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细胞生长停滞
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  growth arrest
     But the mechanisms of them are different:VEGI induces apoptosis of endothelial cells,activates nuclear factor-κB and maintains the growth arrest of endothelial cells in G0/G1 interfaces; whereas cyclo-VEGI mostly inhibits both the combination of vascular endothelial growth factor,fibroblast growth factor-2 and their receptors,the transduction of vascular endothelial growth factor signals.
     但两者作用机理不同,VEGI诱导内皮细胞凋亡,激活核转录因子NF-κB和维持G0/G1期细胞生长停滞,而cyclo-VEGI抑制血管内皮生长因子(vascular endothelial growth factor,VEGF)和成纤维细胞生长因子-2(fibro-blast growth factor-2,FGF-2)与各自受体结合及VEGF信号转导。
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     Gut-enriched Kruppel-like factor (GKLF) is a newly identified eukaryotic zinc finger protein expressed extensively in the gastrointestinal tract, the expression of which is associated with growth arrest.
     胃肠富集Kruppel样因子 (GKLF)是一个新近发现的真核锌指蛋白 ,它在胃肠道表达丰富 ,其表达与细胞生长停滞有关联 .
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     Compared with control,GRC-1/pCMV-p27 presented a significant drop in telomerase activity expression,accompanied by remarkable apoptosis and growth arrest.
     结果 :转染 p2 7质粒的GRC - 1细胞端粒酶活性显著下降 ,伴有细胞凋亡、细胞生长停滞
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     Gut-enriched Kruppel-like factor (GKLF) is a newly identified eukaryotic zinc finger protein expressed extensively in the gastrointestinal tract, and its expression is associated with growth arrest. Previous work showed that GKLF expression was down-regulated in esophageal squamous cancer.
     胃肠富集Kruppel样因子 (GKLF)是一个新近发现的真核锌指蛋白 ,它在胃肠道表达丰富 ,其表达与细胞生长停滞有关联。
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     The phenotypes of senescent chondrocytes includes irreversible growth arrest: senescence-associated-gal (SA-gal) expression, telomere shortening, and altered differentiation.
     目前认为其机制为基因表达的程序性或减进性改变,包括肿瘤抑制基因p53和pRb等在细胞生长停滞中的作用; 端粒结合蛋白和端粒酶对端粒长度的调节;
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  growth arrest in s phase
     It might result from inducing growth arrest in S phase and apoptosis.
     其机制可能在于联合用药诱导细胞生长停滞和细胞凋亡。
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  “细胞生长停滞”译为未确定词的双语例句
     Results: the VSMC proliferation was significantly inhibited (P<0.01)and the cells were stagnated on G 0/G 1 phase.
     结果:川芎嗪可显著地抑制VSMC增殖(P <0 .0 1) ,使细胞生长停滞于G0 /G1期;
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     stage. After incubated with arsenic trioxide for 48 hours ,the rate of G1 cell in PC-3 cells is 44.5% 43.2% ,47.4%, 48.3%, 55.9% 65.1% respectively when the concentration of arsenic trioxide is 0 1 2, 3, 6 10mol/L.
     浙江大学2004届博士研究生毕业论文泌尿外科专业学位三氧化二砷可使PC一3细胞生长停滞于G:期,0、1、2、3、6小时后G,期细胞数目百分比分别为44.5%、43.2%、47.4%、、10林mol/L的三氧化二砷作用48
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     However it has significant effect on the growth-suppression and clonogenic formation of the cultured cells as well as induction of apoptosis and micronucleus formation when it was cultred with Na~131I; BrdUrd can increase the number of cells in G_1/S phase.
     BrdUrd组与空白组比较对细胞生长抑制、凋亡及微核形成无促进作用,仅对细胞生长周期有一定的影响,可使细胞生长停滞于G_1/S期,然而BrdUrd+辐射组与辐射组相比可明显观察到BrdUrd可增加Na~(131)I的辐射效应,表现在凋亡指数增高、生长抑制增强、微核形成增多。
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     About (20.13± 3.84)% hepatocytes had apoptosis in 7 h in group B and about (49.04± 1.44)% apoptotic hepatocytes growth ceased in the G_2/M stage.
     PAAF诱导7h后(20.13±3.84)%的肝细胞发生凋亡,其中(49.04±1.44)%细胞生长停滞在G2/M期。 电镜(TEM)下可见典型的晚期凋亡肝细胞;
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     Conclusion DMSO can inhibit the DNA pol β exprssion of the esophageal carcinoma Eca109 cells and block the cell cycle at the G 1/G 0 phase.
     结论 DMSO可抑制Eca 10 9细胞polβ的表达 ,使Eca10 9细胞生长停滞于G1/G0 期
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  growth arrest
Cellular dammage was observed at a concentration of 0,5 mg HMF/ml of medium, growth arrest at 1 mg/ml.
      
