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糖对照组
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  glucose control group
     high glucose control group cultured in culture medium containing 30 mmol/L glucose and 10 g/L demasorb (DMS);
     高糖对照组,培养液含30mmol/L葡萄糖+10g/L二甲亚砜;
短句来源
     The levels of TGF-β1 and ECM ( extracellular matrix ) proteins in the L158, 809 group and cilazapril group are obviously lower than that of the high glucose control group .
     而L158,809组和西拉普利组TGF-β_1和细胞外基质(ECM)蛋白水平明显低于高糖对照组,且TGF-β_1 mRNA水平亦表达明显降低。
短句来源
     The A value in the high glucose+Xiaokening group at 72 hours was 0.538±0.023, and it was lower than that in the high glucose control group (P < 0.05).
     高糖+消可宁组药物刺激72h后系膜细胞吸光度值为0.538±0.023,低于高糖对照组(P<0.05)。
短句来源
     Results : Compared with low glucose control group, the mesangial celis under high glucose me-dium show excessive proliferation and more TGF-β1, fibronectin, laminin and type Ⅳ collagen in the supernatant. The expressicn of TGF-β1 mRNA was also significantly increased under high glucose.
     结果:与低糖对照组相比,高糖对照组系膜细胞过度增殖,细胞上清液中TGF-β_1、纤维连接蛋白、层粘连蛋白和Ⅳ胶原浓度明显升高,TGF-β_1 mRNA表达也显著升高;
短句来源
     Results: Compared with low glucose control group, the mesangial c ells under high glucose medium showed excessive proliferation and there were the high levels of TGF-a1, fibronectin, laminin and type Ⅳcollagen in the supern atant.
     结果:与低糖对照组相比,高糖对照组系膜细胞增殖过度,细胞上清液中TGF-β1、纤维连接蛋白、层黏连蛋白和Ⅳ型胶原含量明显升高;
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  “糖对照组”译为未确定词的双语例句
     Results: The plasma levels of glucose, insulin, NO and GSP were higher and insulin sensitivity was lower in sucrose fed group than in control group.
     结果:高糖对照组血糖、血浆胰岛素、GSP及NO水平高于正常对照组,胰岛素敏感指数低于正常对照组;
短句来源
     But the levels of TGF-a1 and ECM (extracellular matrix) proteins in the L158,809 group and cilazapril group are obviously lower than that of the high g lucose control group.
     而西拉普利组和L158,809组系膜细胞增殖和细胞上清液中TGF-β1、基质蛋白含量均明显低于高糖对照组
短句来源
     (4) Apoptotic rate and caspase-3 activity of mesothelial cells was significantly lower in 0.1μmol/L CsA group than that in control.
     (4)0.1μmol/L CsA组间皮细胞凋亡率和caspase-3活性显著低于高糖对照组(P<0.05)。
短句来源
     And in the same time, the expression of AM and Cfh were also reduced. Conclusions1. adrenomedullin and Complement factor H could inhibit the over-expression of extracellular matrix in mesangial cells induced by high glucose, which showed the renal protective functions. 2. Diovan, atorvastatin and pioglitazone all showed renoprotective functions in a certain extent, which mechanism might concerned with the inhibition of TGF-β_1 expression.
     2.高糖状态下培养的肾脏系膜细胞分别应用代文、阿托伐他汀和匹格列酮干预后细胞上清TGF-β_1、LN和Ⅳ型胶原的含量较高糖对照组明显减低,TGF-β_1mRNA,AMmRNA和CfhmRNA的表达亦较高糖对照组显著减低,AM和Cfh的蛋白表达也较高糖对照组显著降低。
短句来源
     the media and high group's hemolysin was increased respectively 28. 1% (P<0.05), 28. 4% (p<0.05); the media dose group's NK cell activity was increased 84. 3% (p<0. 05). These results indicated that the chitosan's functions were affective signiticantly on lowering hyperlipemia, lowering hyperglycimia and enhanc ing immunity.
     壳聚糖降糖作用结果表明:经口给予各剂量组小鼠壳聚糖21d后,与高糖对照组相比,低、中、高剂量组的空腹血糖值分别降低20. 9%(p<0.001)、 19,2%p<0.001)、18.4%(p<0?
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  相似匹配句对
     Chickens in group C were as controls.
     C对照
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     allergosis treated by prednisone group.
     对照
短句来源
     The contrast group was given ordinary oral medicine to lower the blood sugar.
     对照予一般口服降药物治疗。
短句来源
     and in the DMEM group, only DMEM was contained, which served as the control group.
     DMEM高培养基作为对照;
短句来源
     Group B was high-glucose control with 33mmol/L glucose in medium.
     B为高(33mmol/L)对照;
短句来源
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  glucose control group
Liver glutamine synthetase activity was lower in the -Zn-glucose group and in the fructose groups than in the glucose control group.
      
