伤后内膜增生的影响。方法 :8~ 10周龄 SD大鼠 ,分为雄性组和雌性组 ,每组 2 1只 ,各组又平分为 3个亚组 :去势对照组 ,雌二醇组 ,他莫昔芬组。应用 F2 .0 经皮腔内冠状动脉成形术 ( PTCA)球囊导管损伤血管内膜。2周后处死动物 ,取出左、右颈总动脉作切片观察。结果 :雄性组 :内膜面积、内膜面积 /肌层面积值 ,雌二醇组均小于去势对照组 (均 P <0 .0 5 ) ;他莫昔芬组与去势对照组无显著性差异 (均 P >0 .0 5 )。雌性组 :内膜面积、内膜面积 /肌层面积值 ,雌二醇组均小于去势对照组 (均 P <0 .0 5 ) ,而他莫昔芬组与去势对照组相比亦无统计学差异 (均 P >0 .0 5 )。结论 :雌二醇对去势雄性、雌性大鼠颈总动脉损伤后均有抑制内膜增生作用 ;他莫昔芬拮抗雌二醇的作用 ,提示雌二醇通过受体抑制内膜增生

 
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