We found further features of senescence in Ras-transduced endothelial cells, such as growth arrest and the lack of AP-1 serum inducibility.
      
Adenoviral overexpression of p21 led to growth arrest by induction of G1- and G2/M-cell cycle arrest.
      
Results: The LCRG1 gene potently inhibited tumorgenesis in vitro and in vivo, as showed by dramatic growth arrest observed in cell growth analysis and suppression of anchorage-independent growth and tumorigenicity in nude mice.
      
Results: Somatostatin ccould induce gallbladder cancer cell growth arrest in S phase.
      
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  growth arrest in s phase
Results: Somatostatin ccould induce gallbladder cancer cell growth arrest in S phase.
      


Aim To observe the induction of apoptosis in vascular smooth muscle cell (SAC) by the introduction of wild-type P53 gene and investigate the mechanism of inhibition for SMC proliferation by wild-type P53 gene.Methods A replication--deficient adenovirus vector encoding a wild-type P53,AdCMV P53,was constructed and trans feeted into the cultured rabbit aortic SMC.The cell cycle of SMC was analysed with flow cytometry. The 3H-thymidine incorporation assay was used to measure DNA synthesis in SAC. The apoptotic...

Aim To observe the induction of apoptosis in vascular smooth muscle cell (SAC) by the introduction of wild-type P53 gene and investigate the mechanism of inhibition for SMC proliferation by wild-type P53 gene.Methods A replication--deficient adenovirus vector encoding a wild-type P53,AdCMV P53,was constructed and trans feeted into the cultured rabbit aortic SMC.The cell cycle of SMC was analysed with flow cytometry. The 3H-thymidine incorporation assay was used to measure DNA synthesis in SAC. The apoptotic cells was determined by termmed deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and agarose gel electrophoresis.Results Introduction of wild-type P53 gene into SMC can arrest 77% of AdCMV P53--infected cells at GO/GI phases of the cell cycle, leading to inhibition of DNA synthesis. Overexpression of wild-type P53 induced apoptosis of cells infected with AdCMV P53 as detected by TUNEL and flow cytometry. Electrophoresis of genomic DNA showed internucleosomal fragments of DNA isolated from the AdCMV P53--infected SMC.Conclusion Wild-type P53 gene suppress SMC pro liferation by induction of apoptosis in SMC.

为观察野生型P53基因诱导血管平滑肌细胞凋亡的现象,探讨对生型P53基因导入抑制平滑肌细胞增殖的作用机理,构建了野生型P53基因的重组腺病毒载体,体外转染兔主动脉血管平滑肌细胞。应用流式细胞议分析细胞周期,氚标胸腺嘧啶脱氧核苷掺入试验检测DNA合成,琼脂糖凝胶电泳观察DNA区带图谱,末端脱氧核苷酸转移酶介导的dUTP切口末端标记技术原位检测细胞凋亡。结果发现,野生型P53基因重组腺病毒载体转梁平滑肌细胞后,细胞内DNA合成减少。流式细胞仪分析显示77%的平滑肌细胞生长停滞在G0/Gl期,约45%的细胞发生细胞凋亡。dUTP切口末端标记阳性细胞百分率为40%~50%。DNA在琼脂糖凝胶电泳中呈现阶梯状区带图谱。以上结果提示,野生型P53基因通过诱导细胞凋亡对血管平滑肌细胞增殖起抑制作用。

In order to study the bladder carcinoma cell growth suppression by introduction of foreign retinoblastoma (Rb) gene and explore a gene therapy approach for bladder cancer, a replication-deficient adenovirus vector encoding a wild-type Rb, AdCMVRb, was constructed and transfected into the cultured human bladder carcinoma cell line EJ. The efficiency of gene transfection and expression was detected by immunochemical staining, Western blotting and polymerase chain reaction. The role of Rb in suppressing EJ growth...