Female Wistar rats received 10 vol% ethanol or 2.5% glucose (control group) in their drinking water for 45 days.
      


The purpose of this study was to investigate the chitosan's effects on lowering hyperlipemia, lowering hyperglycemia and enhancing immunity .The effect of chotosan on hyperlipemia was investigated in male SD rats. There were respectively hyperlipemia control group, low dose group (83. 3mg/kg .bw),media dose group (166. 7mg/kg..bw) and high dose group (333. 3mg/kg .bw) .All groups were fed with chitosan 4 weeds.The results showed that:comparing with hyperlipemia control group me media and high dose group's cholesterol...

The purpose of this study was to investigate the chitosan's effects on lowering hyperlipemia, lowering hyperglycemia and enhancing immunity .The effect of chotosan on hyperlipemia was investigated in male SD rats. There were respectively hyperlipemia control group, low dose group (83. 3mg/kg .bw),media dose group (166. 7mg/kg..bw) and high dose group (333. 3mg/kg .bw) .All groups were fed with chitosan 4 weeds.The results showed that:comparing with hyperlipemia control group me media and high dose group's cholesterol level was lowered respectiuely 10. 5% (P<0. 01), 14. 2% (P<0.01); low, media and high dose group's triglyceride lowered respectively 27. 5% (P<0.01), 18. 8% (p<0. 01) and 26. 1% (P<0. 01); low, media and high dose group's high density lipoprotein cholesterol increased respectively 16. 5% (P<0.01), 32. 7% (p<0.001) and 50.4% (p<0.001) .The effects of chitosan on lowering hyperglycemia and enhancing imunity were investigated in Kurmingfemale mice.There were three dose groups: low dose group (166. 7 mg/kg..bw) I media dose group (333. 3 mg/kg. .bw) and high dose group (666. 7 mg/kg..bw) .There were the control group of the effect on enhancing immunity and the hyperglycemia model group of the effect on lowing hyperlycemia.All groups were fed with chitosan 3 weeks .The results of effect on lowering hyperlycemia indicated:colnparing with hyperglycemia control group, the low,media and high dose group's blood sugar was lowered respectively 14. 1% (P<0. 05), 18.8% (p<0. 01) and 24. 9% (p<0. 01) .The blood sugar difference between 2 hour's and 0 hour's blood sugar after giving 50% glucose was lowered respectively 40. 0% (P<0. 001) , 30.1% (p<0.001) and 20. 6% (p<0.001) The results of effect on enhancing immunity Indicated: comparing with control group, the low, the media and high dose group's carbon expurgation phagocytosis index was increased respectively 9.1% (P<0.01), 14. 8% (p<0.001) and 13. 4% (p<0.001); the low,media and high dose group's delayed hypersen sitivity was increased respectively 82. 5% (P<0.01) , 82. 5% (p<0. 001) and 105. 3% (p<0. 001); the media and high group's hemolysin was increased respectively 28. 1% (P<0.05), 28. 4% (p<0.05); the media dose group's NK cell activity was increased 84. 3% (p<0. 05). These results indicated that the chitosan's functions were affective signiticantly on lowering hyperlipemia, lowering hyperglycimia and enhanc ing immunity.

