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肾小
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  renal corpuscle
     The Study on the Relationship Between Cellular Proliferation and Apoptosis of Renal Corpuscle in Developing Mouse
     不同发育阶段小鼠肾小体细胞增殖与凋亡的关系研究
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     The density and average diameter of the renal corpuscle decrease is bound to follow the increase in fetal month.
     随胎龄增长 ,肾小体面数密度在下降。 肾小体随机断面的平均直径和平均横截面积也略有下降。
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  renal tabular
     STUDY ON THE INGURY EFFECT OF RENAl ISCHEMIC REPERFUSION RABBIT SERUN ON CULTURED HUMAN RENAL TABULAR CELL NAD ITS MECHANISM
     肾缺血再灌流性兔血清致人肾小管细胞损伤的作用及机制研究
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  “肾小”译为未确定词的双语例句
     and ColⅠ in B3、B7、B14 groups was various(P<0.01)and significantly higher than that in groupsA3、A7、A14(P<0.01), in groups C3、C7、C14, The protein level of COX-2、TGF-?
     C组与B组平行相比,ColⅠ表达量有显著降低(P<0.01)。 TGF-β1在A组少量表达于肾小管细胞胞浆,A3 、A7、A14之间无差异(P>0.05)。
短句来源
     Results (1) The tubular cell proliferation was inhibited by FK506 in a dose-dependent manner, being reduced to 95%±7% and 20%±3% when FK506 added was 0.01 μmol/L and 10 μmol/L, respectively.
     结果 ①FK5 0 6以浓度依赖方式抑制肾小管细胞的增殖 ,当FK5 0 6浓度为 0 .0 1μmol/L和 10 μmol/L时 ,细胞增殖分别为对照组的 95 %± 7%和 2 0 %± 3% ;
短句来源
     (2) The production of endogenous TGF-β by tubular cells was enhanced by FK506. When the concentration of FK506 was 0, 1 and 5 μmol/L, the TGF-β in culture medium was (488.03±46.70),(702 16±46 83) and (677 73±24 15) ng/L, respectively.
     ②FK5 0 6促进肾小管细胞产生TGF - β ; 当FK5 0 6浓度为 0、1、5 μmol/L时 ,TGF - β含量分别为 (4 88.0 3±46 .70 )ng/L、(70 2 .16± 46 .83)ng/L、(6 77.73± 2 4.15 )ng/L ;
短句来源
     Effects of GS Rb_1 and Rg_1 on Cultured Renal Tubular Cells Injured by Hypoxia-reoxygenation
     人参皂苷Rb_1与Rg_1对肾小管细胞缺氧复氧损伤模型的影响
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     The cathepsin B expression significantly negatively correlated with the integral calculus of tubulointerstitial injury(r=-0.89,P<0.01),24h urine protein(r=-0.23,P<0.01) and NAG(r=-0.75,P<0.01).
     CB表达与肾小管肾间质损害积分、24h尿蛋白量和NAG呈显著负相关(r分别为-0.89、-0.23和-0.75,P均<0.01)。
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  相似匹配句对
     MR diagnosis of small renal cell carcinoma
     癌的MR表现
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     CT Diagnosis of small Renal Cell Carcinoma(SRCC)
     癌的CT研究
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     Little Tom
     汤姆
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     LITTLE STONE
     石头
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  renal corpuscle
No significant hybridization signal was detected either in the distal tubule, renal corpuscle or peritubular tissues.
      
In the renal corpuscle, podocytes showed the most conspicuous labelling.
      
A mathematical model of the renal corpuscle is presented and used to quantify the effect on filtration rate, nephron blood flow and hydrostatic pressure in the glomerular capillaries of variations in: 1.
      
Each nephron had five segments; 1) renal corpuscle, 2) ciliated neck segment with or without a naphrostome, 3) proximal tubule, 4) ciliated intermediate segment and 5) distal tubule.
      
The nephron has the following parts: renal corpuscle, neck segment, proximal tubule, intermediate segment, distal tubule and connecting tubule.
      
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(1) After oral administration of 5 mg/kg of HCT to normal intact saline-loaded rats, a significant increase in K~+ excretion in urine was observed only in three out of seven experiments, and in the other four, a tendency of increase could still be noticed, though the changes were statistically non-significant. On the other hand, the same dose of HCT orally administered to adrenalectomized rats, both waterloaded and saline-loaded, did not cause any increase in K~+ excretion in all experiments. However, when a...