In order to study the bladder carcinoma cell growth suppression by introduction of foreign retinoblastoma (Rb) gene and explore a gene therapy approach for bladder cancer, a replication-deficient adenovirus vector encoding a wild-type Rb, AdCMVRb, was constructed and transfected into the cultured human bladder carcinoma cell line EJ. The efficiency of gene transfection and expression was detected by immunochemical staining, Western blotting and polymerase chain reaction. The role of Rb in suppressing EJ growth was observed by cell-counting, [3H]thymidine incorporation and flow cytometry. The results showed that wild-type Rb gene could be transfected effectively into cultured EJ with Ad-CMVRb and could arrest the cells at GO/Gl phases of the cell cycle, leading to inhibition of DNA synthesis. The results demonstrated the potential of adenovirus-mediated Rb gene therapy for bladder cancer.

为探讨腺病毒载体介导的外源性Rb基因导入对膀胱癌细胞生长的抑制作用,为膀胱癌的基因治疗提供实验依据,构建了Rb基因的复制缺陷型重组腺病毒载体.体外转染人膀胱癌细胞株EJ.应用免疫组化法、免疫印迹及聚合酶链反应技术检测外源性Rb基因腺病毒载体的转染效率及Rb基因表达效果;用流式细胞仪分析细胞周期;以细胞计数及同位素掺入技术观察外源性Rb基因对EJ细胞生长的抑制效果.结果显示腺病毒载体可有效地将外源基因导入EJ细胞.Rb基因重组腺病毒载体转染细胞后,胞内DNA合成减少,细胞生长受到抑制.流式细胞仪分析显示68%的EJ细胞生长停滞在GO/GI期.结果提示,外源性Rb基因重组腺病毒载体转染膀胱癌细胞可有效抑制细胞生长

Objective To test and study the effect of inhibition on the growth of ovarian cancer cell line CAOV3 transfected by the recombinant Rb gene adenovirus vector. Methods The recombinant Rb gene and the LacZ gene in adenovirus vector were constructed and transfected into the CAOV3 cell line separately. The Rb gene expression was detected by immunohistochemical assay and agarose gel electrophoresis,etc. The inhibition on the growth of CAOV3 was tested by flow cytometry and methyl thiazolyl tetrazolium...

Objective To test and study the effect of inhibition on the growth of ovarian cancer cell line CAOV3 transfected by the recombinant Rb gene adenovirus vector. Methods The recombinant Rb gene and the LacZ gene in adenovirus vector were constructed and transfected into the CAOV3 cell line separately. The Rb gene expression was detected by immunohistochemical assay and agarose gel electrophoresis,etc. The inhibition on the growth of CAOV3 was tested by flow cytometry and methyl thiazolyl tetrazolium assay, etc. Results The constructed recombinant Rb gene adenovirus vector could infect cells with high level expression of Rb protein, and Rb cDNA could be found in the transfected cells. The proliferation of transfected CAOV3 cells was inhibited evidently. Sixty eight per cent of cells were arrested at G 0、G 1 phases of cell cycle. Conclusions The recombinant Rb gene adenovirus vector could transform CAOV3 cells efficiently and inhibit CAOV3 cell growth. It might be a new approach of gene therapy for ovarian cancer.

目的 探讨外源性Rb基因对卵巢癌细胞生长的抑制作用 ,为卵巢癌的基因治疗提供实验依据。方法 通过腺病毒介导的Rb基因 ,于体外转染卵巢癌细胞株CAOV3。应用免疫组织化学、DNA琼脂糖电泳等方法 ,检测外源性Rb基因的导入及其表达。通过四甲基偶氮唑蓝比色法及流式细胞术等 ,观察转染Rb基因的CAOV3细胞的生长情况。结果 重组腺病毒载体可有效于体外转染卵巢癌细胞株CAOV3;转染外源性Rb基因后 ,CAOV3细胞内可检测到Rb基因及其蛋白表达 ;CAOV3细胞生长受到抑制 ,约 6 8%的细胞生长停滞于G0 期及G1期。结论 外源性Rb基因可通过腺病毒载体有效转染卵巢癌细胞株CAOV3,抑制CAOV3细胞的生长。

 
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