对壳聚糖的降血脂、降血糖和增强免疫作用进行初步研究。降血脂研究采用 SD大鼠,分低(83.3mg/kg.bw)、中(166.7mg/kg.bw)、高(33.3mg/kg.bw)三个剂量组和一个高脂对照组。经口给予各剂量组大鼠壳聚糖28d后,与高脂以照组相比,中、高剂量组的血清总胆固醇含量分别降低10.5%(P<0.01)、 14.2%(P<0.01);低、中、高剂量组的血清总甘油三酯含量分别降低27.5%(p<0.01)、 18.8%(p<0.01)和26.1%(P<0.01);低、中、高剂量组的血清高密度脂蛋白胆固醇分别升高工6.5%(p<0.01)、32.7%(p<0.001)、50.4%(p<0.001)。降糖和增强免疫功能的研究采用健康昆明种小鼠,分低(166.7 mg/kg.bw)、中(333.3 mg/kg.bw)、高(666.7 mg/kg.bw)三个剂量组,免疫功能研究设空白对照组,降糖功能研究设高糖模型组。壳聚糖降糖作用结果表明:经口给予各剂量组小鼠壳聚糖21d后,与高糖对照组相比,低、中、高剂量组的空腹血糖值分别降低20. 9%(p<0.001)、 19,2%p<0.001)、...

对壳聚糖的降血脂、降血糖和增强免疫作用进行初步研究。降血脂研究采用 SD大鼠,分低(83.3mg/kg.bw)、中(166.7mg/kg.bw)、高(33.3mg/kg.bw)三个剂量组和一个高脂对照组。经口给予各剂量组大鼠壳聚糖28d后,与高脂以照组相比,中、高剂量组的血清总胆固醇含量分别降低10.5%(P<0.01)、 14.2%(P<0.01);低、中、高剂量组的血清总甘油三酯含量分别降低27.5%(p<0.01)、 18.8%(p<0.01)和26.1%(P<0.01);低、中、高剂量组的血清高密度脂蛋白胆固醇分别升高工6.5%(p<0.01)、32.7%(p<0.001)、50.4%(p<0.001)。降糖和增强免疫功能的研究采用健康昆明种小鼠,分低(166.7 mg/kg.bw)、中(333.3 mg/kg.bw)、高(666.7 mg/kg.bw)三个剂量组,免疫功能研究设空白对照组,降糖功能研究设高糖模型组。壳聚糖降糖作用结果表明:经口给予各剂量组小鼠壳聚糖21d后,与高糖对照组相比,低、中、高剂量组的空腹血糖值分别降低20. 9%(p<0.001)、 19,2%p<0.001)、18.4%(p<0?

Diabetic rats was preparated by streptozotocin. After establishment of diabetic model, treatment with C-peptide for 8 weeks shows protective effect on diabetic nephropathy. The effect manifested as reduced glomerular volume and reduced cross-sectional glomerular area when compared with untreated rats.

以链脲佐菌素制备糖尿病大鼠模型 ,造模后C肽治疗 8周 ,以肾小球体积及肾小球截面积为指标 ,均较高糖对照组下降 ,显示对糖尿病肾病有保护作用。

Objective: To explore the effect of L158, 809 (angiotensin Ⅱ receptor blockers, ARBs) and Cilazapril (Angiotensin converting enzyme inhibitor, ACEI) on the ex-pression of transforming growth factor-β1 ( TGF-β1 ) and secretion of fibronectin, laminin and type Ⅳ collagen from the cultured human mesangial cells . Methods: Human mesangial cells were cultured in different glucose (5.6 mmol/L and 30 mmol/L) and agents (1, 10, 100 and 500 μmol/L) concentrations . The proliferation of mesangial cells were detected at...