(1) After oral administration of 5 mg/kg of HCT to normal intact saline-loaded rats, a significant increase in K~+ excretion in urine was observed only in three out of seven experiments, and in the other four, a tendency of increase could still be noticed, though the changes were statistically non-significant. On the other hand, the same dose of HCT orally administered to adrenalectomized rats, both waterloaded and saline-loaded, did not cause any increase in K~+ excretion in all experiments. However, when a sodium retaining steroid, DOCA, was given in addition to HCT, a significant increase was invariably noticed. This, therefore, may serve as an experimental evidence in direct support of Edmonds' hypothesis, derived from his clinical observations, that aldosterone might play an important role in the Na~+-K~+ exchange in question. (2) Acotazolamide, a potent carbonic anhydrase inhibitor, was found to retain partially its effect of increasing K~+ excretion in adrenalectomized rats, and this was potentiated by the combined use of DOCA. From these results it is evident that the cessation of Na~+-H~+ exchange by carbonic anhydrase inhibition and the level of aldosterone are the two independent conditions essential for the Na~+-K~+ exchange in question. When they are combined, the effect is apparently potentiated. (3) An aldosterone antagonist 7-thioacotyl spirolactone was shown to be capable of antagonizing the effect of DOCA on the K~+ excretion, but without any action on that of acotazolamide. This gives further evidence for the specificity of its aldosterone antagonistic action, and it also supports the view that acotazolamide acts independently.

(一)正常大白鼠盐水負荷时,口服5毫克/公斤HCT,在7次实驗中,有3次实驗表現显著排鉀增多,而另外4次則虽也均有排鉀增高傾向,但統計测驗不显著。推測和各批正常员体內醛固酮水平高低有关。 (二)去腎上腺大白鼠,无論水負荷或盐水負荷,口服5毫克/公斤HCT,在6次实驗中均不能增加鉀排泄,但預先肌肉注射DOCA后,就轉为明显,从而直接証明了ECT的增加排鉀和体內醛固酮水平高低密切相关。 (三)碳酸酐酶抑制剂AAA,在去腎上腺大白鼠仍能表現其增加排鉀的作用,而加用DOCA后就更加明显,可見碳酸酐酶抑制及醛固酮均为影响远端腎小管鈉鉀交换的因素,但其中任何一个因素都非唯一因素,两者作用机制不同,却都能促进鈉鉀交换,故当两者同时存在时,排鉀作用就表現得最为明显。 (四)醛固酮对抗剂SL能糾正利尿药因加用DOCA后引起的排鉀作用,但不能直接对抗AAA所产生的排鉀增多,再次証明SL在鉀排泄上和DOCA也起着专一性的竞爭性对抗作用。

Zhuling, Grifolla umbellata Pilat, often used in combination with other herbaceous drugs for the treatment of edema in Chinese medicine, was studied for its diuretic effect in unanaesthetized dogs. It was found that the decoction of this drug, given intravenously or intra-muscularly, produced a marked increase in urine output as well as a substantial increase in the excretion of sodium, chloride and potassium.

猪苓煎剂,相当于生药0.25—0.50克/公斤的剂量,靜脉或肌肉注射,对不麻醉犬具有比較明显的利尿作用,并能促进鈉、氯、鉀等电解貭的排出。猪苓的这种作用可能主要是由于抑制了腎小管重吸收机能的結果。

The ~(14)C-labeled gossypol acetic acid (Sp.Act.2.665μci/mg) used in this experiment and the care and trea-tment of animals were the same asthe previous report.Wistar adult malerats selected for uniformity of weight(about 200g) were placed in individu-al metabolic cages,the feces,urine andexpired air were collected daily formeasurement in one group of animalsfollowing a single oral dose (20μci/7.5 mg) of ~(14)C-gossypol,acetie acid.The animals were anesthetized and kil-led after varying intervals of time (i.e.12...