Objective: To explore the effect of L158, 809 (angiotensin Ⅱ receptor blockers, ARBs) and Cilazapril (Angiotensin converting enzyme inhibitor, ACEI) on the ex-pression of transforming growth factor-β1 ( TGF-β1 ) and secretion of fibronectin, laminin and type Ⅳ collagen from the cultured human mesangial cells . Methods: Human mesangial cells were cultured in different glucose (5.6 mmol/L and 30 mmol/L) and agents (1, 10, 100 and 500 μmol/L) concentrations . The proliferation of mesangial cells were detected at 24, 48 and 72 h. Then the mesangial cells are divided into four groups, low glucose (5.6 mmol/L) control group, high glucose (30 mmol/L) control group, L158,809 (10 μmol/L) group and cilazapril (10μmol/L) group. Forty-eight hours later, the expression of TGF-β1 were detected by RT-PCR. Concentrations of TGF-β1, fibronection, laminin and type Ⅳ collagen in the su-pematants of the mesangial cells were determined by ELJSA and radioimmunoassay methods. Results : Compared with low glucose control group, the mesangial celis under high glucose me-dium show excessive proliferation and more TGF-β1, fibronectin, laminin and type Ⅳ collagen in the supernatant. The expressicn of TGF-β1 mRNA was also significantly increased under high glucose. The levels of TGF-β1 and ECM ( extracellular matrix ) proteins in the L158, 809 group and cilazapril group are obviously lower than that of the high glucose control group . The expression of TGF-β1 mRNA was markedly decreased in the L158, 809 group and dlazapril group com-pared with that of high glucose control group . Con-clusion : High glucose stimulated the cultured human

目的:观察血管紧张素受体拮抗剂(ARBs)L158,809和血管紧张素转换酶(ACE)抑制剂西拉普利对体外培养人肾小球系膜细胞转化生成因子(TGF-β_1)表达和纤维连接蛋白、层粘连蛋白和Ⅳ型胶原分泌的影响。方法:分别在不同葡萄糖浓度(5.6 mmol/L和30 mmol/L)和药物浓度(1、10、100和500 μ mol/L)下体外培养人肾小球系膜细胞,分别于24、48和72 h后测定细胞增殖。然后将系膜细胞分为低糖(5.6 mmol/L)对照组(LG)、高糖(30 mmol/L)对照组(HG)、L158,809(10 μmol/L)组和西拉普利(10 μmol/L)组,48 h后,分别用RT-PCR法测定TGF-β_1表达,ELISA和放射免疫法测定细胞上清液中TGF-β_1、纤维连接蛋白、层粘连蛋白和Ⅳ胶原浓度。结果:与低糖对照组相比,高糖对照组系膜细胞过度增殖,细胞上清液中TGF-β_1、纤维连接蛋白、层粘连蛋白和Ⅳ胶原浓度明显升高,TGF-β_1 mRNA表达也显著升高;而L158,809组和西拉普利组TGF-β_1和细胞外基质(ECM)蛋白水平明显低于高糖对照组$$...

目的:观察血管紧张素受体拮抗剂(ARBs)L158,809和血管紧张素转换酶(ACE)抑制剂西拉普利对体外培养人肾小球系膜细胞转化生成因子(TGF-β_1)表达和纤维连接蛋白、层粘连蛋白和Ⅳ型胶原分泌的影响。方法:分别在不同葡萄糖浓度(5.6 mmol/L和30 mmol/L)和药物浓度(1、10、100和500 μ mol/L)下体外培养人肾小球系膜细胞,分别于24、48和72 h后测定细胞增殖。然后将系膜细胞分为低糖(5.6 mmol/L)对照组(LG)、高糖(30 mmol/L)对照组(HG)、L158,809(10 μmol/L)组和西拉普利(10 μmol/L)组,48 h后,分别用RT-PCR法测定TGF-β_1表达,ELISA和放射免疫法测定细胞上清液中TGF-β_1、纤维连接蛋白、层粘连蛋白和Ⅳ胶原浓度。结果:与低糖对照组相比,高糖对照组系膜细胞过度增殖,细胞上清液中TGF-β_1、纤维连接蛋白、层粘连蛋白和Ⅳ胶原浓度明显升高,TGF-β_1 mRNA表达也显著升高;而L158,809组和西拉普利组TGF-β_1和细胞外基质(ECM)蛋白水平明显低于高糖对照组,且TGF-β_1 mRNA水平亦表达明显降低。结论:高糖可刺激体外培养系膜细胞过度增殖,TGF-β_1表达增高,ECM蛋白分泌明显增加,而L158,809和西拉普利均可抑制高糖环境下上述现象。

 
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