The ~(14)C-labeled gossypol acetic acid (Sp.Act.2.665μci/mg) used in this experiment and the care and trea-tment of animals were the same asthe previous report.Wistar adult malerats selected for uniformity of weight(about 200g) were placed in individu-al metabolic cages,the feces,urine andexpired air were collected daily formeasurement in one group of animalsfollowing a single oral dose (20μci/7.5 mg) of ~(14)C-gossypol,acetie acid.The animals were anesthetized and kil-led after varying intervals of time (i.e.12 hours,1,2,4,9 and 14 days,3animals for each time).The bloodwas collected and various organ tis-sues as well as the contents of gastro-intestinal tract were removed,lyophili-zed and weighed ground for liquidscintillation counting by oxygen com-bustion.The free and bound gossypolwere extracted from parts of the aboveorgans,and an analysis of the ratioChanges of the free to bound gossypol(F/B) in the metabolic process wasmade.To the daily dose group,therats were given labeled gossypol atthe dosage of 4.5μci/5 mg daily and were anesthetized and killed 2 weeks,3 weeks,one and two weeks following the withdrawal of the drug (2 animalsfor each time period).Samples of tis-sues and excreta were prepared formeasurement according to the proce-dures as described above.The resultsobtained were summarized as follows.1.It was found that the injected~(14)C-labeled gossypol excreted rapidlythrough feces,urine and expired airfollowing the oral administration.Themain pathway of excretion was fromthe feces,followed by exhaled CO_2 andurine.The amount of ~(14)C eliminated in19 days was 83.50% in feces,11.73%in expired CO_2 and 2.51% in urine. The high excretion rate in feces sug-gested that the circulation and me-tabolism of gossypol through liver-bile-feces were the main pathway of elim-ination and detoxication of the gos-sypol from the body.The exhaledCO_2 appeared to be a metabolic pro-ducts of decarbonylation of formyl-~(14)C-gossypol,and thus,the decarbo-nylation is also one of the pathway ofelimination and dtoxication of gossypol.The low gossypol excretion in urine might be related to their nonionized large molecules of gossypol which were uneasied to pass through the renal glomeruli but were more favored toreabsorption by the renal tubules.2.After a single oral dose of~(14)C-labeled gossypol to male rats at thedosage of 2oμci/7.5mg/animal,thetime taken for the elimination fromthe body of one half of the radioac-tivity was 60 hours (i.e.t1/2=2.5days).According to this half-life valueof excretion,it was possible to cal-culate that the time for the clearanceof gossypol from the body would beat the 23rd day or nearly so,it wasmostly corresponding to our data thatit took 19 days to eliminate 97.74%of the dose from the animal body.3.The data obtained by radioac-tivity measurement of the tissues fromrats fed ~(14)C-labeled gossypol demon-strated that the contents and the epi-thelial lining of gastro-intestinal tractand the liver had the highest specificradioactivity.They reached their peaklevels one day following a single oral dosing.The blood also reached its peak at the first day,however,its specific activity was lower than that of the above visceral organs.The specific radioactivity in the heart,kidney,sple-en,lung,pancreas,diaphragm andtestis were low at the early stages ofdrug adiministration,but rapidly rea-ched to their peak at the 4—9th day.Among the organs,the spleen,kidneyand heart contained more higher speci-fic activity than that of other organs.The endocrine organs such as adrenal,pituitary and thyroid gland also con-tained a fairly high specific activity.Whereas,the hypothalamus,medullaoblongata and spinal cord had the lo-west activity only.The specific acti-vity in various organs decreased ingeneral with the increase of time dura-tion,and dropped to their minimumamount 19 days after the administra-tion.4.The pharmacokinetics of ~(14)C-gossypol in rats that on daily dosingwere almost the same as in the rats ofsingle oral dosing group.Two weeksfollowing the administration,all tis-sues contained radioactivity,with the brain having the lowest activity.The contents and tissues of alimentary canal as well as liver had the highest specific acitivity also,followed by spleen,kidney,heart,lung pancrease,diaphragm and testis.They reached their peak levels after 3 weeks of daily dosing.But thereafter,the specific acitivitysteadily decreased to a lower level.Two weeks after the withdrawal oftreatment,the activity in various tis-sues decreased to their minimum am-ounts.These reaults indicated thatthe pharmacokinetics of ~(14)C-gossypolin both dosage groups were basicallysimilar in distribution pattern,and thedata of quantitative measurement andautoradiographic investigation werecoincided with each other either.5.The results demonstrated thatthe ratios of free gossypol (F) to boundgossypol (B) in the contents and tissuesof different parts of the gastro-intes-tinal tract,liver,and feces were lowat the early stages of drug administr-ation.However,the value of theseratios had progressively increased withtime in both dosing grops.These data suggested that the gossypol might mainly metabolized as a binding form during early stages of medication within rat body.Subsequently,the proportion of free gossypol and other metabolites increased with time throughoxidation,hydrolysis and decarbonyla-tion of the bound gossypol in varioustissues,resulting in soluble or air formand cxcreted via feces,urine and expir-ed air.

1.大鼠口服标记棉酚后迅速通过粪、尿和呼气排出。粪排出量最多,占口服总剂量的83.5%;其次为呼气中的~(14)CO_2,占11.73%;尿中的含量最少,只占2.51%。经粪排出率最高,表明通过肝脏—胆汁—粪的代谢和排泄是排除体棉酚的主要途径和解毒过程。呼气中的CO_2是棉酚代谢过程中脱羰基作用的产物,这一过程也是体内棉酚解毒过程的一种方式。尿中排泄量低,可能与棉酚的非离子化态大分子结构不易通透肾小球而有利于肾小管的重吸收有关。2.大鼠一次口服标记棉酚20微居里/7.5毫克后,从体内排出总剂量的半量的时间(t(1/2))为2.5天,按排泄半量规律推算,从体内清除所需的时间约为服药后的第23天左右,与我们在第19天实测的体内残留率比例大体相符。3.分布于脏器组织中的标记棉酚的定量测定结果表明:胃、肠道内容物,胃、肠道组织和肝脏中的比活性最高,在服药后1天即到达它们的高峰强度水平。血液的活性在1天内亦到达高峰。但其比活性较上述脏器组织为低。心、肾、脾、肺、胰、膈肌和睾丸等主要脏器组织的比活性在服药后的初期较低。到第4天才达到它们各自的高峰水平。其中脾、肾、心的比活性较其他脏器为高,内分泌腺...

1.大鼠口服标记棉酚后迅速通过粪、尿和呼气排出。粪排出量最多,占口服总剂量的83.5%;其次为呼气中的~(14)CO_2,占11.73%;尿中的含量最少,只占2.51%。经粪排出率最高,表明通过肝脏—胆汁—粪的代谢和排泄是排除体棉酚的主要途径和解毒过程。呼气中的CO_2是棉酚代谢过程中脱羰基作用的产物,这一过程也是体内棉酚解毒过程的一种方式。尿中排泄量低,可能与棉酚的非离子化态大分子结构不易通透肾小球而有利于肾小管的重吸收有关。2.大鼠一次口服标记棉酚20微居里/7.5毫克后,从体内排出总剂量的半量的时间(t(1/2))为2.5天,按排泄半量规律推算,从体内清除所需的时间约为服药后的第23天左右,与我们在第19天实测的体内残留率比例大体相符。3.分布于脏器组织中的标记棉酚的定量测定结果表明:胃、肠道内容物,胃、肠道组织和肝脏中的比活性最高,在服药后1天即到达它们的高峰强度水平。血液的活性在1天内亦到达高峰。但其比活性较上述脏器组织为低。心、肾、脾、肺、胰、膈肌和睾丸等主要脏器组织的比活性在服药后的初期较低。到第4天才达到它们各自的高峰水平。其中脾、肾、心的比活性较其他脏器为高,内分泌腺中的肾上腺、垂体和甲状腺的比活性亦较高。而神经系统中的丘脑下部、延脑和脊髓的比活性则均较低。各脏器的比活性随时间而递减下降,到第19天后均下降至微量水平。4.连续给药组脏器组织中的标记棉酚分布动态与上述一次给药组基本相同。连续每日服药2周后,所有组织均出现放射活性,其中脑组织的比活性最低,胃、肠道壁及其内容物以及肝的比活性最高。其次为脾、肺、心、肾、胰、膈肌和睾丸。这些主要脏器在连续服药3周后达到各自的比活性高峰水平。以后即逐渐下降。停药2周后均下降至微量水平。上述结果表明两个给药组的棉酚分布的变化动态基本一致,定质和定位的结果亦基本相符。5.棉酚的代谢:两个服药剂量组的胃、肠道组织,肝组织,胃、肠道内容物和粪中的游离棉酚(F)和结合棉酚(B)的比值,在服药后的初期均较小。以后随时间而逐渐递增。反映了棉酚在体内的早期代谢形式以结合棉酚为主,以后在脏器组织中通过氧化、分解或转化,游离棉酚及其代谢产物的比例增加,通过粪、尿和呼气(脱羰基后的CO_2)排出。

 
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